Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Chymase uptake by cardiomyocytes results in myosin degradation in cardiac volume overloadHeliyon.  5. 2019
2017 The therapeutic potential of CFTR modulators for COPD and other airway diseasesCurrent Opinion in Pharmacology.  34:132-139. 2017
2017 Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failureAJP - Heart and Circulatory Physiology.  313:H32-H45. 2017
2016 Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulatorCellular and Molecular Biology Letters.  21. 2016
2016 Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overloadJournal of Molecular and Cellular Cardiology.  92:1-9. 2016
2016 A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulatorFederation proceedings.  30:201-213. 2016
2015 Volume overload induces autophagic degradation of procollagen in cardiac fibroblastsJournal of Molecular and Cellular Cardiology.  89:241-250. 2015
2015 ▵F508 CFTR surface stability is regulated by DAB2 and CHIP-mediated ubiquitination in post-endocytic compartmentsPLoS ONE.  10. 2015
2015 Characterization of intracellular aggresomes by fluorescent microscopyMethods in Molecular Biology.  1258:307-317. 2015
2014 Rescuing ΔF508 CFTR with trimethylangelicin, A dual-acting corrector and potentiatorAJP - Lung Cellular and Molecular Physiology.  307:L431-L434. 2014
2013 The silent codon change I507-ATC→ATT contributes to the severity of the AF508 CFTR channel dysfunctionFederation proceedings.  27:4630-4645. 2013
2012 Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulatorBiochemical Journal.  441:633-643. 2012
2011 ARFGAP1 promotes AP-2-dependent endocytosisNature Cell Biology.  13:559-567. 2011
2011 CFTR expression regulation by the unfolded protein responseMethods in Enzymology.  491:3-24. 2011
2011 Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and AtaxiaNeurobiology of Disease.  41:11-22. 2011
2010 Targets for cystic fibrosis therapy: Proteomic analysis and correction of mutant cystic fibrosis transmembrane conductance regulatorExpert Review of Proteomics.  7:495-506. 2010
2009 ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagyCytobiologie.  88:215-226. 2009
2005 Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine proteinNeurobiology of Disease.  20:656-665. 2005
2005 Nuclear aggresomes form by fusion of PML-associated aggregatesCell regulation.  16:4905-4917. 2005
2004 The Ca2+ homeostasis defects in a pgm2Δ strain of Saccharomyces cerevisiae are caused by excessive vacuolar Ca2+ uptake mediated by the Ca2+-ATPase Pmc1pJournal of Biological Chemistry.  279:38495-38502. 2004
2003 Traffic-independent function of the Sar1p/COPII machinery in proteasomal sorting of the cystic fibrosis transmembrane conductance regulatorJournal of Cell Biology.  160:157-163. 2003
2002 Intracellular glucose 1-phosphate and glucose 6-phosphate levels modulate Ca2+ homeostasis in Saccharomyces cerevisiaeJournal of Biological Chemistry.  277:45751-45758. 2002
2000 Loss of the major isoform of phosphoglucomutase results in altered calcium homeostasis in Saccharomyces cerevisiaeJournal of Biological Chemistry.  275:5431-5440. 2000
1999 The vacuolar Ca2+/H+ exchanger Vcx1p/Hum1p tightly controls cytosolic Ca2+ levels in S. cerevisiaeFEBS Letters.  451:132-136. 1999
1999 The Golgi apparatus plays a significant role in the maintenance of Ca2+ homeostasis in the vps33Δ vacuolar biogenesis mutant of saccharomyces cerevisiaeJournal of Biological Chemistry.  274:5939-5947. 1999
1995 The efficiency of translation termination is determined by a synergistic interplay between upstream and downstream sequences in Saccharomyces cerevisiaeJournal of Molecular Biology.  251:334-345. 1995
1995 The posttranslational modification of phosphoglucomutase is regulated by galactose induction and glucose repression in Saccharomyces cerevisiaeJournal of Bacteriology.  177:3087-3094. 1995

Education And Training

  • Doctor of Philosophy in Microbiology, University of Alabama at Birmingham 1999
  • Bachelor of Science or Mathematics in Biochemistry, 1988
  • Full Name

  • Lianwu Fu