Karen Iles

Karen Iles
Director of Conflict of Interest Review Board

Associate Professor (P), Health Behavior , School of Public Health

Selected Publications

Academic Article

Year	Title	Altmetric
2014	Heat-shock response increases lung injury caused by pseudomonas aeruginosa via an Interleukin-10-dependent mechanism in mice. Anesthesiology. 120:1450-1462. 2014
2013	IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism 2013
2013	Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Shock. 39:189-196. 2013
2012	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury 2012
2011	Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa - Induced lung injury in mice. American Journal of Respiratory Cell and Molecular Biology. 45:632-641. 2011
2011	PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice. Thorax. 66:788-796. 2011
2009	Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species 2009
2009	Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radical Biology and Medicine. 46:866-875. 2009
2009	Reactive species and pulmonary edema. Expert Review of Respiratory Medicine. 3:487-496. 2009
2007	Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter 2007
2006	Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression 2006
2006	4-Hydroxynonenal induces rat γ-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling. American Journal of Respiratory Cell and Molecular Biology. 34:174-181. 2006
2006	The Adp-stimulated NADPH oxidase activates the ASK-1/MMK4/JNK pathway in alveolar macrophages 2006
2005	Fatty acid transduction of nitric oxide signaling: Multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands. Journal of Biological Chemistry. 280:42464-42475. 2005
2005	HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells. Free Radical Biology and Medicine. 39:355-364. 2005
2005	Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal. Free Radical Biology and Medicine. 38:547-556. 2005
2004	Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress. Molecular cell biology research communications : MCBRC. 423:116-125. 2004
2004	Analysis of Transcription Factor Remodeling in Phase II Gene Expression with Curcumin. Methods in Enzymology. 378:302-318. 2004
2003	Cytoprotection against oxidative stress and the regulation of glutathione synthesis 2003
2003	Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. 2003
2003	HNE - Signaling pathways leading to its elimination. Molecular Aspects of Medicine. 24:189-194. 2003
2002	4-Hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells. Free Radical Biology and Medicine. 33:974-987. 2002
2002	A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile. 2002
2002	AP-1 activation through endogenous H2O2 generation by alveolar macrophages. Free Radical Biology and Medicine. 32:1304-1313. 2002
2002	A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile 2002
2002	Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinase. Molecular cell biology research communications : MCBRC. 405:231-240. 2002
2002	Macrophage signaling and respiratory burst. Immunologic Research. 26:95-105. 2002
1998	The role of cuznsod in the susceptibility to alloxan-induced diabetes 1998
1996	The effect of dietary copper manipulation and pancreatic CuZn on the susceptibility to IDDM 1996
1995	Chronic ethanol feeding increases the quantity of Gαs-protein in rat liver plasma membranes. Hepatology. 21:1154-1160. 1995