Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Effect of positive airway pressure therapy in children with obstructive sleep apnea syndrome: does positive airway pressure use reduce pedestrian injury risk?Sleep Health.  5:161-165. 2019
2019 Circadian regulation of membrane physiology in neural oscillators throughout the brainEuropean Journal of Neuroscience2019
2019 Misaligned core body temperature rhythms impact cognitive performance of hospital shift work nursesNeurobiology of Learning and Memory2019
2019 Shift Work Disrupts Circadian Regulation of the Transcriptome in Hospital NursesJournal of Biological Rhythms2019
2018 Editorial overview: Circadian rhythmsCurrent Opinion in Physiology.  5:iii-v. 2018
2018 Behavioral and SCN neurophysiological disruption in the Tg-SwDI mouse model of Alzheimer's diseaseNeurobiology of Disease.  114:194-200. 2018
2018 Genetic deletion of the circadian clock transcription factor BMAL1 and chronic alcohol consumption differentially alter hepatic glycogen in miceAJP - Gastrointestinal and Liver Physiology.  314:G431-G447. 2018
2018 Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric DisordersNeural Plasticity.  2018:5892657. 2018
2018 High dietary sodium causes dyssynchrony of the renal molecular clock in ratsAJP - Renal Physiology.  314:F89-F98. 2018
2017 Correcting delayed circadian phase with bright light therapy predicts improvement in ADHD symptoms: A pilot studyJournal of Psychiatric Research.  91:105-110. 2017
2017 GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticityHippocampus.  27:890-898. 2017
2017 Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleusEuropean Journal of Neuroscience.  45:1102-1110. 2017
2017 The impact of meal timing on cardiometabolic syndrome indicators in shift workersChronobiology International.  34:337-348. 2017
2017 The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleusFrontiers in Neuroendocrinology.  44:35-82. 2017
2016 Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitabilityNature Communications.  7. 2016
2016 Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant miceBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids.  1861:1579-1595. 2016
2016 Sleep-deprived motor vehicle operators are unfit to drive: A multidisciplinary expert consensus statement on drowsy drivingSleep Health.  2:94-99. 2016
2016 Synchronized time-keeping is key to healthy mood regulation (Commentary on Landgraf et al.)European Journal of Neuroscience.  43:1307-1308. 2016
2016 Cortical PGC-1?-dependent transcripts are reduced in postmortem tissue from patients with schizophreniaSchizophrenia Bulletin.  42:1009-1017. 2016
2015 GIRK channels mediate the nonphotic effects of exogenous melatoninJournal of Neuroscience.  35:14957-14965. 2015
2015 The molecular circadian clock and alcohol-induced liver injuryBiomolecules.  5:2504-2537. 2015
2015 Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in miceAJP - Gastrointestinal and Liver Physiology.  308:G964-G974. 2015
2015 KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expressionJournal of Lipid Research.  56:227-240. 2015
2015 Circadian biology: The early bird catches the morning shiftCurrent Biology.  25:R269-R271. 2015
2015 Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleusJournal of Biological Rhythms.  30:155-160. 2015
2015 Obstructive sleep apnea syndrome increases pedestrian injury risk in childrenJournal of Pediatrics.  166:109-114. 2015
2014 Does excessive daytime sleepiness affect children's pedestrian safety?SLEEP.  37:283-287. 2014
2014 Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heartJournal of Biological Rhythms.  29:257-276. 2014
2014 Circadian clock control of endocrine factorsNature Reviews Endocrinology.  10:466-475. 2014
2014 Formation of α-synuclein lewy neurite-like aggregates in axons impedes the transport of distinct endosomesCell regulation.  25:4010-4023. 2014
2014 Sleep strategies of night-shift nurses on days off: Which ones are most adaptive?Frontiers in Neurology.  5. 2014
2014 Suprachiasmatic nucleus function and circadian entrainment are modulated by G protein-coupled inwardly rectifying (GIRK) channelsJournal of Physiology.  592:5079-5092. 2014
2013 Adults With ADHD-Without Insomnia History Have Subclinical Sleep Disturbance but Not Circadian Delay: An ADHD Phenotype?Journal of Attention Disorders.  17:583-588. 2013
2013 Shift work and circadian dysregulation of reproductionFrontiers in Endocrinology.  4. 2013
2013 Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleusJournal of Neurophysiology.  110:1097-1106. 2013
2013 Chronic Ethanol Consumption Disrupts the Core Molecular Clock and Diurnal Rhythms of Metabolic Genes in the Liver without Affecting the Suprachiasmatic NucleusPLoS ONE.  8. 2013
2013 Complete sleep-wake cycle reversal related to ADHD detected by actigraphyAnnals of Clinical Psychiatry.  25. 2013
2013 Metabolism as an integral cog in the mammalian circadian clockworkCritical Reviews in Biochemistry and Molecular Biology.  48:317-331. 2013
2013 Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in miceInternational Journal of Obesity.  37:843-852. 2013
2013 Delayed sleep timing and symptoms in adults with attention-deficit/ hyperactivity disorder: A controlled actigraphy studyChronobiology International.  30:598-606. 2013
2013 Circadian clocks, brain function, and developmentAnnals of the New York Academy of Sciences.  1306:43-67. 2013
2013 Complete sleep-wake cycle reversal related to ADHD detected by actigraphyAnnals of Clinical Psychiatry.  25:307-308. 2013
2012 Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase 3Neuroscience.  226:1-9. 2012
2012 Motor restlessness, sleep disturbances, thermal sensory alterations and elevated serum iron levels in BTBD9 mutant miceHuman Molecular Genetics.  21:3984-3992. 2012
2012 The effects of glycogen synthase kinase-3beta in serotonin neuronsPLoS ONE.  7. 2012
2012 Retinal dopamine mediates multiple dimensions of light-adapted visionJournal of Neuroscience.  32:9359-9368. 2012
2012 Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington DiseaseExperimental Neurology.  236:171-178. 2012
2012 Divergent roles of clock genes in retinal and suprachiasmatic nucleus circadian oscillatorsPLoS ONE.  7. 2012
2012 Neuropeptide Y-induced phase shifts of PER2::LUC rhythms are mediated by long-term suppression of neuronal excitability in a phase-specific mannerChronobiology International.  29:91-102. 2012
2011 O-glcnacylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clockJournal of Biological Chemistry.  286:44606-44619. 2011
2011 Ramelteon for insomnia related to attention-deficit/ hyperactivity disorder (ADHD)Psychopharmacology Bulletin.  44. 2011
2011 CHRONIC ALCOHOL CONSUMPTION DISRUPTS THE CIRCADIAN CLOCK IN THE LIVER BUT NOT IN THE SUPRACHIASMATIC NUCLEUSHepatology.  54:969A-969A. 2011
2011 Shift work in nurses: Contribution of phenotypes and genotypes to adaptationPLoS ONE.  6. 2011
2011 Erratum: Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 9, (3785-3790) DOI: 10.1073/pnas.1011920108)Proceedings of the National Academy of Sciences.  108:6689. 2011
2011 Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in miceChronobiology International.  28:187-203. 2011
2011 Gastrin-releasing peptide modulates fast delayed rectifier potassium current in Per1-expressing SCN neuronsJournal of Biological Rhythms.  26:99-106. 2011
2011 Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporterProceedings of the National Academy of Sciences.  108:3785-3790. 2011
2011 Perinatal photoperiod imprints the circadian clockNature Neuroscience.  14:25-27. 2011
2010 Dysregulation of inflammatory responses by chronic circadian disruptionJournal of Immunology.  185:5796-5805. 2010
2009 Comment on "the Arabiclopsis circadian clock incorporates a cADPR-based feedback loop"Science.  326. 2009
2009 Ryanodine receptors are regulated by the circadian clock and implicated in gating photic entrainmentJournal of Neuroscience.  29:11717-11719. 2009
2009 Beyond Prozac: Generation and characterization of SSRI Insensitive Transgenic MiceFederation proceedings.  23. 2009
2009 Population encoding by circadian clock neurons organizes circadian behaviorJournal of Neuroscience.  29:1670-1676. 2009
2008 Interactions of GABAA receptor activation and light on period mRNA expression in the suprachiasmatic nucleusJournal of Biological Rhythms.  23:16-25. 2008
2007 Gastrin-releasing peptide mediates light-like resetting of the suprachiasmatic nucleus circadian pacemaker through cAMP response element-binding protein and Per1 activationJournal of Neuroscience.  27:12078-12087. 2007
2006 GABAA receptor activation suppresses Period 1 mRNA and Period 2 mRNA in the suprachiasmatic nucleus during the mid-subjective dayEuropean Journal of Neuroscience.  23:3328-3336. 2006
2006 Paradoxical effects of NPY in the suprachiasmatic nucleusEuropean Journal of Neuroscience.  23:2488-2494. 2006
2005 Circadian control during the day and night: Role of neuropeptide Y Y5 receptors in the suprachiasmatic nucleusBrain Research Bulletin.  65:513-519. 2005
2004 Neuropeptide Y and N-methyl-D-aspartic acid interact within the suprachiasmatic nuclei to alter circadian phaseNeuroscience.  126:559-565. 2004
2004 Tetrodotoxin administration in the suprachiasmatic nucleus prevents NMDA-induced reductions in pineal melatonin without influencing Per1 and Per2 mRNA levelsEuropean Journal of Neuroscience.  19:2808-2814. 2004
2004 Tetrodotoxin administration in the suprachiasmatic nucleus prevents NMDA-induced reductions in pineal melatonin without influencing Per1 and Per2 mRNA levelsEuropean Journal of Neuroscience.  19:2808-2814. 2004
2003 Tetrodotoxin blocks the circadian effects of NMDA during the day but not at nightNeuroReport.  14:641-644. 2003

Education And Training

  • Doctor of Philosophy in Neuroscience, Georgia State University 2004
  • Master of Social or Behavioral Sciences in Psychology, Georgia State University 2001
  • Bachelor of Arts in Psychology, King College 1996
  • Vanderbilt University Biological Sciences, Postdoctoral Fellowship 2009
  • Full Name

  • Karen Gamble