Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Temporal efficacy of a sulforaphane-based broccoli sprout diet in prevention of breas cancer through modulation of epigenetic mechanismsCancer Prevention Research.  11:451-464. 2018
2018 The effects of combinatorial genistein and sulforaphane in breast tumor inhibition: Role in epigenetic regulationInternational Journal of Molecular Sciences.  19. 2018
2017 Combinatorial bioactive botanicals re-sensitize tamoxifen treatment in ER-negative breast cancer via epigenetic reactivation of ERα expressionScientific Reports.  7. 2017
2017 Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibitionPLoS ONE.  12. 2017
2016 Age-related epigenetic drift and phenotypic plasticity loss: Implications in prevention of age-related human diseasesEpigenomics.  8:1637-1651. 2016
2016 Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicalsEpigenomics.  8:1019-1037. 2016
2014 Impact of epigenetic dietary compounds on transgenerational prevention of human diseasesAAPS Journal.  16:27-36. 2014
2013 Epigallocatechin gallate and sulforaphane combination treatment induce apoptosis in paclitaxel-resistant ovarian cancer cells through hTERT and Bcl-2 down-regulationExperimental Cell Research.  319:697-706. 2013
2013 Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancerMolecular Cancer.  12. 2013
2013 Epigenetic Regulation of Multiple Tumor-Related Genes Leads to Suppression of Breast Tumorigenesis by Dietary GenisteinPLoS ONE.  8. 2013
2013 Analysis of biomarkers of caloric restriction in aging cellsMethods in Molecular Biology.  1048:19-29. 2013
2013 Cell senescence culturing methodsMethods in Molecular Biology.  1048:1-10. 2013
2013 Enhancement of cisplatin-mediated apoptosis in ovarian cancer cells through potentiating G2/M arrest and p21 upregulation by combinatorial epigallocatechin gallate and sulforaphaneJournal of Oncology2013
2012 Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modificationsPLoS ONE.  7. 2012
2012 Epigenetic food: a new approach for cancer prevention and therapy.J. of Nutrition & Food Sciences.  1000E. 2012
2012 Potential of resveratrol in inhibiting cancer and slowing aging.J. of Nutrition & Food Sciences.  S5001. 2012
2011 Combined chromatin immunoprecipitation and bisulfite methylation sequencing analysisMethods in Molecular Biology.  791:239-251. 2011
2011 DNA methylation detection: Bisulfite genomic sequencing analysisMethods in Molecular Biology.  791:11-21. 2011
2011 Epigenetic regulation of caloric restriction in agingBMC Medicine.  9. 2011
2011 Insufficient DNA methylation affects healthy aging and promotes age-related health problemsClinical Epigenetics.  2:349-360. 2011
2011 P16INK4A suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanismsPLoS ONE.  6. 2011
2011 2D difference gel electrophoresis analysis of different time points during the course of neoplastic transformation of human mammary epithelial cellsJournal of Proteome Research.  10:447-458. 2011
2011 A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinomaBMC Cancer.  11. 2011
2010 Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cellsMolecular Cancer.  9. 2010
2010 Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expressionFederation proceedings.  24:1442-1453. 2010
2010 Impact on DNA methylation in cancer prevention and therapy by bioactive dietary componentsCurrent Medicinal Chemistry.  17:2141-2151. 2010
2009 Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanismsInternational Journal of Cancer.  125:286-296. 2009
2009 Strategies targeting telomerase inhibitionMolecular Biotechnology.  41:194-199. 2009
2008 Gene-environment interactions and epigenetic basis of human diseasesCurrent Issues in Molecular Biology.  10:25-36. 2008
2007 ECRG2 inhibits cancer cell migration, invasion and metastasis through the down-regulation of uPA/plasmin activity.Carcinogenesis.  28:2274-2281. 2007
2006 Identification of a novel polymorphism Arg290Gln of esophageal cancer related gene 1 ( ECRG1 ) and its related risk to esophageal squamous cell carcinomaCarcinogenesis.  27:798-802. 2006
2005 Monoclonal antibodies to esophageal cancer-related gene2 proteinHybridoma.  24:86-91. 2005

Chapter

Year Title Altmetric
2015 Transgenerational epigenetic regulation by environmental factors in human diseases.  209-222. 2015
2010 Dietary effect on epigenetics during the aging process.  407-416. 2010

Education And Training

  • Doctor of Philosophy Level Degree in Oncology and Cancer Biology, Peking Union Medical College 2006
  • Full Name

  • Yuanyuan Li