Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy.Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  7:e010239. 2018
2018 Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis.STEM CELLS.  36:1368-1379. 2018
2018 Bone Marrow Transplantation after Nonmyeloablative Treosulfan Conditioning Is Curative in a Murine Model of Sickle Cell Disease.Biology of Blood and Marrow Transplantation.  24:1554-1562. 2018
2016 The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.EMBO Reports.  17:887-900. 2016
2016 Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene Correction.Scientific Reports.  6:30422. 2016
2015 Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene Targeting.Cell Reports.  12:1668-1677. 2015
2012 Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.Cell Stem Cell.  10:570-582. 2012
2012 SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency.Proceedings of the National Academy of Sciences.  109:3772-3777. 2012
2011 PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.STEM CELLS.  29:229-240. 2011
2010 KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.Nature Genetics.  42:742-744. 2010
2009 Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells.STEM CELLS.  27:1042-1049. 2009
2008 SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation.Nature Medicine.  14:773-777. 2008
2006 Correction of sickle cell disease by homologous recombination in embryonic stem cells.Blood.  108:1183-1188. 2006
2006 Differential binding of erythroid Krupple-like factor to embryonic/fetal globin gene promoters during development.Journal of Biological Chemistry.  281:16052-16057. 2006
2003 Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells.Blood.  102:4312-4319. 2003
2000 Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic interventionBlood.  96. 2000
1995 End joining of genomic DNA and transgene DNA in fertilized mouse eggs.Gene.  165:173-181. 1995
1995 Autonomous, erythroid-specific DNase I hypersensitive site formed by human beta-globin locus control region (LCR) 5' HS 2 in transgenic mice.Developmental Biology.  169:728-732. 1995
1991 Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice.Proceedings of the National Academy of Sciences.  88:1626-1630. 1991

Education And Training

  • Bachelor of Science or Mathematics in Microbiology, University of Alabama
  • Doctor of Philosophy in Biochemistry, University of Alabama at Birmingham
  • Full Name

  • Kevin Pawlik
  • Blazerid

  • kpawlik