Positions

Overview

  • Dr. Sun's laboratory is exploring the genetic control of aging in mammals and vertebrates. We are studying the endocrine mechanisms and nutritional factors for their effects on longevity and aging.

    The physiological role of the somatotropic axis in the control of aging in mammals and vertebrates
    The dietary factors on aging and longevity: calorie restriction vs. methionine restriction
    Interventions studies of age-related diseases such as Diabetes and Alzheimer’s disease
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Effects of rapamycin on growth hormone receptor knockout miceProceedings of the National Academy of Sciences.  115:E1495-E1503. 2018
    2017 Longevity is impacted by growth hormone action during early postnatal periodeLife.  6. 2017
    2017 Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal miceGeroscience.  39:347-356. 2017
    2016 Growth hormone actions during development influence adult phenotype and longevityExperimental Gerontology.  86:22-27. 2016
    2016 Brown adipose tissue function is enhanced in long-lived, male ames dwarf miceEndocrinology.  157:4744-4753. 2016
    2016 Original Research: Metabolic alterations from early life thyroxine replacement therapy in male Ames dwarf mice are transientProceedings of the Society for Experimental Biology and Medicine.  241:1764-1771. 2016
    2016 Long-lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high-fat diet on metabolic function and energy expenditureAging Cell.  15:509-521. 2016
    2016 Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune SenescenceCell Reports.  14:1571-1580. 2016
    2016 Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signalingAging.  8:539-546. 2016
    2015 Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle ageAGE.  37:1-14. 2015
    2015 Thyroxine modifies the effects of growth hormone in Ames dwarf miceAging.  7:241-255. 2015
    2014 Liver-Specific gh receptor gene-Disrupted (lighrko) mice have decreased endocrine igf-I, increased local igf-I, and altered body size, body composition, and adipokine profilesEndocrinology.  155:1793-1805. 2014
    2014 Tissue-specific GHR knockout mice: Metabolic phenotypesFrontiers in Endocrinology.  5. 2014
    2013 Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in miceeLife.  2013. 2013
    2013 Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genesAJP - Endocrinology and Metabolism.  305. 2013
    2013 Somatotropic signaling: Trade-offs between growth, reproductive development, and longevityPhysiological Reviews.  93:571-598. 2013
    2013 Links between growth hormone and agingEndokrynologia Polska.  64:46-52. 2013
    2013 Duration of rapamycin treatment has differential effects on metabolism in miceCell Metabolism.  17:456-462. 2013
    2012 Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespanAJP - Endocrinology and Metabolism.  303. 2012
    2012 Meta-profiles of gene expression during aging: Limited similarities between mouse and human and an unexpectedly decreased inflammatory signaturePLoS ONE.  7. 2012
    2011 Complex roles of Sirtuin 1 in cancer and agingJournal of Laboratory and Clinical Medicine.  157:273-275. 2011
    2011 Hepatic response to oxidative injury in long-lived Ames dwarf miceFederation proceedings.  25:398-408. 2011
    2009 Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genesFree Radical Biology and Medicine.  47:1753-1761. 2009
    2009 Life-span extension in mice by preweaning food restriction and by methionine restriction in middle ageJournals of Gerontology, Series A.  64:711-722. 2009
    2007 Adult neurogenesis in the hippocampus of long-lived mice during agingJournals of Gerontology, Series A.  62:117-125. 2007
    2006 Insulin-like growth factor-I stimulates histone H3 and H4 acetylation in the brain in vivoEndocrinology.  147:5480-5490. 2006
    2006 Hippocampal IGF-1 expression, neurogenesis and slowed aging: Clues to longevity from mutant miceAGE.  28:181-189. 2006
    2005 Increased neurogenesis in dentate gyrus of long-lived Ames dwarf miceEndocrinology.  146:1138-1144. 2005
    2005 Long-lived growth hormone receptor knockout mice: Interaction of reduced insulin-like growth factor I/insulin signaling and caloric restrictionEndocrinology.  146:851-860. 2005
    2005 Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived miceNeurobiology of Aging.  26:929-937. 2005
    2004 Divergent effects of caloric restriction on gene expression in normal and long-lived miceJournals of Gerontology, Series A.  59:784-788. 2004
    2000 Dimensionless ρ* scaling of particle transport in DIII-D L mode dischargesNuclear Fusion.  40:799-806. 2000

    Research Overview

  • Dr. Sun's current research focus on nutrition and hormonal signals during early-life development can influence the long-term health and the development of age-related diseases.

    Learn more about Dr. Sun's research on his lab website. He is currently recruiting motivated postdoctoral fellows, graduate students, research associates, and undergraduates. Candidates from a variety of backgrounds will be considered, provided they make a compelling case for contributing to the objectives and goals of the lab.

    Biology of Aging, Endocrinology, Obesity, Neurodegenerative disease
  • Education And Training

  • Doctor of Science or Mathematics in Molecular Physiology, Southern Illinois University System : Carbondale 2005
  • Doctor of Medicine, 1999
  • Full Name

  • Liou Sun