Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Mitochondria in health and disease 2018
2017 Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome 2017
2017 Mitochondrial determinants of cancer health disparities 2017
2017 Numtogenesis as a mechanism for development of cancer 2017
2017 Special Issue: Mitochondria in Cancer 2017
2017 Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma 2017
2017 Epigenetic modification of miR-663 controls mitochondriatonucleus retrograde signaling and tumor progression 2017
2015 Mitoepigenetics: The different shades of grey 2015
2015 Mitochondrial DNA polymerase POLG1 disease mutations and germline variants promote tumorigenic properties 2015
2015 Human REV3 DNA polymerase zeta localizes to mitochondria and protects the mitochondrial genome 2015
2015 Mitochondrial biology: From molecules to diseases 2015
2014 OXPHOS dysfunction regulates integrin-β1 modifications and enhances cell motility and migration 2014
2014 Global genetic determinants of mitochondrial DNA copy number 2014
2014 Mitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis 2014
2013 Natural selection of mitochondria during somatic lifetime promotes healthy aging 2013
2013 Reduced Mitochondrial DNA Content Associates with Poor Prognosis of Prostate Cancer in African American Men 2013
2013 Systems biology approaches to evaluate arsenic toxicity and carcinogenicity: An overview 2013
2012 Is there a link between mitochondrial reserve respiratory capacity and aging? 2012
2012 CAG repeat variants in the POLG1 gene encoding mtDNA polymerase-gamma and risk of breast cancer in African-American women 2012
2012 Mitochondrial regulation of epigenetics and its role in human diseases 2012
2011 The importance of mitochondrial DNA in aging and cancer 2011
2011 Cellular model of Warburg Effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin 2011
2011 Genetic insights into OXPHOS defect and its role in cancer 2011
2010 Illness-induced exacerbation of Leigh syndrome in a patient with the MTATP6 mutation, m. 9185 T>C 2010
2010 NADPH oxidase 4 is an oncoprotein localized to mitochondria 2010
2010 Vital function of PRELI and essential requirement of its LEA motif 2010
2010 SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress 2010
2010 Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS Q61L 2010
2009 MtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice 2009
2009 Mutations in mitochondrial DNA polymerase-γ promote breast tumorigenesis 2009
2009 Mitochondrial DNA polymorphism and risk of cancer 2009
2007 DNA replication stress is a determinant of chronological lifespan in budding yeast 2007
2007 Mitochondria and human cancer 2007
2006 Saccharomyces cerevisiae polymerase ζ functions in mitochondria 2006
2006 Mitochondria damage checkpoint, aging, and cancer 2006
2006 Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer 2006
2005 Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis 2005
2004 Cellular aging of mitochondrial DNA-depleted cells 2004
2004 Mitochondria damage checkpoint in apoptosis and genome stability 2004
2004 Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline 2004
2004 Resistance of mitochondrial DNA-depleted cells against cell death: Role of mitochondrial superoxide dismutase 2004
2004 Genome-wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiae 2004
2004 Mitochondrial dysfunction is a common phenotype in aging and cancer 2004
2003 Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae 2003
2002 A colony color method identifies the vulnerability of mitochondria to oxidative damage 2002
2002 Mitochondria as targets for detection and treatment of cancer. 2002
2001 Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype 2001
2001 Need for public debate about fertility treatments [1] 2001
2001 Human Homolog of the MutY Repair Protein (hMYH) Physically Interacts with Proteins Involved in Long Patch DNA Base Excision Repair 2001
2000 The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion 2000
2000 The human cyclin B1 protein modulates sensitivity of DNA mismatch repair deficient prostate cancer cell lines to alkylating agents 2000
1997 A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A 1997
1997 Yeast plasmids. 1997
1995 Replication protein A binds to regulatory elements in yeast DNA repair and DNA metabolism genes 1995
1991 Mitochondrial protein import: isolation and characterization of the Saccharomyces cerevisiae MFT1 gene 1991
A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae
A novel role for mitochondria in regulating epigenetic modification in the nucleus
Cancer cell mitochondria confer apoptosis resistance and promote metastasis
Cancer cell mitochondria confer apoptosis resistance and promote metastasis
Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment
Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors
Evaluation of cell types for assessment of cytogenetic damage in arsenic exposed population
HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLα and hMLH1-hEXO1 complexes
Impaired OXPHOS complex III in breast cancer
Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants
Mitochondria as determinant of nucleotide pools and chromosomal stability
Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
Mitochondrial correlation microscopy and nanolaser spectroscopy - New tools for biophotonic detection of cancer in single cells
Mitochondrial impairment in p53-deficient human cancer cells
Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus
Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic
NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury
Nanotechnology in cancer detection and treatment
Single molecule mtDNA fiber FISH for analyzing numtogenesis
Sustained early disruption of mitochondrial function contributes to arsenic-induced prostate tumorigenesis
Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion
Xenogenic transfer of isolated murine mitochondria into human ρ0 cells can improve respiratory function
hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer

Book

Year Title Altmetric
2009 Mitochondria and cancer 2009
2006 Oxidative stress, disease and cancer 2006
2006 Preface 2006

Chapter

Year Title Altmetric
2014 Leptin Signaling in the Regulation of Stem and Cancer Stem Cells.  347-360. 2014
2009 Mitochondria and cancer.  1-21. 2009
2006 Oxidative stress and multistage carcinogenesis.  705-732. 2006

Education And Training

  • Doctor of Philosophy in Biology, 1989
  • Master of Science in Biology, 1981
  • Bachelor of Science or Mathematics in Biology, 1978
  • Full Name

  • Keshav Singh