Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 mTOR deletion in neural crest cells disrupts cardiac outflow tract remodeling and causes a spectrum of cardiac defects through the mTORC1 pathwayDevelopmental Biology.  477:241-250. 2021
2021 Epigenetic Regulation of Cardiac Neural Crest CellsFrontiers in Cell and Developmental Biology.  9. 2021
2020 CHD7 regulates cardiovascular development through ATP-dependent and -independent activities 2020
2020 β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascadeScience Translational Medicine.  12. 2020
2019 SEMA6D regulates perinatal cardiomyocyte proliferation and maturation in miceDevelopmental Biology.  452:1-7. 2019
2019 Complex regulation of mitochondrial function during cardiac development 2019
2019 Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma AngiogenesisSTEM CELLS.  37:453-462. 2019
2018 mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial developmentPLoS Genetics.  14. 2018
2018 Role of semaphorin signaling during cardiovascular development 2018
2017 Effective attenuation of adenosine a1r signaling by neurabin requires oligomerization of neurabinMolecular Pharmacology.  92:630-639. 2017
2017 The amyloid precursor protein modulates α2A-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitmentThe FASEB Journal.  31:4434-4446. 2017
2017 Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α2A adrenergic receptor ligandsNeuropharmacology.  116:38-49. 2017
2017 Pdgfrb is a direct regulatory target of TGFβ signaling in atrioventricular cushion mesenchymal cellsPLoS ONE.  12. 2017
2017 Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart diseaseJCI insight.  2. 2017
2017 MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancerOncotarget.  8:41451-41464. 2017
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.Cardiovascular Research.  112:532-542. 2016
2016 Functions of miRNAs during mammalian heart developmentInternational Journal of Molecular Sciences.  17. 2016
2015 Spinophilin is indispensable for the α2B adrenergic receptor-elicited hypertensive responsePLoS ONE.  10. 2015
2015 Noradrenergic dysfunction in Alzheimer's diseaseFrontiers in Neuroscience.  9. 2015
2015 SEMA6D expression and patient survival in breast invasive carcinomaInternational Journal of Breast Cancer.  2015. 2015
2014 α2A adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction 2014
2014 Critical roles of miRNA-mediated regulation of TGFβ signalling during mouse cardiogenesisCardiovascular Research.  103:258-267. 2014
2014 CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in miceHuman Molecular Genetics.  23:2145-2156. 2014
2013 Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic heartsBiochemical and Biophysical Research Communications.  441:751-756. 2013
2013 Cross-talk from β-adrenergic receptors modulates α2A -adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilinJournal of Biological Chemistry.  288:29193-29205. 2013
2013 Myocardial Mycn is essential for mouse ventricular wall morphogenesisDevelopmental Biology.  373:53-63. 2013
2012 Vascular smooth muscle cell smad4 gene is important for mouse vascular development 2012
2012 Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine 2012
2011 The antidepressant desipramine is an arrestin-biased ligand at the α2A-adrenergic receptor driving receptor down-regulation in vitro and in vivoJournal of Biological Chemistry.  286:36063-36075. 2011
2011 Alternative splicing of T-box transcription factor genesBiochemical and Biophysical Research Communications.  412:513-517. 2011
2011 Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factorBiochemical and Biophysical Research Communications.  409:338-343. 2011
2011 Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling 2011
2011 Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesisMechanisms of Development.  128:200-207. 2011
2011 Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryosDevelopmental Dynamics.  240:211-220. 2011
2011 Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type BHuman Molecular Genetics.  20:271-285. 2011
2011 Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in miceDevelopmental Biology.  356:359-369. 2011
2010 Enhanced hypotensive, bradycardic, and hypnotic responses to α2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the α2A-adrenergic receptorMolecular Pharmacology.  78:279-286. 2010
2009 Epitope-tagged receptor knock-in mice reveal that differential desensitization of α2-adrenergic responses is because of ligand-selective internalizationJournal of Biological Chemistry.  284:13233-13243. 2009
2008 Protein kinase A phosphorylation of spinophilin modulates its interaction with the α2A-adrenergic receptor (AR) and alters temporal properties of α2AAR internalizationJournal of Biological Chemistry.  283:14516-14523. 2008
2008 Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defectsDevelopmental Biology.  316:417-430. 2008
2007 Myocardial Smad4 is essential for cardiogenesis in mouse embryosCirculation Research.  101:277-285. 2007
2007 Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic heartsDevelopmental Biology.  301:276-286. 2007
2006 Tgfβ signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development 2006
2006 Fgf8 is required for anterior heart field development 2006
2006 Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valvesCirculation Research.  98:923-930. 2006
2003 An essential role of Bmp4 in the atrioventricular septation of the mouse heartGenes and Development.  17:2362-2367. 2003
2003 Support for a meiotic recombination initiation complex: Interactions among Rec102p, Rec104p, and Spo11pMolecular and Cellular Biology.  23:5928-5938. 2003
2002 Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1Molecular and Cellular Biology.  22:7633-7644. 2002
2002 Phylogenetic footprinting reveals multiple regulatory elements involved in control of the meiotic recombination gene, REC102Yeast.  19:99-114. 2002
1999 Coordination of the initiation of recombination and the reductional division in meiosis in Saccharomyces cerevisiae 1999
1997 Recombination and the progression of meiosis in Saccharomyces cerevisiae 1997

Principal Investigator On

  • Critical Functions of Myocardial Nmyc in the Developing Mouse Heart  awarded by American Heart Association (Southeast Affiliate)
  • Critical Roles of CHD7 During Mouse Cardiogenesis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Critical Roles of Sertad 1 During Nouse Heart Development (Grant in Aid Mechanism)  awarded by American Heart Association (Southeast Affiliate)
  • Epigenetic Regulation of Cardiac Neural Crest Cell Development  awarded by American Heart Association
  • Epigenetic Regulation of Heart Development  awarded by American Heart Association
  • Examine the Impact of Congenital Heart Diseases on Alzheimer's Disease.  awarded by American Heart Association
  • Functions of CHD7 in Regulating Cardiogenesis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Genetic Test of FAM3B as the Causative Gene for the Heart Defects in Down Syndrome  awarded by American Heart Association
  • Molecular Mechanisms Regulating Mouse Valvulogenesis  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Regulation of Gene Expression by Chd7 in Embryonic Cardiomyocytes  awarded by CHARGE SYNDROME FOUNDATION, INC.
  • Regulation of TEFbeta Signaling by microRNAs During Cardiogenesis  awarded by American Heart Association (Southeast Affiliate)
  • Roles of Semaphorin Signaling in Breast Cancer Racial Disparities  awarded by National Cancer Institute/NIH/DHHS
  • The Roles of Semaphorin Signaling During Valvuloseptal Development  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Education And Training

  • Doctor of Science in Biological and Biomedical Sciences, University of Iowa 2002
  • Doctor of Medicine, Peking University 1992
  • Full Name

  • Kai Jiao