Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Gemcitabine treatment promotes immunosuppressive microenvironment in pancreatic tumors by supporting the infiltration, growth, and polarization of macrophagesScientific Reports.  8. 2018
2018 Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercisedBMC Immunology.  19. 2018
2017 Emerging evidence for the role of differential tumor microenvironment in breast cancer racial disparity: A closer look at the surroundingsCarcinogenesis.  38:757-765. 2017
2013 Moderate aerobic exercise alters migration patterns of antigen specific T helper cells within an asthmatic lungBrain, Behavior, and Immunity.  34:67-78. 2013
2012 Noninvasive bioluminescence imaging in small animalsILAR news.  53:103-115. 2012
2010 β2-Integrins in demyelinating disease: Not adhering to the paradigmJournal of Leukocyte Biology.  87:397-403. 2010
2010 Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma modelBrain, Behavior, and Immunity.  24:153-159. 2010
2009 Epithelial cells as immune effector cells: The role of CD40Seminars in Immunology.  21:289-292. 2009
2009 Bioluminescence-based visualization of CD4 T cell dynamics using a T lineage-specific luciferase transgenic modelBMC Immunology.  10. 2009
2009 Effector and suppressor roles for LFA-1 during the development of experimental autoimmune encephalomyelitisJournal of Neuroimmunology.  206:22-27. 2009
2008 Noninvasive bioluminescence imaging in small animalsILAR news.  49:103-115. 2008
2007 Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporterInternational Immunology.  19:1165-1173. 2007
2002 Cutting edge: Molecular analysis of the negative regulatory function of lymphocyte activation gene-3Journal of Immunology.  169:5392-5395. 2002
2002 Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3)European Journal of Immunology.  32:2255-2263. 2002

Research Overview

  • My personal research remains in the steady pursuit to understand Th and Treg cell function, differentiation and trafficking during over-active immune responses: allergic asthma, lupus, colitis, and EAE. Most recently, my interests are pursuing the delineation of Th cell function while applying a stressor, such as exercise. I hope to extend our current knowledge of psycho-neuroimmunolgy by elucidating the intracellular modifications that result in altered Th and Treg cell activation/differentiation thresholds along with differences in T regulatory cell population numbers and potency during chronic activation of adrenergic receptors.

    Most recently, I have expanded my studies to include the role of stress and/or exercise in Th and Treg cell migration patterns within the pancreatic adenocarcinoma tumor microenvironment.
  • Teaching Overview

  • It is my intention to train undergraduates in basic laboratory research and to teach portions of the Biomedical Science core curriculum. Student research experiences focus on learning Th cell culture techniques and Th cell-mediated over-active immune response animal science models. Students are encouraged to design experiments, utilize current literature and execute appropriate controls while in training. Promising projects are published in peer-reviewed journals and presented at national conferences. While teaching undergraduates, their coursework is complied of Intro to Pharmacology, focusing on drug design and drug mechanism of action; along with Molecular Basis of Human Genomics, focusing on the genetic origins of human disease, personalized medicine, usage of public bioinformatic databases/software and genetic laboratory techniques.
  • Education And Training

  • Doctor of Philosophy in Microbiology, University of Alabama at Birmingham 2007
  • Bachelor of Science or Mathematics in Chemistry, Centre College 2001
  • University of Alabama at Birmingham Department of Physiology and Biophysics, Postdoctoral Fellowship 2010
  • Awards And Honors

    Full Name

  • Kari Dugger