Selected Publications

Academic Article

Year Title Altmetric
2020 Georgia Abortion Law and Our Commitment to Patients 2020
2008 Dawn of the era of biologics in the treatment of the rheumatic diseases 2008
2005 Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts 2005
2004 Presentation of the 2004 Founders' Medal to J. Claude Bennett, MD. 2004
2003 FcγRs modulate cytotoxicity of anti-Fas antibodies: Implications for agonistic antibody-based therapeutics 2003
2003 TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis 2003
2002 Folic acid and folinic acid supplementation during low-dose methotrexate therapy for rheumatoid arthritis: Comment on the article by van Ede et al [6] 2002
2001 Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity 2001
2001 Prospects for autoimmune disease: Research advances in rheumatoid arthritis 2001
1998 T cell receptor peptide vaccination in rheumatoid arthritis: A placebo- controlled trial using a combination of V(β)3, V(β)14, and V(β)17 peptides 1998
1998 In situ hybridization analysis of immunoglobulin heavy chain variable gene expression with family specific oligonucleotide probes 1998
1998 The effect of methotrexate and 7-hydroxymethotrexate on rat adjuvant arthritis and on urinary aminoimidazole carboxamide excretion 1998
1998 Clonally-related immunoglobulin V(H) domains and nonrandom use of D(H) gene segments in rheumatoid arthritis synovium 1998
1998 Enhanced expression of immunoglobulin κ light chains with unusually long CDR3 regions in patients with rheumatoid arthritis 1998
1998 Nondepleting humanized anti-CD4 monoclonal antibody in patients with refractory rheumatoid arthritis 1998
1998 Rheumatoid arthritis: Anticytokine therapies on the horizon 1998
1998 Dendritic cells from Peyer's patch and spleen induce different T helper cell responses 1998
1997 Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein 1997
1997 Biologic agents for treating rheumatoid arthritis: Concepts and progress 1997
1997 Vaccination against rheumatoid arthritis. Concepts and progress 1997
1996 In situ hybridization and QC-RT-PCR analysis of arthroscopic biopsies of early rheumatoid arthritis synovial tissue 1996
1996 Recombinant soluble tumor necrosis factor receptor (p80) fusion protein: Toxicity and dose finding trial in refractory rheumatoid arthritis 1996
1996 Suppression of in vitro IgM rheumatoid factor production by diphtheria toxin interleukin 2 recombinant fusion protein (DAB 486IL-2) in patients with refractory rheumatoid arthritis 1996
1996 Vβ17 T cell receptor peptide vaccination in rheumatoid arthritis: Results of phase I dose escalation study 1996
1996 Editorial overview: Rheumatoid arthritis 1996
1996 Dendritic cells from different tissues induce production of different T cell cytokine profiles 1996
1996 Quantitative analysis of immunoglobulin Vκ CDR3 lengths in rheumatoid arthritis: Evidence of antigenic selection or dysregulation of gene rearrangement 1996
1995 Identifying nursing research priorities: general and neuroscience specific at an acute care hospital. 1995
1995 Regeneration of t cells after chemotherapy 1995
1995 Analysis of Immunoglobulin Gamma Heavy Chains from Rheumatoid Arthritis Synovium Evidence of Antigen‐Driven Selection 1995
1995 Characterization of human Fas gene: Exon/intron organization and promoter region 1995
1995 Dendritic cells regulate development of alloantigenic and mitogenic T(H)1 versus T(H)2 responses 1995
1995 Double‐blind, placebo‐controlled multicenter trial using chimeric monoclonal anti‐cd4 antibody, cm‐t412, in rheumatoid arthritis patients receiving concomitant methotrexate 1995
1995 Immunoglobulin gene expression in rheumatoid arthritis 1995
1995 In Situ Hybridization Analysis of Immunoglobulin VH Gene Family Expression in Rheumatoid Arthritis 1995
1995 Interleukin‐2 diphtheria fusion protein (dab486il‐2) in refractory rheumatoid arthritis a double‐blind, placebo‐controlled trial with open‐label extension 1995
1995 Molecular characterization of monoclonal igm derived from human b cell lines expressing the 4c9 rheumatoid factor associated idiotype 1995
1995 Progressive joint destruction in a human immunodeficiency virus‐infected patient with rheumatoid arthritis 1995
1995 Rheumatoid arthritis: Editorial overview 1995
1995 Somatic mutation and CDR3 lengths of immunoglobulin κ light chains expressed in patients with rheumatoid arthritis and in normal individuals 1995
1995 Synovial biopsy of the knee joint under direct visualization by needle arthroscopy 1995
1995 Vβ17 T‐Cell Receptor Peptide Vaccine: Results of a Phase I Dose‐Finding Study in Patients with Rheumatoid Arthritis 1995
1994 Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis: A double-blind, placebo-controlled trial 1994
1994 Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients 1994
1994 Human rheumatoid factors with restrictive specificity for rabbit immunoglobulin G: Auto- and multi-reactivity, diverse VH gene segment usage and preferential usage of VλIIlb 1994
1994 Occurrence of deficient galactosylation of serum IgG prior to the onset of rheumatoid arthritis 1994
1994 Erratum: Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients (Blood (June 15, 1994) 152:12 (5940)) 1994
1994 Evidence of antigen receptor-influenced oligoclonal B lymphocyte expansion in the synovium of a patient with longstanding rheumatoid arthritis 1994
1994 Expression of rheumatoid factor idiotypes 17.109, 6b6.6 and 4c9 in the sera of pima indians 1994
1994 HLA in ankylosing spondylitis: Is HLA-B27 the only MHC gene involved in disease pathogenesis? 1994
1994 Leucovorin Versus Folic Acid in the Treatment of Methotrexate Toxicity: Comment on the Article by Shiroky et a1 1994
1994 Survival impact of autoantibodies in systemic lupus erythematosus 1994
1994 T Cell Influence on Superantigen‐Induced Arthritis in MRL‐lpr/lpr Mice 1994
1994 The future of biologies in the treatment of rheumatoid arthritis 1994
1994 Treatment of refractory rheumatoid arthritis with a chimeric ANTI‐CD4 monoclonal antibody 1994
1993 Analysis of immunoglobulin gamma heavy chain expression in synovial tissue of a patient with rheumatoid arthritis 1993
1993 Anticardiolipin antibodies in systemic lupus erythematosus: Clinical correlates, HLA associations, and impact on survival 1993
1993 Antifolates in rheumatoid arthritis: A hypothetical mechanism of action 1993
1993 Divergent T-cell cytokine profiles induced by dendritic cells from different tissues 1993
1993 Do nonimmunologically mediated pathways play a role in the pathogenesis of rheumatoid arthritis? 1993
1993 Effects of Nonsteroidal Antiinflammatory Drugs on Bone Loss in Chronic Inflammatory Disease 1993
1993 Experience with a chimeric monoclonal anti-CD4 antibody in the treatment of refractory rheumatoid arthritis 1993
1993 Folate supplementation and methotrexate [3] 1993
1993 Host factors in the pathogenesis of arthritis triggered by infectious organisms 1993
1993 Increased spontaneous secretion of rheumatoid factor by intestinal lamina propria mononuclear cells from Crohn's disease but not ulcerative colitis patients 1993
1993 Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: Two cellular mechanisms explain joint destruction? 1993
1993 New approaches to the therapy of autoimmune diseases: Rheumatoid arthritis as a paradigm 1993
1993 Nonperipheral accelerated nodulosis in a methotrexate‐treated rheumatoid arthritis patient 1993
1993 The use of monozygotic and dizygotic twins to estimate the effects of inheritance on the levels of immunoglobulin isotypes and antibodies to phosphocholine 1993
1993 Use of a chimeric monoclonal anti‐CD4 antibody in patients with refractory rheumatoid arthritis 1993
1992 Abnormal galactosylation of serum IgG in patients with systemic lupus erythematosus and members of families with high frequency of autoimmune diseases 1992
1992 Scanning electron microscopic evaluation of the arthritis in MRL/lpr mice 1992
1992 A rheumatoid factor from a normal individual encoded by VH2 and VkII gene segments 1992
1992 Controlled trial of methotrexate versus 10-deazaaminopterin in the treatment of rheumatoid arthritis 1992
1992 Digital subtraction radiography for the assessment of bone changes in rheumatoid arthritis 1992
1992 Efficacy and safety of 10‐deazaaminopterin in the treatment of rheumatoid arthritis: A one‐year continuation, double‐blind study 1992
1992 Expressing our inner thoughts: How to organize and write a clinical research project grant application 1992
1992 Infection as a cause of reactive arthritis, ankylosing spondylitis, and rheumatic fever 1992
1992 Local immune responses in certain extra-articular manifestations of rheumatoid arthritis 1992
1992 Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin 1992
1992 The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis 1992
1991 Apolipoprotein A-I decreases neutrophil degranulation and superoxide production 1991
1991 Infection as a cause of arthritis 1991
1991 Rheumatology 1991
1991 Cellular origins of human polymeric and monomeric IgA: enumeration of single cells secreting polymeric IgA1 and IgA2 in peripheral blood, bone marrow, spleen, gingiva and synovial tissue 1991
1991 Genetic studies of four highly homologous rheumatoid factor-associated Vk genes in rheumatoid arthritis patients and normal individuals 1991
1991 In search of Mr. Wizard. Presidential address to the American Society for Clinical Investigation, Seattle, Washington, 4 May 1991 1991
1991 Local iga and igm rheumatoid factor production in autoimmune MRL/ipr mice 1991
1991 Reply 1991
1991 The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip 1991
1990 Occurrence of a rheumatoid factor cross-reactive kappa light-chain idiotope in rheumatoid arthritis families 1990
1990 Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation 1990
1990 Achieving consensus on an algorithm for the treatment of rheumatoid arthritis with Methotrexate 1990
1990 Achieving consensus on an algorithm for the treatment of rheumatoid arthritis with methotrexate 1990
1990 Correlation of serologic indicators of inflammation with effectiveness of nonsteroidal antiinflammatory drug therapy in rheumatoid arthritis 1990
1990 Dissociation of expression of two rheumatoid factor cross-reactive κ L chain idiotopes in rheumatoid arthritis 1990
1990 Elucidating the pathogenesis of autoimmune disease: recent advances at the molecular level and relevance to oral mucosal disease 1990
1990 Lupus‐inducing drugs alter the structure of supercoiled circular dna domains 1990
1990 Monoclonal antibody 6b6.6 defines a cross‐reactive kappa light chain idiotope on human monoclonal and polyclonal rheumatoid factors 1990
1990 Osteoarthritis: Definitions and criteria 1990
1990 Rheumatoid factor and human disease 1990
1990 Structural characterization of the second major cross‐reactive idiotype group of human rheumatoid factors. Association with the VH4 Gene Family 1990
1990 Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis: Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression 1990
1990 Synergism of interleukin 7 with the thymocyte growth factors interleukin 2, interleukin 6, and tumor necrosis factor α in the induction of thymocyte proliferation 1990
1990 The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand 1990
1989 The reply 1989
1989 Local production of IgA- and IgM-rheumatoid factors in adult periodontal disease 1989
1989 Valvular Heart Disease in Systemic Lupus Erythematosus 1989
1989 AS and a 9.2 kb Pvu II class I HLA DNA restriction fragment. 1989
1989 Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue 1989
1989 Comment on the article by Tomana et al 1989
1989 Enhancement of IL-2-induced T cell proliferation by a novel factor(s) present in murine spleen dendritic cell-T cell culture supernatants 1989
1989 Exquisite sensitivity of dendritic cells to ultraviolet radiation and temperature changes 1989
1989 Identification of peptide hormones of the amphipathic helix class using the helical hydrophobic moment algorithm 1989
1989 Immunopathology of rheumatoid arthritis 1989
1989 Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells 1989
1989 Methotrexate-induced liver abnormalities in rheumatoid arthritis 1989
1989 Molecular analysis of HLA‐D region genes in seropositive rheumatoid arthritis 1989
1989 Mucosal homeostasis: Role of interleukins, isotype-specific factors and contrasuppression in the iga response 1989
1989 Radiologic assessment as an outcome measure in rheumatoid arthritis 1989
1989 Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis 1989
1989 Severe reversible interstitial pneumonitis induced by low dose methotrexate 1989
1989 Viral arthritis in humans 1989
1988 Molecular genetic studies of rheumatoid arthritis 1988
1988 Restriction fragment length polymorphism analysis in ankylosing spondylitis 1988
1988 Occurrence of polymeric IgA1 rheumatoid factor in the acquired immune deficiency syndrome 1988
1988 Abnormal glycosylation of serum igg from patients with chronic inflammatory diseases 1988
1988 Autoimmunity to collagen in adult periodontal disease 1988
1988 Clinically significant valvular heart disease in systemic lupus erythematosus 1988
1988 Etiopathogenesis of rheumatoid arthritis-like disease in MRL/1 mice: II. Ultrastructural basis of joint destruction 1988
1988 Features of renal vasculitis in autoimmune MRL 1pr/1pr mice: Phenotypes and functional properties of infiltrating cells 1988
1988 Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins 1988
1988 Letters 1988
1988 Occurrence of a μchain idiotope in two human monoclonal RF which also share a κchain idiotope 1988
1988 Re: Methotrexate in the treatment of arthritis and connective tissue disease 1988
1988 Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells 1988
1988 Rheumatoid factor diversity 1988
1988 The MRL-ipr/ipr mouse. A model for the study of rheumatoid arthritis 1988
1988 Ultrastructural study of Sjögren's syndrome‐like disease in MRM mice 1988
1987 Analysis of restriction fragment length polymorphisms in rheumatic diseases 1987
1987 Specificity of monoclonal anti-Z-DNA antibodies from unimmunized MRL/Mp-lpr/lpr mice 1987
1987 Streptococcal serotype carbohydrate represents a novel class of type 2 antigen which is T-independent 1987
1987 Toxicity to methotrexate in rheumatoid arthritis 1987
1987 Enhanced in vitro IgM rheumatoid factor synthesis in seropositive rheumatoid arthritis families 1987
1987 Analysis of paraprotein transport into the saliva by using anti-idiotype antibodies 1987
1987 Acute cryoglobulinemic renal failure after intravenous infusion of gamma globulin 1987
1987 Toxicity due to remission inducing drugs in RA. 1987
1987 A low molecular weight, heat‐labile factor enhances neutrophil fc receptor–mediated lysosomal enzyme release and phagocytosis 1987
1987 Airways disease in rheumatoid arthritis patients 1987
1987 Analyses of hla linkage in white families with multiple cases of seropositive rheumatoid arthritis 1987
1987 Association of a 9.2‐kilobase pvu ii class i major histocompatibility complex restriction fragment length polymorphism with ankylosing spondylitis 1987
1987 Development of clinical criteria for osteoarthritis 1987
1987 Differential expression of IgA- and IgM-rheumatoid factors in human disease: evidence for independent regulation of rheumatoid factor isotype production. 1987
1987 Humoral sensitivity to native collagen types I-VI in the arthritis of MRL I mice 1987
1987 Immunological studies of IgA nephropathy: familial and racial aspects. 1987
1987 Lack of association between hla–dr2 and clinical response to methotrexate in patients with rheumatoid arthritis 1987
1987 Review of the national arthritis advisory board symposium, “molecular biology: its potential for advancing rheumatology research” 1987
1987 Striking Elevation of Serum IgA, IgA-Containing Immune Complexes, and IgA Rheumatoid Factor in Clinically Silent Dermatitis Herpetiformis 1987
1986 VH Gene expression is restricted in anti-igG antibodies from MRL autoimmune mice 1986
1986 HLA antigens and gold toxicity in American blacks with rheumatoid arthritis 1986
1986 Circulating immune complexes and immunoglobulin A rheumatoid factor in patients with mesangial immunoglobulin A nephropathies 1986
1986 DR2 positivity and response to methotrexate in rheumatoid arthritis 1986
1986 Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee 1986
1986 Induction of neutrophil enzyme release by rheumatoid factors: Evidence for differences based on molecular characteristics 1986
1986 Interleukin 1-like factor produced by a hybrid of an adherent mouse spleen cell and a thymoma cell 1986
1986 Molecular forms of IgA rheumatoid factor in serum and synovial fluid of patients with rheumatoid arthritis 1986
1986 Rheumatoid arthritis associated with expanded populations of granular lymphocytes 1986
1985 Interaction of DNA with connective tissue matrix proteins reveals preferential binding to type V collagen 1985
1985 Activity of rheumatoid factors of different molecular sizes: Comparison of autologous monomeric and polymeric monoclonal IgA rheumatoid factors 1985
1985 Comment on letter by Alarcón et al 1985
1985 Etiopathogenesis of the rheumatoid arthritis–like disease in MRL/1 mice. I. The histomorphologic basis of joint destruction 1985
1985 HLA‐Bw35 and gold toxicity in rheumatoid arthritis 1985
1985 IgA rheumatoid factor synthesis by dissociated synovial cells. Characterization and relationship to IgM rheumatoid factor synthesis 1985
1985 IgA-IgG immune complexes and rheumatoid factor in IgA nephropathy 1985
1985 Immunoglobulin subclass distribution of synovial plasma cells in rheumatoid arthritis determined by use of monoclonal anti-subclass antibodies 1985
1985 In vitro IgM and IgM rheumatoid factor production and response to remittive agents in rheumatoid arthritis 1985
1985 Production of immunoglobulin and rheumatoid factor by lymphoid cells in rheumatoid pericardium 1985
1985 Solid-phase radioimmunoassay for human neutrophil elastase: A sensitive method for determining secreted and cell-associated enzyme 1985
1985 The carpometacarpal ratio: A useful method for assessing disease progression in rheumatoid arthritis 1985
1985 [8] Antiisotypic antibodies 1985
1984 Isotype-specificity of helper T cell clones: Fcα receptors regulate T and B cell collaboration for IgA responses 1984
1984 Preferential induction of polyclonal IgA secretion by murine peyer’s patch dendritic cell-T cell mixtures 1984
1984 In vitro synthesis of IgM and IgM rheumatoid factor in seronegative arthritides 1984
1984 Isotype specificity of helper T cell clones peyer’s patch Th cells preferentially collaborate with mature IgA B cells for IgA responses 1984
1984 Dr Antigens and Gold Toxicity in white rheumatoid arthritis patients 1984
1984 Effects of ultraviolet light and interleukin-1 on dendritic cell function 1984
1984 Mucosal Immunoregulation: Environmental Lipopolysaccharide and GALT T Lymphocytes Regulate the IgA Response 1984
1984 Partial characterisation of the high and low molecular weight forms of P388D1‐derived interleukin 1 1984
1984 Penicillamine-induced Myositis. Observations and unique features in two patients and review of the literature 1984
1984 Peyer's Patch Dendritic Cells: Isolation and Functional Comparison with Murine Spleen Dendritic Cells 1984
1984 Rheumatoid myositis 1984
1983 Local synthesis of IgM and IgM rheumatoid factor in rheumatoid pleuritis 1983
1983 DR antigen distribution in blacks with rheumatoid arthritis 1983
1983 Accessory cells in Murine Peyer’s patch: I. Identification and enrichment of a functional dendritic cell 1983
1983 CREG antigens differentially influence expression of extraarticular manifestations in whites and blacks with rheumatoid arthritis 1983
1983 Lymphoid Cell Responses to Bacterial Cell Wall Components: Murine B‐Cell Responses to a Purified Cell Wall Moiety of Actinomyces 1983
1983 Seronegative rheumatoid arthritis and b7‐creg: disparate results 1983
1983 Serum IgA1 and IgA2 in normal adults and patients with systemic lupus erythematosus and hepatic disease 1983
1983 Suppression of in vitro monoclonal human rheumatoid factor synthesis by antiidiotypic antibody. Target cells and molecular requirements 1983
1982 In vitro regulation of IgA subclass synthesis: I. Discordance between plasma cell production and antibody secretion 1982
1982 Murine peyer’s patch T cell clones: Characterization of antigen-specific helper T cells for immunoglobulin a responses 1982
1982 A quantitative assay for IgA rheumatoid factor 1982
1982 Buffer electrofocusing of Interleukin I 1982
1982 An enzymatic method for preparation of dissociated murine Peyer's patch cells enriched for macrophages 1982
1982 Differential patterns of in vitro IgM rheumatoid factor synthesis in seronegative and seropositive rheumatoid arthritis 1982
1982 Seronegative rheumatoid arthritis. 1982
1981 Lymphoid cell responses to bacterial cell wall components: Polyclonal and immune responses of murine B cells to Streptococcus mutans carbohydrate antigens 1981
1981 Interleukin 1: Production by P388D1 cells attached to microcarrier beads 1981
1981 Suppressor T Cells Prevent in Vitro Expression of IgM Rheumatoid Factor in Some Healthy Adults 1981
1980 Production of predominantly polymeric IgA by human peripheral blood lymphocytes stimulated in vitro with mitogens 1980
1980 A sensitive radioimmunoassay for quantitation of igm rheumatoid factor 1980
1980 Dermal fibrosis in spinal cord injury patients 1980
1980 Enhanced in vitro synthesis of igm rheumatoid factor in rheumatoid arthritis 1980
1980 In vitro synthesis of IgM rheumatoid factor by lymphocytes from healthy adults 1980

Education And Training

  • Doctor of Medicine in Immunology, Harvard University 1972
  • Full Name

  • William Koopman