Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Helicobacter pylori infection is associated with an altered gastric microbiota in children 2017
2017 Differential regulation of CD103 (αE integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands 2017
2017 CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophages 2017
2015 Mother-to-child HIV-1 transmission events are differentially impacted by breast milk and its components from HIV-1-infected women 2015
2015 Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4F 2015
2015 Human gastric epithelial cells contribute to gastric immune regulation by providing retinoic acid to dendritic cells 2015
2014 Microbiota, the immune system, black moods and the brain—melancholia updated 2014
2014 Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells 2014
2014 Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responses 2014
2014 Exosomes in the gut 2014
2014 Vaginal myeloid dendritic cells transmit founder HIV-1 2014
2013 Role of childhood infection in the sequelae of H. Pylori disease 2013
2013 Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children 2013
2013 Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells 2013
2013 Renal macrophages in autosomal recessive polycystic kidney disease 2013
2012 Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F 2012
2011 Extracellular matrix-associated cytokines regulate CD4+ effector T-cell responses in the human intestinal mucosa 2011
2011 Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages 2011
2011 Intestinal macrophages and response to microbial encroachment 2011
2011 Stromal regulation of human gastric dendritic cells restricts the Th1 response to helicobacter pylori 2011
2010 Inflammation anergy in human intestinal macrophages is due to Smad-induced IκBα expression and NF-κB inactivation 2010
2010 Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages 2010
2010 Human primary gastric dendritic cells induce a Th1 response to H. pylori 2010
2010 Dendritic cells transmit HIV-1 through human small intestinal mucosa 2010
2010 GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium 2010
2010 IL-17 activates the canonical NF-κB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16 2010
2010 Renal CD14 expression correlates with the progression of cystic kidney disease 2010
2009 Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection 2009
2009 Selective advantage of inflammation anergy in gut macrophages 2009
2008 Helicobacter pylori Gastritis in Children Is Associated With a Regulatory T-Cell Response 2008
2007 Gliadin peptides activate blood monocytes from patients with celiac disease 2007
2006 Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease 2006
2006 Cytomegalovirus blocks intestinal stroma-induced down-regulation of macrophage HIV-1 infection 2006
2006 Mucosal IL-8 and TGF-β recruit blood monocytes: Evidence for cross-talk between the lamina propria stroma and myeloid cells 2006
2006 Isolation and purification of human intestinal macrophages. 2006
2006 Isolation of human monocyte populations. 2006
2005 Intestinal macrophages: Unique effector cells of the innate immune system 2005
2005 Poliovirus replicons encoding the B subunit of Helicobacter pylori urease protect mice against H. pylori infection 2005
2005 Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity 2005
2005 Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. 2005
2001 Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities 2001
2000 Quantitative analysis of Helicobacter pylori infection in a mouse model 2000
2000 Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-γ, gene-deficient mice 2000
2000 Inflammatory cytokine mRNA expression during early and persistent Helicobacter pylori infection in nonhuman primates 2000
1999 Poliovirus replicons encoding the B subunit of Helicobacter pylori urease elicit a Th1 associated immune response 1999
1998 African trypanosome infections in mice that lack the interferon-γ receptor gene: Nitric oxide-dependent and -independent suppression of T-cell proliferative responses and the development of anaemia 1998
1998 Nitric oxide produced in the lungs of mice immunized with the radiation- attenuated schistosome vaccine is not the major agent causing challenge parasite elimination 1998
1996 Impaired immunity and altered pulmonary responses in mice with a disrupted interferon-γ receptor gene exposed to the irradiated Schistosoma mansoni vaccine 1996
1996 Kinetics and mechanism of effector focus formation in the lungs of mice vaccinated with irradiated cercariae of Schistosoma mansoni 1996
1993 Pulmonary granulomatous hypersensitivity: Cell-mediated responses to embolized schistosome larvae and eggs 1993
1993 Functional and phenotypic properties of the CD4+ T cell population in a murine pulmonary delayed-type hypersensitivity response. 1993
1993 Immunity to Schistosoma mansoni in mice vaccinated with irradiated cercariae: Cytokine interactions in the pulmonary protective response 1993
1993 Phenotypic and functional properties of Th lines and clones recognizing larval antigens of Schistosoma mansoni 1993
1992 Monoclonal antibody to IFN-γ modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae 1992
1992 T cell-derived cytokines associated with pulmonary immune mechanisms in mice vaccinated with irradiated cercariae of Schistosoma mansoni 1992
1992 The generation of interferon-gamma-producing T lymphocytes in skin-draining lymph nodes, and their recruitment to the lungs, is associated with protective immunity to Schistosoma mansoni 1992
1991 Patterns of cytokine production and proliferation by T lymphocytes differ in mice vaccinated or infected with Schistosoma mansoni 1991

Chapter

Year Title Altmetric
2015 Mucosal Macrophages in Defense and Regulation.  543-556. 2015
2012 Intestinal macrophages in defense of the mucosa.  159-70. 2012
2005 Antigen handling and presentation by mucosal dendritic cells and macrophages.  451-485. 2005
2005 Involvement of Dendritic Cells in the Pathogenesis of Inflammatory Bowel Disease.  117-33. 2005
2001 Macrophage effector function.  19.1-19.9. 2001

Investigator On

  • Sialylation-dependent Mechanisms Driving Pancreatic Cancer Progression  awarded by National Cancer Institute/NIH/DHHS 2018 - 2023
  • Stem Cell Organogenesis Unit  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2019
  • Mechanism of Cytomegalovirus-induced Mucosal Inflammation  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2019
  • Role of Gastric Microbiota in Protecting Children from Precancerous Inflammation in H. Pylori Infection  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2017 - 2019
  • Cytomegalovirus Infection Exacerbates Macrophage-driven Inflammation in Inflammatory Bowel Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2019
  • Elucidating Protective Mechanisms Against Gastric Cancer  awarded by DeGregorio Family Foundation 2015 - 2017
  • Mechanisms of Apoptotic Cell Clearance in the Human Stomach  awarded by University of California, San Diego 2011 - 2014
  • Mechanism for CMV-Induced Exacerbation of Inflammation in IBD  awarded by Crohn's & Colitis Foundation of America 2013
  • HDL Modulation of Monocyte Function in Endotoxemia  awarded by National Institute of General Medical Sciences/NIH/DHHS 2008 - 2013
  • Mucosal HIV and Immunobiology Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2013
  • Mechanism for CMV-Induced Exacerbation of Inflammation in IBD  awarded by Crohn's & Colitis Foundation of America 2010 - 2012
  • Full Name

  • Lesley Smythies