Positions

Overview

  • Lisa M. Schwiebert received a BS degree in Chemistry from Bates College in 1986 and a PhD in Biochemistry from Dartmouth College in 1993. After completing her postdoctoral training in Clinical Immunology at Johns Hopkins University, she was appointed as an instructor in the Department of Medicine at Johns Hopkins University. Dr. Schwiebert joined the faculty of the Department of Physiology and Biophysics at UAB in 1997 as an Assistant Professor and was promoted to Associate Professor with tenure in 2003; she was promoted to Professor in 2013. In 2007, she was appointed Associate Dean for Postdoctoral Education.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2016 Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthmaAJP - Lung Cellular and Molecular Physiology.  310:L328-L336. 2016
    2014 Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airwaysAJP - Lung Cellular and Molecular Physiology.  306. 2014
    2014 Development and maintenance of a biospecimen repository for clinical samples derived from pulmonary patientsClinical and Translational Science.  7:336-341. 2014
    2014 Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsivenessLaboratory Investigation.  94:1312-1325. 2014
    2013 Moderate aerobic exercise alters migration patterns of antigen specific T helper cells within an asthmatic lungBrain, Behavior, and Immunity.  34:67-78. 2013
    2013 Use of the cockroach antigen model of acute asthma to determine the ammunomodulatory role of early exposure to gastrointestinal infectionMethods in Molecular Biology.  1032:271-286. 2013
    2012 Site-specific dynamics of CD11b+ and CD103+ dendritic cell accumulations following ozone exposureAJP - Lung Cellular and Molecular Physiology.  303. 2012
    2012 The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22Journal of Immunology.  189:3653-3660. 2012
    2012 The F508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosaBMC Physiology.  12. 2012
    2012 Feasibility of exercising adults with asthma: a randomized pilot studyAllergy, Asthma & Clinical Immunology.  8. 2012
    2011 Free radical-producing myeloid-derived regulatory cells: Potent activators and suppressors of lung inflammation and airway hyperresponsivenessMucosal Immunology.  4:503-518. 2011
    2011 Postexposure administration of a β2-agonist decreases chlorine-induced airway hyperreactivity in miceAmerican Journal of Respiratory Cell and Molecular Biology.  45:88-94. 2011
    2010 Repeated bouts of moderate-intensity aerobic exercise reduce airway reactivity in a murine asthma modelAmerican Journal of Respiratory Cell and Molecular Biology.  42:243-249. 2010
    2010 Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma modelBrain, Behavior, and Immunity.  24:153-159. 2010
    2009 Epithelial cells as immune effector cells: The role of CD40Seminars in Immunology.  21:289-292. 2009
    2009 Loss of Thy-1 inhibits alveolar development in the newborn mouse lungAJP - Lung Cellular and Molecular Physiology.  296. 2009
    2009 Requisite role for the dectin-1 β-glucan receptor in pulmonary defense against aspergillus fumigatusJournal of Immunology.  182:4938-4946. 2009
    2009 Acute exercise decreases airway inflammation, but not responsiveness, in an allergic asthma modelAmerican Journal of Respiratory Cell and Molecular Biology.  40:83-89. 2009
    2008 SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilationNature Medicine.  14:773-777. 2008
    2008 CD40 ligation decreases its protein half-life at the cell surfaceEuropean Journal of Immunology.  38:864-869. 2008
    2007 Genomics and proteomics of lung disease: Conference summaryAJP - Lung Cellular and Molecular Physiology.  293. 2007
    2006 Perspectives, translational research, and letters to the editorAJP - Lung Cellular and Molecular Physiology.  290. 2006
    2006 A new era of opportunities in lung researchAJP - Lung Cellular and Molecular Physiology.  290. 2006
    2005 RU486 blocks the anti-inflammatory effects of exercise in a murine model of allergen-induced pulmonary inflammationBrain, Behavior, and Immunity.  19:413-422. 2005
    2004 Aerobic Exercise Attenuates Airway Inflammatory Responses in a Mouse Model of Atopic AsthmaJournal of Immunology.  172:4520-4526. 2004
    2004 Cystic fibrosis, gene therapy, and lung inflammation: For better or worse?AJP - Lung Cellular and Molecular Physiology.  286. 2004
    2003 Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipidsAmerican Journal of Physiology - Cell Physiology.  284. 2003
    2003 Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipids.American Journal of Physiology - Cell Physiology.  284:C791-C804. 2003
    2003 Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motifMolecular and Cellular Biology.  23:594-606. 2003
    2002 Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expressionJournal of Biological Chemistry.  277:49952-49957. 2002
    2002 CD40-mediated activation of NF-κB in airway epithelial cellsJournal of Biological Chemistry.  277:37054-37063. 2002
    2002 Enhancement of MHC class II-restricted responses by receptor-mediated uptake of peptide antigensJournal of Immunology.  169:2337-2345. 2002
    2002 Extracellular ATP signaling and P2X nucleotide receptors in monolayers of primary human vascular endothelial cellsAmerican Journal of Physiology - Cell Physiology.  282. 2002
    2002 Extracellular ATP signaling and P2X nucleotide receptors in monolayers of primary human vascular endothelial cells.American Journal of Physiology - Cell Physiology.  282:C289-C301. 2002
    2001 Improved oxygenation promotes CFTR maturation and trafficking in MDCK monolayersAmerican Journal of Physiology - Cell Physiology.  280. 2001
    2001 Cystic Fibrosis Transmembrane Conductance Regulator Facilitates ATP Release by Stimulating a Separate ATP Release Channel for Autocrine Control of Cell Volume RegulationJournal of Biological Chemistry.  276:6621-6630. 2001
    2001 Improved oxygenation promotes CFTR maturation and trafficking in MDCK monolayers.American Journal of Physiology - Cell Physiology.  280:C135-C145. 2001
    2000 Proinflammatory and Th2-derived cytokines modulate CD40-mediated expression of inflammatory mediators in airway epithelia: Implications for the role of epithelial CD40 in airway inflammationJournal of Immunology.  165:2214-2221. 2000
    2000 Differential display analysis of inflammatory genes in airway epithelium.Methods in Molecular Medicine.  44:133-141. 2000
    1999 Nucleotides regulate NaCl transport in mIMCD-K2 cells via P2X and P2Y purinergic receptorsAJP - Renal Physiology.  277. 1999
    1999 Nucleotides regulate NaCl transport in mIMCD-K2 cells via P2X and P2Y purinergic receptors.American Journal of Physiology.  277:F552-F559. 1999
    1999 Chemokine expression in CF epithelia: Implications for the role of CFTR in RANTES expressionAmerican Journal of Physiology - Cell Physiology.  276. 1999
    1999 Cytokine regulation of CC and CXC chemokine expression by human astrocytesJournal of NeuroVirology.  5:82-94. 1999
    1999 Epithelial P2X purinergic receptor channel expression and functionJournal of Clinical Investigation.  104:875-884. 1999
    1998 Characterization of CFTR expression and chloride channel activity in human endotheliaAmerican Journal of Physiology - Cell Physiology.  275. 1998
    1998 Characterization of CFTR expression and chloride channel activity in human endothelia.American Journal of Physiology.  275:C1555-C1564. 1998
    1998 CD40 expression and function in human airway epitheliaFederation proceedings.  12. 1998
    1997 HLA-DRA promoter polymorphism and diversity generation within the immune systemHuman Genetics.  99:801-805. 1997
    1997 Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokinesJournal of Clinical Investigation.  99:926-936. 1997
    1997 Identification of Novel Inducible Genes in Airway EpitheliumAmerican Journal of Respiratory Cell and Molecular Biology.  17:106-113. 1997
    1997 Phenotyping and Cytokine Regulation of the BEAS-2B Human Bronchial Epithelial Cell: Demonstration of Inducible Expression of the Adhesion Molecules VCAM-1 and ICAM-1American Journal of Respiratory Cell and Molecular Biology.  17:571-582. 1997
    1996 The epithelium as a target of glucocorticoid action in the treatment of asthmaAmerican Journal of Respiratory and Critical Care Medicine.  154. 1996
    1996 The epithelium as a target of glucocorticoid action in the treatment of asthma.American Journal of Respiratory and Critical Care Medicine.  154:S16-S19. 1996
    1996 Glucocorticosteroid inhibition of cytokine production: Relevance to antiallergic actionsJournal of Allergy and Clinical Immunology.  97:143-152. 1996
    1995 Modulation of MHC class II expression in human cells by dexamethasoneCellular Immunology.  165:12-19. 1995
    1990 Contact-dependent B-cell activation by helper T cells.Research in immunology.  141:412-417. 1990

    Book

    Year Title Altmetric
    2005 Foreword. Chemokines, Chemokine Receptors,and Disease: A comprehensive view ofchemokine biology.  Ed. 55.  2005

    Research Overview

  • The main focus of the laboratory is to understand the physiologic mechanisms that underlie lung immunity through molecular, whole animal, and translational approaches.

    Airway inflammation; lung function; asthma and exercise
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Dartmouth College 1993
  • Full Name

  • Lisa Schwiebert