Positions

Overview

  • Dr. Keith (Tony) Jones received his Medical Degree from the University of Alabama (UA) School of Medicine in 1986. He completed an anesthesiology residency and postgraduate studies at Mayo Clinic, which included advanced training in Neuroanesthesia and a Postdoctoral NIH Research fellowship. Dr. Jones was a member of the faculty of the Mayo Clinic College of Medicine and practiced in the Department of Anesthesiology at Mayo Clinic for 15 year, and then served as the Alfred Habeeb Professor and Chair of the Department of Anesthesiology and Perioperative Medicine at the University of Alabama at Birmingham (UAB) from July 2006 to October 2017. Dr. Jones is currently the President of the University of Alabama Health Services Foundation and Chief Physician Executive of the UAB Health System. Dr. Jones also serves on the Joint Operating Leadership Council for UAB Medicine and the Executive Cabinet of the UAB Health System, as well as Senior Associate Dean for Clinical Affairs in the UA School of Medicine.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Incidence of Venous Air Embolism During Endoscopic Retrograde Cholangiopancreatography.Anesthesia and Analgesia.  127:420-423. 2018
    2016 The Effect of Implementation of Preoperative and Postoperative Care Elements of a Perioperative Surgical Home Model on Outcomes in Patients Undergoing Hip Arthroplasty or Knee Arthroplasty.Anesthesia and Analgesia.  124:1450-1458. 2016
    2016 Perceptions about the relative importance of patient care-related topics: a single institutional survey of its anesthesiologists, nurse anesthetists, and surgeons.BMC Anesthesiology.  16:19. 2016
    2015 Perioperative Surgical Home: Perspective II.Anesthesiology Clinics.  33:771-784. 2015
    2014 The perioperative surgical home: how anesthesiology can collaboratively achieve and leverage the triple aim in health care.Anesthesia and Analgesia.  118:1131-1136. 2014
    2014 Risk Factors Associated with Reoperation for Bleeding following Liver Transplantation.HPB Surgery.  2014:816246. 2014
    2013 Halothane binds to druggable sites in the [Ca2+] 4-calmodulin (CaM) complex, but does not inhibit [Ca 2+]4-CaM activation of kinaseJournal of the Serbian Chemical Society.  78:1655-1670. 2013
    2013 The Perioperative Surgical Home: how can it make the case so everyone wins?BMC Anesthesiology.  13:6. 2013
    2009 Prolonged treatment of porcine pulmonary artery with nitric oxide decreases cGMP sensitivity and cGMP-dependent protein kinase specific activity.AJP - Lung Cellular and Molecular Physiology.  296:L121-L129. 2009
    2008 Volatile anesthetic binding to proteins is influenced by solvent and aliphatic residues.Journal of Chemical Information and Computer Sciences.  48:2066-2073. 2008
    2007 Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide.AJP - Lung Cellular and Molecular Physiology.  293:L84-L95. 2007
    2007 H(2)O(2)-induced kinetic and chemical modifications of smooth muscle myosin: correlation to effects of H(2)O(2) on airway smooth muscle.Journal of Biological Chemistry.  282:4336-4344. 2007
    2006 Prediction of volatile anesthetic binding sites in proteins.Biophysical Journal.  91:3405-3414. 2006
    2006 Prolonged relaxation consistent with persistent soluble guanylyl cyclase activation in canine pulmonary artery following brief treatment with nitric oxide donors.Life Sciences.  79:2001-2009. 2006
    2006 Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G protein.Anesthesiology.  105:313-324. 2006
    2006 Nitric oxide sensitivity in pulmonary artery and airway smooth muscle: a possible role for cGMP responsiveness.AJP - Lung Cellular and Molecular Physiology.  290:L1018-L1027. 2006
    2006 Halothane does not inhibit the functional coupling between the beta2-adrenergic receptor and the Galphas heterotrimeric G protein.Anesthesiology.  104:754-762. 2006
    2006 Reliability and validity of an assessment of usual phytoestrogen consumption (United States).Cancer Causes and Control.  17:85-93. 2006
    2006 NO responsiveness in pulmonary artery and airway smooth muscle: the role of cGMP regulation.AJP - Lung Cellular and Molecular Physiology.  290:L200-L208. 2006
    2005 Contrasting effects of puerarin and daidzin on glucose homeostasis in mice.Journal of Agricultural and Food Chemistry.  53:8760-8767. 2005
    2005 Effect of halothane on galphai-3 and its coupling to the M2 muscarinic receptor.Anesthesiology.  103:1015-1025. 2005
    2005 Anesthetics inhibit membrane receptor coupling to the Gq/11 heterotrimeric G protein in airway smooth muscle.Anesthesiology.  103:296-305. 2005
    2004 On the terminology for describing the length-force relationship and its changes in airway smooth muscle.Journal of applied physiology: respiratory, environmental and exercise physiology.  97:2029-2034. 2004
    2004 Saturation transfer difference nuclear magnetic resonance spectroscopy as a method for screening proteins for anesthetic binding.Molecular Pharmacology.  66:929-935. 2004
    2004 Anesthetics inhibit acetylcholine-promoted guanine nucleotide exchange of heterotrimeric G proteins of airway smooth muscle.Anesthesiology.  101:120-126. 2004
    2004 The effects of hexanol on Galpha(i) subunits of heterotrimeric G proteins.Anesthesia and Analgesia.  98:660-667. 2004
    2003 Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry.Journal of Agricultural and Food Chemistry.  51:4213-4218. 2003
    2003 Effect of halothane on the guanosine 5' triphosphate binding activity of G-protein alphai subunits.Anesthesiology.  99:105-111. 2003
    2003 Dual effects of hexanol and halothane on the regulation of calcium sensitivity in airway smooth muscle.Anesthesiology.  98:871-880. 2003
    2003 A novel mechanism by which hydrogen peroxide decreases calcium sensitivity in airway smooth muscleAJP - Lung Cellular and Molecular Physiology.  284. 2003
    2003 A novel mechanism by which hydrogen peroxide decreases calcium sensitivity in airway smooth muscle.AJP - Lung Cellular and Molecular Physiology.  284:L324-L332. 2003
    2002 Fast track anesthesia for liver transplantation reduces postoperative ventilation time but not intensive care unit stay.Liver Transplantation and Surgery.  8:670-675. 2002
    2002 Effects of primary alcohols on airway smooth muscle.Anesthesiology.  96:428-437. 2002
    2002 Differential effects of soluble and particulate guanylyl cyclase on Ca(2+) sensitivity in airway smooth muscle.Journal of applied physiology: respiratory, environmental and exercise physiology.  92:257-263. 2002
    2001 Calcium sensitization produced by G protein activation in airway smooth muscleAJP - Lung Cellular and Molecular Physiology.  281. 2001
    2001 Calcium sensitization produced by G protein activation in airway smooth muscle.AJP - Lung Cellular and Molecular Physiology.  281:L631-L638. 2001
    2001 The effects of ethanol on CA(2+) sensitivity in airway smooth muscle.Anesthesia and Analgesia.  92:767-774. 2001
    2001 Halothane increases smooth muscle protein phosphatase in airway smooth muscle.Anesthesiology.  94:129-136. 2001
    2000 Identification and characterization of two G protein-coupled receptors for neuropeptide FF.Journal of Biological Chemistry.  275:39324-39331. 2000
    2000 Relationship between force and regulatory myosin light chain phosphorylation in airway smooth muscleAJP - Lung Cellular and Molecular Physiology.  279. 2000
    2000 Relationship between force and regulatory myosin light chain phosphorylation in airway smooth muscle.AJP - Lung Cellular and Molecular Physiology.  279:L52-L58. 2000
    2000 S-nitrosoglutathione-induced decrease in calcium sensitivity of airway smooth muscleAJP - Lung Cellular and Molecular Physiology.  278. 2000
    2000 S-nitrosoglutathione-induced decrease in calcium sensitivity of airway smooth muscle.AJP - Lung Cellular and Molecular Physiology.  278:L521-L527. 2000
    2000 Effects of intravenous anesthetics on Ca2+ sensitivity in canine tracheal smooth muscle.Anesthesiology.  92:133-139. 2000
    1999 Hydrogen peroxide decreases Ca(2+) sensitivity in airway smooth muscle by inhibiting rMLC phosphorylation.American Journal of Physiology.  277:L816-L822. 1999
    1999 Hydrogen peroxide decreases Ca2+ sensitivity in airway smooth muscle by inhibiting rMLC phosphorylationAJP - Lung Cellular and Molecular Physiology.  277. 1999
    1999 Hydrogen peroxide decreases Ca2+sensitivity in airway smooth muscle by inhibiting rMLC phosphorylation.AJP - Lung Cellular and Molecular Physiology.  277:L816-L822. 1999
    1999 F-actin stabilization increases tension cost during contraction of permeabilized airway smooth muscle in dogs.Journal of Physiology.  519 Pt 2:527-538. 1999
    1999 ATP hydrolysis during contraction of permeabilized airway smooth muscleAJP - Lung Cellular and Molecular Physiology.  277. 1999
    1999 ATP hydrolysis during contraction of permeabilized airway smooth muscle.American Journal of Physiology.  277:L334-L342. 1999
    1999 Effect of halothane on intracellular calcium oscillations in porcine tracheal smooth muscle cellsAJP - Lung Cellular and Molecular Physiology.  276. 1999
    1999 Effect of halothane on intracellular calcium oscillations in porcine tracheal smooth muscle cells.American Journal of Physiology.  276:L81-L89. 1999
    1999 cGMP modulation of Ca2+ sensitivity in airway smooth muscle.American Journal of Physiology.  276:L35-L40. 1999
    1999 cGMP modulation of Ca2+sensitivity in airway smooth muscle.AJP - Lung Cellular and Molecular Physiology.  276:L35-L40. 1999
    1999 cGMP modulation of Ca2+sensitivity in airway smooth muscleAJP - Lung Cellular and Molecular Physiology.  276. 1999
    1998 Halothane attenuates calcium sensitization in airway smooth muscle by inhibiting G-proteins.Anesthesiology.  89:1543-1552. 1998
    1998 Drug-specific effects of volatile anesthetics on Ca2+ sensitization in airway smooth muscle.Anesthesia and Analgesia.  87:425-429. 1998
    1998 cGMP-independent mechanism of airway smooth muscle relaxation induced by S-nitrosoglutathioneAmerican Journal of Physiology - Cell Physiology.  275. 1998
    1998 cGMP-independent mechanism of airway smooth muscle relaxation induced by S-nitrosoglutathione.American Journal of Physiology - Cell Physiology.  275:C468-C474. 1998
    1998 cGMP-independent mechanism of airway smooth muscle relaxation induced by S-nitrosoglutathione.American Journal of Physiology.  275:C468-C474. 1998
    1998 Effect of phorbol esters on Ca2+ sensitivity and myosin light-chain phosphorylation in airway smooth muscle.American Journal of Physiology.  274:C1253-C1260. 1998
    1998 Effect of phorbol esters on Ca2+sensitivity and myosin light-chain phosphorylation in airway smooth muscleAmerican Journal of Physiology - Cell Physiology.  274. 1998
    1998 Mechanisms of cerebral arterial relaxations to hydrogen peroxideFederation proceedings.  12. 1998
    1998 Cross-bridge cycling kinetics, actomyosin ATPase activity and myosin heavy chain isoforms in skeletal and smooth respiratory muscles.Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology.  119:435-450. 1998
    1998 The role of cGMP in the relaxation to nitric oxide donors in airway smooth muscle.European Journal of Pharmacology.  341:225-233. 1998
    1997 Role of protein kinase C in calcium sensitization during muscarinic stimulation in airway smooth muscleAJP - Lung Cellular and Molecular Physiology.  273. 1997
    1997 Role of protein kinase C in calcium sensitization during muscarinic stimulation in airway smooth muscle.AJP - Lung Cellular and Molecular Physiology.  273:L775-L781. 1997
    1997 Role of protein kinase C in calcium sensitization during muscarinic stimulation in airway smooth muscle.American Journal of Physiology.  273:L775-L781. 1997
    1997 Muscarinic receptor stimulation modulates the effect of halothane on Mn2+ influx in airway smooth muscleAmerican Journal of Physiology - Cell Physiology.  273. 1997
    1997 Muscarinic receptor stimulation modulates the effect of halothane on Mn2+ influx in airway smooth muscle.American Journal of Physiology.  273:C868-C873. 1997
    1997 Stereospecific effects of ketamine enantiomers on canine tracheal smooth muscle.British Journal of Pharmacology.  121:1378-1382. 1997
    1997 Halothane attenuation of calcium sensitivity in airway smooth muscle. Mechanisms of action during muscarinic receptor stimulation.Anesthesiology.  87:94-101. 1997
    1997 Halothane inhibits agonist-induced potentiation of rMLC phosphorylation in permeabilized airway smooth muscle.American Journal of Physiology.  273:L80-L85. 1997
    1997 Halothane inhibits agonist-induced potentiation of rmlc phosphorylation in permeabilized airway smooth muscleAJP - Lung Cellular and Molecular Physiology.  273. 1997
    1997 The effects of halothane pretreatment on manganese influx induced by muscarinic stimulation of airway smooth muscle.Anesthesia and Analgesia.  84:1366-1371. 1997
    1997 Calcium concentration-dependent mechanisms through which ketamine relaxes canine airway smooth muscle.Anesthesiology.  86:1104-1111. 1997
    1996 Friction in airway smooth muscle: mechanism, latch, and implications in asthma.Journal of applied physiology: respiratory, environmental and exercise physiology.  81:2703-2712. 1996
    1996 The role of free/total prostate-specific antigen ratio in the prediction of final pathologic stage for men with clinically localized prostate cancer.Urology.  48:51-54. 1996
    1996 Halothane reduces myofilament Ca2+ sensitivity during muscarinic receptor stimulation of airway smooth muscle.American Journal of Physiology.  271:L719-L725. 1996
    1996 Halothane reduces myofilament Ca2+sensitivity during muscarinic receptor stimulation of airway smooth muscleAJP - Lung Cellular and Molecular Physiology.  271. 1996
    1996 Use of nitric oxide-nucleophile adducts as biological sources of nitric oxide: effects on airway smooth muscle.Journal of Pharmacology and Experimental Therapeutics.  278:1269-1275. 1996
    1996 Halothane and potassium channels in airway smooth muscle.British Journal of Anaesthesia.  76:847-853. 1996
    1995 Halothane reduces force and intracellular Ca2+ in airway smooth muscle independently of cyclic nucleotides.American Journal of Physiology.  268:L166-L172. 1995
    1995 Halothane reduces force and intracellular Ca2+ in airway smooth muscle independently of cyclic nucleotidesAJP - Lung Cellular and Molecular Physiology.  268. 1995
    1994 A computer-controlled, closed-loop infusion system for infusing muscle relaxants: its use during motor-evoked potential monitoring.Journal of cardiothoracic anesthesia.  8:40-44. 1994
    1994 Effects of halothane on the relationship between cytosolic calcium and force in airway smooth muscle.American Journal of Physiology.  266:L199-L204. 1994
    1994 Halothane and pertussis toxin-sensitive G proteins in airway smooth muscle.Anesthesia and Analgesia.  78:328-334. 1994
    1994 Changes in cytosolic cGMP and calcium in airway smooth muscle relaxed by 3-morpholinosydnonimineAmerican Journal of Physiology.  266. 1994
    1994 Changes in cytosolic cGMP and calcium in airway smooth muscle relaxed by 3-morpholinosydnonimineAmerican Journal of Physiology.  266. 1994
    1994 Changes in cytosolic cGMP and calcium in airway smooth muscle relaxed by 3-morpholinosydnonimine.American Journal of Physiology.  266:L9-16. 1994
    1994 Effects of halothane on the relationship between cytosolic calcium and force in airway smooth muscleAmerican Journal of Physiology.  266. 1994
    1994 Effects of halothane on the relationship between cytosolic calcium and force in airway smooth muscleAmerican Journal of Physiology.  266. 1994
    1993 A versatile, computer-controlled, closed-loop system for continuous infusion of muscle relaxants.Mayo Clinic Proceedings.  68:1074-1080. 1993
    1993 Severe HELLP syndrome presenting with acute gum bleeding following toothbrushing at 38 weeks' gestation.American Journal of Critical Care.  2:395-396. 1993
    1993 Halothane alters cytosolic calcium transient in tracheal smooth muscle.American Journal of Physiology.  265:L80-L86. 1993
    1993 Factors influencing the direct actions of volatile anesthetics on airway smooth muscle.Anesthesiology.  78:1102-1111. 1993
    1993 Halothane alters cytosolic calcium transient in tracheal smooth muscleAmerican Journal of Physiology.  265. 1993
    1992 Method of intraoperative monitoring of neuromuscular function and residual blockade in the recovery room.Minnesota Medicine.  75:23-26. 1992

    Research Overview

  • In addition to his many teaching, mentorship and clinical activities, Dr. Jones has been a prolific researcher with interests in airway smooth muscle physiology and pharmacology, and the cellular and biochemical mechanisms by which volatile anesthetics and reactive oxygen species alter smooth muscle function. More recently, his research interests include health services research with an emphasis on models of perioperative care. He has authored or co-authored more than 160 scholarly works. His studies have been supported by research grants from the National Institutes of Health. Dr. Jones also serves as a member of the Board of Directors for the International Anesthesia Research Society.
  • Education And Training

  • Doctor of Medicine in Anesthesiology Residency Program, University of Alabama at Birmingham
  • Full Name

  • Tony Jones
  • Blazerid

  • kaj04