Positions

Overview

  • Suzanne E. Lapi, Ph.D. completed her undergraduate studies and Ph.D. at Simon Fraser University in Burnaby, BC, Canada. She went on to complete a postdoctoral appointment at UCSF working with Henry VanBrocklin, PhD on the development of imaging agents for PSMA in prostate cancer before being recruited as a faculty member at Washington University in St. Louis where she ultimately stayed on as a tenured Associate Professor until 2015. Dr. Lapi is currently an Associate Professor of Radiology and Chemistry and Cyclotron Facility Director where she oversees production of PET radionuclides and radiopharmaceuticals for preclinical and clinical trials. Her research interests are in the development and translation of new PET radionuclides and imaging agents. She is very interested in moving imaging agents forward to clinical use and she is currently producing isotopes and radiopharmaceuticals for several clinical trials. In particular, Dr. Lapi has extensive experience in the preclinical and clinical research use of 89Zr antibodies. Dr. Lapi has over 50 publications and a track record of grants in the area of isotope production, molecular imaging and training of the next generation of radiochemists. She is President of the Radiopharmaceutical Sciences Council of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) and has been a Board member of the Nuclear Division of the American Chemical Society (ACS) for the past 4 years. She is a board member of the International Society of Radiopharmaceutical Sciences (ISRS) and has been active in many projects with the International Atomic Energy Agency (IAEA). She also continues to be a strong advocate of radiopharmaceutical sciences and the training of future radiochemists.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke-induced Pneumonia.American Journal of Respiratory and Critical Care Medicine.  198:1288-1301. 2018
    2018 Production and Use of the First-Row Transition Metal PET Radionuclides 43,44Sc, 52Mn, and 45Ti.Journal of Nuclear Medicine.  59:1655-1659. 2018
    2018 Impaired copper transport in schizophrenia results in a copper-deficient brain state: a new side to the dysbindin story.World Journal of Biological Psychiatry.  1-37. 2018
    2018 Evaluation of [89Zr]trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative breast cancer.Breast Cancer Research and Treatment.  169:523-530. 2018
    2018 Essential Metal Uptake in Gram-negative Bacteria: X-ray Fluorescence, Radioisotopes, and Cell Fractionation.Journal of Visualized Experiments2018
    2018 Targeting HER2 in Nuclear Medicine for Imaging and Therapy.Molecular Imaging.  17:1536012117745386. 2018
    2017 Production of Zr-89 using sputtered yttrium coin targets 89Zr using sputtered yttrium coin targets.Nuclear Medicine and Biology.  50:11-16. 2017
    2017 Radiosynthesis and Biological Distribution of18F-Labeled Perfluorinated Alkyl SubstancesEnvironmental Science and Technology Letters.  4:211-215. 2017
    2017 White paper on nuclear astrophysics and low-energy nuclear physics, Part 2: Low-energy nuclear physicsProgress in Particle and Nuclear Physics.  94:68-124. 2017
    2017 Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52.PLoS ONE.  12:e0174351. 2017
    2017 Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: Feasibility of an antibody-based companion diagnostic agentOncotarget.  8:104303-104314. 2017
    2016 PET/MRI of Hypoxic Atherosclerosis Using 64Cu-ATSM in a Rabbit Model.Journal of Nuclear Medicine.  57:2006-2011. 2016
    2016 [89Zr]Trastuzumab: Evaluation of Radiation Dosimetry, Safety, and Optimal Imaging Parameters in Women with HER2-Positive Breast Cancer.Clinical Positron Imaging.  18:952-959. 2016
    2016 New Methods for the Site-Selective Placement of Peptides on a Microelectrode Array: Probing VEGF-v107 Binding as Proof of Concept.ACS Chemical Biology.  11:2829-2837. 2016
    2016 Imaging of hypoxia in mouse atherosclerotic plaques with (64)Cu-ATSM.Nuclear Medicine and Biology.  43:534-542. 2016
    2016 Working Together to Advance Women in Nuclear Medicine.Journal of Nuclear Medicine.  57:14N. 2016
    2016 Calibration setting numbers for dose calibrators for the PET isotopes (52)Mn, (64)Cu, (76)Br, (86)Y, (89)Zr, (124)I.Applied Radiation and Isotopes.  113:89-95. 2016
    2016 Microfluidic Preparation of a 89Zr-Labeled Trastuzumab Single-Patient Dose.Journal of Nuclear Medicine.  57:747-752. 2016
    2016 Development of 89Zr-Ontuxizumab for in vivo TEM-1/endosialin PET applications.Oncotarget.  7:13082-13092. 2016
    2016 Pretargeted Immuno-PET: Overcoming Limitations of Space and Time.Journal of Nuclear Medicine.  57:332-333. 2016
    2016 A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury.Journal of Nuclear Cardiology.  24:558-570. 2016
    2016 Evaluation of Cu-64 and Ga-68 Radiolabeled Glucagon-Like Peptide-1 Receptor Agonists as PET Tracers for Pancreatic β cell Imaging.Clinical Positron Imaging.  18:90-98. 2016
    2015 Synthesis and Biological Evaluation of (S)-Amino-2-methyl-4-[(76)Br]bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor Imaging.Journal of Medicinal Chemistry.  58:8542-8552. 2015
    2015 Harvesting (67)Cu from the Collection of a Secondary Beam Cocktail at the National Superconducting Cyclotron Laboratory.Analytical Chemistry.  87:10323-10329. 2015
    2015 Production and separation of (186g)Re from proton bombardment of (186)WC.Nuclear Medicine and Biology.  42:530-535. 2015
    2015 Investigating the pharmacokinetics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using (111) Ag as a radiotracer.Journal of Labelled Compounds and Radiopharmaceuticals.  58:234-241. 2015
    2015 Evaluation of hypoxia with copper-labeled diacetyl-bis(N-methylthiosemicarbazone).Seminars in Nuclear Medicine.  45:177-185. 2015
    2015 Cross-sections for (p,x) reactions on natural chromium for the production of (52,52m,54)Mn radioisotopes.Applied Radiation and Isotopes.  96:154-161. 2015
    2015 Cyclotron Production of High-Specific Activity 55Co and In Vivo Evaluation of the Stability of 55Co Metal-Chelate-Peptide Complexes.Molecular Imaging.  14:526-533. 2015
    2015 Preclinical Positron Emission Tomographic Imaging of Acute Hyperoxia Therapy of Chronic Hypoxia during Pregnancy.Molecular Imaging.  14:366-372. 2015
    2014 Immuno-PET of epithelial ovarian cancer: harnessing the potential of CA125 for non-invasive imaging.EJNMMI Research.  4:60. 2014
    2014 Evaluation of (89)Zr-pertuzumab in Breast cancer xenografts.Molecular Pharmaceutics.  11:3988-3995. 2014
    2014 Feasibility of isotope harvesting at a projectile fragmentation facility: ⁶⁷Cu.Scientific Reports.  4:6706. 2014
    2014 Specific activity measurement of ⁶⁴Cu: a comparison of methods.Applied Radiation and Isotopes.  90:117-121. 2014
    2014 Development of a Radiolabeled Irreversible Peptide Ligand for PET Imaging of Vascular Endothelial Growth Factor.Journal of Nuclear Medicine.  55:1029-1034. 2014
    2014 Investigation of a vitamin B12 conjugate as a PET imaging probe.ChemMedChem.  9:1244-1251. 2014
    2014 Design and construction of a water target system for harvesting radioisotopes at the National Superconducting Cyclotron LaboratoryNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment.  747:62-68. 2014
    2014 Glypican-3-targeted 89Zr PET imaging of hepatocellular carcinoma: where antibody imaging dares to tread.Journal of Nuclear Medicine.  55:708-709. 2014
    2014 Synthesis, complex stability and small animal PET imaging of a novel64Cu-labelled cryptand moleculeMedChemComm.  5:958-962. 2014
    2013 Imaging of CD47 expression in xenograft and allograft tumor models.Molecular Imaging.  12. 2013
    2013 Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging.Molecular Pharmaceutics.  10:3655-3664. 2013
    2013 Cyclotron Production of (99m)Tc using (100)Mo2C targets.Nuclear Medicine and Biology.  40:939-945. 2013
    2013 Effects of chelator modifications on (68)Ga-labeled [Tyr (3)]octreotide conjugates.Clinical Positron Imaging.  15:606-613. 2013
    2013 Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions.Dalton Transactions.  42:12005-12014. 2013
    2013 Designing the magic bullet? The advancement of immuno-PET into clinical use.Journal of Nuclear Medicine.  54:1171-1174. 2013
    2013 The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials.MedChemComm.  4:1015-1017. 2013
    2013 A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35years of the ISRC?Nuclear Medicine and Biology.  40:314-320. 2013
    2013 An alternate approach to the production of radioisotopes for nuclear medicine applications.Review of Scientific Instruments.  84:034705. 2013
    2013 Initial characterization of a dually radiolabeled peptide for simultaneous monitoring of protein targets and enzymatic activity.Nuclear Medicine and Biology.  40:190-196. 2013
    2013 Detection of rapalog-mediated therapeutic response in renal cancer xenografts using ⁶⁴Cu-bevacizumab immunoPET.PLoS ONE.  8:e58949. 2013
    2013 Development and characterization of 89Zr-labeled panitumumab for immuno-positron emission tomographic imaging of the epidermal growth factor receptor.Molecular Imaging.  12:17-27. 2013
    2013 Development and characterization of 89Zr-labeled panitumumab for immuno-positron emission tomographic imaging of the epidermal growth factor receptorMolecular Imaging.  12:1-11. 2013
    2013 Imaging the L-type amino acid transporter-1 (LAT1) with Zr-89 immunoPET.PLoS ONE.  8:e77476. 2013
    2012 Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis.Applied Radiation and Isotopes.  70:2539-2544. 2012
    2012 A semi-automated system for the routine production of copper-64.Applied Radiation and Isotopes.  70:1803-1806. 2012
    2012 A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35 years of the ISRC?Nuclear Medicine and Biology.  39:601-608. 2012
    2012 THE EFFECTS OF IRON AND COPPER AVAILABILITY ON THE COPPER STOICHIOMETRY OF MARINE PHYTOPLANKTON(1).Journal of Phycology.  48:312-325. 2012
    2012 89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast Tumors.Pharmaceuticals.  5:79-93. 2012
    2011 The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86.Future Medicinal Chemistry.  3:599-621. 2011
    2011 A new and simple calibration-independent method for measuring the beam energy of a cyclotron.Applied Radiation and Isotopes.  69:247-253. 2011
    2010 Copper-uptake kinetics of coastal and oceanic diatomsJournal of Phycology.  46:1218-1228. 2010
    2009 Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer.Journal of Nuclear Medicine.  50:2042-2048. 2009
    2009 Positron Emission Tomography Imaging of Hypoxia.PET Clinics.  4:39-47. 2009
    2008 Molecular sidebands of refractory elements for ISOLNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms.  266:4252-4256. 2008
    2008 Erratum: Precise measurement of the β decay and electron capture of Na22, Au198, and Au196 in low-temperature metal hosts, and reexamination of lifetime modifications (Physical Review C (2008) 77 (065502))Physical Review C - Nuclear Physics.  78. 2008
    2008 Precise measurement of the β decay and electron capture of Na22, Au198, and Au196 in low-temperature metal hosts, and reexamination of lifetime modificationsPhysical Review C - Nuclear Physics.  77. 2008
    2008 The effects of Cu and Fe availability on the growth and Cu:C ratios of marine diatomsLimnology and Oceanography.  53:2451-2461. 2008
    2007 55Cobalt complexes with pendant carbohydrates as potential PET imaging agents.Applied Radiation and Isotopes.  65:1303-1308. 2007
    2007 Production cross-sections of 181-186Re isotopes from proton bombardment of natural tungsten.Applied Radiation and Isotopes.  65:345-349. 2007
    2007 Visualization of the flow of a fiber suspension through a sudden expansion using PETAIChE Journal.  53:327-334. 2007
    2006 Production of intense radioactive beams using low energy protonsHigh Energy Physics and Nuclear Physics -Beijing-.  30:675-679. 2006
    2006 Production of intense radioactive beams at ISAC using low-energy protonsCanadian Journal of Physics.  84:325-333. 2006
    2005 Printed sources for Positron Emission Tomography (PET)IEEE Transactions on Nuclear Science.  52:114-118. 2005
    2004 Cellular and whole-plant chloride dynamics in barley: insights into chloride-nitrogen interactions and salinity responses.Planta.  218:615-622. 2004

    Chapter

    Year Title Altmetric
    2014 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals.  47-79. 2014

    Principal Investigator On

    Education And Training

  • Doctor of Philosophy in Chemistry, Simon Fraser University
  • Full Name

  • Suzanne Lapi
  • Blazerid

  • lapi