Positions

Overview

  • Dr. Sun's laboratory is exploring the genetic control of aging in mammals and vertebrates. We are studying the endocrine mechanisms and nutritional factors for their effects on longevity and aging.

    The physiological role of the somatotropic axis in the control of aging in mammals and vertebrates
    The dietary factors on aging and longevity: calorie restriction vs. methionine restriction
    Interventions studies of age-related diseases such as Diabetes and Alzheimer’s disease
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Physiological and metabolic characteristics of novel double-mutant female mice with targeted disruption of both growth hormone-releasing hormone and growth hormone receptorAging Cell.  20. 2021
    2021 The effects of early-life growth hormone intervention on tissue specific histone H3 modifications in long-lived Ames dwarf miceAging.  13:1633-1648. 2021
    2020 Insulin sensitivity in long-lived growth hormone-releasing hormone knockout miceAging.  12:18033-18051. 2020
    2020 Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormoneAging.  12:9761-9780. 2020
    2020 Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: Evidence for altered mitochondrial function and amino acid metabolismAging.  12:3473-3485. 2020
    2016 Long-lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high-fat diet on metabolic function and energy expenditureAging Cell.  15:509-521. 2016
    2016 Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signalingAging.  8:539-546. 2016
    2015 Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle ageAGE.  37:1-14. 2015
    2015 Thyroxine modifies the effects of growth hormone in Ames dwarf miceAging.  7:241-255. 2015
    2013 Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes 2013
    2012 Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan 2012
    2006 Hippocampal IGF-1 expression, neurogenesis and slowed aging: Clues to longevity from mutant miceAGE.  28:181-189. 2006

    Research Overview

  • Dr. Sun's current research focus on nutrition and hormonal signals during early-life development can influence the long-term health and the development of age-related diseases.

    Learn more about Dr. Sun's research on his lab website. He is currently recruiting motivated postdoctoral fellows, graduate students, research associates, and undergraduates. Candidates from a variety of backgrounds will be considered, provided they make a compelling case for contributing to the objectives and goals of the lab.

    Biology of Aging, Endocrinology, Obesity, Neurodegenerative disease
  • Teaching Activities

  • BY698 - Nonthesis Research (Summer Term 2021) 2021
  • BY798 - Nondissertation Research (Summer Term 2021) 2021
  • BY362 - Neurobiology (Spring Term 2021) 2021
  • BY398 - Undergrad Research - RES (Spring Term 2021) 2021
  • BY662 - Introductory Neurobiology (Spring Term 2021) 2021
  • BY698 - Nonthesis Research (Spring Term 2021) 2021
  • BY699 - Thesis Research (Spring Term 2021) 2021
  • BY698 - Nonthesis Research (Fall Term 2020) 2020
  • BY698 - Nonthesis Research (Summer Term 2020) 2020
  • BY362 - Neurobiology (Spring Term 2020) 2020
  • BY618 - Colloquium in Biology of Aging (Spring Term 2020) 2020
  • BY662 - Introductory Neurobiology (Spring Term 2020) 2020
  • BY698 - Nonthesis Research (Spring Term 2020) 2020
  • BY495 - Special Topics in Biology (Fall Term 2019) 2019
  • BY618 - Colloquium in Biology of Aging (Fall Term 2019) 2019
  • BY695 - Special Topics in Biology I (Fall Term 2019) 2019
  • BY698 - Nonthesis Research (Fall Term 2019) 2019
  • BY718 - Colloquium in Biology of Aging (Fall Term 2019) 2019
  • BY362 - Neurobiology (Spring Term 2019) 2019
  • BY662 - Introductory Neurobiology (Spring Term 2019) 2019
  • BY698 - Nonthesis Research (Spring Term 2019) 2019
  • BY718 - Colloquium in Biology of Aging (Spring Term 2019) 2019
  • BY499 - Biology Seminar (Fall Term 2018) 2018
  • BY618 - Colloquium in Biology of Aging (Fall Term 2018) 2018
  • BY718 - Colloquium in Biology of Aging (Fall Term 2018) 2018
  • BY362 - Neurobiology (Spring Term 2018) 2018
  • BY397 - Advanced Directed Readings (Spring Term 2018) 2018
  • BY499 - Biology Seminar (Fall Term 2017) 2017
  • BY687 - Seminar in Endocrinology (Fall Term 2017) 2017
  • BY398 - Undergrad Research - RES (Summer Term 2017) 2017
  • BY362 - Neurobiology (Spring Term 2017) 2017
  • BY397 - Advanced Directed Readings (Spring Term 2017) 2017
  • BY398 - Undergrad Research - RES (Spring Term 2017) 2017
  • BY695 - Special Topics in Biology I (Spring Term 2017) 2017
  • BY698 - Nonthesis Research (Spring Term 2017) 2017
  • BY698 - Nonthesis Research (Fall Term 2016) 2016
  • BY798 - Nondissertation Research (Fall Term 2016) 2016
  • BY398 - Undergrad Research - RES (Spring Term 2016) 2016
  • BY499 - Biology Seminar (Spring Term 2016) 2016
  • BY687 - Seminar in Endocrinology (Spring Term 2016) 2016
  • BY787 - Seminar in Endocrinology (Spring Term 2016) 2016
  • Education And Training

  • Doctor of Science or Mathematics in Molecular Physiology, Southern Illinois University System : Carbondale 2005
  • Doctor of Medicine, 1999
  • Full Name

  • Liou Sun