Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 FTY720 enhances the anti-tumor activity of carboplatin and tamoxifen in a patient-derived xenograft model of ovarian cancer.Cancer Letters.  436:75-86. 2018
2018 Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma.Oncotarget.  9:22665-22679. 2018
2017 Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors.Scientific Reports.  7:17787. 2017
2017 JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma.Molecular Cancer Therapeutics.  17:107-118. 2017
2017 Pediatric Anaplastic Embryonal Rhabdomyosarcoma: Targeted Therapy Guided by Genetic Analysis and a Patient-Derived Xenograft Study.Frontiers in Oncology.  7:327. 2017
2016 Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin.Oncotarget.  7:86660-86674. 2016
2016 The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype.Cancer Research.  76:3978-3988. 2016
2016 The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models.Oncogene.  35:833-845. 2016
2015 ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actinin.Oncogene.  34:1553-1562. 2015
2015 The role of ICAM-2 in neuroblastoma.Oncoscience.  2:915-916. 2015
2013 N-glycosylation of ICAM-2 is required for ICAM-2-mediated complete suppression of metastatic potential of SK-N-AS neuroblastoma cells.BMC Cancer.  13:261. 2013
2013 Development and histopathological characterization of tumorgraft models of pancreatic ductal adenocarcinoma.PLoS ONE.  8:e78183. 2013
2009 Cell adhesion molecules as targets for therapy of neuroblastoma.Cancer Biology and Therapy.  8:306-311. 2009
2008 ICAM-2 expression mediates a membrane-actin link, confers a nonmetastatic phenotype and reflects favorable tumor stage or histology in neuroblastoma.PLoS ONE.  3:e3629. 2008
2007 Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma.Cancer Research.  67:22-25. 2007
2006 Development of a tumor-selective approach to treat metastatic cancer.PLoS ONE.  1:e23. 2006
2006 Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy.Molecular Cancer Therapeutics.  5:1577-1584. 2006
2005 Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.Chemico-Biological Interactions.  157-158:247-252. 2005
2005 Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.Journal of Medicinal Chemistry.  48:5543-5550. 2005
2005 The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.Molecular Pharmacology.  67:1874-1881. 2005
2005 Development of prodrugs for enzyme-mediated, tumor-selective therapy.Current Medicinal Chemistry Anticancer Agents.  5:107-113. 2005
2004 Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.Molecular Cancer Therapeutics.  3:903-909. 2004
2003 Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies.Molecular Cancer Therapeutics.  2:1171-1181. 2003
2003 Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism.Bioorganic and Medicinal Chemistry.  11:3237-3244. 2003

Education And Training

  • Doctor of Philosophy in Pharmacology, Florida Agricultural & Mechanical University
  • Full Name

  • Karina Yoon
  • Blazerid

  • kyoon