Positions

Overview

  • I am a board-certified gynecologic pathologist with 21-year expertise in light-, immunofluorescence-, and high-resolution confocal-microscopy. I work as a staff pathologist at the UAB hospital and examine surgical tissues and provide the diagnoses. In my research projects, I have been involved in numerous collaborative studies and evaluated human, mouse and rat tissues. Pathologic findings have ranged from bacterial and viral infection, immune complex deposition and histopathology of female reproductive organs ranging from precancerous lesions to invasive carcinoma. My role in these studies was to review the protocols for immunofluorescence and immunohistochemical staining, perform tissue processing and embedding, and imaging studies using laser scanning confocal microscopy. My previous experience involved human islet cells isolation and pre-transplant preparation, pump perfusion of rat kidney and heart, quantification of extracellular matrix in kidney and heart, acute and chronic renal rejection, and HIV virion identification in the intestinal tissue. Most recently, I evaluated a passive mouse model of IgA nephropathy using image analysis with morphometric, densitometric, and co-localization studies.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Treatment of low-grade endometrial stromal sarcoma in a nulligravid woman.Gynecologic Oncology.  151:6-9. 2018
    2018 Molecular Response to Neoadjuvant Chemotherapy in High-Grade Serous Ovarian Carcinoma.Cell Growth and Differentiation.  16:813-824. 2018
    2018 Severity and properties of cardiac damage caused by Streptococcus pneumoniae are strain dependent.PLoS ONE.  13:e0204032. 2018
    2017 A Case of a Chorionic Bump: New Sonographic-Histopathologic Findings With Review of the Literature.Journal of Ultrasound in Medicine.  36:1968-1970. 2017
    2017 Malignant Brenner tumor associated with a germline BRCA2 mutation.Gynecologic Oncology Reports.  21:17-19. 2017
    2016 First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics.Journal of Acquired Immune Deficiency Syndromes.  73:489-496. 2016
    2016 PcpA Promotes Higher Levels of Infection and Modulates Recruitment of Myeloid-Derived Suppressor Cells during Pneumococcal Pneumonia.Journal of Immunology.  196:2239-2248. 2016
    2015 New Insights into the Pathogenesis of IgA Nephropathy.Kidney Diseases.  1:8-18. 2015
    2015 The Effects of CFTR and Mucoid Phenotype on Susceptibility and Innate Immune Responses in a Mouse Model of Pneumococcal Lung Disease.PLoS ONE.  10:e0140335. 2015
    2014 Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responses.Journal of Immunology.  193:5604-5612. 2014
    2014 Vaginal myeloid dendritic cells transmit founder HIV-1.Journal of Virology.  88:7683-7688. 2014
    2014 Obesity is associated with higher 4E-BP1 expression in endometrial cancer.Current Biomarker Findings.  2014:1-7. 2014
    2014 Extramedullary hematopoiesis in uterine leiomyoma associated with numerous intravascular thrombi.Case Reports in Pathology.  2014:957395. 2014
    2013 IgA nephropathy: molecular mechanisms of the disease.Annual Review of Pathology: Mechanisms of Disease.  8:217-240. 2013
    2012 Erratum: Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy (Journal of Clinical Investigation (2011) 121, 10 (3991-4002) DOI: 10.1172/JCI45563)Journal of Clinical Investigation.  122:778. 2012
    2011 IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells.Nephrology Dialysis Transplantation.  26:3451-3457. 2011
    2011 Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy.Journal of Clinical Investigation.  121:3991-4002. 2011
    2011 Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages.PLoS Pathogens.  7:e1002060. 2011
    2010 Impact of a weekly multidisciplinary tumor board conference on the management of women with gynecologic malignancies.International Journal of Gynecological Cancer.  20:1321-1325. 2010
    2010 Juxtatumoral stromal reactions in uterine endometrioid adenocarcinoma and their prognostic significance.International Journal of Gynecologic Pathology.  29:562-567. 2010
    2010 Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation.Journal of Biological Chemistry.  285:19593-19604. 2010
    2010 Human primary gastric dendritic cells induce a Th1 response to H. pylori.Mucosal Immunology.  3:260-269. 2010
    2010 Dendritic cells transmit HIV-1 through human small intestinal mucosa.Journal of Leukocyte Biology.  87:663-670. 2010
    2009 p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia.Journal of Lower Genital Tract Disease.  13:145-153. 2009
    2009 Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection.Journal of Virology.  83:3258-3267. 2009
    2008 Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses.Vaccine.  26:1541-1551. 2008
    2008 Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts.Circulation Research.  102:185-192. 2008
    2008 Helicobacter pylori gastritis in children is associated with a regulatory T-cell response.Gastroenterology.  134:491-499. 2008
    2008 IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1.Journal of Clinical Investigation.  118:629-639. 2008
    2008 Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy.Kidney and Blood Pressure Research.  31:29-37. 2008
    2007 Genistein attenuates the hypertensive effects of dietary NaCl in hypertensive male rats.Endocrinology.  148:5396-5402. 2007
    2007 Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation.AJP - Heart and Circulatory Physiology.  292:H2607-H2612. 2007
    2007 Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast disease.American Journal of Pathology.  170:1064-1076. 2007
    2007 ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells.Journal of applied physiology: respiratory, environmental and exercise physiology.  102:390-398. 2007
    2006 A prospective blinded evaluation of the accuracy of frozen section for the surgical management of endometrial cancer.Obstetrics and Gynecology.  108:1375-1379. 2006
    2006 Cytomegalovirus blocks intestinal stroma-induced down-regulation of macrophage HIV-1 infection.Journal of Leukocyte Biology.  80:1111-1117. 2006
    2006 Recurrence of endometrial adenocarcinoma in a prior Bartholin's cyst marsupialization incision.Gynecologic Oncology.  103:749-751. 2006
    2006 Mucosal IL-8 and TGF-beta recruit blood monocytes: evidence for cross-talk between the lamina propria stroma and myeloid cells.Journal of Leukocyte Biology.  80:492-499. 2006
    2005 Nasal colonization with Streptococcus pneumoniae includes subpopulations of surface and invasive pneumococci.Infection and Immunity.  73:6945-6951. 2005
    2005 IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells.Kidney International.  67:504-513. 2005
    2004 AL-amyloidosis is underdiagnosed in renal biopsies.Nephrology Dialysis Transplantation.  19:3050-3053. 2004
    2004 Estradiol and progestins differentially modulate leukocyte infiltration after vascular injury.Circulation.  109:234-241. 2004
    2003 Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae.Journal of Infectious Diseases.  188:339-348. 2003
    2003 Mitochondrial targets of oxidative stress during renal ischemia/reperfusion.Archives of Biochemistry and Biophysics.  412:27-33. 2003
    2003 Multiple Langerhans cell nodules in an incidental thymectomy.Archives of Pathology and Laboratory Medicine.  127:218-220. 2003
    2002 Interactions of human mesangial cells with IgA and IgA-containing immune complexes.Kidney International.  62:465-475. 2002
    1997 Transposon mutagenesis: Cloning of chromosomal DNA from the site of Tn916 insertion using polymerase chain reactionBiotechnology Letters.  11:51-54. 1997

    Research Overview

  • My research is based on projects which require histopathologic evaluation of the tissue and cells, light and confocal microscopy and image analysis.The most important manuscripts are concerning IgA nephropathy and gynecologic diseases
  • Teaching Overview

  • 2003 - Present: Resident and fellow teaching 2003 - Present: Gynecologic Oncology Tumor Board 2008 - 2014: Module Director, Reproductive Systems, UASOM 2014 - Present: Reproductive module, small groups
  • Education And Training

  • Doctor of Medicine, Charles University in Prague
  • Full Name

  • Lea Novak
  • Blazerid

  • lnovak