Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Loss of FOXP3 and TSC1 accelerates prostate cancer progression through synergistic transcriptional and posttranslational regulation of c-MycCancer Research.  79:1413-1425. 2019
2018 FOXP3 activates SUMO-conjugating UBC9 gene in MCF7 breast cancer cellsInternational Journal of Molecular Sciences.  19. 2018
2017 MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancerBreast Cancer Research.  19. 2017
2017 CD24 is a genetic modifier for risk and progression of prostate cancerMolecular Carcinogenesis.  56:641-650. 2017
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.Cardiovascular Research.  112:532-542. 2016
2016 Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cellsOncotarget.  7:28935-28946. 2016
2016 Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cellsClinical Cancer Research.  22:2545-2554. 2016
2016 CD24 genetic variants contribute to overall survival in patients with gastric cancerWorld Journal of Gastroenterology.  22:2373-2382. 2016
2016 The Key Regulator for Language and Speech Development, FOXP2, is a Novel Substrate for SUMOylationJournal of Cellular Biochemistry.  117:426-438. 2016
2015 FOXP3 controls an MIR-146/NF-κB negative feedback loop that inhibits apoptosis in breast cancer cellsCancer Research.  75:1703-1713. 2015
2015 FOXP3-MIR-146-NF-κB axis and therapy for precancerous lesions in prostateCancer Research.  75:1714-1724. 2015
2015 Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivationNature Communications.  6. 2015
2015 FOXP3-microRNA-146-NF-κB as oncotargetOncoscience.  2:839-840. 2015
2015 SEMA6D expression and patient survival in breast invasive carcinomaInternational Journal of Breast Cancer.  2015. 2015
2014 SUMOylation of FOXM1B alters its transcriptional activity on regulation of MiR-200 family and JNK1 in MCF7 human breast cancer cellsInternational Journal of Molecular Sciences.  15:10233-10251. 2014
2014 The growth inhibitory effect of 17-DMAG on ALK and MYCN double-positive neuroblastoma cell lineTumor Biology.  35:3229-3235. 2014
2013 Acidic residue Glu199 increases SUMOylation level of nuclear hormone receptor NR5A1International Journal of Molecular Sciences.  14:22331-22345. 2013
2013 IPEX Syndrome, FOXP3 and Cancer.J Syndr.  1. 2013
2013 FOXP3 Regulates Sensitivity of Cancer Cells to Irradiation by Transcriptional Repression of BRCA1Cancer Research.  73:2170-2180. 2013
2013 SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 geneJournal of Cellular Biochemistry.  114:589-598. 2013
2012 Inactivation of X-linked tumor suppressor genes in human cancerFuture Oncology.  8:463-481. 2012
2012 A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosisAmerican Journal of Translational Research.  4:347-356. 2012
2011 FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1.Molecular Cell.  44:770-784. 2011
2011 Identification of a Tumor Suppressor Relay between the FOXP3 and the Hippo Pathways in Breast and Prostate CancersCancer Research.  71:2162-2171. 2011
2010 Association Between Hepatitis B Viral Burden in Chronic Infection and a Functional Single Nucleotide Polymorphism of the PDCD1 GeneJournal of Clinical Immunology.  30:855-860. 2010
2010 Signalling through FOXP3 as an X-linked tumor suppressorThe International journal of biochemistry.  42:1784-1787. 2010
2010 Synergistic Activation of the Mc2r Promoter by FOXL2 and NR5A1 in Mice1Biology of Reproduction.  83:842-851. 2010
2010 X-linked tumor suppressors: perplexing inheritance, a unique therapeutic opportunityTrends in Genetics.  26:260-265. 2010
2009 Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.Cancer Cell.  16:336-346. 2009
2009 Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predispositionProceedings of the National Academy of Sciences.  106:17134-17139. 2009
2009 CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infectionHepatology.  50:735-742. 2009
2009 FOXP3 Up-regulates p21 Expression by Site-Specific Inhibition of Histone Deacetylase 2/Histone Deacetylase 4 Association to the LocusCancer Research.  69:2252-2259. 2009
2008 Laforin Negatively Regulates Cell Cycle Progression through Glycogen Synthase Kinase 3 -Dependent MechanismsMolecular and Cellular Biology.  28:7236-7244. 2008
2007 FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.Cell.  129:1275-1286. 2007
2007 A Dinucleotide Deletion in CD24 Confers Protection against Autoimmune DiseasesPLoS Genetics.  3:e49-e49. 2007
2006 Impact of IGF-I and CYP19 Gene Polymorphisms on the Survival of Patients With Metastatic Prostate CancerJournal of Clinical Oncology.  24:1982-1989. 2006
2005 An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancerBiochemical and Biophysical Research Communications.  331:958-963. 2005
2005 CA repeat polymorphism in the insulin-like growth factor-I gene is associated with increased risk of prostate cancer and benign prostatic hyperplasiaInternational Journal of Oncology2005
2004 Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2: implication for prostate cancer riskProstate Cancer and Prostatic Diseases.  7:333-337. 2004
2004 Clinical characteristics of normotensive renal transplant recipients with microalbuminuria and effects of angiotensin II type I receptor antagonist on urinary albumin excretionInternational Journal of Urology.  11:585-591. 2004
2004 INCREASED RISK OF BLADDER CANCER ASSOCIATED WITH A GLUTATHIONE PEROXIDASE 1 CODON 198 VARIANTJournal of Urology, The.  172:728-732. 2004
2004 Polymorphism within the cyclin D1 gene is associated with an increased risk of carcinoma in situ in patients with superficial bladder cancerUrology.  64:74-78. 2004
2003 Polymorphisms in prostate-specific antigen (PSA) gene, risk of prostate cancer, and serum PSA levels in Japanese populationCancer Letters.  202:53-59. 2003
2003 Increased risk of prostate cancer and benign prostatic hyperplasia associated with transforming growth factor-beta 1 gene polymorphism at codon10Carcinogenesis.  25:237-240. 2003
2002 Cyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancerCarcinogenesis.  23:257-264. 2002
2002 Single Nucleotide Polymorphisms in the 3' Untranslated Region of Vascular Endothelial Growth Factor Gene in Japanese Population with or without Renal Cell Carcinoma.Tohoku Journal of Experimental Medicine.  198:181-190. 2002
FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2Journal of Clinical Investigation

Education And Training

  • Doctor of Science in Urology Residency Program, Akita University 2002
  • Full Name

  • Lizhong Wang