Positions

Selected Publications

Academic Article

Year Title Altmetric
2014 Heat-shock response increases lung injury caused by pseudomonas aeruginosa via an Interleukin-10-dependent mechanism in miceAnesthesiology.  120:1450-1462. 2014
2013 IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism 2013
2013 Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transportShock.  39:189-196. 2013
2012 Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury 2012
2011 Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa - Induced lung injury in miceAmerican Journal of Respiratory Cell and Molecular Biology.  45:632-641. 2011
2011 PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in miceThorax.  66:788-796. 2011
2009 Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species 2009
2009 Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathwayFree Radical Biology and Medicine.  46:866-875. 2009
2009 Reactive species and pulmonary edemaExpert Review of Respiratory Medicine.  3:487-496. 2009
2007 Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter 2007
2006 Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression 2006
2006 4-Hydroxynonenal induces rat γ-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signalingAmerican Journal of Respiratory Cell and Molecular Biology.  34:174-181. 2006
2006 The Adp-stimulated NADPH oxidase activates the ASK-1/MMK4/JNK pathway in alveolar macrophages 2006
2005 Fatty acid transduction of nitric oxide signaling: Multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligandsJournal of Biological Chemistry.  280:42464-42475. 2005
2005 HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cellsFree Radical Biology and Medicine.  39:355-364. 2005
2005 Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenalFree Radical Biology and Medicine.  38:547-556. 2005
2004 Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stressMolecular cell biology research communications : MCBRC.  423:116-125. 2004
2004 Analysis of Transcription Factor Remodeling in Phase II Gene Expression with CurcuminMethods in Enzymology.  378:302-318. 2004
2003 Cytoprotection against oxidative stress and the regulation of glutathione synthesis 2003
2003 Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. 2003
2003 HNE - Signaling pathways leading to its eliminationMolecular Aspects of Medicine.  24:189-194. 2003
2002 4-Hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cellsFree Radical Biology and Medicine.  33:974-987. 2002
2002 A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile. 2002
2002 AP-1 activation through endogenous H2O2 generation by alveolar macrophagesFree Radical Biology and Medicine.  32:1304-1313. 2002
2002 A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile 2002
2002 Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinaseMolecular cell biology research communications : MCBRC.  405:231-240. 2002
2002 Macrophage signaling and respiratory burstImmunologic Research.  26:95-105. 2002
1998 The role of cuznsod in the susceptibility to alloxan-induced diabetes 1998
1996 The effect of dietary copper manipulation and pancreatic CuZn on the susceptibility to IDDM 1996
1995 Chronic ethanol feeding increases the quantity of Gαs-protein in rat liver plasma membranesHepatology.  21:1154-1160. 1995

Chapter

Year Title Altmetric
2016 Carcinogens, Environmental.  422-437. 2016
2016 Environmental Health: Overview.  487-498. 2016
2011 Glutathione.  3-20. 2011

Education And Training

  • Doctor of Philosophy Level Degree in Nutrition Sciences, 1998
  • Master's Level Degree in Biology / Biological Sciences, 1994
  • Bachelor's Level Degree in Biology / Biological Sciences, 1992
  • Full Name

  • Karen Iles