Positions

Overview

  • Dr. Bernard is an Assistant Professor in the UAB Division of Pulmonary, Allergy, and Critical Care Medicine. She began her research training by earning degrees in Life Sciences and Cellular Biology & Physiology from France's University of Nice. She followed this initial training with an MSc in Pharmacology and a PhD in Molecular and Cellular Biology, also from the University of Nice. Dr. Bernard worked as a postdoctoral fellow in the UAB Department of Physiology & Biophysics starting in 2004, before taking on research responsibilities in Georgia's Emory School of Medicine. In 2011, she returned to UAB, this time working in the Division of Pulmonary, Allergy, and Critical Care Medicine. She is currently engaged in research on idiopathic pulmonary fibrosis.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Fibronectin on the surface of extracellular vesicles mediates fibroblast invasionAmerican Journal of Respiratory Cell and Molecular Biology.  60:279-288. 2019
    2019 Glutaminolysis epigenetically regulates antiapoptotic gene expression in idiopathic pulmonary fibrosis fibroblastsAmerican Journal of Respiratory Cell and Molecular Biology.  60:49-57. 2019
    2018 Erratum to: Metformin reverses established lung fibrosis in a bleomycin model (Nature Medicine, (2018), 24, 8, (1121-1127), 10.1038/s41591-018-0087-6)Nature Medicine.  24:1627. 2018
    2018 Metformin reverses established lung fibrosis in a bleomycin modelNature Medicine.  24:1121-1131. 2018
    2018 Collagen biosynthesis in pulmonary fibrosis: Unraveling the metabolic webAmerican Journal of Respiratory Cell and Molecular Biology.  58:545-546. 2018
    2018 Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activationJournal of Biological Chemistry.  293:1218-1228. 2018
    2017 Mitochondrial dysfunction in pulmonary fibrosisAnnals of the American Thoracic Society.  14:S383-S388. 2017
    2017 NADPH Oxidase 4 (Nox4) suppresses mitochondrial biogenesis and bioenergetics in lung fibroblasts via a nuclear factor erythroid-derived 2-like 2 (Nrf2)-dependent pathwayJournal of Biological Chemistry.  292:3029-3038. 2017
    2016 Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary FibrosisScientific Reports.  6. 2016
    2016 Novel mechanisms for the antifibrotic action of nintedanibAmerican Journal of Respiratory Cell and Molecular Biology.  54:51-59. 2016
    2015 Glycolytic reprogramming in myofibroblast differentiation and lung fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  192:1462-1474. 2015
    2015 Metabolic reprogramming is required for myofibroblast contractility and differentiationJournal of Biological Chemistry.  290:25427-25438. 2015
    2014 NADPH oxidases in lung health and diseaseAntioxidants and Redox Signaling.  20:2838-2853. 2014
    2014 Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalanceScience Translational Medicine.  6. 2014
    2013 Origin and evolution of the cystic fibrosis transmembrane regulator protein R domainGene.  523:137-146. 2013
    2013 Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosisJournal of Clinical Investigation.  123:1096-1108. 2013
    2013 Histone modifications in senescence-associated resistance to apoptosis by oxidative stressRedox Biology.  1:8-16. 2013
    2010 Identification of RL-TGR, a coreceptor involved in aversive chemical signalingProceedings of the National Academy of Sciences.  107:12339-12344. 2010
    2010 Cross-linking of ΔF508-CFTR promotes its trafficking to the plasma membrane.Channels.  4:251-254. 2010
    2010 ATP-independent CFTR channel gating and allosteric modulation by phosphorylationProceedings of the National Academy of Sciences.  107:3888-3893. 2010
    2010 Cross-linking of ΔF508-CFTR promotes its trafficking to the plasma membraneChannels.  4. 2010
    2009 Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanismsJournal of Biological Chemistry.  284:30754-30765. 2009
    2007 Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide-binding domainsJournal of Biological Chemistry.  282:4533-4544. 2007
    2007 Enhancement of P2Y 6 -induced Cl - secretion by IL-13 and modulation of SK4 channels activity in human bronchial cellsCellular Physiology and Biochemistry.  20:483-494. 2007
    2005 Vasotocin and vasopressin stimulation of the chloride secretion in the human bronchial epithelial cell line, 16HBE14o-British Journal of Pharmacology.  144:1037-1050. 2005
    2003 Modulation of Calcium-dependent Chloride Secretion by Basolateral SK4-like Channels in a Human Bronchial Cell LineJournal of Membrane Biology.  196:15-31. 2003

    Chapter

    Year Title Altmetric
    2010 Neutrophil elastase-mediated modulation of pathophysiology in cystic fibrosis lung disease.  87-111. 2010

    Research Overview

  • Dr. Bernard's research background and training is in biochemistry and cellular biology of the lung. She completed her postdoctoral training at the University of Alabama at Birmingham, where her research focused on identifying mechanisms by which correctors and/or potentiators rescue CFTR (Cystic Fibrosis Transmembrane conductance Regulator) expression and/or activity in the airway epithelium. Her research interests have evolved to studies of lung injury-repair and myofibroblast biology. Her research has recently shown that metabolic reprogramming is an essential feature of myofibroblast differentiation. She is also working in collaboration with Southern Research Institute (SRI) on identifying specific inhibitors of the NADPH oxidase 4 (Nox4). Specifically, she assisted in the 30,000 compound library HTS by developing cell-based assays of Nox4 activity and myofibroblast activation, as well as animal models of lung fibrosis (including the aging model).
  • Education And Training

  • University of Nice-Sophia, Other
  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, University of Nice-Sophia Antipolis 2004
  • Full Name

  • Karen Bernard