Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease.BBA - Molecular Basis of Disease.  1863:1157-1170. 2017
2015 Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.PLoS Genetics.  11:e1005290. 2015
2015 Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction.Molecular Neurodegeneration.  10:3. 2015
2015 Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14.Frontiers in Molecular Neuroscience.  8:11. 2015
2014 A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.Journal of Physiology.  592:571-586. 2014
2013 The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formationLearning and Memory.  21:748-752. 2013
2013 Neuronal ubiquitin homeostasis.Cell Biochemistry and Biophysics.  67:67-73. 2013
2013 Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14).PLoS ONE.  8:e84042. 2013
2012 Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14American Journal of Physiology - Cell Physiology.  302:C698-C708. 2012
2012 Usp14 deficiency increases tau phosphorylation without altering tau degradation or causing tau-dependent deficits.PLoS ONE.  7:e47884. 2012
2011 Ubiquitin homeostasis is critical for synaptic development and function.Journal of Neuroscience.  31:17505-17513. 2011
2010 Enhancement of proteasome activity by a small-molecule inhibitor of USP14.Nature.  467:179-184. 2010
2009 The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions.Journal of Neuroscience.  29:10909-10919. 2009
2009 The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice.PLoS Genetics.  5:e1000631. 2009
2009 Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1Journal of Neuroscience.  29:7857-7868. 2009
2009 Transgenic rescue of ataxia mice reveals a male-specific sterility defect.Developmental Biology.  325:33-42. 2009
2008 Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.Molecular and Cellular Neuroscience.  39:539-548. 2008
2008 Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.Molecular Brain.  1:17. 2008
2006 Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14.Journal of Neuroscience.  26:11423-11431. 2006
2005 Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice.Journal of Neurochemistry.  95:724-731. 2005
2003 Neurological disease: UPS stops delivering!Trends in Pharmacological Sciences.  24:18-23. 2003
2002 Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease.Nature Genetics.  32:420-425. 2002
2002 Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export.EMBO Journal.  21:1800-1810. 2002
2001 Mutations in Cdh23 Cause Nonsyndromic Hearing Loss in waltzer MiceGenomics.  74:228-233. 2001
2001 Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activityFederation proceedings.  15:1288-1290. 2001
2000 A mutation in Rab27a causes the vesicle transport defects observed in ashen miceProceedings of the National Academy of Sciences.  97:7933-7938. 2000
2000 A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase IIGenetics.  154:557-571. 2000
2000 The status of voltage-dependent calcium channels in alpha 1E knock-out miceJournal of Neuroscience.  20:8566-8571.. 2000
1994 Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiaeJournal of Cell Biology.  127:1173-1184. 1994
1993 NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability.Molecular and Cellular Biology.  13:2730-2741. 1993
1992 Legionella pneumophilia infection and cytokine productionAdvances in Experimental Medicine and Biology.  319. 1992

Teaching Activities

  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2017) 2017
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2017) 2017
  • NBL240 - Special Topics Neuroscience 3 (Spring Term 2017) 2017
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2017) 2017
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2017) 2017
  • NBL399 - Senior Seminar in Neuroscience (Spring Term 2017) 2017
  • NBL401 - Collo in Basic Cog & Clin Neur (Spring Term 2017) 2017
  • NBL773 - Neuronal Signaling JC (Spring Term 2017) 2017
  • PY401 - Neuroscience Seminar (Spring Term 2017) 2017
  • STH201 - Research Approaches (Spring Term 2017) 2017
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2016) 2016
  • NBL399 - Senior Seminar in Neuroscience (Fall Term 2016) 2016
  • NBL399 - Senior Seminar in Neuroscience (Fall Term 2016) 2016
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2016) 2016
  • NBL399 - Senior Seminar in Neuroscience (Spring Term 2016) 2016
  • NBL399 - Senior Seminar in Neuroscience (Spring Term 2016) 2016
  • NBL773 - Neuronal Signaling JC (Spring Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2015) 2015
  • NBL399 - Senior Seminar in Neuroscience (Fall Term 2015) 2015
  • GBS784 - STEM CELL BIOLOGY (Spring Term 2015) 2015
  • NBL773 - Neuronal Signaling JC (Spring Term 2015) 2015
  • GBS791 - GRADUATE NEUROSCIENCE DISCUSSION (Spring Term 2013) 2013
  • GBS791 - Grad Neuro Discussion (Spring Term 2012) 2012
  • NBL712 - Graduate Medical Neuroscience (Spring Term 2011) 2011
  • GBS732 - GRADUATE NEUROSCIENCE DISCUSSION (Spring Term 2011) 2011
  • NBL712 - Graduate Medical Neuroscience (Spring Term 2010) 2010
  • NEUR725 - Grd Neur Dicussion (Spring Term 2010) 2010
  • NBL725 - Sem Practice in Cell Mol Neuro (Fall Term 2009) 2009
  • CMB790 - CMB Laboratory Methods (Spring Term 2009) 2009
  • NEUR708 - Laboratory Methods (Spring Term 2009) 2009
  • CMB790 - CMB Laboratory Methods (Fall Term 2008) 2008
  • CMB790 - CMB Laboratory Methods (Spring Term 2008) 2008
  • CMB790 - CMB Laboratory Methods (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Genetics, University of Florida
  • Full Name

  • Scott Wilson
  • Blazerid

  • livvy01