Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Heterozygous Pkhd1 C642* mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidneyAJP - Renal Physiology.  316:F463-F472. 2019
2019 Truncating PKHD1 and PKD2 mutations alter energy metabolismAJP - Renal Physiology.  316:F414-F425. 2019
2019 Mks6 mutations reveal tissue-and cell type-specific roles for the cilia transition zoneFederation proceedings.  33:1440-1455. 2019
2018 NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancernpj Breast Cancer.  4. 2018
2018 A CreER mouse to study melanin concentrating hormone signaling in the developing brainDevelopmental Genetics.  56. 2018
2018 Neurofibromin (NF1) genetic variant structure–function analyses using a full-length mouse cDNAHuman Mutation.  39:816-821. 2018
2018 Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumorsOncogene.  37:1610-1623. 2018
2017 Improved Oviduct Transfer Surgery for Genetically Modified Rat Production.Bio-protocol.  7. 2017
2017 Updated nomenclature for human and mouse neurofibromatosis type 1 genesNeurology Genetics.  3. 2017
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in miceCardiovascular Research.  112:532-542. 2016
2016 Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer.Bio-protocol.  6. 2016
2016 Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technologyDisease Models & Mechanisms.  9:1169-1179. 2016
2016 Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type IDisease Models & Mechanisms.  9:759-767. 2016
2016 Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human DiseasePLoS Genetics.  12. 2016
2016 The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotypeCancer Research.  76:3978-3988. 2016
2016 NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1Human Molecular Genetics.  25:1703-1713. 2016
2016 Novel hypomorphic alleles of the mouse tyrosinase gene induced by CRISPR-Cas9 nucleases cause non-albino pigmentation phenotypesPLoS ONE.  11. 2016
2016 Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouseDevelopmental Biology.  412:208-218. 2016
2016 CRYβA3/A1-crystallin knockout develops nuclear cataract and causes impaired lysosomal cargo clearance and calpain activationPLoS ONE.  11. 2016
2015 KIAA0556 is a novel ciliary basal body component mutated in Joubert syndromeGenome Biology.  16. 2015
2015 Mitochondrial genetics regulate breast cancer Tumorigenicity and Metastatic potentialCancer Research.  75:4429-4436. 2015
2013 Erratum: Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload (Biochemical Journal (2013) 455 (157-167))Biochemical Journal.  456:147. 2013
2013 Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overloadBiochemical Journal.  455:157-167. 2013
2013 Effects of risperidone on energy balance in female C57BL/6J miceObesity Research.  21:1850-1857. 2013
2013 An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissueCilia.  2. 2013
2013 Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant miceProceedings of the National Academy of Sciences.  110:7796-7801. 2013
2012 Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesisCilia.  1. 2012
2012 Noninvasive bioluminescence imaging in small animalsILAR news.  53:103-115. 2012
2012 Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosisClinical and Experimental Metastasis.  29:315-325. 2012
2011 ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptorJournal of Biological Chemistry.  286:39654-39662. 2011
2011 Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclastsPLoS ONE.  6. 2011
2011 Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulationDevelopmental Biology.  360:66-76. 2011
2010 Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndromeNeurobiology of Disease.  39:169-180. 2010
2009 Generating conditional mutants to analyze ciliary functions: the use of Cre-lox technology to disrupt cilia in specific organs.Methods in Cell Biology.  93:305-330. 2009
2009 Risperidone alters food intake, core body temperature, and locomotor activity in micePhysiology and Behavior.  96:457-463. 2009
2009 Utilization of conditional alleles to study the role of the primary cilium in obesity.Methods in Cell Biology.  94:162-179. 2009
2008 Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid MetabolismCell Metabolism.  8:468-481. 2008
2008 G2E3 is a dual function ubiquitin ligase required for early embryonic developmentJournal of Biological Chemistry.  283:22304-22315. 2008
2008 Noninvasive bioluminescence imaging in small animalsILAR news.  49:103-115. 2008
2007 Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signalingBiochemistry.  46:11389-11397. 2007
2007 Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney DiseaseCurrent Biology.  17:1586-1594. 2007
2007 Structural insights into the role of the ACTH receptor cysteine residues on receptor functionAJP - Regulatory, Integrative and Comparative Physiology.  293. 2007
2007 Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2Journal of Biological Chemistry.  282:22448-22459. 2007
2007 No effect of dietary fat on short-term weight gain in mice treated with atypical antipsychotic drugsInternational Journal of Obesity.  31:1014-1022. 2007
2006 Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone miceJournal of Immunology.  177:8748-8756. 2006
2005 HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in micePsychopharmacology.  180:279-285. 2005
2005 Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistanceProceedings of the National Academy of Sciences.  102:6207-6212. 2005
2003 Partial duplication of the APBA2 gene in chromosome 15q13 corresponds to duplicon structuresBMC Genomics.  4. 2003
2003 Putative targets of CNS melanocortin receptor activityAnnals of the New York Academy of Sciences.  994:211-217. 2003
2000 A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse.Endocrinology.  141:3518-3521. 2000
2000 Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2Nature Genetics.  24:403-409. 2000
2000 A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouseEndocrinology.  141:3518-3521. 2000
1998 Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonistsAJP - Regulatory, Integrative and Comparative Physiology.  274. 1998
1998 Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists.American Journal of Physiology.  274:R931-R938. 1998
1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndromeFederation proceedings.  11. 1997
1997 Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genesJournal of Bone and Mineral Research.  12:1570-1576. 1997
1997 Structural organization of the human vitamin D receptor chromosomal gene and its promoter.Molecular Endocrinology -Baltimore-.  11:1165-1179. 1997
1997 Targeted disruption of the melanocortin-4 receptor results in obesity in miceCell.  88:131-141. 1997
1997 Role of melanocortlnergic neurons in feeding and the agouti obesity syndromeNature.  385:165-168. 1997
1997 Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the Agouti obesity syndromeMolecular Endocrinology -Baltimore-.  11:630-637. 1997
1997 Structural organization of the human vitamin D receptor chromosomal gene and its promoterMolecular Endocrinology -Baltimore-.  11:1165-1179. 1997
1996 Melanocortin antagonists define two distinct pathways of cardiovascular control by α- and γ-melanocyte-stimulating hormonesJournal of Neuroscience.  16:5182-5188. 1996
1996 The melanocortin receptors: Agonists, antagonists, and the hormonal control of pigmentationRecent Progress in Hormone Research.  51:287-317. 1996
1995 Cyclic Lactam α-Melanotropin Analogues of Ac-Nle4-cyclo[Asp5, D-Phe7, Lys10] α-Melanocyte-Stimulating Hormone-(4-10)-NH2 with Bulky Aromatic Amino Acids at Position 7 Show High Antagonist Potency and Selectivity at Specific Melanocortin ReceptorsJournal of Medicinal Chemistry.  38:3454-3461. 1995
1995 Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heartMolecular Endocrinology -Baltimore-.  9:637-645. 1995
1993 Recombinant creatine kinase proteins and proposed standards for creatine kinase isoenzyme and subform assaysClinical Chemistry.  39:1598-1601. 1993
1993 The human osteocalcin promoter directs bone-specific vitamin D-regulatable gene expression in transgenic miceMolecular Endocrinology -Baltimore-.  7:462-467. 1993
1988 Point mutations in the human vitamin D receptor gene associated with hypocalcemic ricketsScience.  242:1702-1705. 1988

Education And Training

  • Doctor of Philosophy, Baylor College of Medicine 1994
  • Full Name

  • Robert Kesterson