Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Dietary oxalate and kidney stone formationAJP - Renal Physiology.  316:F409-F413. 2019
2019 Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.Lancet Respiratory Medicine.  7:227-238. 2019
2019 Optical spectroscopic properties recorded for simple BOPHY dyes in condensed media: The mirror-symmetry factorSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.  208:57-64. 2019
2018 Age at first birth in women is genetically associated with increased risk of schizophreniaScientific Reports.  8. 2018
2018 Heteroatom Donor-Decorated Polymer-Immobilized Ionic Liquid Stabilized Palladium Nanoparticles: Efficient Catalysts for Room-Temperature Suzuki-Miyaura Cross-Coupling in Aqueous MediaJournal fur Praktische Chemie.  360:3716-3731. 2018
2018 Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x)Nature Genetics.  50:1755. 2018
2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traitsNature Genetics.  50:1412-1425. 2018
2018 Translating GWAS in rheumatic disease: approaches to establishing mechanism and function for genetic associations with ankylosing spondylitisBriefings in Functional Genomics.  17:308-318. 2018
2018 APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies.Alzheimer's and Dementia.  14:1137-1147. 2018
2018 Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 SubphenotypesCell.  173:1705-1715.e16. 2018
2018 A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia.American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.  177:454-467. 2018
2018 Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.American Journal of Human Genetics.  102:1185-1194. 2018
2018 Hydroxyproline metabolism and oxalate synthesis in primary hyperoxaluriaJournal of the American Society of Nephrology.  29:1615-1623. 2018
2018 Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.Nature Genetics.  50:538-548. 2018
2018 AltHapAlignR: Improved accuracy of RNA-seq analyses through the use of alternative haplotypesComputer applications in the biosciences : CABIOS.  34:2401-2408. 2018
2018 Distinct HLA associations of LGI1 and CASPR2-antibody diseasesBrain.  141:2263-2271. 2018
2018 End-to-end communication in a linear supermolecule with a BOPHY centre and: N, N -dimethylanilino-based terminalsNew Journal of Chemistry.  42:4835-4842. 2018
2018 Highly efficient aqueous phase reduction of nitroarenes catalyzed by phosphine-decorated polymer immobilized ionic liquid stabilized PdNPsCatalysis Science and Technology.  8:1454-1467. 2018
2017 Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophreniaTranslational Psychiatry.  7:e1155. 2017
2017 Thermally-Activated, Delayed Fluorescence in O,B,O- and N,B,O-Strapped Boron Dipyrromethene DerivativesJournal of Physical Chemistry A.  121:2096-2107. 2017
2017 An investigational RNAi therapeutic targeting glycolate oxidase reduces oxalate production in models of primary hyperoxaluriaJournal of the American Society of Nephrology.  28:494-503. 2017
2017 Highly efficient aqueous phase chemoselective hydrogenation of α,β-unsaturated aldehydes catalysed by phosphine-decorated polymer immobilized IL-stabilized PdNPsGreen Chemistry.  19:1635-1641. 2017
2017 Synthesis of 2-aminoBODIPYs by palladium catalysed aminationJournal of the Chemical Society, Perkin Transactions 1.  15:7643-7653. 2017
2016 Probiotic properties of Oxalobacter formigenes: an in vitro examinationArchiv fur Mikrobiologie.  198:1019-1026. 2016
2016 RNA interference in the treatment of renal stone disease: Current status and future potentialsInternational Journal of Surgery.  36:713-716. 2016
2016 Ascorbic acid intake and oxalate synthesisUrolithiasis.  44:289-297. 2016
2016 Effects of alanine: Glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assayBBA - Molecular Basis of Disease.  1862:1055-1062. 2016
2016 Triaryl-Like MONO-, BIS-, and TRISKITPHOS Phosphines: Synthesis, Solution NMR Studies, and a Comparison in Gold-Catalyzed Carbon-Heteroatom Bond Forming 5-exo-dig and 6-endo-dig CyclizationsOrganometallics.  35:1265-1278. 2016
2016 Oxalate Concentrations in Human Gastrointestinal FluidJournal of Endourology and Part B, Videourology.  30:S8-S11. 2016
2016 Lowering urinary oxalate excretion to decrease calcium oxalate stone diseaseUrolithiasis.  44:27-32. 2016
2016 Metabolism of 13C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenaseBBA - Molecular Basis of Disease.  1862:233-239. 2016
2016 Oxalate formation from glyoxal in erythrocytesUrology.  88:226.e11-226.e15. 2016
2016 Circularly Polarized Luminescence from Helically Chiral N,N,O,O-Boron-Chelated DipyrromethenesChemistry - A European Journal.  22:93-96. 2016
2016 Efficient and selective oxidation of sulfides in batch and continuous flow using styrene-based polymer immobilised ionic liquid phase supported peroxotungstatesRSC Advances.  6:73118-73131. 2016
2016 Proteome Dynamics of the Specialist Oxalate Degrader Oxalobacter formigenes.Journal of Proteomics and Bioinformatics.  9:19-24. 2016
2016 Response of germfree mice to colonization by Oxalobacter formigenes and altered Schaedler floraApplied and Environmental Microbiology.  82:6952-6960. 2016
2015 Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3BBA - Molecular Basis of Disease.  1852:2700-2705. 2015
2015 Synthesis of 3-aminoBODIPY dyes via copper-catalyzed vicarious nucleophilic substitution of 2-halogeno derivativesJournal of the Chemical Society, Perkin Transactions 1.  13:3819-3829. 2015
2015 Efficient and selective hydrogen peroxide-mediated oxidation of sulfides in batch and segmented and continuous flow using a peroxometalate-based polymer immobilised ionic liquid phase catalystGreen Chemistry.  17:1559-1571. 2015
2015 Analysis of commercial kidney stone probiotic supplementsUrology.  85:517-521. 2015
2015 Oxalobacter formigenes colonization and oxalate dynamics in a mouse modelApplied and Environmental Microbiology.  81:5048-5054. 2015
2014 Palladium-catalyzed suzuki-miyaura cross-couplings with 2-diethylphosphonato-substituted aryl-and naphthylboronate esters as the nucleophilic partner: A complementary approach to the synthesis of biaryl monophosphonatesOrganometallics.  33:5209-5219. 2014
2014 Fish oil supplementation and urinary oxalate excretion in normal subjects on a low-oxalate dietUrology.  84:779-782. 2014
2014 An efficient Cu(II)-bis(oxazoline)-based polymer immobilised ionic liquid phase catalyst for asymmetric carbon-carbon bond formationGreen Chemistry.  16:1470-1479. 2014
2014 ReplyUrology.  84:782. 2014
2013 Internet program for facilitating dietary modifications limiting kidney stone riskCanadian Journal of Urology.  20:6922-6926. 2013
2013 The genetic composition of Oxalobacter formigenes and its relationship to colonization and calcium oxalate stone diseaseUrological Research.  41:187-196. 2013
2013 Electron-rich trialkyl-type dihydro-KITPHOS monophosphines: Efficient ligands for palladium-catalyzed suzuki-miyaura cross-coupling. Comparison with their biaryl-like KITPHOS monophosphine counterpartsOrganometallics.  32:1773-1788. 2013
2013 The effects of oxazyme on oxalate degradation: Results and implications of in vitro experimentsJournal of Endourology and Part B, Videourology.  27:284-287. 2013
2012 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibitionBBA - Molecular Basis of Disease.  1822:1544-1552. 2012
2012 Synthesis of an electron-rich KITPHOS monophosphine, preparation of derived metal complexes and applications in catalysisNature Protocols.  7:1870-1883. 2012
2012 Sensitivity of human strains of oxalobacter formigenes to commonly prescribed antibioticsUrology.  79:1286-1289. 2012
2012 The impact of dietary calcium and oxalate ratios on stone riskUrology.  79:1226-1229. 2012
2012 Glyoxal formation and its role in endogenous oxalate synthesisAdvances in Urology2012
2012 An efficient recyclable peroxometalate-based polymer-immobilised ionic liquid phase (PIILP) catalyst for hydrogen peroxide-mediated oxidationGreen Chemistry.  14:925-929. 2012
2012 Hydroxyproline metabolism in mouse models of primary hyperoxaluriaAJP - Renal Physiology.  302. 2012
2012 Metabolism of [ 13C 5]hydroxyproline in vitro and in vivo: Implications for primary hyperoxaluriaAJP - Gastrointestinal and Liver Physiology.  302. 2012
2012 Asymmetric carbonyl-ene and Friedel-Crafts reactions catalysed by Lewis acid platinum group metal complexes of the enantiopure atropisomeric biaryl-like diphosphine (S)-Me 2 -CATPHOS: A comparison with BINAPTetrahedron: Asymmetry.  23:209-216. 2012
2012 Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometryAnalytical Biochemistry.  421:121-124. 2012
2011 Variability in urinary oxalate measurements between six international laboratoriesNephrology Dialysis Transplantation.  26:3954-3959. 2011
2011 Ruthenium complexes of κ(P)-and κ(P)-η 6 - coordinated KITPHOS monophosphines: Efficient catalysts for the direct ortho arylation of 2-phenylpyridine and N-phenylpyrazole with aryl chloridesOrganometallics.  30:6010-6016. 2011
2011 Re: Oxalate and sucralose absorption in idiopathic calcium oxalate stone formersJournal of Urology, The.  186:1916-1917. 2011
2011 Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: Implications for hydroxyproline metabolism in primary hyperoxaluriaPLoS ONE.  6. 2011
2011 Impact of dietary calcium and oxalate, and oxalobacter formigenes colonization on urinary oxalate excretionJournal of Urology, The.  186:135-139. 2011
2011 Metabolism of primed, constant infusions of [1,2-13C 2] glycine and [1-13C1] phenylalanine to urinary oxalateMetabolism.  60:950-956. 2011
2011 Gold-catalyzed cyclizations: A comparative study of ortho,ortho'- substituted KITPHOS monophosphines with their biaryl monophosphine counterpart SPHOSJournal fur Praktische Chemie.  353:749-759. 2011
2011 Oxalate and sucralose absorption in idiopathic calcium oxalate stone formersUrology.  78:475.e9-475.e13. 2011
2010 Metabolism of fructose to oxalate and glycolateHormone and Metabolic Research.  42:868-873. 2010
2010 Efficient cycloisomerization of propargyl amides by electrophilic gold(I) complexes of KITPHOS monophosphines: A comparative studyOrganometallics.  29:4139-4147. 2010
2010 Ortho, ortho′-Substituted KITPHOS monophosphines: Highly efficient ligands for palladium-catalyzed C-C and C-N bond formationJournal fur Praktische Chemie.  352:201-211. 2010
2009 Rhodium complexes of (R)-Me-CATPHOS and (R)-(S)-JOSIPHOS: highly enantioselective catalysts for the asymmetric hydrogenation of (E)- and (Z)-β-aryl-β-(enamido)phosphonatesTetrahedron: Asymmetry.  20:1437-1444. 2009
2009 Intravenous ascorbic acid infusions and oxalate productionMetabolism.  58:888. 2009
2009 Increased protein intake on controlled oxalate diets does not increase urinary oxalate excretionUrological Research.  37:63-68. 2009
2009 Effect of soda consumption on urinary stone risk parametersJournal of Endourology and Part B, Videourology.  23:347-350. 2009
2009 Gold(I) complexes of KITPHOS monophosphines: Efficient cycloisomerisation catalystsJournal fur Praktische Chemie.  351:576-582. 2009
2008 Electron-rich, bicyclic biaryl-like KITPHOS monophosphines via [4+2] cycloaddition between 1-alkynylphosphine oxides and anthracene: Highly efficient ligands for palladium-catalysed C-N and C-C bond formationJournal fur Praktische Chemie.  350:1801-1806. 2008
2008 Biaryl-like CATPHOS diphosphines via double diels-alder cycloaddition between 1,4-bis(diphenylphosphinoyl)buta-1,3-diyne and anthracenes: Efficient ligands for the palladium-catalyzed amination of aromatic bromides and α-arylation of ketonesOrganometallics.  27:1679-1682. 2008
2008 Synthesis of highly substituted pyrrolidines via palladium-catalyzed cyclization of 5-vinyloxazolidinones and activated alkenesTetrahedron.  64:3744-3750. 2008
2008 Oxazoline-substituted prolinamide-based organocatalysts for the direct intermolecular aldol reaction between cyclohexanone and aromatic aldehydesEuropean Journal of Organic Chemistry.  1759-1766. 2008
2007 Efficient asymmetric carbonyl-ene reactions catalyzed by platinum metal lewis acid complexes of conformationally flexible NUPHOS diphosphines: A comparison with BINAPOrganometallics.  26:6453-6461. 2007
2007 Metal-dependent reactivity of electrophilic platinum group metal lewis acid catalysts: Competitive alkene dimerization, intramolecular friedel-crafts alkylation, and carbonyl-ene reactivityOrganometallics.  26:5961-5966. 2007
2007 Rhodium-catalyzed double [2 + 2 + 2] cycloaddition of 1,4- bis(diphenylphosphinoyl)buta-1,3-diyne with tethered diynes: A modular, highly versatile single-pot synthesis of NU-BIPHEP biaryl diphosphinesOrganic Letters.  9:4925-4928. 2007
2007 Variability of Oxalobacter Formigenes and Oxalate in Stool SamplesJournal of Urology, The.  178:2186-2190. 2007
2007 Phosphorus NMR and ab initio modelling of P-N bond rotamers of a sterically crowded chiral β-P 4 S 3 diamideJournal of Inorganic and General Chemistry.  633:1442-1450. 2007
2007 Intestinal and renal handling of oxalate loads in normal individuals and stone formersUrological Research.  35:111-117. 2007
2007 Asymmetric hydrogenation of ketones with ruthenium complexes of rac- and enantiopure (S,S)-1,2-bis((diphenylphosphino)methyl)cyclohexane: A comparative study with rac- and (R)-BINAPOrganometallics.  26:2465-2468. 2007
2007 Recyclable copper catalysts based on imidazolium-tagged bis(oxazolines): A marked enhancement in rate and enantioselectivity for Diels-Alder reactions in ionic liquidJournal fur Praktische Chemie.  349:951-963. 2007
2006 Asymmetric platinum group metal-catalyzed carbonyl-ene reactions: Carbon-carbon bond formation versus isomerizationJournal of Organic Chemistry.  71:9751-9764. 2006
2006 Hydroxyproline ingestion and urinary oxalate and glycolate excretionKidney International.  70:1929-1934. 2006
2006 Modular synthesis of a new class of bis(amino-oxazoline) using palladium-catalyzed Buchwald-Hartwig amination methodologyOrganometallics.  25:4341-4350. 2006
2006 Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2Nephrology Dialysis Transplantation.  21:2292-2295. 2006
2006 The first insoluble polymer-bound palladium complexes of 2-pyridyldiphenylphosphine: Highly efficient catalysts for the alkoxycarbonylation of terminal alkynesChemical Communications.  88-90. 2006
2006 Phosphorus NMR characterisation of P-N bond rotamers of a α-P 4 S 3 amide with a conformationally constrained chiral substituentJournal of Inorganic and General Chemistry.  632:425-432. 2006
2006 Enantiospecific formation of 3,6-dihydro-1H-pyridin-2-ones: Low-pressure palladium-catalysed decarboxylative carbonylation of 3-tosyl-5-vinyloxazolidin- 2-onesSYNTHESIS.  227-230. 2006
2005 Synthesis of highly substituted pyrrolidines via palladium catalysed formal [2+3] cycloaddition of 5-vinyloxazolidin-2-ones to activated alkenesTetrahedron Letters.  46:6261-6264. 2005
2005 Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux.Laryngoscope.  115:1473-1478. 2005
2005 Ruthenium complexes of six-electron-donor NUPHOS-Type diphosphines: Highly selective catalysts for the hydrocarboxylation of terminal alkynesOrganometallics.  24:2633-2644. 2005
2005 2-Aryl-5,5-bisoxazolin-2-yl[1,3]dioxanes as solution phase and immobilised ligands for highly enantioselective cyclopropanationsTetrahedron: Asymmetry.  16:1415-1418. 2005
2005 Mitochondrial hydroxyproline metabolism: Implications for primary hyperoxaluriaAmerican Journal of Nephrology.  25:171-175. 2005
2004 Highly efficient asymmetric hetero-diels-alder reactions of carbonyl compounds catalyzed by Lewis acid platinum complexes of conformationally flexible NUPHOS-type diphosphinesOrganometallics.  23:6127-6133. 2004
2004 Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease.Laryngoscope.  114:2129-2134. 2004
2004 Responsiveness to a pandemic alert: Use of reverse genetics for rapid development of influenza vaccinesLancet.  363:1099-1103. 2004
2004 Comparative study of diastereoisomer interconversion in chiral BINOL-ate and diamine platinum complexes of conformationally flexible NUPHOS diphosphinesOrganometallics.  23:1055-1064. 2004
2003 Highly Efficient Asymmetric Lewis Acid Catalysis with Platinum Group Complexes of Conformationally Flexible 1,3-Butadiene-Bridged Diphosphines, NUPHOSOrganic Letters.  5:3863-3866. 2003
2003 Ruthenium complexes of the 1,4-bis(diphenylphosphino)-1,3-butadiene-bridged diphosphine 1,2,3,4-Me 4 -NUPHOS: Solvent-dependent interconversion of four- and six-electron donor coordination and transfer hydrogenation activityOrganometallics.  22:1452-1462. 2003
2003 Diastereoselective synthesis of 3,6-disubstituted 3,6-dihydropyridin-2-onesTetrahedron Letters.  44:757-760. 2003
2003 Total synthesis of deoxymannojirimycin and D-mannolactam via carbonylation of 5-vinyloxazolidin-2-onesTetrahedron.  59:281-286. 2003
2002 Diastereospecific carbonylation of π-allylpalladium complexes to give 3,6-disubstituted 3,6-dihydro-1H-pyridin-2-onesTetrahedron.  58:6659-6664. 2002
2002 Iminophosphines: Synthesis, formation of 2,3-dihydro-1 H-benzo[1,3]azaphosphol-3-ium salts and N-(pyridin-2-yl)-2-diphenylphosphinoylaniline, coordination chemistry and applications in platinum group catalyzed Suzuki coupling reactions and hydrosilylationsJournal of Organometallic Chemistry.  650:231-248. 2002
2002 Synthesis of a new class of 1,4-bis(diphenylphosphino)-1,3-butadiene bridged diphosphine, NUPHOS, via zirconium-mediated reductive coupling of alkynes and diynes: Applications in palladium-catalyzed cross-coupling reactionsOrganometallics.  21:1383-1399. 2002
2001 Selectivity for the methoxycarbonylation of ethylene versus CO-ethylene copolymerization with catalysts based on C 4 -bridged bidentate phosphines and phospholesJournal of Organometallic Chemistry.  640:182-196. 2001
2001 Zirconium-mediated synthesis of a new class of 1,4-bis(diphenylphosphino)-1,3-butadiene-bridged diphosphine, NUPHOS: Highly efficient catalysts for palladium-mediated cross couplingsJournal of the American Chemical Society.  123:5110-5111. 2001
2001 New phosphorus sulfide cyanides and amides: Assigning phosphorus NMR spectra of polycyclic compounds using low-level ab initio calculations of shieldingsPhosphorus, Sulfur, and Silicon and the Related Elements.  168-169:209-214. 2001
2000 Remarkable differences in catalyst activity and selectivity for the production of methyl propanoate versus CO-ethylene copolymer by a series of palladium complexes of related C4-bridged diphosphinesOrganometallics.  19:4957-4967. 2000
2000 Synthesis of δ-lactones from 2-alkynyl epoxides and 4-alkynyl-1,3-dioxolan-2-ones by palladium catalysed carbonylation and conjugate nucleophilic additionJournal of the Chemical Society, Perkin Transactions 1.  3188-3190. 2000
2000 Enantioselective synthesis of 3,6-dihydro-1H-pyridin-2-ones: Unexpected regioselectivity in the palladium-catalyzed decarboxylative carbonylation of 5-vinyloxazolidin-2-ones [1]Journal of the American Chemical Society.  122:2944-2945. 2000
1996 Cleavage of MEM ethers by tetrahalozincate reagentsTetrahedron.  52:15257-15266. 1996
1996 Asymmetric copper-catalysed alkene cyclopropanation and aziridination using tartrate-derived bis-oxazoline ligandsTetrahedron Letters.  37:6189-6192. 1996
1996 New Tartrate-Derived Bis-Oxazoline Ligands for Enantioselective Cyclopropanation and Aziridination of AlkenesSYNLETT.  1996:677-678. 1996
1994 An examination of the structures of iodosylbenzene (PhIO) and the related imido compound, PhINSO 2 -4-Me-C 6 H 4 , by X-ray powder diffraction and EXAFS (extended X-ray absorption fine structure) spectroscopyJournal of the Chemical Society, Chemical Communications.  2367-2368. 1994
1991 Total synthesis of the anthelmintic macrolide avermectin B1aJournal of the Chemical Society, Perkin Transactions 1.  667-692. 1991
1991 Synthesis of the alkaloids (-)-heliotridane and (-)-isoretronecanol via π-allyltricarbonyliron lactam complexes.Tetrahedron Letters.  32:7119-7122. 1991
1990 Assessment of butene-1,4-diols as starting materials for the preparation of π-Allyltricarbonyliron complexesTetrahedron.  46:4063-4082. 1990

Chapter

Year Title Altmetric
2015 Role of Oxalobacter formigenes colonization in calcium oxalate kidney stone disease.  77-84. 2015
2008 Recent Developments in Alkyne Carbonylation.  251-290. 2008
2007 Carbenes and Nitrenes.  175-193. 2007
2007 Carbenes and Nitrenes.  213-230. 2007
2007 Carbenes and Nitrenes.  183-200. 2007

Education And Training

  • Doctor of Philosophy in Physiology, Newcastle University 2001
  • Full Name

  • John Knight