Positions

Overview

  • Suzanne E. Lapi, Ph.D. completed her undergraduate studies and Ph.D. at Simon Fraser University in Burnaby, BC, Canada. She went on to complete a postdoctoral appointment at UCSF working with Henry VanBrocklin, PhD on the development of imaging agents for PSMA in prostate cancer before being recruited as a faculty member at Washington University in St. Louis where she ultimately stayed on as a tenured Associate Professor until 2015.

    Dr. Lapi is currently an Associate Professor of Radiology and Chemistry and Cyclotron Facility Director where she oversees production of PET radionuclides and radiopharmaceuticals for preclinical and clinical trials. Her research interests are in the development and translation of new PET radionuclides and imaging agents. She is very interested in moving imaging agents forward to clinical use and she is currently producing isotopes and radiopharmaceuticals for several clinical trials. In particular, Dr. Lapi has extensive experience in the preclinical and clinical research use of 89Zr antibodies.

    Dr. Lapi has over 50 publications and a track record of grants in the area of isotope production, molecular imaging and training of the next generation of radiochemists. She is President of the Radiopharmaceutical Sciences Council of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) and has been a Board member of the Nuclear Division of the American Chemical Society (ACS) for the past 4 years. She is a board member of the International Society of Radiopharmaceutical Sciences (ISRS) and has been active in many projects with the International Atomic Energy Agency (IAEA). She also continues to be a strong advocate of radiopharmaceutical sciences and the training of future radiochemists.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Isotope harvesting at FRIB: Additional opportunities for scientific discoveryJournal of Physics G: Nuclear and Particle Physics.  46. 2019
    2019 Panitumumab-IRDye800CW for Fluorescence-Guided Surgical Resection of Colorectal CancerJournal of Surgical Research.  239:44-51. 2019
    2019 89Zr-DFO-Cetuximab as a Molecular Imaging Agent to Identify Cetuximab Resistance in Head and Neck Squamous Cell CarcinomaCancer Biotherapy and Radiopharmaceuticals.  34:288-296. 2019
    2019 Pulmonary carcinoid surface receptor modulation using histone deacetylase inhibitorsCancers.  11. 2019
    2019 Imaging of HER2 with [ 89 Zr]pertuzumab in response to T-DM1 therapyCancer Biotherapy and Radiopharmaceuticals.  34:209-217. 2019
    2019 Manganese-52 production cross-section measurements via irradiation of natural chromium targets up to 20 MeVApplied Radiation and Isotopes.  147:165-170. 2019
    2019 Pyrazolopyrimidinones, a novel class of copper-dependent bactericidal antibiotics against multi-drug resistant: S. aureusMetallomics.  11:784-798. 2019
    2019 The surprisingly large neutron capture cross-section of 88 ZrNature.  565:328-330. 2019
    2019 A growth model of neuroendocrine tumor surrogates and the efficacy of a novel somatostatin-receptor–guided antibody-drug conjugate: Perspectives on clinical response?Surgery2019
    2019 Current and future imaging methods for evaluating response to immunotherapy in neuro-oncologyTheranostics.  9:5085-5104. 2019
    2019 Improved production of 76Br, 77Br and 80mBr via CoSe cyclotron targets and vertical dry distillationNuclear Medicine and Biology2019
    2019 Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47ScEJNMMI Research.  9. 2019
    2019 Production of 15 O for medical applications via the 16 O(g,n) 15 O reactionJournal of Nuclear Medicine.  60:424-428. 2019
    2019 Radiochlorine: An underutilized halogen toolRadiochimica Acta2019
    2019 Radiometals for imaging and theranostics, current production, and future perspectivesJournal of Labelled Compounds and Radiopharmaceuticals.  62:615-634. 2019
    2019 The Impact of Positron Range on PET Resolution, Evaluated with Phantoms and PHITS Monte Carlo Simulations for Conventional and Non-conventional RadionuclidesClinical Positron Imaging2019
    2018 Macrophage Rac2 is required to reduce the severity of cigarette smoke-induced pneumoniaAmerican Journal of Respiratory and Critical Care Medicine.  198:1288-1301. 2018
    2018 Production and Use of the First-Row Transition Metal PET Radionuclides 43,44Sc, 52Mn, and 45TiJournal of Nuclear Medicine.  59:1655-1659. 2018
    2018 Evaluation of [ 89 Zr]trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative breast cancerBreast Cancer Research and Treatment.  169:523-530. 2018
    2018 Essential metal uptake in gram-negative bacteria: X-ray fluorescence, radioisotopes, and cell fractionationJournal of Visualized Experiments.  2018. 2018
    2018 Targeting HER2 in Nuclear Medicine for Imaging and TherapyMolecular Imaging.  17. 2018
    2018 Impaired copper transport in schizophrenia results in a copper-deficient brain state: A new side to the dysbindin storyWorld Journal of Biological Psychiatry2018
    2017 Production of Zr-89 using sputtered yttrium coin targets 89Zr using sputtered yttrium coin targetsNuclear Medicine and Biology.  50:11-16. 2017
    2017 Radiosynthesis and Biological Distribution of 18F-Labeled Perfluorinated Alkyl SubstancesEnvironmental Science and Technology Letters.  4:211-215. 2017
    2017 White paper on nuclear astrophysics and low-energy nuclear physics, Part 2: Low-energy nuclear physicsProgress in Particle and Nuclear Physics.  94:68-124. 2017
    2017 A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injuryJournal of Nuclear Cardiology.  24:558-570. 2017
    2017 Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52PLoS ONE.  12. 2017
    2017 Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: Feasibility of an antibody-based companion diagnostic agentOncotarget.  8:104303-104314. 2017
    2016 PET/MRI of hypoxic atherosclerosis using 64Cu-ATSM in a rabbit modelJournal of Nuclear Medicine.  57:2006-2011. 2016
    2016 [89Zr]Trastuzumab: Evaluation of Radiation Dosimetry, Safety, and Optimal Imaging Parameters in Women with HER2-Positive Breast CancerClinical Positron Imaging.  18:952-959. 2016
    2016 New Methods for the Site-Selective Placement of Peptides on a Microelectrode Array: Probing VEGF-v107 Binding as Proof of ConceptACS Chemical Biology.  11:2829-2837. 2016
    2016 Imaging of hypoxia in mouse atherosclerotic plaques with 64Cu-ATSMNuclear Medicine and Biology.  43:534-542. 2016
    2016 Working Together to Advance Women in Nuclear Medicine.Journal of Nuclear Medicine.  57:14N. 2016
    2016 Calibration setting numbers for dose calibrators for the PET isotopes 52Mn, 64Cu, 76Br, 86Y, 89Zr, 124IApplied Radiation and Isotopes.  113:89-95. 2016
    2016 Microfluidic preparation of a 89Zr-Labeled trastuzumab single-patient doseJournal of Nuclear Medicine.  57:747-752. 2016
    2016 Development of 89Zr-ontuxizumab for in vivo TEM-1/endosialin PET applicationsOncotarget.  7:13082-13092. 2016
    2016 Pretargeted immuno-PET: Overcoming limitations of space and timeJournal of Nuclear Medicine.  57:332-333. 2016
    2016 Evaluation of Cu-64 and Ga-68 Radiolabeled Glucagon-Like Peptide-1 Receptor Agonists as PET Tracers for Pancreatic β cell ImagingClinical Positron Imaging.  18:90-98. 2016
    2015 Harvesting 67Cu from the Collection of a Secondary Beam Cocktail at the National Superconducting Cyclotron LaboratoryAnalytical Chemistry.  87:10323-10329. 2015
    2015 Synthesis and Biological Evaluation of (S)-Amino-2-methyl-4-[76Br]bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor ImagingJournal of Medicinal Chemistry.  58:8542-8552. 2015
    2015 Preclinical positron emission tomographic imaging of acute hyperoxia therapy of chronic hypoxia during pregnancyMolecular Imaging.  14:366-371. 2015
    2015 Production and separation of 186gRe from proton bombardment of 186WCNuclear Medicine and Biology.  42:530-535. 2015
    2015 Investigating the pharmacokinetics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracerJournal of Labelled Compounds and Radiopharmaceuticals.  58:234-241. 2015
    2015 Evaluation of hypoxia with copper-labeled diacetyl-bis(N-Methylthiosemicarbazone)Seminars in Nuclear Medicine.  45:177-185. 2015
    2015 Cross-sections for (p,x) reactions on natural chromium for the production of 52,52m,54 Mn radioisotopesApplied Radiation and Isotopes.  96:154-161. 2015
    2015 Cyclotron production of high-specific activity 55Co and in vivo evaluation of the stability of 55Co metal-chelate-peptide complexesMolecular Imaging.  14:526-532. 2015
    2014 Feasibility of isotope harvesting at a projectile fragmentation facility: 67CuScientific Reports.  4. 2014
    2014 Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factorJournal of Nuclear Medicine.  55:1029-1034. 2014
    2014 Design and construction of a water target system for harvesting radioisotopes at the National Superconducting Cyclotron LaboratoryNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment.  747:62-68. 2014
    2014 Glypican-3-targeted 89Zr PET imaging of hepatocellular carcinoma: Where antibody imaging dares to treadJournal of Nuclear Medicine.  55:708-709. 2014
    2014 Evaluation of 89Zr-pertuzumab in Breast Cancer XenograftsMolecular Pharmaceutics.  11:3988-3995. 2014
    2014 Immuno-PET of epithelial ovarian cancer: harnessing the potential of CA125 for non-invasive imagingArchaeological and Anthropological Sciences.  4. 2014
    2014 Investigation of a vitamin B12 conjugate as a PET imaging probeChemMedChem.  9:1244-1251. 2014
    2014 Specific activity measurement of 64Cu: A comparison of methodsApplied Radiation and Isotopes.  90:117-121. 2014
    2014 Synthesis, complex stability and small animal PET imaging of a novel 64 Cu-labelled cryptand moleculeMedChemComm.  5:958-962. 2014
    2013 Imaging the L-Type Amino Acid Transporter-1 (LAT1) with Zr-89 ImmunoPETPLoS ONE.  8. 2013
    2013 Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imagingMolecular Pharmaceutics.  10:3655-3664. 2013
    2013 Cyclotron Production of 99mTc using 100Mo2C targetsNuclear Medicine and Biology.  40:939-945. 2013
    2013 Effects of Chelator Modifications on 68Ga-Labeled [Tyr 3]Octreotide ConjugatesClinical Positron Imaging.  15:606-613. 2013
    2013 Designing the magic bullet? the advancement of immuno-PET into clinical useJournal of Nuclear Medicine.  54:1171-1174. 2013
    2013 The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobialsMedChemComm.  4:1015-1017. 2013
    2013 A historical perspective on the specific activity of radiopharmaceuticals: What have we learned in the 35years of the ISRC?Nuclear Medicine and Biology.  40:314-320. 2013
    2013 Detection of Rapalog-Mediated Therapeutic Response in Renal Cancer Xenografts Using 64 Cu-bevacizumab ImmunoPETPLoS ONE.  8. 2013
    2013 An alternate approach to the production of radioisotopes for nuclear medicine applicationsReview of Scientific Instruments.  84. 2013
    2013 Initial characterization of a dually radiolabeled peptide for simultaneous monitoring of protein targets and enzymatic activityNuclear Medicine and Biology.  40:190-196. 2013
    2013 Development and characterization of 89Zr-labeled panitumumab for immuno-positron emission tomographic imaging of the epidermal growth factor receptor.Molecular Imaging.  12:17-27. 2013
    2013 Development and characterization of 89Zr-labeled panitumumab for immuno-positron emission tomographic imaging of the epidermal growth factor receptorMolecular Imaging.  12:1-11. 2013
    2013 Imaging of CD47 expression in xenograft and allograft tumor modelsMolecular Imaging.  12. 2013
    2013 Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditionsDalton Transactions.  42:12005-12014. 2013
    2012 Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesisApplied Radiation and Isotopes.  70:2539-2544. 2012
    2012 A semi-automated system for the routine production of copper-64Applied Radiation and Isotopes.  70:1803-1806. 2012
    2012 A historical perspective on the specific activity of radiopharmaceuticals: What have we learned in the 35 years of the ISRC?Nuclear Medicine and Biology.  39:601-608. 2012
    2012 The effects of iron and copper availability on the copper stoichiometry of marine phytoplanktonJournal of Phycology.  48:312-325. 2012
    2012 89Zr-radiolabeled trastuzumab imaging in orthotopic and metastatic breast tumorsPharmaceuticals.  5:79-93. 2012
    2011 The rise of metal radionuclides in medical imaging: Copper-64, zirconium-89 and yttrium-86Future Medicinal Chemistry.  3:599-621. 2011
    2011 A new and simple calibration-independent method for measuring the beam energy of a cyclotronApplied Radiation and Isotopes.  69:247-253. 2011
    2010 Copper-uptake kinetics of coastal and oceanic diatomsJournal of Phycology.  46:1218-1228. 2010
    2009 Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancerJournal of Nuclear Medicine.  50:2042-2048. 2009
    2009 PET Imaging of HypoxiaPET Clinics.  4:39-47. 2009
    2008 Molecular sidebands of refractory elements for ISOLNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms.  266:4252-4256. 2008
    2008 Erratum: Precise measurement of the β decay and electron capture of Na22, Au198, and Au196 in low-temperature metal hosts, and reexamination of lifetime modifications (Physical Review C (2008) 77 (065502))Physical Review C - Nuclear Physics.  78. 2008
    2008 Precise measurement of the β decay and electron capture of Na22, Au198, and Au196 in low-temperature metal hosts, and reexamination of lifetime modificationsPhysical Review C - Nuclear Physics.  77. 2008
    2008 The effects of Cu and Fe availability on the growth and Cu:C ratios of marine diatomsLimnology and Oceanography.  53:2451-2461. 2008
    2007 55Cobalt complexes with pendant carbohydrates as potential PET imaging agentsApplied Radiation and Isotopes.  65:1303-1308. 2007
    2007 Production cross-sections of 181-186Re isotopes from proton bombardment of natural tungstenApplied Radiation and Isotopes.  65:345-349. 2007
    2007 Visualization of the flow of a fiber suspension through a sudden expansion using PETAIChE Journal.  53:327-334. 2007
    2006 Production of intense radioactive beams using low energy protonsHigh Energy Physics and Nuclear Physics -Beijing-.  30:675-679. 2006
    2006 Production of intense radioactive beams at ISAC using low-energy protonsCanadian Journal of Physics.  84:325-333. 2006
    2005 Printed sources for Positron Emission Tomography (PET)IEEE Transactions on Nuclear Science.  52:114-118. 2005
    2004 Cellular and whole-plant chloride dynamics in barley: Insights into chloride-nitrogen interactions and salinity responsesPlanta.  218:615-622. 2004

    Chapter

    Year Title Altmetric
    2014 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals.  47-79. 2014

    Principal Investigator On

  • Private Grant  awarded by IMAGINAB 2018 - 2026
  • Development of Novel Tataniu-45 PET Imaging Agents for PSMA  awarded by SOCIETY OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 2019 - 2021
  • Production of Radioisotopes of Scandium for Imaging and Therapy  awarded by Department of Energy 2019 - 2021
  • Radiolabeled Antibodies Targeting LAT1 for Imaging and Therapy of Prostate Cancer  awarded by National Cancer Institute/NIH/DHHS 2016 - 2020
  • Private Grant  awarded by NAVIDEA BIOPHARMACEUTICALS, INC. 2018 - 2020
  • Dermal Absorption of PFAS  awarded by LAST CALL FOUNDATION 2019
  • Therapeutic Radiopharmaceuticals Labelled with New Emerging Radionuclides (67Cu,186Re, 47Sc)  awarded by International Atomic Energy Agency 2016 - 2019
  • Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy  awarded by Department of Energy 2017 - 2019
  • Integrated Placental Imaging: Novel Methods for Probing Function and Metabolism  awarded by Washington University 2015 - 2019
  • Comprehensive Cancer Center Core Support Grant - Preclinical Imaging Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Support for Students, Postdoctoral Fellows and Trainees to Attend Nuclear and Radiochemistry Symposia at the Spring 2018 ACS Meeting  awarded by Department of Energy 2017 - 2018
  • GE FASTLab2 for the UAB Cyclotron Facility  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2018
  • Preparing for Harvesting Radioisotopes from FRIB  awarded by Department of Energy 2016 - 2018
  • Private Grant  awarded by CELLDEX THERAPEUTICS, INC. 2017 - 2018
  • Production of the Medically Important Radionuclides: 52Mn and 90Nb  awarded by Department of Energy 2016 - 2018
  • Private Grant  awarded by ABBVIE INC 2016 - 2018
  • Imaging for Assessment and Prediction of Response to Therapy for Triple Negative Breast Cancer  awarded by National Cancer Institute/NIH/DHHS 2017 - 2018
  • Direct Production of 99mTc Using a Small Medical Cyclotron  awarded by Department of Energy 2016 - 2017
  • Education And Training

  • Doctor of Philosophy in Chemistry, Simon Fraser University 2007
  • Full Name

  • Suzanne Lapi