Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Mks6 mutations reveal tissue- and cell type-specific roles for the cilia transition zone.Federation proceedings.  fj201801149R. 2018
2018 Neurofibromin (NF1) genetic variant structure-function analyses using a full-length mouse cDNA.Human Mutation.  39:816-821. 2018
2018 A CreER mouse to study melanin concentrating hormone signaling in the developing brain.Developmental Genetics.  56:e23217. 2018
2018 Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.Oncogene.  37:1610-1623. 2018
2018 NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer.npj Breast Cancer.  4:29. 2018
2017 Improved Oviduct Transfer Surgery for Genetically Modified Rat Production.Bio-protocol.  7. 2017
2017 Updated nomenclature for human and mouse neurofibromatosis type 1 genes.Neurology Genetics.  3:e169. 2017
2016 Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer.Bio-protocol.  6. 2016
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.Cardiovascular Research2016
2016 Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology.Disease Models & Mechanisms.  9:1169-1179. 2016
2016 Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I.Disease Models & Mechanisms.  9:759-767. 2016
2016 Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease.PLoS Genetics.  12:e1006220. 2016
2016 The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype.Cancer Research.  76:3978-3988. 2016
2016 NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.Human Molecular Genetics.  25:1703-1713. 2016
2016 Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouse.Developmental Biology.  412:208-218. 2016
2016 CRYβA3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation.PLoS ONE.  11:e0149027. 2016
2016 Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes.PLoS ONE.  11:e0155812. 2016
2015 KIAA0556 is a novel ciliary basal body component mutated in Joubert syndrome.Genome Biology.  16:293. 2015
2015 Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential.Cancer Research.  75:4429-4436. 2015
2013 Erratum: Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload (Biochemical Journal (2013) 455 (157-167))Biochemical Journal.  456:147. 2013
2013 Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload.Biochemical Journal.  455:157-167. 2013
2013 Effects of risperidone on energy balance in female C57BL/6J mice.Obesity Research.  21:1850-1857. 2013
2013 An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue.Cilia.  2:8. 2013
2013 Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice.Proceedings of the National Academy of Sciences.  110:7796-7801. 2013
2012 Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis.Cilia.  1:20. 2012
2012 Noninvasive bioluminescence imaging in small animalsILAR news.  53:103-115. 2012
2012 Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis.Clinical and Experimental Metastasis.  29:315-325. 2012
2011 Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation.Developmental Biology.  360:66-76. 2011
2011 ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptor.Journal of Biological Chemistry.  286:39654-39662. 2011
2011 Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.PLoS ONE.  6:e25838. 2011
2010 Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome.Neurobiology of Disease.  39:169-180. 2010
2009 Risperidone alters food intake, core body temperature, and locomotor activity in mice.Physiology and Behavior.  96:457-463. 2009
2009 Generating conditional mutants to analyze ciliary functions: the use of Cre-lox technology to disrupt cilia in specific organs.Methods in Cell Biology.  93:305-330. 2009
2009 Utilization of conditional alleles to study the role of the primary cilium in obesity.Methods in Cell Biology.  94:163-179. 2009
2008 Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.Cell Metabolism.  8:468-481. 2008
2008 G2E3 is a dual function ubiquitin ligase required for early embryonic development.Journal of Biological Chemistry.  283:22304-22315. 2008
2008 Noninvasive bioluminescence imaging in small animals.ILAR news.  49:103-115. 2008
2007 Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling.Biochemistry.  46:11389-11397. 2007
2007 Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease.Current Biology.  17:1586-1594. 2007
2007 Structural insights into the role of the ACTH receptor cysteine residues on receptor function.AJP - Regulatory, Integrative and Comparative Physiology.  293:R1120-R1126. 2007
2007 Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2.Journal of Biological Chemistry.  282:22448-22459. 2007
2007 No effect of dietary fat on short-term weight gain in mice treated with atypical antipsychotic drugs.International Journal of Obesity.  31:1014-1022. 2007
2006 Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice.Journal of Immunology.  177:8748-8756. 2006
2005 HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice.Psychopharmacology.  180:279-285. 2005
2005 Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.Proceedings of the National Academy of Sciences.  102:6207-6212. 2005
2003 Putative targets of CNS melanocortin receptor activity.Annals of the New York Academy of Sciences.  994:211-217. 2003
2003 Partial duplication of the APBA2 gene in chromosome 15q13 corresponds to duplicon structures.BMC Genomics.  4:15. 2003
2000 A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse.Endocrinology.  141:3518-3521. 2000
2000 Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2.Nature Genetics.  24:403-409. 2000
2000 A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouseEndocrinology.  141:3518-3521. 2000
1998 Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonistsAJP - Regulatory, Integrative and Comparative Physiology.  274. 1998
1998 Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists.American Journal of Physiology.  274:R931-R938. 1998
1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndromeFederation proceedings.  11. 1997
1997 Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genes.Journal of Bone and Mineral Research.  12:1570-1576. 1997
1997 Structural organization of the human vitamin D receptor chromosomal gene and its promoter.Molecular Endocrinology -Baltimore-.  11:1165-1179. 1997
1997 Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome.Molecular Endocrinology -Baltimore-.  11:630-637. 1997
1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice.Cell.  88:131-141. 1997
1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.Nature.  385:165-168. 1997
1997 Structural organization of the human vitamin D receptor chromosomal gene and its promoterMolecular Endocrinology -Baltimore-.  11:1165-1179. 1997
1996 Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte-stimulating hormones.Journal of Neuroscience.  16:5182-5188. 1996
1996 The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation.Recent Progress in Hormone Research.  51:287-317. 1996
1995 Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.Journal of Medicinal Chemistry.  38:3454-3461. 1995
1995 Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart.Molecular Endocrinology -Baltimore-.  9:637-645. 1995
1993 Recombinant creatine kinase proteins and proposed standards for creatine kinase isoenzyme and subform assays.Clinical Chemistry.  39:1598-1601. 1993
1993 The human osteocalcin promoter directs bone-specific vitamin D-regulatable gene expression in transgenic mice.Molecular Endocrinology -Baltimore-.  7:462-467. 1993
1988 Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets.Science.  242:1702-1705. 1988

Principal Investigator On

  • NF1 Gene Rescue in Translational Animal Models  awarded by GILBERT GENE THERAPY INITIATIVE, LLC 2018 - 2021
  • Comprehensive Cancer Center Core Support Grant - Transgenic Animal Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2017 - 2021
  • Collaboration Agreement regarding Manufacture of Genetically modified Animals  awarded by INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH - PUNE (IISER-PUNE) 2017 - 2020
  • Rheumatic Diseases Research Core Centers - Core D: Analytical Genomics and Transgenics Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Comprehensive Cancer Center Core Support Grant - Transgenic Animal Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Active - Transgenic Animal/Embryonic Stem Cell - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Cryopreservation Resources and Emergency Backup Plans for UAB Mouse Models  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2013 - 2015
  • Rheumatic Diseases Core Center: Core D - Gene Targeting Core Facility  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • UAB Core Center for Basic Skeletal Research - Core B  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Role of the MC3-R in Obesity and Metabolic Syndrome  awarded by VANDERBILT UNIVERSITY 2008 - 2011
  • Regulation of RNA Editing in the CNS  awarded by VANDERBILT UNIVERSITY 2007 - 2011
  • Comprehensive Cancer Center Core Support Grant - Transgenic Animal  awarded by National Cancer Institute/NIH/DHHS 2006 - 2011
  • UAB High Throughput DNA AutoGenPrep 965 (SIG)  awarded by National Center for Research Resources/NIH/DHHS 2010 - 2011
  • Investigator On

  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB Diabetes Research Center - Animal Physiology Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • UAB Nutrition Obesity Research Center - Animal Models Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • Exon Skipping to Treat NF1  awarded by GILBERT GENE THERAPY INITIATIVE, LLC 2018 - 2021
  • Exploring Nonsense Suppression as a Treatment for NF1  awarded by GILBERT GENE THERAPY INITIATIVE, LLC 2018 - 2021
  • NF1 RNA Repair Based on Therapeutic Ribozymes  awarded by GILBERT GENE THERAPY INITIATIVE, LLC 2018 - 2021
  • Understanding Ciliary Functions in Mammalian Development  awarded by University of California, San Francisco 2016 - 2021
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2021
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - The Hepato/Renal Fibrocystic Diseases Engineered Models Resource - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • The Hepato/Renal Fibrocystic Disease Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • A Novel Role for IGF-1 Receptor in Growth Hormone Action  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2019
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • RANK Signaling in Osteoclast Differentiation and Function  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2018
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017
  • UAB Nutrition Obesity Research Center (NORC) - Animal Models Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2017
  • UAB Nutrition Obesity Research Center - NORC Core C - Animal Models Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Human Heme Oxygenase-1 Gene Regulation in Renal Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2006 - 2012
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • UAB Core Center for Basic Skeletal Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Education And Training

  • Doctor of Philosophy, Baylor College of Medicine
  • Full Name

  • Robert Kesterson
  • Blazerid

  • kesterso