Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Transcutaneous immunization with pneumococcal surface protein A in miceLaryngoscope.  128:E91-E96. 2018
2017 Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniaeMicrobiology and Immunology.  61:195-205. 2017
2017 Rectal administration of a chlamydial subunit vaccine protects against genital infection and upper reproductive tract pathology in micePLoS ONE.  12. 2017
2017 Rejuvenation of mucosal immunosenescence by adipose tissue-derived mesenchymal stem cellsInternational Immunology.  29:5-10. 2017
2016 The effects of differences in pspA alleles and capsular types on the resistance of Streptococcus pneumoniae to killing by apolactoferrinMicrobial Pathogenesis.  99:209-219. 2016
2016 Adipose-derived mesenchymal stem cells restore impaired mucosal immune responses in aged micePLoS ONE.  11. 2016
2015 Past efforts and future prospects for a nasal influenza vaccineClinical Immunology, Endocrine and Metabolic Drugs.  2:13-26. 2015
2015 A molecular mucosal adjuvant to enhance immunity against pneumococcal infection in the elderly.Immune Network.  15:9-15. 2015
2015 Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-ReviewGerontology.  61:336-342. 2015
2015 Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaquesMucosal Immunology.  8:1144-1153. 2015
2014 A recombinant adenovirus-based vector elicits a specific humoral immune response against the V3 loop of HIV-1 gp120 in mice through the "antigen Capsid-Incorporation" strategyVirology Journal.  11. 2014
2014 Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis mediaInfection and Immunity.  82:364-370. 2014
2014 Mucosal adjuvants for vaccines to control upper respiratory infections in the elderlyExperimental Gerontology.  54:21-26. 2014
2013 Potential Roles of CCR5+ CCR6+ Dendritic Cells Induced by Nasal Ovalbumin plus Flt3 Ligand Expressing Adenovirus for Mucosal IgA ResponsesPLoS ONE.  8. 2013
2012 oral clarithromycin enhances airway immunoglobulin A (IgA) immunity through induction of IgA class switching recombination and B-cell-activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza a virusJournal of Virology.  86:10924-10934. 2012
2012 Inside the Mucosal Immune SystemPLoS Biology.  10. 2012
2012 Novel vaccine development strategies for inducing mucosal immunityExpert Review of Vaccines.  11:367-379. 2012
2012 Notch-ligand expression by NALT dendritic cells regulates mucosal Th1- and Th2-type responsesBiochemical and Biophysical Research Communications.  418:6-11. 2012
2012 A novel combined adjuvant for nasal delivery elicits mucosal immunity to influenza in agingVaccine.  30:803-812. 2012
2012 Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infectionVaccine.  30:466-474. 2012
2011 Functional transforming growth factor-β receptor type ii expression by cd4 + t cells in peyer's patches is essential for oral tolerance inductionPLoS ONE.  6. 2011
2011 Oral-nasopharyngeal dendritic cells mediate T cell-independent IgA class switching on B-1 B cellsPLoS ONE.  6. 2011
2011 Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccinationVaccine.  29:5747-5757. 2011
2011 Elicitation of mucosal immunity by proteins of streptococcus pneumoniaeAdvances in Otorhinolaryngology.  72:25-27. 2011
2011 The nasal dendritic cell-targeting Flt3 ligand as a safe adjuvant elicits effective protection against fatal pneumococcal pneumoniaInfection and Immunity.  79:2819-2828. 2011
2011 Induction of IL-10-producing CD4+ T-cells in chronic periodontitisJournal of Dental Research.  90:653-658. 2011
2011 A combination of Flt3 ligand cDNA and CpG oligodeoxynucleotide as nasal adjuvant elicits protective secretory-IgA immunity to Streptococcus pneumoniae in aged miceJournal of Immunology.  186:2454-2461. 2011
2010 Mucosal regulatory cells in the gastrointestinal tract and periodontiumPeriodontology 2000.  54:247-256. 2010
2010 Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virusMicrobes and Infection.  12:778-783. 2010
2010 Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniaeJournal of Immunology.  185:1755-1762. 2010
2010 Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosisProceedings of the National Academy of Sciences.  107:7419-7424. 2010
2010 Fusobacterium nucleatum envelope protein FomA is immunogenic and binds to the salivary statherin-derived peptideInfection and Immunity.  78:1185-1192. 2010
2010 Oral immunization with Porphyromonas gingivalis outer membrane protein and CpG oligodeoxynucleotides elicits T helper 1 and 2 cytokines for enhanced protective immunityOral Microbiology and Immunology.  25:178-189. 2010
2009 A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiotaProceedings of the National Academy of Sciences.  106:19256-19261. 2009
2009 Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunityJournal of Experimental Medicine.  206:2351-2364. 2009
2009 Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunityVaccine.  27:5982-5988. 2009
2009 Dendritic cell-targeting DNA-based mucosal adjuvants for the development of mucosal vaccinesExpert Review of Vaccines.  8:1183-1193. 2009
2009 Co-administration of cholera toxin and apple polyphenol extract as a novel and safe mucosal adjuvant strategyVaccine.  27:4808-4817. 2009
2009 Mucosal immunosenescence: new developments and vaccines to control infectious diseasesImmunology Today.  30:334-343. 2009
2008 Preferential use of D H reading frame 2 alters B cell development and antigen-specific antibody productionJournal of Immunology.  181:8409-8415. 2008
2008 A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunityVaccine.  26:4849-4859. 2008
2008 Double DNA adjuvant as the new generation immunostimulator in mucosal immune responseJibiinkoka Tenbo.  51:39-42. 2008
2008 Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein σ1Journal of Immunology.  180:5187-5200. 2008
2008 Mucosal CD11b+DCs were Increased in PIRB Knockout MiceFederation proceedings.  22. 2008
2008 Nasal Cholera Toxin Up-regulates Mucosal DCs And B1 B Cells Interactions For The Induction Of Innate IgA CSR.Federation proceedings.  22. 2008
2008 A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migrationJournal of Immunology.  180:8126-8134. 2008
2008 Ovalbumin-Protein σ1 M-Cell Targeting Facilitates Oral Tolerance With Reduction of Antigen-Specific CD4+ T CellsGastroenterology.  135:917-925. 2008
2007 Long- and short-time immunological memory in different strains of mice given nasally an adjuvant-combined nasal influenza vaccineVaccine.  25:6975-6980. 2007
2007 A single intranasal immunization with inactivated influenza virus and α-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous systemVaccine.  25:5189-5198. 2007
2007 Nasal cholera toxin elicits IL-5 anel IL-5 receptor α-chain expressing B-1a B cells for innate mucosal IgA antibody responsesJournal of Immunology.  178:6058-6065. 2007
2007 Mucosal vaccine development for botulinum intoxicationExpert Review of Vaccines.  6:35-45. 2007
2007 Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Aβ1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/ Hu APPswe PS1dE9 mouse model of Alzheimer's diseaseJournal of Gene Medicine.  9:88-98. 2007
2006 Type 1 and 2 T helper cell-mediated colitisCurrent Opinion in Gastroenterology.  22:651-657. 2006
2006 Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin AJournal of Immunology.  177:5524-5532. 2006
2006 A second generation of double mutant cholera toxin adjuvants: Enhanced immunity without intracellular traffickingJournal of Immunology.  177:3045-3054. 2006
2006 Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody productionJournal of Experimental Medicine.  203:1567-1578. 2006
2006 A novel method for delivery of regulatory molecules in the GI tract using Bacillus anthracis protective antigenJournal of Immunology.  176:S243-S243. 2006
2006 Bacillus anthracis edema toxin acts as an adjuvant for enhanced immunity to PA and to unrelated vaccine antigens co-administered by the nasal or the transcutaneous routeJournal of Immunology.  176:S115-S115. 2006
2006 Development and characterization of salivary IL-7 transgenic miceJournal of Immunology.  176:S231-S231. 2006
2006 Enhanced mucosal IgA ab responses in PIR-B knockout miceJournal of Immunology.  176:S244-S244. 2006
2006 Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigensJournal of Immunology.  176:1776-1783. 2006
2005 Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tractInfection and Immunity.  73:6892-6902. 2005
2005 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevationGene Therapy.  12:1079-1088. 2005
2005 Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrheaJournal of Immunology.  174:7423-7432. 2005
2005 Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tractFederation proceedings.  19:A948-A948. 2005
2005 Nasal Toll-like receptor 5 ligand elicits dendritic cell-mediated mucosal and systemic immune responsesFederation proceedings.  19:A5-A5. 2005
2005 A novel neurotoxoid vaccine prevents mucosal botulismJournal of Immunology.  174:2190-2195. 2005
2004 A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primatesJournal of Immunology.  173:6850-6857. 2004
2004 Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunityJournal of Immunology.  173:762-769. 2004
2004 The role of CDR3 diversity restriction in mucosal and systemeic antibody responses following oral immuniation with r-Salmonella expressing tetanus toxinPediatric Research.  55:494A-494A. 2004
2004 Nasal Flt3 Ligand cDNA Elicits CD11c+ CD8+ Dendritic Cells for Enhanced Mucosal ImmunityJournal of Immunology.  172:3612-3619. 2004
2004 CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitisAmerican Journal of Pathology.  165:1257-1268. 2004
2004 Mucosal immunity and tolerance in the elderlyMechanisms of Ageing and Development.  125:889-898. 2004
2004 Pathological Role of Large Intestinal IL-12p40 for the induction of Th2-Type Allergic DiarrheaAmerican Journal of Pathology.  164:1327-1335. 2004
2003 Cholera toxin activates dendritic cells through dependence on MG1-ganglioside which is mediated by NF-κB translocationEuropean Journal of Immunology.  33:3205-3212. 2003
2003 Therapeutic manipulation of the immune system: Enhancement of innate and adaptive mucosal immunityCurrent Pharmaceutical Design.  9:1965-1972. 2003
2003 Effective mucosal immunity to anthrax: Neutralizing antibodies and Th cell responses following nasal immunization with protective antigenJournal of Immunology.  170:5636-5643. 2003
2003 Nasal cholera toxin enhances innate mucosal immune responses.Journal of Dental Research.  82:B218-B218. 2003
2003 Preferential induction of TLR4 expression on gamma 8 T-cells of submandibular glands.Journal of Dental Research.  82:B379-B379. 2003
2003 An interconnected gut-associated lymphoreticular cell and tissue network for antigen-specific intestinal IgA immunityFederation proceedings.  17:C234-C234. 2003
2003 Cholera toxin and heat-labile enterotoxin induce dendritic cell differentiation and prime immunity: differential requirement of glycolipid receptorsFederation proceedings.  17:C88-C88. 2003
2003 Nasal Flt3 ligand plasmid induces antigen-specific immune responses by mucosal dendritic cell recruitmentFederation proceedings.  17:C320-C320. 2003
2003 Neutralizing antibodies and T helper cell responses following nasal immunization with anthrax protective antigenFederation proceedings.  17:C320-C320. 2003
2003 Oral live r-Salmonella expressing fragment C of tetanus toxin induces antigen-specific IgA responses in mice with limited IgH variable region diversityFederation proceedings.  17:C85-C85. 2003
2003 TH1 dependent selection of the mucosal IgA repertoire is unable to overcome the contribution of an altered germline repertoireFederation proceedings.  17:C190-C190. 2003
2003 Cholera toxin adjuvanticity is dependent upon Gm1-mediated NF-κB translocation and activation of dendritic cellsGastroenterology.  124:A73-A73. 2003
2003 T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient miceGastroenterology.  124:672-682. 2003
2003 Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissueJournal of Immunology.  170:1754-1762. 2003
2003 Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactionsInternational Immunology.  15:145-158. 2003
2003 Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunitJournal of Immunology.  170:454-462. 2003
2002 Quantitation of T-cell cytokine responses by ELISA, ELISPOT, flow cytometry and reverse transcriptase-PCR methodsMethods in Microbiology.  32:301-329. 2002
2002 A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced ige antibodiesJournal of Infectious Diseases.  186:1261-1269. 2002
2002 A dilemma for mucosal vaccination: Efficacy versus toxicity using enterotoxin-based adjuvantsVaccine.  20:2431-2438. 2002
2002 An antigen specific colitis model: TNBS (trinitrobenzene sulfonic acid) colitis without EtOH using adoptive T cell transferGastroenterology.  122:A392-A392. 2002
2002 Small intestinal transformation and wasting disease induced in T cell deficient mice by adoptive transfer of CD45RB(Hi) Th2 cellsGastroenterology.  122:A73-A73. 2002
2002 Effects of Self-Etching Primer, Adhesive, NaOCl and H_2O_2 on Lymphocytes : In Vitro Model接着歯学 = Adhesive dentistry.  19. 2002
2001 Highly purified mutant E112K of cholera toxin elicits protective lung mucosal immunity to diphtheria toxinVaccine.  20:756-762. 2001
2001 Resistance of T-cell receptor δ-chain-deficient mice to experimental Candida albicans vaginitisInfection and Immunity.  69:7162-7164. 2001
2001 The pulmonary environment promotes Th2 cell responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulationJournal of Immunology.  167:4518-4526. 2001
2001 A revisit of mucosal IgA immunity and oral toleranceActa Odontologica Scandinavica.  59:301-308. 2001
2001 Elimination of colonic patches with lymphotoxin β receptor-Ig prevents TH2 cell-type colitisJournal of Immunology.  167:2781-2790. 2001
2001 Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitisBiotechnology and Bioengineering.  74:62-69. 2001
2001 Role of mucosal antibodies in viral infectionsCurrent Topics in Microbiology and Immunology.  260:201-228. 2001
2001 A revisit of the hapten-induced colitis model: Adoptive T cell transfer studies.Gastroenterology.  120:A193-A193. 2001
2001 LPS-induced salivary innate and adaptive immunity in aged miceJournal of Dental Research.  80:1332-1332. 2001
2001 Peyer's patches are required for oral tolerance to proteinsProceedings of the National Academy of Sciences.  98:3310-3315. 2001
2001 A role for Peyer's patches in oral tolerance to proteinsFederation proceedings.  15:A368-A368. 2001
2001 Alphavirus based HIV DNA vaccines delivered to mucosal surfacesFederation proceedings.  15:A366-A366. 2001
2001 Alterations in the mucosal immune system during normal pregnancy and lactationFederation proceedings.  15:A371-A371. 2001
2001 Dysfunctional Peyer's patches in aged mice impair oral tolerance inductionFederation proceedings.  15:A367-A367. 2001
2001 Impaired mucosal Th1-type immune responses in aged miceFederation proceedings.  15:A365-A365. 2001
2001 The NALT mucosal immune system is not impaired in aged miceFederation proceedings.  15:A363-A363. 2001
2001 Oral tolerance revisited: Prior oral tolerization abrogates cholera toxin-induced mucosal IgA responsesJournal of Immunology.  166:3114-3121. 2001
2001 Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizing antibodiesVaccine.  19:2061-2070. 2001
2001 Peyer's patches are required for oral tolerance to proteinsProc. Natl Acad. Sci. USA.  98. 2001
2000 Evidence for early aging in the mucosal immune system. (vol 165, pg 5352, 2000)Journal of Immunology.  165:7338-7338. 2000
2000 Evidence for early aging in the mucosal immune systemJournal of Immunology.  165:5352-5359. 2000
2000 Enterotoxin adjuvants have direct effects on T cells and antigen- presenting cells that result in either interleukin-4-dependent or - independent immune responsesJournal of Infectious Diseases.  182:180-190. 2000
2000 Comparison of nasal and oral tolerance for the prevention of collagen induced murine arthritisJournal of Rheumatology.  27:1038-1044. 2000
2000 Alternate mucosal immune system: Organized Peyer's patches are not required for IgA responses in the gastrointestinal tractJournal of Immunology.  164:5184-5191. 2000
2000 Aberrant mucosal immunity in aged mice is due to T cell dysregulationFederation proceedings.  14:A1202-A1202. 2000
2000 Abrogation of lymphotoxin-beta receptor signal pathway inhibits colonic patch genesis and Th2-type colitisFederation proceedings.  14:A975-A975. 2000
2000 An alternate mucosal immune system: Organized Peyer's patches are not required for gastrointestinal IgA responses.Federation proceedings.  14:A1201-A1201. 2000
2000 Both mucosal and systemic lymphocytes contribute to mammary gland development in maternal immunityFederation proceedings.  14:A1202-A1202. 2000
2000 Host response to experimental vaginal candidiasis in delta-chain TCR knock-out miceFederation proceedings.  14:A972-A972. 2000
2000 Oral tolerance blocks cholera toxin induced IgA responsesFederation proceedings.  14:A1198-A1198. 2000
2000 Mucosal vaccination and immune responses in the elderlyVaccine.  18:1675-1680. 2000
2000 Correlation between salivary IgA response and colonization of Streptococcus mutans.Journal of Dental Research.  79:308-308. 2000
2000 Human nasopharyngeal-associated lymphoreticular tissues: Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsilsAmerican Journal of Pathology.  157:2023-2035. 2000
2000 Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitisGastroenterology.  119:724-733. 2000
1999 Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell responseInfection and Immunity.  67:6249-6256. 1999
1999 gammadelta T cells regulate mucosally induced tolerance in a dose-dependent fashion.International Immunology.  11:1907-1916. 1999
1999 Human interleukin-12 enhances interferon-γ-producing influenza-specific memory CD8+ cytotoxic T lymphocytesJournal of Infectious Diseases.  180:1477-1486. 1999
1999 Effects of intranasal immunization on protective immunity against otitis mediaInternational Journal of Pediatric Otorhinolaryngology.  49:S227-S229. 1999
1999 Partial IgA-deficiency with increased Th2-type cytokines in TGF-β1 knockout miceJournal of Immunology.  163:1951-1957. 1999
1999 Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunityJournal of Infectious Diseases.  180:122-132. 1999
1999 Mucosal Th1- versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaquesJournal of Infectious Diseases.  179. 1999
1999 Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responsesJournal of Experimental Medicine.  189:1169-1179. 1999
1999 Strategies for mucosal vaccine developmentAmerican Journal of Tropical Medicine and Hygiene.  60:35-45. 1999
1999 Strategies for mucosal vaccine development.American Journal of Tropical Medicine and Hygiene.  60:35-45. 1999
1999 Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactionsJournal of Immunology.  162:1904-1909. 1999
1999 γδ T cells regulate mucosally induced tolerance in a dose-dependent fashionInternational Immunology.  11:1907-1916. 1999
1998 2.4 Measuring Cytokine Responses by ELISA, ELISPOT and RT-PCR MethodsMethods in Microbiology.  25:257-286. 1998
1998 Nasal immunization of nonhuman primates with simian immunodeficiency virus p55(gag) and cholera toxin adjuvant induces Th1/Th2 help for virus- specific immune responses in reproductive tissuesJournal of Immunology.  161:5952-5958. 1998
1998 Immune Responses against Outer Membrane Protein P6 of Nontypeable Haemophilus influenzae耳鼻咽喉科免疫アレルギー.  16:172-173. 1998
1998 Human milk proteins including secretory IgA fail to elicit tolerance after feedingInternational Immunology.  10:537-545. 1998
1998 Organized Peyer's patches are not required for mucosal IgA responses in the gut of LTβR-Ig treated miceFederation proceedings.  12. 1998
1998 The CD40-CD40L signal pathway is essential for mucosally-induced tolerance.Federation proceedings.  12:A599-A599. 1998
1998 Trinitrobenzene sulfonic acid (TNBS) induced colitis in IFN-gamma deficient mice.Federation proceedings.  12:A595-A595. 1998
1998 gamma delta T cells are not essential for the establishment of mucosally-induced high dose toleranceFederation proceedings.  12:A598-A598. 1998
1998 A mucosal intranet: Intestinal Epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytesJournal of Immunology.  160:2188-2196. 1998
1998 Lack of orally induced systemic unresponsiveness in IFN-γ knockout miceJournal of Immunology.  160:1687-1693. 1998
1998 Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaquesJournal of Infectious Diseases.  177:26-33. 1998
1998 Inflammatory mediators of the terminal dentition in adult and early onset periodontitisJournal of Periodontal Research.  33:212-225. 1998
1998 Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristicsGastroenterology.  115:866-873. 1998
1998 Measuring cytokine responses by ELISA, ELISPOT and RT-PCR methodsMETHODS IN MICROBIOLOGY, VOL 25.  25:257-286. 1998
1997 A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestineBiochemical and Biophysical Research Communications.  241:797-802. 1997
1997 Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primatesJournal of Immunology.  158:5321-5329. 1997
1997 A T cell/B cell/epithelial cell internet for mucosal inflammation and immunitySpringer Seminars in Immunopathology.  18:477-494. 1997
1997 An interleukin-7 internet for intestinal intraepithelial T cell development: Knockout of ligand or receptor reveal differences in the immunodeficient stateEuropean Journal of Immunology.  27:2133-2138. 1997
1997 A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunityProceedings of the National Academy of Sciences.  94:5267-5272. 1997
1997 Functional γδ t-lymphocyte defect associated with human immunodeficiency virus infectionsMolecular Medicine.  3:60-71. 1997
1997 Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticityJournal of Experimental Medicine.  185:1203-1210. 1997
1997 A nontoxic mutant of cholera toxin elicits mucosal immunity to vaccines given intranasally.Journal of Allergy and Clinical Immunology.  99:146-146. 1997
1997 Complete deficiency of intraepithelial gamma delta T cell development in IL-7R(-/-) but not IL-7(-/-) mice.Journal of Allergy and Clinical Immunology.  99:990-990. 1997
1997 Helper T subsets and cytokines for mucosal immunity and tolerance.Behring Institute Mitteilungen.  44-52. 1997
1997 Intranasal combined SIV vaccine induces both Th1 and Th2 responses in mucosal tissues of rhesus macaques.Journal of Allergy and Clinical Immunology.  99:144-144. 1997
1997 Molecular and cellular mechanisms for periodontal diseases: Role of Th1 and Th2 type cytokines in induction of mucosal inflammationJournal of Periodontal Research.  32:115-119. 1997
1997 Molecular and cellular mechanisms for periodontal diseases: Role of Th1 and Th2 type cytokines in induction of mucosal inflammationJournal of Periodontal Research.  32:115-119. 1997
1997 Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation.Journal of Periodontal Research.  32:115-119. 1997
1997 Oral recombinant Salmonella elicits mucosal IgA responses but accelerates colitis in IL-10 knockout mice.Journal of Allergy and Clinical Immunology.  99:1075-1075. 1997
1996 Absence of oral tolerance to human milk proteins (HMP) in miceFederation proceedings.  10. 1996
1996 Comparison of intraepithelial CD8+ and double negative (DN), yst cells for tel and tc2 cytokine synthesisFederation proceedings.  10. 1996
1996 Impaired mucosal iga responses in tcr6-/- miceFederation proceedings.  10. 1996
1996 Mode of vaccine expression by salmonella dictates th cell response: Th2 cell precedes TH1 cell antienterotoxigenic e. coli (ETEC) fimbriae responsesFederation proceedings.  10. 1996
1996 Mucosal immune responses in CD4 knockout miceFederation proceedings.  10. 1996
1996 Mucosally induced tolerance in IL-4-/- but not IFN-γ-/MICEFederation proceedings.  10. 1996
1996 Mutants of cholera toxin lacking cyclic-AMP activity retain adjuvanticityFederation proceedings.  10. 1996
1996 Prophylactic and therapeutic effects of oral and intranasal immunization of bovine type II collagen (CII) on collagen-induced-arthritis (cia) in DBA/1J miceFederation proceedings.  10. 1996
1996 Systemically administrated cholera toxin (ct) induced iga responses in rhesus macaqueSFederation proceedings.  10. 1996
1996 Tip and crypt intestinal epithelial cells express different levels of cd80 and cd86 moleculesFederation proceedings.  10. 1996
1996 Hapten-Induced Model of Murine Inflammatory Bowel Disease: Mucosal Immune Responses and Protection by ToleranceJournal of Immunology.  157:2174-2185. 1996
1996 Oral immunization with simian immunodeficiency virus (SIV) gag p55 and cholera toxin (CT) elicits mucosal immune responses in non-human primates.Federation proceedings.  10:361-361. 1996
1996 Luminometry: A novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responsesJournal of Immunological Methods.  190:189-197. 1996
1996 Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on γδ T-cell receptor-positive intraepithelial lymphocytesProceedings of the National Academy of Sciences.  93:3613-3618. 1996
1996 Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccineInfection and Immunity.  64:1290-1298. 1996
1996 gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses.Journal of Experimental Medicine.  183:1929-1935. 1996
1996 γ/δ T cell-deficient mice have impaired mucosal immunoglobulin a responsesJournal of Experimental Medicine.  183:1929-1935. 1996
1996 Selected Th1 and Th2 cytokine mRNA expression by CD4+T cells isolated from inflamed human gingival tissuesClinical and Experimental Immunology.  103:422-428. 1996
1996 Mucosal immunity: Regulation by helper T cells and a novel method for detectionJournal of Biotechnology.  44:209-216. 1996
1996 Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseasesAmerican Journal of Pathology.  148:331-339. 1996
1996 Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxinJournal of Infectious Diseases.  173:627-635. 1996
1996 Role of γδ T cells in the regulation of mucosal IgA response and oral toleranceAnnals of the New York Academy of Sciences.  778:55-63. 1996
1996 The role of Th1 and Th2 cells for mucosal IgA responsesAnnals of the New York Academy of Sciences.  778:64-71. 1996
1995 Analysis of intestinal intraepithelial lymphocyte (IEL) T cells in mice expressing anti-CD8 immunoglobulin transgenesAdvances in Experimental Medicine and Biology.  371:125-128. 1995
1995 ENHANCED DETECTION OF MUCOSAL AND SYSTEMIC IMMUNE-RESPONSES EMPLOYING BIOLUMINESCENT IMMUNOCHEMICAL PROBESFederation proceedings.  9:A215-A215. 1995
1995 FUNCTIONAL AND PHENOTYPIC CHARACTERIZATION OF INFLUENZA VIRUS-SPECIFIC CD8+/CD45R0+ CTLS AND CORRELATION WITH IFN-GAMMA PRODUCTIONJournal of Cellular Biochemistry.  304-304. 1995
1995 INDUCTION AND REGULATION OF IMMUNE-RESPONSES TO BIOENGINEERED MUCOSAL VACCINESJournal of Cellular Biochemistry.  166-166. 1995
1995 Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestineJournal of Immunology.  154:5611-5619. 1995
1995 Ig-Secreting and interferon-γ-producing cells in mice mucosally immunized with influenza virusAdvances in Experimental Medicine and Biology.  371:1587-1590. 1995
1995 Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4Journal of Immunology.  155:4621-4629. 1995
1995 Polarized Th2 cytokine expression by both mucosal γδ and αβ T cellsEuropean Journal of Immunology.  25:2743-2751. 1995
1994 TNBS-SPECIFIC ORAL TOLERANCE PROTECTS FROM HAPTEN-INDUCED COLITISGastroenterology.  106:A772-A772. 1994
1994 CYTOKINE PRODUCING T-CELLS IN IGA EFFECTOR TISSUES - SYNTHESIS OF IL-5 AND IL-6 BY GAMMA-DELTA TCR+ T-CELLS IN SALIVARY-GLANDFederation proceedings.  8:A787-A787. 1994
1994 CYTOKINE PRODUCTION AND CD45 ISOFORM EXPRESSION BY CD8+ T-CELLS ISOLATED FROM SIV-INFECTED RHESUS MACAQUESFederation proceedings.  8:A494-A494. 1994
1994 IL-2 RECEPTOR AND SIGNAL-TRANSDUCTION IN GAMMA-DELTA-TCR+ INTRAEPITHELIAL LYMPHOCYTES (IELS)Federation proceedings.  8:A507-A507. 1994
1994 T-CELL POPULATIONS ALONG THE RESPIRATORY-TRACT OF BALB/C MICEFederation proceedings.  8:A514-A514. 1994
1994 THE EFFECT OF EPITHELIAL-CELLS ON THE ACTIVATION OF CD3+ IELSFederation proceedings.  8:A207-A207. 1994
1994 CHARACTERIZATION OF VIRGIN AND MEMORY TYPE IFN-GAMMA PRODUCING CD8(+) T-LYMPHOCYTES IN SIV-INFECTED RHESUS MACAQUESAIDS Research and Human Retroviruses.  10:S67-S67. 1994
1994 Characterization of cytokine‐producing cells in mucosal effector sites: CD3+ T cells of Th1 and Th2 type in salivary gland‐associated tissuesEuropean Journal of Immunology.  24:2653-2658. 1994
1994 Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: Signaling of high density αβ T cell receptor+ and γδ T cell receptor+ T cells via T cell receptor‐CD3 complex results in interferon‐γ and interleukin‐5 production, while low density T cells undergo DNA fragmentationEuropean Journal of Immunology.  24:1301-1306. 1994
1994 Function of αbeta; TCR+ and γdelta; TCR+ IELs for the gastrointestinal immune responseInternational Reviews of Immunology.  11:1-14. 1994
1994 Function of αβ TCR+ and γδ TCR + IELs for the Gastrointestinal Immune ResponseInternational Reviews of Immunology.  11:1-14. 1994
1994 Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxinVaccine.  12:903-911. 1994
1994 IL-4 INDUCES APOPTOSIS IN MACROPHAGES ISOLATED FROM INFLAMED GINGIVAL TISSUESJournal of Dental Research.  73:250-250. 1994
1994 Quantitation of human influenza virus-specific cytotoxic T lymphocytes: Correlation of cytotoxicity and increased numbers of IFN-γ producing CD8+ T cellsInternational Immunology.  6:11-19. 1994
1994 TYPE-1 TYPE-2 CYTOKINE PRODUCTION BY CD4+ T-CELLS IN ADULT PERIODONTITISJournal of Dental Research.  73:204-204. 1994
1994 The common mucosal immune system: From basic principles to enteric vaccines with relevance for the female reproductive tractReproduction, Fertility and Development.  6:369-379. 1994
1993 alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses.Journal of Immunology.  151:6681-6691. 1993
1993 Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4American Journal of Pathology.  142:1239-1250. 1993
1993 Function of αβ TCR+ intestinal intraepithelial lymphocytes: Th1-and Th2-type cytokine production by CD4+ CD8- and CD4+ CD8+ T cells for helper activityInternational Immunology.  5:1473-1481. 1993
1993 Characterization of t and b cells isolated from mucosa-associated tissues of the rhesus macaqueCellular Immunology.  151:379-391. 1993
1993 Helper t cell subsets for immunoglobulin a responses: Oral inmaunization with tetanus toxoid and cholera toxinn as adjuvant selectively induces th2 cells in mucosa associated tissuesJournal of Experimental Medicine.  178:1309-1320. 1993
1993 MUCOSAL VACCINE FOR AIDS - ORAL IMMUNIZATION WITH HIV GP120 IN COMBINATION WITH LIPOSOME AND CHOLERA-TOXIN INDUCES ANTIGEN-SPECIFIC IGA PRODUCING CELLSAIDS Research and Human Retroviruses.  9:S36-S36. 1993
1993 NEW PERSPECTIVES IN MUCOSAL IMMUNITY WITH EMPHASIS ON VACCINE DEVELOPMENTSeminars in Hematology.  30:3-15. 1993
1993 New perspectives in mucosal immunity with emphasis on vaccine development.Seminars in Hematology.  30:3-12. 1993
1993 Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues.Journal of Periodontology.  64:400-406. 1993
1993 A SUBSET OF GAMMA-DELTA-TCR+ INTRAEPITHELIAL LYMPHOCYTES (IELS) NATURALLY EXPRESS BOTH IL-2 AND IL-7 RECEPTORSJournal of Immunology.  150:A204-A204. 1993
1993 CHARACTERIZATION T-CELL SUBSETS IN MURINE TRACHEAL INTRAEPITHELIAL LYMPHOCYTES (IELS)Journal of Immunology.  150:A22-A22. 1993
1993 COMPARATIVE-ANALYSIS OF CYTOKINE SECRETION BY LAMINA PROPRIA LYMPHOCYTES (LPLS) FROM THE MOUSE SMALL AND LARGE-INTESTINEJournal of Immunology.  150:A38-A38. 1993
1993 CYTOKINE PRODUCTION IN IGA EFFECTOR SITES - SALIVARY-GLAND GAMMA/DELTA-TCR+ AND ALPHA/BETA-TCR+ T-CELLS SECRETE TYPE-2 LYMPHOKINESJournal of Immunology.  150:A273-A273. 1993
1993 EFFECT OF EXPRESSION OF ANTI-CD8 AS TRANSGENE ON MUCOSAL LYMPHOCYTESJournal of Immunology.  150:A38-A38. 1993
1993 INDUCTION OF PROTECTIVE IMMUNE-RESPONSES TO ORALLY-ADMINISTERED TETANUS TOXOID (TT) USING CHOLERA-TOXIN (CT) AS AN ADJUVANTJournal of Immunology.  150:A35-A35. 1993
1993 QUANTITATION OF HUMAN INFLUENZA-SPECIFIC CTLS - CORRELATION OF CYTOTOXICITY AND INCREASED NUMBERS OF IFN-GAMMA PRODUCING CD8+ T-CELLSJournal of Immunology.  150:A116-A116. 1993
1993 SIGNALING OF LOW-DENSITY ALPHA/BETA-TCR+ AND GAMMA/DELTA-TCR+ IELS VIA THE TCR-CD3 COMPLEX LEADS TO APOPTOSISJournal of Immunology.  150:A278-A278. 1993
1993 Cytokine-specific ELISPOT assay single cell analysis of IL-2, IL-4 and IL-6 producing cellsJournal of Immunological Methods.  160:181-189. 1993
1993 CYTOKINE SECRETION BY INTRAEPITHELIAL (IEL) AND LAMINA PROPRIA LYMPHOCYTES (LPL) FROM MURINE SMALL-BOWEL (SB) AND LARGE-BOWEL (LB)Gastroenterology.  104:A780-A780. 1993
1993 Cytokine profiles of bronchoalveolar lavage cells from mice with influenza pneumonia: Consequences of CD4+ and CD8+ T cell depletionRegional immunology.  5:142-150. 1993
1993 Cytokine synthesis by intestinal intraepithelial lymphocytes: Both γ/δ T cell receptor-positive and α/β T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-γ and IL-5Journal of Immunology.  150:106-114. 1993
1993 Optimizing oral vaccines: Induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvantInfection and Immunity.  61:4272-4279. 1993
1993 The Mycobacterium tuberculosis 71‐kDa heat‐shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytesEuropean Journal of Immunology.  23:2049-2052. 1993
1993 αβ T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2- like function for B cell responsesJournal of Immunology.  151:6681-6691. 1993
1992 Cytokine production and T cell receptor expression by salivary gland T cells and intraepithelial T lymphocytes for the regulation of the IgA responseAdvances in Experimental Medicine and Biology.  327:119-131. 1992
1992 Induction of T helper cells and cytokines for mucosal IgA responsesAdvances in Experimental Medicine and Biology.  327:107-117. 1992
1992 Effects of the Ipr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector siteInternational Immunology.  4:959-968. 1992
1992 Immunoregulatory functions for murine htraepithelial lymphocytes: γ/δ T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while α/β TCR+ T cells provide B cell helpJournal of Experimental Medicine.  175:695-707. 1992
1992 ACTIVATION OF HIGH-DENSITY ALPHA/BETA-TCR+ IELS VIA THE TCR-CD3 COMPLEX RESULTS IN CYTOKINE PRODUCTIONFederation proceedings.  6:A1707-A1707. 1992
1992 CHARACTERIZATION OF RHESUS MACAQUE TCR-CD3 SPECIFIC MONOCLONAL-ANTIBODIESFederation proceedings.  6:A1706-A1706. 1992
1992 MODIFICATION OF THE EXPRESSION OF ASIALOGLYCOPROTEIN RECEPTOR ON HUMAN HEPATOMA-CELLS BY CYTOKINESFederation proceedings.  6:A1861-A1861. 1992
1992 Effects of IL6 on B cells in mucosal immune response and inflammationResearch in immunology.  143:744-749. 1992
1992 Immunoregulatory functions for murine intraepithelial lymphocytes: γδ T cell receptor-positive (TCR^+) T cells abrogate oral tolerance, while αβ TCR^+ T cells provide B cell helpJ. Exp. Med..  175. 1992
1992 Intestinal intraepithelial lymphocyte T cells are resistant to Ipr gene‐induced T cell abnormalitiesEuropean Journal of Immunology.  22:137-145. 1992
1992 Regulation of mucosal immune responses by T lymphocytes: The effect of chronic CD4+T cell deficiency on IgA synthesisRegional immunology.  4:70-78. 1992
1992 The use of the hu-PBL-SCID mouse model to study lymphocyte homing and responsiveness to recall antigensRegional immunology.  4:86-90. 1992
1991 Regulatory functions for murine intraepithelial lymphocytes in mucosal responsesImmunologic Research.  10:324-330. 1991
1991 Role of IL-6 in human antigen-specific and polyclonal IgA responsesAdvances in human genetics.  310:113-121. 1991
1991 Role of interleukin-6 in human and mouse mucosal IgA plasma cell responsesImmunologic Research.  10:418-422. 1991
1991 CYTOKINE PRODUCTION BY TCR1+ T-CELLS - A SUBSET OF IELS PRODUCE BOTH IFN-GAMMA AND IL-5Federation proceedings.  5:A1781-A1781. 1991
1991 CYTOKINE PROFILE OF CD3+ TCR1+ CONTRASUPPRESSOR CELLS IN MURINE IELSFederation proceedings.  5:A1690-A1690. 1991
1991 LAMINA PROPRIA LYMPHOCYTES (LPL) AND INTRAEPITHELIAL LYMPHOCYTES (IEL) IN MRL IPR IPR MICE ARE NOT AFFECTED BY THE IPR GENE MUTATIONFederation proceedings.  5:A1693-A1693. 1991
1991 RAT IELS CONTAIN A HIGH-FREQUENCY OF CD4+, TCR2+ T-CELLSFederation proceedings.  5:A1693-A1693. 1991
1991 ANALYSIS OF IGA RESPONSES IN SIV-INFECTED RHESUS MACAQUESFederation proceedings.  5:A598-A598. 1991
1991 Cytokine regulation of localized inflammation: Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingivaJournal of Immunology.  146:1812-1821. 1991
1991 Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesisJournal of Clinical Investigation.  88:248-252. 1991
1991 Novel function for intestinal intraepithelial lymphocytes: Murine CD3+, γ/δ TCR+ T cells produce IFN-γ and IL-5Journal of Immunology.  147:3736-3744. 1991
1991 Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cellsCellular Immunology.  132:423-432. 1991
1990 Interleukin and localized inflammatory disease: Role of IL-6 in polyclonal IgG and IgA responses in adult periodontitisEos -Roma-.  10:173-174. 1990
1990 Immunoregulatory confluence: T cells, fc receptors and cytokines for iga immune responsesInternational Reviews of Immunology.  6:263-273. 1990
1990 Regulatory function for murine intraepithelial lymphocytes: Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral toleranceJournal of Immunology.  145:2010-2019. 1990
1989 Immunoregulatory function of CD3+, CD4- and CD8- T cells. γδ T cell receptor-positive T cells from nude mice abrogate oral toleranceJournal of Immunology.  143:3415-3422. 1989
1989 Mucosal homeostasis: Role of interleukins, isotype-specific factors and contrasuppression in the iga responseImmunological communications.  18:77-89. 1989
1988 Isotype-specific immunoregulation. Systemic antigen induces splenic T contrasuppressor cells which support IgM and IgG subclass but not IgA responsesJournal of Immunology.  140:1385-1392. 1988
1988 Role of the galt contrasuppressor T cell circuit in isotype-specific immunoregulation.Advances in Experimental Medicine and Biology.  237:649-653. 1988
1988 The role of CD3+, CD4-, and CD8- T cells in mucosal immunoregulationClinical Immunology Newsletter.  9:200-203. 1988
1987 Contrasuppressor cells that break oral tolerance are antigen-specific T cells distinct from T helper (L3T4+), T suppressor (Lyt-2+), and B cellsJournal of Immunology.  139:3251-3259. 1987

Chapter

Year Title Altmetric
2012 Host defenses at mucosal surfaces.  239-251. 2012
2008 Host defenses at mucosal surfaces.  287-303. 2008
2005 Collection and processing of external secretions and tissues of mouse origin.  1841-1852. 2005
2005 Th1/Th2/Th3 cells for regulation of mucosal immunity, tolerance, and inflammation.  539-558. 2005
1997 Mucosal immunity and gnotobiology: Past accomplishments help point to future needs.  209-13. 1997
1996 Regulation of mucosal immune responses by helper T cells and cytokines.  62-81. 1996

Education And Training

  • Doctor of Philosophy in Immunology, Osaka Dental University 1994
  • Full Name

  • Kohtaro Fujihashi