Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophages.Virology.  504:79-87. 2017
2017 Helicobacter pylori infection is associated with an altered gastric microbiota in children.Mucosal Immunology.  10:1169-1177. 2017
2017 Differential regulation of CD103 (αE integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands.Journal of Leukocyte Biology.  101:1169-1180. 2017
2015 Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4F.Biochemical Journal.  467:517-527. 2015
2015 Human gastric epithelial cells contribute to gastric immune regulation by providing retinoic acid to dendritic cells.Mucosal Immunology.  8:533-544. 2015
2015 Mother-to-Child HIV-1 Transmission Events Are Differentially Impacted by Breast Milk and Its Components from HIV-1-Infected Women.PLoS ONE.  10:e0145150. 2015
2014 Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responses.Journal of Immunology.  193:5604-5612. 2014
2014 Vaginal myeloid dendritic cells transmit founder HIV-1.Journal of Virology.  88:7683-7688. 2014
2014 Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells.Federation proceedings.  28:2214-2224. 2014
2014 Exosomes in the gut.Frontiers in Immunology.  5:104. 2014
2014 Microbiota, the immune system, black moods and the brain-melancholia updated.Frontiers in Human Neuroscience.  8:720. 2014
2013 Renal macrophages in autosomal recessive polycystic kidney disease.Nephrology.  18:746. 2013
2013 Role of childhood infection in the sequelae of H. pylori disease.Gut Microbes.  4:426-438. 2013
2013 Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children.Mucosal Immunology.  6:950-959. 2013
2013 Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells.Journal of Immunology.  190:6626-6634. 2013
2012 Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F.Arteriosclerosis, Thrombosis, and Vascular Biology.  32:2631-2639. 2012
2011 Stromal regulation of human gastric dendritic cells restricts the Th1 response to Helicobacter pylori.Gastroenterology.  141:929-938. 2011
2011 Extracellular matrix-associated cytokines regulate CD4+ effector T-cell responses in the human intestinal mucosa.Mucosal Immunology.  4:420-427. 2011
2011 Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages.PLoS Pathogens.  7:e1002060. 2011
2011 Intestinal macrophages and response to microbial encroachment.Mucosal Immunology.  4:31-42. 2011
2010 Renal CD14 expression correlates with the progression of cystic kidney disease.Kidney International.  78:550-560. 2010
2010 Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation.Journal of Biological Chemistry.  285:19593-19604. 2010
2010 Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages.American Journal of Physiology - Cell Physiology.  298:C1538-C1548. 2010
2010 Human primary gastric dendritic cells induce a Th1 response to H. pylori.Mucosal Immunology.  3:260-269. 2010
2010 Dendritic cells transmit HIV-1 through human small intestinal mucosa.Journal of Leukocyte Biology.  87:663-670. 2010
2010 GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium.Journal of Immunology.  184:3648-3655. 2010
2010 IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.Journal of Immunology.  184:2289-2296. 2010
2009 Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection.Journal of Virology.  83:3258-3267. 2009
2009 Selective advantage of inflammation anergy in gut macrophagesMucosal Immunology.  2:378-9. 2009
2008 Helicobacter pylori gastritis in children is associated with a regulatory T-cell response.Gastroenterology.  134:491-499. 2008
2007 Gliadin peptides activate blood monocytes from patients with celiac disease.Journal of Clinical Immunology.  27:201-209. 2007
2006 Cytomegalovirus blocks intestinal stroma-induced down-regulation of macrophage HIV-1 infection.Journal of Leukocyte Biology.  80:1111-1117. 2006
2006 Mucosal IL-8 and TGF-beta recruit blood monocytes: evidence for cross-talk between the lamina propria stroma and myeloid cells.Journal of Leukocyte Biology.  80:492-499. 2006
2006 Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease.Advances in Experimental Medicine and Biology.  579:117-132. 2006
2006 Isolation and purification of human intestinal macrophages.Current protocols in immunology / edited by John E. Coligan ... [et al.].  Chapter 7:Unit-7.6B. 2006
2006 Isolation of human monocyte populations.Current protocols in immunology / edited by John E. Coligan ... [et al.].  Chapter 7:Unit-7.6A. 2006
2005 Intestinal macrophages: unique effector cells of the innate immune system.Immunological Reviews.  206:149-159. 2005
2005 Poliovirus replicons encoding the B subunit of Helicobacter pylori urease protect mice against H. pylori infection.Vaccine.  23:901-909. 2005
2005 Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activityJournal of Clinical Investigation.  115:66-75. 2005
2005 Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity.Journal of Clinical Investigation.  115:66-75. 2005
2001 Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities.Journal of Immunology.  167:2651-2656. 2001
2000 Quantitative analysis of Helicobacter pylori infection in a mouse model.Journal of Immunological Methods.  242:67-78. 2000
2000 Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice.Journal of Immunology.  165:1022-1029. 2000
2000 Inflammatory cytokine mRNA expression during early and persistent Helicobacter pylori infection in nonhuman primates.Journal of Infectious Diseases.  181:783-786. 2000
1999 Poliovirus replicons encoding the B subunit of Helicobacter pylori urease elicit a Th1 associated immune response.Vaccine.  17:2384-2391. 1999
1998 African trypanosome infections in mice that lack the interferon-gamma receptor gene: nitric oxide-dependent and -independent suppression of T-cell proliferative responses and the development of anaemia.Immunology.  94:476-480. 1998
1998 Nitric oxide produced in the lungs of mice immunized with the radiation-attenuated schistosome vaccine is not the major agent causing challenge parasite elimination.Immunology.  93:55-63. 1998
1996 Kinetics and mechanism of effector focus formation in the lungs of mice vaccinated with irradiated cercariae of Schistosoma mansoni.Parasite Immunology.  18:359-369. 1996
1996 Impaired immunity and altered pulmonary responses in mice with a disrupted interferon-gamma receptor gene exposed to the irradiated Schistosoma mansoni vaccine.Immunology.  87:275-282. 1996
1993 Immunity to Schistosoma mansoni in mice vaccinated with irradiated cercariae: cytokine interactions in the pulmonary protective response.Annals of Tropical Medicine and Parasitology.  87:653-657. 1993
1993 Phenotypic and functional properties of Th lines and clones recognizing larval antigens of Schistosoma mansoni.Parasite Immunology.  15:373-382. 1993
1993 Pulmonary granulomatous hypersensitivity: cell-mediated responses to embolized schistosome larvae and eggs.Regional immunology.  5:165-173. 1993
1993 Functional and phenotypic properties of the CD4+ T cell population in a murine pulmonary delayed-type hypersensitivity response.Chest.  103:138S. 1993
1992 Monoclonal antibody to IFN-gamma modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae.Journal of Immunology.  149:3654-3658. 1992
1992 T cell-derived cytokines associated with pulmonary immune mechanisms in mice vaccinated with irradiated cercariae of Schistosoma mansoni.Journal of Immunology.  148:1512-1518. 1992
1992 The generation of interferon-gamma-producing T lymphocytes in skin-draining lymph nodes, and their recruitment to the lungs, is associated with protective immunity to Schistosoma mansoni.Immunology.  75:250-256. 1992
1991 Patterns of cytokine production and proliferation by T lymphocytes differ in mice vaccinated or infected with Schistosoma mansoni.Immunology.  73:327-333. 1991

Chapter

Year Title Altmetric
2015 Mucosal Macrophages in Defense and Regulation.  543-556. 2015
2012 Intestinal macrophages in defense of the mucosa.  159-70. 2012
2005 Antigen handling and presentation by mucosal dendritic cells and macrophages.  451-485. 2005
2005 Involvement of Dendritic Cells in the Pathogenesis of Inflammatory Bowel Disease.  117-33. 2005
2001 Macrophage effector function.  19.1-19.9. 2001

Investigator On

  • Sialylation-dependent Mechanisms Driving Pancreatic Cancer Progression  awarded by National Cancer Institute/NIH/DHHS 2018 - 2023
  • Mechanism of Cytomegalovirus-induced Mucosal Inflammation  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2020
  • Stem Cell Organogenesis Unit  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2019
  • Role of Gastric Microbiota in Protecting Children from Precancerous Inflammation in H. Pylori Infection  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2017 - 2019
  • Cytomegalovirus Infection Exacerbates Macrophage-driven Inflammation in Inflammatory Bowel Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2019
  • Elucidating Protective Mechanisms Against Gastric Cancer  awarded by DeGregorio Family Foundation 2015 - 2017
  • Mechanisms of Apoptotic Cell Clearance in the Human Stomach  awarded by University of California, San Diego 2011 - 2014
  • Mechanism for CMV-Induced Exacerbation of Inflammation in IBD  awarded by Crohn's & Colitis Foundation of America 2013
  • HDL Modulation of Monocyte Function in Endotoxemia  awarded by National Institute of General Medical Sciences/NIH/DHHS 2008 - 2013
  • Mucosal HIV and Immunobiology Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2013
  • Mechanism for CMV-Induced Exacerbation of Inflammation in IBD  awarded by Crohn's & Colitis Foundation of America 2010 - 2012
  • Education And Training

  • Bachelor of Science or Mathematics in Biology, University of London
  • Doctor of Philosophy in Plant Physiology, University of London
  • Full Name

  • Lesley Smythies
  • Blazerid

  • lesmy