Selected Publications

Academic Article

Year Title Altmetric
2017 The therapeutic potential of CFTR modulators for COPD and other airway diseases.Current Opinion in Pharmacology.  34:132-139. 2017
2017 Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.AJP - Heart and Circulatory Physiology.  313:H32-H45. 2017
2016 Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload.Journal of Molecular and Cellular Cardiology.  92:1-9. 2016
2016 A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator.Federation proceedings.  30:201-213. 2016
2016 Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator.Cellular and Molecular Biology Letters.  21:23. 2016
2015 Volume overload induces autophagic degradation of procollagen in cardiac fibroblasts.Journal of Molecular and Cellular Cardiology.  89:241-250. 2015
2015 Characterization of intracellular aggresomes by fluorescent microscopy.Methods in Molecular Biology.  1258:307-317. 2015
2015 ΔF508 CFTR surface stability is regulated by DAB2 and CHIP-mediated ubiquitination in post-endocytic compartments.PLoS ONE.  10:e0123131. 2015
2014 Rescuing ΔF508 CFTR with trimethylangelicin, a dual-acting corrector and potentiator.AJP - Lung Cellular and Molecular Physiology.  307:L431-L434. 2014
2013 The silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunction.Federation proceedings.  27:4630-4645. 2013
2012 Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator.Biochemical Journal.  441:633-643. 2012
2011 ARFGAP1 promotes AP-2-dependent endocytosis.Nature Cell Biology.  13:559-567. 2011
2011 CFTR expression regulation by the unfolded protein response.Methods in Enzymology.  491:3-24. 2011
2011 Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia.Neurobiology of Disease.  41:11-22. 2011
2010 Targets for cystic fibrosis therapy: proteomic analysis and correction of mutant cystic fibrosis transmembrane conductance regulator.Expert Review of Proteomics.  7:495-506. 2010
2009 ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy.Cytobiologie.  88:215-226. 2009
2005 Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein.Neurobiology of Disease.  20:656-665. 2005
2005 Nuclear aggresomes form by fusion of PML-associated aggregates.Cell regulation.  16:4905-4917. 2005
2004 The Ca2+ homeostasis defects in a pgm2Delta strain of Saccharomyces cerevisiae are caused by excessive vacuolar Ca2+ uptake mediated by the Ca2+-ATPase Pmc1p.Journal of Biological Chemistry.  279:38495-38502. 2004
2003 Traffic-independent function of the Sar1p/COPII machinery in proteasomal sorting of the cystic fibrosis transmembrane conductance regulator.Journal of Cell Biology.  160:157-163. 2003
2002 Intracellular glucose 1-phosphate and glucose 6-phosphate levels modulate Ca2+ homeostasis in Saccharomyces cerevisiae.Journal of Biological Chemistry.  277:45751-45758. 2002
2000 Loss of the major isoform of phosphoglucomutase results in altered calcium homeostasis in Saccharomyces cerevisiae.Journal of Biological Chemistry.  275:5431-5440. 2000
1999 The vacuolar Ca2+/H+ exchanger Vcx1p/Hum1p tightly controls cytosolic Ca2+ levels in S. cerevisiae.FEBS Letters.  451:132-136. 1999
1999 The Golgi apparatus plays a significant role in the maintenance of Ca2+ homeostasis in the vps33Delta vacuolar biogenesis mutant of Saccharomyces cerevisiae.Journal of Biological Chemistry.  274:5939-5947. 1999
1995 The efficiency of translation termination is determined by a synergistic interplay between upstream and downstream sequences in Saccharomyces cerevisiae.Journal of Molecular Biology.  251:334-345. 1995
1995 The posttranslational modification of phosphoglucomutase is regulated by galactose induction and glucose repression in Saccharomyces cerevisiae.Journal of Bacteriology.  177:3087-3094. 1995

Education And Training

  • Bachelor of Science or Mathematics in Biochemistry, Foreign University
  • Doctor of Philosophy in Microbiology, University of Alabama at Birmingham
  • Full Name

  • Lianwu Fu