Positions

Overview

  • John C. Kappes (b. 1957), Associate Professor of Medicine and Microbiology, completed his undergraduate studies in biology at Thomas More College (B.A. in Biology, 1981) and received his Ph.D. in Microbiology and Experimental Medicine from St. Thomas Institute in 1986. Dr. Kappes completed his postdoctoral fellowship studying the molecular pathogenesis of human immunodeficiency viruses and joined the UAB faculty in 1989.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model 2019
    2019 Growth hormone (GH) receptor (GHR)-specific inhibition of GH-Induced signaling by soluble IGF-1 receptor (sol IGF-1R) 2019
    2018 Incomplete downregulation of CD4 expression affects HIV-1 Env conformation and antibody-dependent cellular cytotoxicity responses. 2018
    2018 Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1 2018
    2017 Potent in vivo NK cellmediated elimination of HIV-1-infected cells mobilized by a gp120-bispecific and hexavalent broadly neutralizing fusion protein 2017
    2017 Glycosylation benchmark profile for HIV-1 envelope glycoprotein production based on eleven Env trimers 2017
    2017 Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies 2017
    2017 Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV 2017
    2017 Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein 2017
    2017 Antigenic characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein precursor incorporated into nanodiscs 2017
    2017 Specific stabilization of CFTR by phosphatidylserine 2017
    2017 The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria 2017
    2017 Substitution of Yor1p NBD1 residues improves the thermal stability of human cystic fibrosis transmembrane conductance regulator 2017
    2017 The cystic fibrosis transmembrane conductance regulator potentiator ivacaftor augments mucociliary clearance abrogating cystic fibrosis transmembrane conductance regulator inhibition by cigarette smoke 2017
    2016 Diversity of antiviral IgG effector activities observed in HIV-infected and vaccinated subjects 2016
    2016 Expression and purification of the alpha subunit of the epithelial sodium channel, ENaC 2016
    2016 Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma 2016
    2016 High-throughput humanized mouse models for evaluation of HIV-1 therapeutics and pathogenesis 2016
    2016 Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells 2016
    2015 Optimized Replicating Renilla Luciferase Reporter HIV-1 Utilizing Novel Internal Ribosome Entry Site Elements for Native Nef Expression and Function 2015
    2015 A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface 2015
    2015 Erratum to: A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface [Mol Biotechnol, DOI 10.1007/s12033-014-9830-5] 2015
    2015 Erratum to: A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface 2015
    2015 A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface 2015
    2015 Comparative analysis of the glycosylation profiles of membrane-anchored HIV-1 envelope glycoprotein trimers and soluble gp140 2015
    2015 In vivo activation of human NK cells by treatment with an interleukin-15 superagonist potently inhibits acute in vivo HIV-1 infection in humanized mice 2015
    2015 The vaginal acquisition and dissemination of HIV-1 infection in a novel transgenic mouse model is facilitated by coinfection with herpes simplex virus 2 and is inhibited by microbicide treatment 2015
    2015 Therapeutic intervention of proanthocyanidins on the migration capacity of melanoma cells is mediated through PGE2 receptors and β-catenin signaling molecules 2015
    2014 Macrophage infection via selective capture of HIV-1-infected CD4+ T cells 2014
    2014 Combinatorial Therapy With Tamoxifen and Trifluoperazine Effectively Inhibits Malignant Peripheral Nerve Sheath Tumor Growth by Targeting Complementary Signaling Cascades 2014
    2014 Global panel of HIV-1 env reference strains for standardized assessments of vaccine-elicited neutralizing antibodies 2014
    2014 High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse 2014
    2014 Erratum: Resveratrol Enhances Airway Surface Liquid Depth in Sinonasal Epithelium by Increasing Cystic Fibrosis Transmembrane Conductance Regulator Open Probability (PLoS ONE (2014) 9:1 (DOI:10.1371/annotation/d852ff1d-2824- 4f4d-80f2-9be7a42a5f25)) 2014
    2014 A survey of detergents for the purification of stable, active human cystic fibrosis transmembrane conductance regulator (CFTR) 2014
    2014 Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation 2014
    2014 Correction to Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation [Journal of Cell Biology, 206, 7, (2014), 867-876] 2014
    2014 Development of a luciferase based viral inhibition assay to evaluate vaccine induced CD8 T-cell responses 2014
    2014 Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains 2014
    2014 Optimization and validation of a neutralizing antibody assay for HIV-1 in A3R5 cells 2014
    2014 Vaginal myeloid dendritic cells transmit founder HIV-1 2014
    2013 Relative resistance of HIV-1 founder viruses to control by interferon-alpha 2013
    2013 Impact of HIV-1 backbone on neutralization sensitivity: Neutralization profiles of heterologous envelope glycoproteins expressed in native subtype C and CRF01-AE backbone 2013
    2013 Detection of HIV-1 neutralizing antibodies in a human CD4 +/CXCR4+/CCR5+ T-lymphoblastoid cell assay system 2013
    2013 Resveratrol enhances airway surface liquid depth in sinonasal epithelium by increasing cystic fibrosis transmembrane conductance regulator open probability 2013
    2013 The silent codon change I507-ATC→ATT contributes to the severity of the AF508 CFTR channel dysfunction 2013
    2013 Lyn Facilitates Glioblastoma Cell Survival under Conditions of Nutrient Deprivation by Promoting Autophagy 2013
    2013 Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees 2013
    2013 Mice Transgenic for CD4-Specific Human CD4, CCR5 and Cyclin T1 Expression: A New Model for Investigating HIV-1 Transmission and Treatment Efficacy 2013
    2013 Phenotypic properties of transmitted founder HIV-1 2013
    2013 L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor 2013
    2013 Optimization of the transductional efficiency of lentiviral vectors: Effect of sera and polycations 2013
    2013 Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clones 2013
    2013 Mucosal tissue tropism and dissemination of HIV-1 subtype B acute envelope-expressing chimeric virus 2013
    2012 HIV-1 Expressing the Envelopes of Transmitted/Founder or Control/Reference Viruses Have Similar Infection Patterns of CD4 T-Cells in Human Cervical Tissue Ex Vivo 2012
    2012 Short communication: HIV type 1 escapes inactivation by saliva via rapid escape into oral epithelial cells 2012
    2012 A young hispanic with c.1646G>A mutation exhibits severe cystic fibrosis lung disease: Is ivacaftor an option for therapy? 2012
    2012 Selected drugs with reported secondary cell-differentiating capacity prime latent HIV-1 infection for reactivation 2012
    2012 Antibody-dependent cellular cytotoxicity against primary hivinfected CD4 + T cells is directly associated with the magnitude of surface igg binding 2012
    2012 Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials 2012
    2012 Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replication 2012
    2012 Selective impact of HIV disease progression on the innate immune system in the human female reproductive tract 2012
    2012 Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7 2012
    2012 The role of natural killer (NK) cells and nk cell receptor polymorphisms in the assessment of HIV-1 neutralization 2012
    2012 Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages 2012
    2012 Purification of CFTR for mass spectrometry analysis: Identification of palmitoylation and other post-translational modifications 2012
    2011 IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation 2011
    2011 Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infection 2011
    2011 L1 stimulation of human glioma cell motility correlates with FAK activation 2011
    2011 High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses 2011
    2011 An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum 2011
    2011 Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages 2011
    2011 Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent manner 2011
    2010 Replication competent molecular clones of HIV-1 expressing Renilla luciferase facilitate the analysis of antibody inhibition in PBMC 2010
    2010 Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cells 2010
    2010 A synonymous single nucleotide polymorphism in ΔF508 CFTR alters the secondary structure of the mRNA and the expression of the mutant protein 2010
    2010 Anti-HIV activity in cervical-vaginal secretions from HIV-Positive and -Negative women correlate with innate antimicrobial levels and IgG antibodies 2010
    2010 Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination 2010
    2010 Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce β-chemokines 2010
    2010 GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium 2010
    2010 Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection 2010
    2010 Differential inhibition of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and TZM-bl cells by endotoxin-mediated chemokine and gamma interferon production 2010
    2009 Cystin localizes to primary cilia via membrane microdomains and a targeting motif 2009
    2009 Tetherin-Driven Adaptation of Vpu and Nef Function and the Evolution of Pandemic and Nonpandemic HIV-1 Strains 2009
    2009 P04-12. Characterization of leukopak PBMC phenotypes and biotypes for optimal performance in HIV-1 neutralization assays 2009
    2009 P04-23. HIV-1 neutralization is impacted by the PBMC donor used for both virus growth and target cells, and the effects are neutralization reagent-specific 2009
    2009 P05-04. Neutralizing antibodies induced by immunization with liposomal gp41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes 2009
    2009 P20-15. Evaluation of HIV-1 subtype B acute envelope-expressing infectious molecular clones 2009
    2009 S01-04 OA. Phenotypic analyses of CD8+ T cells that mediate virus inhibition from HIV-1 vaccinees and HIV-1+ virus controllers 2009
    2009 Clinical and molecular characterization of S1118F-CFTR 2009
    2009 New virologic reagents for neutralizing antibody assays 2009
    2009 Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection 2009
    2009 COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting 2009
    2009 Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes. 2009
    2008 Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling 2008
    2008 Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling 2008
    2007 Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents 2007
    2007 Neural progenitor cell transplantation and imaging in a large animal model 2007
    2007 HIV-1 Protease Dimer Interface Mutations that Compensate for Viral Reverse Transcriptase Instability in Infectious Virions 2007
    2007 Breast cancer metastasis to bone: Evaluation of bioluminescent imaging and microSPECT/CT for detecting bone metastasis in immunodeficient mice 2007
    2007 Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation 2007
    2007 Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host 2007
    2007 Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy 2007
    2007 Analysis of Amino Acids in the β7-β8 Loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase for their Role in Virus Replication 2007
    2006 Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay 2006
    2006 Kinetics of metastatic breast cancer cell trafficking in bone 2006
    2006 Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function 2006
    2005 Analysis of human immunodeficiency virus type 1 reverse transcriptase subunit structure/function in the context of infectious virions and human target cells 2005
    2005 Identification of amino acid residues in the human immunodeficiency virus type-1 reverse transcriptase tryptophan-repeat motif that are required for subunit interaction using infectious virions 2005
    2004 Clonal selection for transcriptionally active viral oncogenes during progression to cancer 2004
    2004 Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway 2004
    2004 Subunit-specific analysis of the human immunodeficiency virus type 1 reverse transcriptase in vivo 2004
    2003 Replication of chimeric human immunodeficiency virus type 1 (HIV-1) containing HIV-2 integrase (IN): Naturally selected mutations in IN augment DNA synthesis 2003
    2003 Erratum: Antibody neutralization and escape by HIV-1 (Nature (2003) 422 (307-312)) 2003
    2003 Antibody neutralization and escape by HIV-1 2003
    2003 Production of trans-lentiviral vector with predictable safety. 2003
    2002 Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy 2002
    2002 The promoter of the human proliferating cell nuclear antigen gene is not sufficient for cell cycle-dependent regulation in organotypic cultures of keratinocytes 2002
    2002 The conformation of the mature dimeric human immunodeficiency virus type 1 RNA genome requires packaging of pol protein 2002
    2002 Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells 2002
    2001 Moloney murine leukemia virus integrase protein augments viral DNA synthesis in infected cells 2001
    2001 Safety considerations in vector development 2001
    2001 Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1 2001
    2001 Analysis of lenti- and trans-lentiviral vector genetic recombination. 2001
    2000 Analysis of human immunodeficiency virus type 1 containing HERV-K protease 2000
    2000 Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120 2000
    2000 Development of a novel trans-lentiviral vector that affords predictable safety 2000
    2000 Lentiviral vector transduction of hematopoietic stem cells that mediate long-term reconstitution of lethally irradiated mice 2000
    1999 Targeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1 1999
    1999 Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex 1999
    1998 The cysteine-cysteine family of chemokines RANTES, MIP-1α, and MIP-1β induce trypanocidal activity in human macrophages via nitric oxide 1998
    1997 Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein 1997
    1997 Functional RT and IN incorporated into HIV-1 particles independently of the Gag/Pol precursor protein 1997
    1996 Inhibition of human and simian immunodeficiency virus protease function by targeting Vpx-protease-mutant fusion protein into viral particles 1996
    1996 Proteolytic activity of human immunodeficiency virus Vpr-and Vpx-protease fusion proteins 1996
    1995 Assessment of antiretroviral therapy by plasma viral load testing: Standard and ICD HIV-1 p24 antigen and viral RNA (QC-PCR) assays compared 1995
    1995 Polyclonal Rabbit Antisera that Detect the Vpr Protein of SIVSM and SIVMAC on Immunoblots of Purified Virions 1995
    1995 Targeting foreign proteins to human immunodeficiency virus particles via fusion with Vpr and Vpx 1995
    1995 The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures 1995
    1995 Viral protein X 1995
    1994 Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein 1994
    1994 Optimization of quantitative culture assay for human immunodeficiency virus from plasma 1994
    1993 Determination of plasma viral load in HIV-1 infection by quantitative competitive polymerase chain reaction 1993
    1993 A Short-Term Clinical Evaluation of L-697,661, a Non-Nucleoside Inhibitor of HIV-1 Reverse Transcriptase 1993
    1993 Viral dynamics in primary HIV-1 infection 1993
    1993 High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR 1993
    1993 Intracellular transport and virion incorporation of vpx requires interaction with other virus type-specific components 1993
    1993 Viral dynamics in primary HIV-1 infection [21] 1993
    1991 High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection 1991
    1991 Human immunodeficiency virus type 2 vpx protein augments viral infectivity 1991
    1991 Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: Identification of replication-competent and -defective viral genomes 1991
    1990 Molecular characterization of an attenuated human immunodeficiency virus type 2 isolate 1990
    1988 Enhanced in vitro reactivation of latent herpes simplex virus from neural and peripheral tissues with hexamethylenebisacetamide 1988
    1988 Antibody to herpes simplex virus (Hsv) icp-35 proteins after hsv challenge of animals immunized with hsv subunit vaccines 1988
    1988 Enhanced in vitro reactivation of herpes simplex virus type 2 from latency infected guinea-pig neural tissues by 5-azacytidine 1988
    1988 Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIV(MAC) 1988
    1988 West African HIV-2-related human retrovirus with attenuated cytopathicity 1988
    1987 Antibody Response to Herpes Simplex Virus Glycoprotein d: Effects of Acyclovir and Relation to Recurrence 1987
    1986 Antibody response, recurrence patterns and subsequent herpes simplex virus type 2 (HSV-2) re-infection following initial HSV-2 infection of guinea-pigs: Effects of acyclovir 1986

    Research Overview

  • Dr. Kappes' research is focused on studying the molecular biology of the human immunodeficiency virus type 1 (HIV-1), and the development of lentiviral-based vectors for gene delivery. These studies are helping to understand how infectious virions are formed and how the viral enzymes [reverse transcriptase (RT) and integrase (IN)], function during the early stages of the virus life cycle. By using virion associated HIV accessory proteins (Vpr and Vpx), Dr. Kappes has developed an approach for incorporating functional RT and IN into virions independently of the normal Gag-Pol packaging pathway. This has uncoupled the RT and IN function from Gag-Pol function and enabled, for the first time, a detailed molecular analysis of reverse transcription and integration in the context of replicating virus (in vivo). Based on the principles of incorporating RT and IN in trans, Dr. Kappes has developed a new generation of HIV/lentiviral-based vectors for gene therapy. Lentiviral vectors appear to be well suited for gene therapy since they can transduce nondividing (somatic) cells. By separating the expression of RT and IN from the other vector components it is possible to produce lentiviral vectors with minimal risk of recombination and the generation of replication competent virus.
  • Investigator On

  • CA-VIMC Molecular Virology Core (UAB)  awarded by Duke University 2016 - 2021
  • Virologic Strategies for ADVANCEd lmmunoAssays  awarded by INTERNATIONAL AIDS VACCINE INITIATIVE 2016 - 2020
  • A Novel Role for IGF-1 Receptor in Growth Hormone Action  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2019
  • Pathogenesis of Rebound SIV/HIV Viremia After Antiretroviral Therapy  awarded by Northwestern University 2017 - 2019
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • UAB CF Research and Translation Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2018
  • UAB CF Research and Translation Core Center - Core A: Cell Model and Assay Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2018
  • A Comprehensive Evaluation of Microgravity Protein Crystallization  awarded by NASA - National Aeronautics & Space Administration 2011 - 2016
  • Innovative Solutions Toward a 3D CFTR Structure  awarded by Cystic Fibrosis Foundation 2013 - 2016
  • Vaginal Dendritic Cells Selectively Transmit HIV-1 Founder Virus  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2016
  • CTVIMC2 - Discovery VIA Project and Clinical Trial Testing Core  awarded by Imperial College of Science, Technology & Medicine 2015 - 2016
  • UAB CF Research and Translation Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2016
  • UAB CF Research and Translation Core Center - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2016
  • Production & Crystallization of Membrane Protein for 3D Structure  awarded by National Institute of General Medical Sciences/NIH/DHHS 2010 - 2015
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Crystallization and Structure Determination of Full-Length CFTR Protein  awarded by Cystic Fibrosis Foundation 2005 - 2013
  • Mucosal HIV and Immunobiology Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2013
  • CHAVI - Center for HIV/AIDS Vaccine Immunology  awarded by Duke University 2005 - 2012
  • Development of a Robust PBMC-Based HIV-1 Neutralizing Antibody Assay: Generation of Reference Env-Containing Renilla Luciferase Reporter Back Bone Proviral DNA Reagents and Methods.  awarded by Duke University 2008 - 2011
  • Full Name

  • John Kappes