• EDUCATION: MD 2007 Ross University, Dominica, West Indies POSTDOCTORAL TRAINING: Resident, Anatomic and Clinical Pathology, 2007-2011, East Carolina University, Greenville, NC Fellow, Transfusion Medicine, 2011-2012, Yale University, New Haven, CT Fellow, Hematopathology, 2012-2013, Virginia Commonwealth University, Richmond, VA ACADEMIC AND CLINICAL APPOINTMENTS: Assistant Professor, Transfusion Medicine, 2013 to present, University of Alabama at Birmingham, Birmingham, AL
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Monitoring Fondaparinux in the Setting of Antithrombin Deficiency.Laboratory Medicine.  50:208-211. 2019
    2019 Fat embolism syndrome due to bone marrow necrosis in patients with hemoglobinopathies: A life-threatening complication mimicking thrombotic thrombocytopenic purpuraAmerican Journal of Hematology.  94:E64-E66. 2019
    2019 Clinical factors and biomarkers predict outcome in patients with immune-mediated thrombotic thrombocytopenic purpuraHaematologica.  104:166-175. 2019
    2019 Solving the calcium gluconate shortage in real-time: Mistakes made and lessons learnedJournal of Clinical Apheresis2019
    2019 Validation and cost-effectiveness of an in-house dithiothreitol (DTT) treatment protocol for daratumumab patients in a large tertiary care hospital provides gateway for implementation in smaller community hospitalsTransfusion and Apheresis Science2019
    2018 Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic PurpuraArteriosclerosis, Thrombosis, and Vascular Biology.  38:2731-2743. 2018
    2018 Debunking superstition: Analyzing the cloud phenomenon in apheresis—Results of a 35-month studyJournal of Clinical Apheresis.  33:616-618. 2018
    2018 Rat poisoning: A challenging diagnosis with clinical and psychological implicationsLaboratory Medicine.  49:272-275. 2018
    2018 Therapeutic plasma exchange For Hashimoto's encephalopathyJournal of Clinical Apheresis.  33:444-446. 2018
    2018 Blood prime for patients with single-needle access requiring extracorporeal photopheresis: How to do and why it may be usefulJournal of Clinical Apheresis.  33:121-123. 2018
    2018 Critical updates in the 7 th edition of the American Society for Apheresis guidelinesJournal of Clinical Apheresis.  33:78-94. 2018
    2018 Hospital-acquired anemia due to diagnostic and therapy-related blood loss in inpatients with myasthenia gravis receiving therapeutic plasma exchangeJournal of Clinical Apheresis.  33:14-20. 2018
    2018 Management of chronic myeloid leukemia in the setting of pregnancy: when is leukocytapheresis appropriate? A case report and review of the literatureTransfusion.  58:456-460. 2018
    2018 New subcutaneous PowerFlow port results in cost and time-savings in a busy outpatient apheresis clinicJournal of Clinical Apheresis2018
    2017 Survey on transfusion-transmitted cytomegalovirus and cytomegalovirus disease mitigationArchives of Pathology and Laboratory Medicine.  141:1705-1711. 2017
    2017 ADAMTS13 test and/or PLASMIC clinical score in management of acquired thrombotic thrombocytopenic purpura: a cost-effective analysisTransfusion.  57:2609-2618. 2017
    2017 Red blood cell exchange: 2015 American Society for Apheresis consensus conference on the management of patients with sickle cell diseaseJournal of Clinical Apheresis.  32:342-367. 2017
    2017 Safety of the use of group A plasma in trauma: the STAT studyTransfusion.  57:1879-1884. 2017
    2017 “Black cloud” vs. “white cloud” physicians – Myth or reality in apheresis medicine?Journal of Clinical Apheresis.  32:235-239. 2017
    2017 Mutations in Coagulation Factor VIII Are Associated with More Favorable Outcome in Patients with Cutaneous Melanoma.TH Open.  1:e113-e121. 2017
    2017 Diabetes-related cardiac dysfunctionEndocrinology and Metabolism.  32:171-179. 2017
    2017 More apheresis medicine abstracts should be published into manuscripts for clinical useJournal of Clinical Apheresis.  32:203-204. 2017
    2017 High Frequency of Mutations in Genes Encoding Factor VIII, von Willebrand Factor, and ADAMTS13 in Skin Cutaneous Melanoma.American Journal of Clinical Pathology.  147:S155-S156. 2017
    2017 Increased Plasma Levels of Human Neutrophil Peptides and Complement Activation Markers in Patients With Acquired Thrombotic Thrombocytopenic Purpura.American Journal of Clinical Pathology.  147:S154. 2017
    2017 Platelet Transfusion Reactions With Respect to Transfusion Indications: A Single-Center Analysis.American Journal of Clinical Pathology.  147:S169-S170. 2017
    2017 Usage Pattern of 4-Factor Prothrombin Complex Concentrate in a Tertiary Care Center.American Journal of Clinical Pathology.  147:S179-S180. 2017
    2017 A safe and effective management strategy for BCVIJournal of Trauma and Acute Care Surgery.  82:228. 2017
    2017 Ficin-treated red cells help identify clinically significant alloantibodies masked as reactions of undetermined specificity in gel microtubesLaboratory Medicine.  48:24-28. 2017
    2017 Hypertriglyceridemia in pregnancyTransfusion.  57:2824-2825. 2017
    2017 Plasma Transfusion Demystified: A Review of the Key Factors Influencing the Response to Plasma TransfusionLaboratory Medicine.  48:108-112. 2017
    2016 Acquired autoimmune thrombotic thrombocytopenic purpura in a case of severe haemophilia AHaemophilia.  22:e565-e567. 2016
    2016 Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpuraHaematologica.  101:1319-1326. 2016
    2016 Cryoprecipitate AHF vs. fibrinogen concentrates for fibrinogen replacement in acquired bleeding patients – an economic evaluationVox Sanguinis.  111:292-298. 2016
    2016 Therapeutic plasma exchange for intractable pruritus secondary to primary sclerosing cholangitisJournal of Clinical Apheresis.  31:495-496. 2016
    2016 Therapeutic plasma exchange in two patients with stiff-person syndromeJournal of Clinical Apheresis.  31:493-494. 2016
    2016 High percentage of evanescent red cell antibodies in patients with sickle cell disease highlights need for a national antibody databaseSouthern Medical Journal.  109:588-591. 2016
    2016 Anti–Blood Group Antibodies in Intravenous Immunoglobulin May Complicate Interpretation of Antibody Titers in ABO-Incompatible TransplantationAmerican Journal of Transplantation.  16:2483-2486. 2016
    2016 Apheresis research–more abstracts should be published as full manuscripts to provide more evidence for clinical practice guidelinesJournal of Clinical Apheresis.  31:353-358. 2016
    2016 Mathematical model and calculation to predict the effect of prophylactic plasma transfusion on change in international normalized ratio in critically ill patients with coagulopathyTransfusion.  56:926-932. 2016
    2016 Pathology consultation on the diagnosis and treatment of thrombotic microangiopathies (TMAs)American Journal of Clinical Pathology.  145:158-165. 2016
    2015 Plasma vs. cryoprecipitate for fibrinogen replacement in therapeutic plasma exchange proceduresJournal of Clinical Apheresis.  30:382-383. 2015
    2015 A possible case of a haemolytic transfusion reaction caused by anti-Lea antibodyBlood Transfusion.  13:535-536. 2015
    2015 Gamma radiation-enhanced thermal diffusion of iron ions into II-VI semiconductor crystalsOptical Materials Express.  5:558-565. 2015
    2015 Rhesus immune globulin dosing in the obesity epidemic eraArchives of Pathology and Laboratory Medicine.  139:1084. 2015
    2014 Transfusion-Related Adverse Events, Reference module in Biomedical ScienceElsevier2014
    2014 Incidence of acute transfusion reactions to platelets in hospitalized pediatric patients based on the US hemovigilance reporting system.Transfusion.  54:1666-1672. 2014
    2014 Periprocedural management of patients on anticoagulantsClinics in Laboratory Medicine.  34:595-611. 2014
    2013 Catastrophic Antiphospholipid Syndrome Distinguishing Features for Diagnosis and Treatment.ASCP Case Reports2013
    2012 International Forum on Prophylactic Platelet Transfusions.Vox Sanguinis2012
    2006 Complications of plasma exchange in patients treated for clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome [1]Transfusion.  46:154-156. 2006
    2005 The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: All patients, idiopathic patients, and patients with severe ADAMTS-13 deficiencyJournal of Thrombosis and Haemostasis.  3:1432-1436. 2005


    Year Title Altmetric
    2017 Preface 2017
    2017 Transfusion medicine, apheresis, and hemostasis: Review questions and case studies 2017
    2014 A Quick Guide to Transfusion Medicine- second edition 2014


    Year Title Altmetric
    2018 Pretransfusion Testing.  41-51. 2018
    2017 Patient blood management.  201-218. 2017
    2017 Posttest.  511-525. 2017
    2017 Pretest.  1-16. 2017
    2017 Pretransfusion testing.  143-167. 2017
    2017 Statistics and general principles of laboratory management.  17-42. 2017

    Research Overview

  • Thrombotic Thrombocytopenic Purpura; Management of anticoagulant medications; Blood Management in Community Settings; Proper and advanced use of blood products; Discordance of laboratory tests to monitor heparin therapy
  • Education And Training

  • Doctor of Medicine, Ross University - School of Veterinary Medicine 2007
  • East Carolina University School of Medicine, Residency 2011
  • East Carolina University, Residency 2011
  • Virginia Commonwealth University Health System, Postdoctoral Fellowship 2013
  • Yale University School of Medicine, Postdoctoral Fellowship 2012
  • Full Name

  • Lawrence Williams