Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90Scientific Reports.  12. 2022
2020 Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological studyNature Communications.  11. 2020
2018 Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tauJAMA Neurology.  75:989-998. 2018
2017 Transethnic genome-wide scan identifies novel Alzheimer's disease lociAlzheimer's and Dementia.  13:727-738. 2017
2016 Assessment of the genetic variance of late-onset Alzheimer's diseaseNeurobiology of Aging.  41:200.e13-200.e20. 2016
2016 Alzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 lociPLoS One.  11. 2016
2015 Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analysesAlzheimer's and Dementia.  11:1439-1451. 2015
2015 Association of long runs of homozygosity with Alzheimer disease among African American individualsJAMA Neurology.  72:1313-1323. 2015
2015 Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization StudyPLoS Medicine.  12. 2015
2015 Rarity of the alzheimer disease-protective APP A673T variant in the United StatesJAMA Neurology.  72:209-216. 2015
2014 Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: A genome-wide association studyJAMA Neurology.  71:1394-1404. 2014
2014 Latent information in fluency lists predicts functional decline in persons at risk for Alzheimer diseaseCortex.  55:202-218. 2014
2013 Lower hippocampal volume predicts decrements in lane control among drivers with amnestic mild cognitive impairmentJournal of Geriatric Psychiatry and Neurology.  26:259-266. 2013
2013 MRI volume of the medial frontal cortex predicts financial capacity in patients with mild Alzheimer's disease 2013
2011 Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's diseaseNature Genetics.  43:436-443. 2011
2010 Brain metabolic vorrelates of decision making in amnestic mild cognitive impairment 2010
2010 Magnetic resonance imaging volume of the angular gyri predicts financial skill deficits in people with amnestic mild cognitive impairmentJournal of the American Geriatrics Society.  58:265-274. 2010
2009 Neurocognitive predictors of financial capacity across the dementia spectrum: Normal aging, mild cognitive impairment, and Alzheimer's diseaseJournal of the International Neuropsychological Society.  15:258-267. 2009
2009 Clinical interview assessment of financial capacity in older adults with mild cognitive impairment and Alzheimer's diseaseJournal of the American Geriatrics Society.  57:806-814. 2009
2009 Declining financial capacity in mild cognitive impairment: A 1-year longitudinal studyNeurology.  73:928-934. 2009
2008 Medical decision-making capacity in mild cognitive impairment: A 3-year longitudinal studyNeurology.  71:1474-1480. 2008
2008 Medical decision-making capacity in cognitively impaired Parkinson's disease patients without dementiaMovement Disorders.  23:1867-1874. 2008
2008 Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) with Alzheimer's diseaseAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics.  147:363-369. 2008
2008 Cognitive models of medical decision-making capacity in patients with mild cognitive impairmentJournal of the International Neuropsychological Society.  14:297-308. 2008
2008 Hemoglobin binding to Aβ and HBG2 SNP association suggest a role in Alzheimer's diseaseNeurobiology of Aging.  29:185-193. 2008
2008 Awareness of deficits in financial abilities in patients with mild cognitive impairment: Going beyond self-informant discrepancyAmerican Journal of Geriatric Psychiatry.  16:650-659. 2008
2008 Candidate gene discovery procedure after follow-up confirmatory analyses of candidate regions of interests for Alzheimer's disease in the NIMH sibling datasetDisease Markers.  24:293-309. 2008
2008 Declining financial capacity in patients with mild Alzheimer disease: A one-year longitudinal studyAmerican Journal of Geriatric Psychiatry.  16:209-219. 2008
2007 Elevated brain scyllo-inositol concentrations in patients with Alzheimer's diseaseNMR in Biomedicine.  20:709-716. 2007
2007 Medical decision-making capacity in patients with mild cognitive impairmentNeurology.  69:1528-1535. 2007
2007 Executive function is associated with brain proton magnetic resonance spectroscopy in amnestic mild cognitive impairmentJournal of Clinical and Experimental Neuropsychology.  29:599-609. 2007
2007 Effects of chronic stress and interleukin-10 gene polymorphisms on antibody response to tetanus vaccine in family caregivers of patients with Alzheimer's diseasePsychosomatic Medicine.  69:551-559. 2007
2007 Brain proton mrs is correlated with financial abilities in patients with Alzheimer's disease 2007
2007 Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease genetics initiative cohortAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics.  144:220-227. 2007
2007 A polymorphism in SOD2 is associated with development of Alzheimer's diseaseGenes, Brain and Behavior.  6:770-776. 2007
2006 Declining medical decision-making capacity in mild AD: A two-year longitudinal studyBehavioral Sciences and the Law.  24:453-463. 2006
2006 Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses 2006
2006 Amnestic mild cognitive impairment: Diagnostic outcomes and clinical prediction over a two-year time periodJournal of the International Neuropsychological Society.  12:166-175. 2006
2005 Medical decision-making in neurodegenerative disease: Mild AD and PD with cognitive impairmentNeurology.  65:483-485. 2005
2005 Pro- and anti-apoptotic evidence for cholinergic denervation and hippocampal sympathetic ingrowth in rat dorsal hippocampusExperimental Neurology.  194:182-190. 2005
2005 Gender differences in glutathione metabolism in Alzheimer's diseaseJournal of Neuroscience Research.  79:861-867. 2005
2005 The effect of central cholinergic and noradrenergic denervation on hippocampal sympathetic ingrowth and apoptosis-like reactivity in the ratBrain Research.  1033:68-77. 2005
2004 Medical Comorbidity in Black and White Patients with Alzheimer's DiseaseSouthern Medical Journal.  97:2-6. 2004
2003 Loss of Calculation Abilities in Patients with Mild and Moderate Alzheimer DiseaseJAMA Neurology.  60:1585-1589. 2003
2003 Self- and Informant Report of Financial Abilities in Patients with Alzheimer's Disease: Reliable and Valid?Journal of the American Geriatrics Society.  51:1621-1626. 2003
2003 Impaired financial abilities in mild cognitive impairment: A direct assessment approachNeurology.  60:449-457. 2003
2003 Results of a high-resolution genome screen of 437 Alzheimer's Disease familiesHuman Molecular Genetics.  12:23-32. 2003
2001 Hippocampal sympathetic ingrowth occurs following 192-IgG-Saporin administrationBrain Research.  911:158-162. 2001
2001 Investigation of association of 13 polymorphisms in eight genes in southeastern African American Alzheimer disease patients as compared to age-matched controlsAmerican Journal of Medical Genetics Part A.  105:332-342. 2001
2001 Competency to consent to medical treatment in cognitively impaired patients with Parkinson's diseaseNeurology.  56:17-24. 2001
2001 Loss of financial capacity in Alzheimer's disease: The role of working memory 2001
2000 Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: The NIMH Alzheimer disease genetics initiativeAmerican Journal of Medical Genetics Part A.  96:823-830. 2000
2000 Apoptotic protein expression and activation of caspases is changed following cholinergic denervation and hippocampal sympathetic ingrowth in rat hippocampusNeuroscience.  101:541-546. 2000
2000 The severe mini-mental state examination: A new neuropsychologic instrument for the bedside assessment of severely impaired patients with Alzheimer diseaseAlzheimer Disease and Associated Disorders.  14:168-175. 2000
2000 Effect of phospholipase C and protein kinase C following cholinergic denervation and hippocampal sympathetic ingrowth in rat hippocampusNeuroscience.  99:25-31. 2000
2000 Assessing financial capacity in patients with Alzheimer disease: A conceptual model and prototype instrumentJAMA Neurology.  57:877-884. 2000
2000 Cognitive models of physicians' legal standard and personal judgments of competency in patients with Alzheimer's diseaseJournal of the American Geriatrics Society.  48:919-927. 2000
2000 Consistency of physicians' legal standard and personal judgments of competency in patients with Alzheimer's diseaseJournal of the American Geriatrics Society.  48:911-918. 2000
2000 Densitometric analysis of G(αo) protein subunit levels from postmortem Alzheimer disease hippocampal and prefrontal cortical membranesAlzheimer Disease and Associated Disorders.  14:53-57. 2000
2000 Differential automatic processing deficits in early stage Alzheimer's disease 2000
2000 Effects of pertussis toxin and Gα-protein-specific antibodies on phosphoinositide hydrolysis in rat brain membranes after cholinergic denervation and hippocampal sympathetic ingrowthExperimental Neurology.  161:724-732. 2000
2000 Longitudinal course of behavioral problems during Alzheimer's disease: Linear versus curvilinear patterns of decline 2000
1999 Error behaviors associated with loss of competency in Alzheimer's diseaseNeurology.  53:1983-1992. 1999
1999 Factor structure of capacity to consent to medical treatment in patients with alzheimer's disease: An Exploratory StudyJournal of Forensic Neuropsychology.  1:27-48. 1999
1999 A method for assessing clinically relevant individual cognitive change in older adult populations 1999
1999 Executive dysfunction and loss of capacity to consent to medical treatment in patients with Alzheimer's disease.Seminars in clinical neuropsychiatry.  4:41-49. 1999
1998 Polymorphic tetranucleotide repeat site within intron 7 of the β-amyloid precursor protein gene and its lack of association with Alzheimer's diseaseHuman Genetics.  103:86-89. 1998
1998 In replyJournal of the American Geriatrics Society.  46:250-251. 1998
1997 Cholinergic activity and amyloid precursor protein metabolismBrain Research Reviews.  25:50-69. 1997
1997 Cholinergic denervation and sympathetic ingrowth result in persistent changes in hippocampal muscarinic receptorsNeuroscience.  80:413-418. 1997
1997 Effect of hippocampal sympathetic ingrowth and cholinergic denervation on hippocampal phospholipase C activity and G-protein functionNeuroscience.  77:111-120. 1997
1997 ApoE-4 and age at onset of Alzheimer's disease: The NIMH genetics initiativeNeurology.  48:139-147. 1997
1997 Cognitive models that predict physician judgments of capacity to consent in mild Alzheimer's diseaseJournal of the American Geriatrics Society.  45:458-464. 1997
1997 Consistency of physician judgments of capacity to consent in mild Alzheimer's diseaseJournal of the American Geriatrics Society.  45:453-457. 1997
1997 Development and validation of a structured telephone interview for dementia assessment (STIDA): The NIMH genetics initiativeJournal of Geriatric Psychiatry and Neurology.  10:161-167. 1997
1997 Gender roles and caregiving stress: An examination of subjective appraisals of specific primary stressors in Alzheimer's caregiversAging and Mental Health.  1:158-165. 1997
1997 Knowledge about Alzheimer disease among primary care physicians, psychologists, nurses, and social workersAlzheimer Disease and Associated Disorders.  11:99-106. 1997
1997 Magnetic resonance cisternography in the diagnosis of delayed iatrogenic cerebrospinal fistula: A case reportJournal of Neuroimaging.  7:244-247. 1997
1997 Regional stability of cerebral blood flow measured by repeated technetium-99m-HMPAO SPECT: Implications for the study of state-dependent changeJournal of Nuclear Medicine.  38:6-13. 1997
1997 Subscale validity of the Mattis Dementia Rating ScaleArchives of Clinical Neuropsychology.  12:269-275. 1997
1996 Sympathetic sprouting reverses decreases in membrane-associated activity of protein kinase C following septohippocampal denervation of the rat hippocampusBrain Research.  708:205-208. 1996
1996 A multicenter double-blind study of controlled-release physostigmine for the treatment of symptoms secondary to Alzheimer's diseaseNeurology.  47:1389-1395. 1996
1996 Association between Alzheimer's disease and bound autochthonous IgM on T cellsJournal of the American Geriatrics Society.  44:1362-1365. 1996
1996 Decision-Making Capacity-ReplyJAMA Neurology.  53:589-590. 1996
1996 The consortium to establish a registry for Alzheimer's disease (CERAD). Part XIII. Obtaining autopsy in Alzheimer's diseaseNeurology.  46:142-145. 1996
1996 Toward a neurologic model of competency: Cognitive predictors of capacity to consent in Alzheimer's disease using three different legal standardsNeurology.  46:666-672. 1996
1996 Utility of Mini-Mental State Exam scores in predicting functional impairment among White and African American dementia patients 1996
1995 The effect of hippocampal sympathetic ingrowth and cholinergic denervation on hippocampal M2 cholinergic receptorsBrain Research.  684:201-205. 1995
1995 Hippocampal sympathetic ingrowth and cholinergic denervation uniquely alter muscarinic receptor subtypes in the hippocampusBrain Research.  676:386-393. 1995
1995 The effect of cholinergic denervation and hippocampal sympathetic ingrowth on the internalization of muscarinic receptors in rat hippocampusBrain Research.  676:394-397. 1995
1995 Assessing the Competency of Patients with Alzheimer's Disease Under Different Legal Standards: A Prototype InstrumentJAMA Neurology.  52:949-954. 1995
1995 Neuropsychologic Predictors of Competency in Alzheimer's Disease using a Rational Reasons Legal StandardJAMA Neurology.  52:955-959. 1995
1995 Neuropsychological test performance in african-american And white patients with alzheimer's diseaseNeurology.  45:2207-2211. 1995
1995 Psychological, Social, and Health Impact of Caregiving: A Comparison of Black and White Dementia Family Caregivers and NoncaregiversPsychology and Aging.  10:540-552. 1995
1995 Relationship between level of insight and severity of dementia in Alzheimer diseaseAlzheimer Disease and Associated Disorders.  9:101-104. 1995
1995 SSCP analysis and sequencing of the human prion protein gene (PRNP) detects two different 24 bp deletions in an atypical Alzheimer's disease familyAmerican Journal of Medical Genetics Part A.  60:12-18. 1995
1994 Determining the competency of Alzheimer patients to consent to treatment and researchAlzheimer Disease and Associated Disorders.  8:5-18. 1994
1994 Hippocampal sympathetic ingrowth and cholinergic denervation alter hippocampal muscarinic cholinergic receptors 1994
1994 Reliability and Validity of Nincds-Adrda Criteria for Alzheimer's Disease: The National Institute of Mental Health Genetics InitiativeJAMA Neurology.  51:1198-1204. 1994
1993 Female circulating sex hormones and hippocampal sympathetic ingrowthBehavioural Brain Research.  55:29-38. 1993
1993 Autopsy in dementing illness: Who participates?Alzheimer Disease and Associated Disorders.  7:80-87. 1993
1993 Recruitment of black elderly for clinical research studies of dementia: The CERAD experienceGerontologist.  33:561-565. 1993
1992 Cholinergic denervation alters [3H]phorbol-12,13-dibutyrate binding to rat hippocampal membranesBrain Research.  587:343-347. 1992
1992 Focal Cognitively Mediated Blood-Flow Activation in Alzheimer's Disease PatientsNeuropsychology.  6:137-148. 1992
1992 Hippocampal phosphoinositide turnover is altered by hippocampal sympathetic ingrowth and cholinergic denervation 1992
1991 Alzheimer’s diseaseSouthern Medical Journal.  84:32-40. 1991
1991 Interaction of neurotransmitter systems in the hippocampus: A study of some behavioral effects of hippocampal sympathetic ingrowth 1991
1991 Paraneoplastic vasculitic neuropathy: A treatable neuropathyMuscle and Nerve.  14:152-156. 1991
1991 The Clinical Validity of the Mattis Dementia Rating Scale in Staging Alzheimer's DementiaJournal of Geriatric Psychiatry and Neurology.  4:18-25. 1991
1991 The Relationship of High-Intensity Signals on Magnetic Resonance Images to Cognitive and Psychiatric State in Alzheimer's DiseaseJAMA Neurology.  48:1136-1140. 1991
1990 Adrenoreceptor antagonist treatment influences recovery of learning following medial septal lesions and hippocampal sympathetic ingrowth 1990
1990 Biological and Neuropsychological Characterization of Physostigmine Responders and Nonresponders in Alzheimer's DiseaseJournal of the American Geriatrics Society.  38:113-122. 1990
1990 Biological and neuropsychological characterization fo physostigmine responders and nonresponders in Alzheimer's diseaseJournal of the American Geriatrics Society.  38:133-122. 1990
1990 The effect of gonadal steroids on the behavioral and biochemical effects of hippocampal sympathetic ingrowthPhysiology and Behavior.  48:507-513. 1990
1990 The effect of long-term physostigmine administration in alzheimer's diseaseNeurology.  40:1350-1354. 1990
1989 Reversal of an Aluminum-Induced Behavioral Deficit by Administration of DeferoxamineBehavioral Neuroscience.  103:779-783. 1989
1989 Chronic septal lesions cause upregulation of cholinergic but not noradrenergic hippocampal phosphoinositide hydrolysisBrain Research.  488:387-389. 1989
1989 HTLV-I-associated myelopathy and polymyositis in a US nativeNeurology.  39:1572-1575. 1989
1988 The role of cortical sympathetic ingrowth in the behavioral effects of nucleus basalis magnocellularis lesionsBrain Research.  474:353-358. 1988
1988 Chronic, oral aluminum administration to rats: Cognition and cholinergic parameters 1988
1988 Re: MRI and dementiaNeurology.  38:166-167. 1988
1988 Role of gender in the behavioral effects of peripheral sympathetic ingrowthExperimental Neurology.  99:315-325. 1988
1987 Alterations in regulatory behaviors induced by medial septal lesions and superior cervical ganglionectomyBrain Research.  408:131-140. 1987
1987 Cholinergic Neurons, Learning, and Recovery of FunctionBehavioral Neuroscience.  101:644-652. 1987
1987 Failure of chronic physostigmine to ameliorate working memory deficits after medial septal lesionsExperimental Neurology.  96:456-461. 1987
1987 Magnetic resonance imaging and the diagnosis of dementiaNeurology.  37:540-543. 1987
1987 Passive-avoidance learning after medial septal lesions: Effect of experience and the peripheral sympathetic nervous systemExperimental Neurology.  97:542-554. 1987
1986 Peripheral sympathetic ingrowth can alter metabolic activity within the hippocampal formationExperimental Neurology.  91:622-627. 1986
1986 The superior cervical ganglia and learning of a spatial memory taskPhysiology and Behavior.  37:419-421. 1986
1985 Cholinergic influences on hippocampal glucose metabolismNeuroscience.  15:359-369. 1985
1984 Cholinergic denervation of the hippocampal formation does not produce long-term changes in glucose metabolismExperimental Neurology.  85:128-138. 1984
1984 Facilitated reversal learning of a spatial-memory task by medical septal injections of 6-hydroxydopamineExperimental Neurology.  85:69-77. 1984
1984 Motor neuron disease presenting with respiratory failure. Report of two casesPostgraduate medicine.  76:216-218. 1984
1983 Hand Weakness in the ElderlyJournal of the American Geriatrics Society.  31:223-227. 1983
1983 Pneumocephaly from Epidural AnesthesiaSouthern Medical Journal.  76:399-400. 1983
1983 Sympathetic sprouting and recovery of a spatial behaviorExperimental Neurology.  82:379-390. 1983
1978 Organismic states and their effect on recovery from neurosurgery: a new perspective with implications for a general theoryBrain, Behavior and Evolution.  15:19-40. 1978
1977 Growth, endocrinological and behavioral deficits after monosodium l-glutamate in the neonatal rat: possible involvement of arcuate dopamine neuron damagePsychoneuroendocrinology.  2:179-196. 1977
1977 Lack of effect of chronically administered thyrotropin-releasing hormone (TRH) on regional rat brain tyrosine hydroxylase activity 1977
1975 A critical evaluation of body weight loss following lateral hypothalamic lesionsPhysiology and Behavior.  15:133-136. 1975
1975 Effect of the light-dark cycle on neuroendocrine and behavioral responses to scheduled feedingPhysiology and Behavior.  15:245-247. 1975
1975 Influence of ovarian hormones on the recovery period following hypothalamic lesionsJournal of Comparative Psychology.  88:194-201. 1975
1975 Modification of feeding patterns by glucodynamic hormonesBehavioral biology.  13:457-465. 1975
1975 Neuroendocrine conditioning: conditioned feeding after alterations in glucose utilizationAmerican Journal of Physiology.  228:392-396. 1975
1975 Septal rage: Mitigation by pre-surgical treatment with p-chlorophenylalanine 1975
1974 The effects of dark and light on the functional recovery following lateral hypothalamic lesionsLife Sciences.  15:2079-2087. 1974
1974 Effect of size of food on food consumption: Some neurophysiological considerationsJournal of Comparative Psychology.  86:658-663. 1974
1974 Acceleration of functional recovery following lateral hypothalamic damage by means of electrical stimulation in the lesioned areasPhysiology and Behavior.  12:897-899. 1974
1974 Lateral hypothalamic syndrome: Its modification by obesity and leannessPhysiology and Behavior.  13:345-347. 1974
1974 The effects of early malnutrition on the recovery following lateral hypothalamic lesions 1974
1973 Modification of the recovery period after lateral hypothalamic lesions 1973
1973 Glucodynamic hormones modify the recovery period after lateral hypothalamic lesionsScience.  182:59-60. 1973

Principal Investigator On

Education And Training

  • Doctorate in Psychology, University of Miami 2000
  • Doctor of Medicine, University of Miami 1977
  • Full Name

  • Lindy Harrell