Positions

Overview

  • As an immunologist by training, my ongoing research focuses on immunogenetic factors in several infectious diseases, especially HIV/AIDS.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 HLA-DQB1*06 is a risk marker for chlamydia reinfection in African American women.Genes and Immunity.  20:69-73. 2019
    2018 Fc-gamma receptor IIA and IIIA variants in two African cohorts: Lack of consistent impact on heterosexual HIV acquisition, viral control, and disease progression.Virology.  525:132-142. 2018
    2018 Immunogenetic factors in early immune control of human immunodeficiency virus type 1 (HIV-1) infection: Evaluation of HLA class I amino acid variants in two African populations.Human Immunology.  79:166-171. 2018
    2018 Herpes Zoster in Persons Living with HIV-1 Infection: Viremia and Immunological Defects Are Strong Risk Factors in the Era of Combination Antiretroviral Therapy.Frontiers in Public Health.  6:70. 2018
    2016 Dynamics and Correlates of CD8 T-Cell Counts in Africans with Primary Human Immunodeficiency Virus Type 1 Infection.Journal of Virology.  90:10423-10430. 2016
    2016 Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression.Journal of Experimental Medicine.  213:2049-2063. 2016
    2016 Brief Report: Enhanced Allogeneic Cellular Responses to Mismatched HLA-B Antigens Results in More Efficient Killing of HIV Infected Cells.Journal of Acquired Immune Deficiency Syndromes.  71:493-497. 2016
    2016 Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.PLoS Pathogens.  12:e1005369. 2016
    2015 HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.PLoS Pathogens.  11:e1005111. 2015
    2015 Imputation of class I and II HLA loci using high-density SNPs from ImmunoChip and their associations with Kawasaki disease in family-based study.European Journal of Immunogenetics.  42:140-146. 2015
    2015 Immunogenetic influences on acquisition of HIV-1 infection: consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2).Genes and Immunity.  16:213-220. 2015
    2015 Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression.Proceedings of the National Academy of Sciences.  112:E1480-E1489. 2015
    2015 CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: findings from an African cohort with prospective data.Frontiers in Microbiology.  6:670. 2015
    2015 Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients.PLoS Pathogens.  11:e1004565. 2015
    2014 Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions.Human Genetics.  133:1187-1197. 2014
    2014 Mitochondrial DNA variation and virologic and immunological HIV outcomes in African Americans.AIDS.  28:1871-1878. 2014
    2014 HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck.Science.  345:1254031. 2014
    2014 Host genetics and immune control of HIV-1 infection: fine mapping for the extended human MHC region in an African cohort.Genes and Immunity.  15:275-281. 2014
    2014 Dynamics of viremia in primary HIV-1 infection in Africans: insights from analyses of host and viral correlates.Virology.  449:254-262. 2014
    2014 KIR2DS4 promotes HIV-1 pathogenesis: new evidence from analyses of immunogenetic data and natural killer cell function.PLoS ONE.  9:e99353. 2014
    2013 Dimorphic HLA-B signal peptides differentially influence HLA-E- and natural killer cell-mediated cytolysis of HIV-1-infected target cells.Clinical and Experimental Immunology.  174:414-423. 2013
    2013 Variants in interleukin family of cytokines genes influence clearance of high risk HPV in HIV-1 coinfected African-American adolescents.Human Immunology.  74:1696-1700. 2013
    2013 HLA-B*57 versus HLA-B*81 in HIV-1 infection: slow and steady wins the race?Journal of Virology.  87:4043-4051. 2013
    2013 Cumulative impact of host and viral factors on HIV-1 viral-load control during early infection.Journal of Virology.  87:708-715. 2013
    2013 Genetic associations with 25-hydroxyvitamin D deficiency in HIV-1-infected youth: fine-mapping for the GC/DBP gene that encodes the vitamin D-binding protein.Frontiers in Genetics.  4:234. 2013
    2013 Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed.PLoS ONE.  8:e64813. 2013
    2013 Recent advances in research of HIV infection: implications of viral and host genetics on treatment and prevention.Community Genetics.  16:31-36. 2013
    2012 Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents.Journal of Reproductive Immunology.  96:84-89. 2012
    2012 HIV-1 dynamics: a reappraisal of host and viral factors, as well as methodological issues.Viruses.  4:2080-2096. 2012
    2012 A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.Vaccine.  30:4778-4784. 2012
    2012 Erratum: Genetic variations and heterosexual HIV-1 infection: Analysis of clustered genes encoding CC-motif chemokine ligands (Genes and Immunity (2012) 13 (202-205) DOI:10.1038/gene.2011.70)Genes and Immunity.  13:444. 2012
    2012 HLA-B signal peptide polymorphism influences the rate of HIV-1 acquisition but not viral load.Journal of Infectious Diseases.  205:1797-1805. 2012
    2012 Genetic variations and heterosexual HIV-1 infection: analysis of clustered genes encoding CC-motif chemokine ligands.Genes and Immunity.  13:202-205. 2012
    2012 Protocol for analyzing human leukocyte antigen variants and sexually transmitted infections: from genotyping to immunoassays.Methods in Molecular Biology.  903:359-380. 2012
    2012 Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.PLoS Pathogens.  8:e1003041. 2012
    2011 Human leukocyte antigen variants B*44 and B*57 are consistently favorable during two distinct phases of primary HIV-1 infection in sub-Saharan Africans with several viral subtypes.Journal of Virology.  85:8894-8902. 2011
    2011 The role of HLA-DR-DQ haplotypes in variable antibody responses to anthrax vaccine adsorbed.Genes and Immunity.  12:457-465. 2011
    2011 Identification of three immunologic correlates for HIV type 1 pathogenesis in youth.AIDS Research and Human Retroviruses.  27:639-646. 2011
    2011 The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African Americans.Human Immunology.  72:312-318. 2011
    2011 Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians.Retrovirology.  8:22. 2011
    2011 Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers.Journal of Virology.  85:2316-2324. 2011
    2011 Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couples.Journal of Infectious Diseases.  203:487-495. 2011
    2011 Disparate associations of HLA class I markers with HIV-1 acquisition and control of viremia in an African population.PLoS ONE.  6:e23469. 2011
    2010 Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescents.PLoS ONE.  5:e13384. 2010
    2010 Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationships.PLoS ONE.  5:e9629. 2010
    2010 Human leukocyte antigen class I supertypes and HIV-1 control in African Americans.Journal of Virology.  84:2610-2617. 2010
    2010 CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription.Journal of Experimental Medicine.  207:51-59. 2010
    2009 Predictors of suboptimal virologic response to highly active antiretroviral therapy among human immunodeficiency virus-infected adolescents: analyses of the reaching for excellence in adolescent care and health (REACH) project.Archives of Pediatrics and Adolescent Medicine.  163:1100-1105. 2009
    2009 Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth.Human Genetics.  126:685-696. 2009
    2009 OA06-03. Dynamics of CTL epitope escape and reversion in an African subtype C cohortRetrovirology.  6. 2009
    2009 Gene copy number: learning to count past two.Nature Medicine.  15:1127-1129. 2009
    2009 The major histocompatibility complex conserved extended haplotype 8.1 in AIDS-related non-Hodgkin lymphoma.Journal of Acquired Immune Deficiency Syndromes.  52:170-179. 2009
    2009 Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs.PLoS ONE.  4:e7157. 2009
    2009 Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients.Journal of Experimental Medicine.  206:909-921. 2009
    2009 Adaptation of HIV-1 to human leukocyte antigen class I.Nature.  458:641-645. 2009
    2009 Host genetics and HIV-1 viral load set-point in African-Americans.AIDS.  23:673-677. 2009
    2008 Human leukocyte antigen class I genotypes in relation to heterosexual HIV type 1 transmission within discordant couples.Journal of Immunology.  181:2626-2635. 2008
    2008 Immunogenetic correlates of Neisseria gonorrhoeae infection in adolescents.Sexually Transmitted Diseases.  35:656-661. 2008
    2008 Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients.Journal of Experimental Medicine.  205:1009-1017. 2008
    2007 Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents.AIDS.  21:2387-2397. 2007
    2007 Haplotype inference for present-absent genotype data using previously identified haplotypes and haplotype patterns.Computer applications in the biosciences : CABIOS.  23:2399-2406. 2007
    2007 Interleukin-10 gene (IL10) polymorphisms and human papillomavirus clearance among immunosuppressed adolescents.Cancer Epidemiology, Biomarkers and Prevention.  16:1626-1632. 2007
    2007 CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection.Genes and Immunity.  8:224-231. 2007
    2006 Conserved extended haplotypes of the major histocompatibility complex: further characterization.Genes and Immunity.  7:450-467. 2006
    2006 Cohort- and time-specific associations of CTLA4 genotypes with HIV-1 disease progression.AIDS.  20:1583-1590. 2006
    2006 Human leukocyte antigen B58 supertype and human immunodeficiency virus type 1 infection in native Africans.Journal of Virology.  80:6056-6060. 2006
    2006 Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults.Clinical and Experimental Immunology.  144:117-124. 2006
    2005 Association between human leukocyte antigen class II alleles and genotype of Borrelia burgdorferi in patients with early lyme disease.Journal of Infectious Diseases.  192:2020-2026. 2005
    2005 Interleukin (IL)-2 and IL-12 responses to Chlamydia trachomatis infection in adolescents.Clinical and Experimental Immunology.  142:548-554. 2005
    2005 A case-control study to examine HLA haplotype associations in patients with posttreatment chronic Lyme disease.Journal of Infectious Diseases.  192:1010-1013. 2005
    2005 Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme.Cancer Epidemiology, Biomarkers and Prevention.  14:2040-2044. 2005
    2005 HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma.Journal of Medical Virology.  76:302-310. 2005
    2005 Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents.Journal of Infectious Diseases.  191:1084-1092. 2005
    2005 Influence of host genetic variation on susceptibility to HIV type 1 infection.Journal of Infectious Diseases.  191 Suppl 1:S68-S77. 2005
    2004 Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescents.Journal of Infectious Diseases.  190:1723-1729. 2004
    2004 Molecular typing of human leukocyte antigen and related polymorphisms following whole genome amplification.Tissue Antigens.  64:286-292. 2004
    2004 Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples.Lancet.  363:2137-2139. 2004
    2004 HLA-DRB1 and -DQB1 alleles and haplotypes in Zambian couples and their associations with heterosexual transmission of HIV type 1.Journal of Infectious Diseases.  189:1696-1704. 2004
    2004 Cytokine and chemokine gene polymorphisms among ethnically diverse North Americans with HIV-1 infection.Journal of Acquired Immune Deficiency Syndromes.  35:446-454. 2004
    2004 HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination.Hepatology.  39:978-988. 2004
    2004 HLA allele sharing and HIV type 1 viremia in seroconverting Zambians with known transmitting partners.AIDS Research and Human Retroviruses.  20:19-25. 2004
    2004 Pharmacogenomic perspectives of chronic hepatitis C virus (HCV) infection.Pharmacogenomics Journal.  4:171-174. 2004
    2003 T cell responses in HIV type 1-infected adolescent minorities share similar epitope specificities with whites despite significant differences in HLA class I alleles.AIDS Research and Human Retroviruses.  19:1017-1026. 2003
    2003 Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in 3 cohorts of white men.Journal of Infectious Diseases.  188:856-863. 2003
    2003 Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities.Journal of Acquired Immune Deficiency Syndromes.  33:426-438. 2003
    2003 The complexity of HLA class II (DRB1, DQB1, DM) associations with disseminated Mycobacterium avium complex infection among HIV-1-seropositive whites.Journal of Acquired Immune Deficiency Syndromes.  33:140-145. 2003
    2003 Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection.Journal of Infectious Diseases.  187:1264-1271. 2003
    2003 The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy.AIDS.  17 Suppl 4:S51-S60. 2003
    2002 Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents.AIDS.  16:2275-2284. 2002
    2002 Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1.Journal of Virology.  76:8276-8284. 2002
    2002 CCR2 and CCR5 genotypes in HIV type 1-infected adolescents: limited contributions to variability in plasma HIV type 1 RNA concentration in the absence of antiretroviral therapy.AIDS Research and Human Retroviruses.  18:403-412. 2002
    2002 C-C chemokine receptor 2 and C-C chemokine receptor 5 genotypes in patients treated for chronic hepatitis C virus infection.Immunologic Research.  26:167-175. 2002
    2002 Distribution of chemokine receptor CCR2 and CCR5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression.Journal of Virology.  76:662-672. 2002
    2001 Is protection in HIV infection due to Bw4 or not to Bw4?Lancet Infectious Diseases.  1:221-222. 2001
    2001 Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines.Journal of Virology.  75:8681-8689. 2001
    2001 Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection.Hepatology.  33:708-712. 2001
    2001 Novel alleles at the lymphotoxin alpha (LTalpha) locus mark extended HLA haplotypes in native Africans.Human Immunology.  62:269-278. 2001
    2001 TAPI polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies.Human Immunology.  62:256-268. 2001
    2001 Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans.Genes and Immunity.  2:32-40. 2001
    2000 Tumor necrosis factor gene polymorphisms in patients with cirrhosis from chronic hepatitis C virus infection.Genes and Immunity.  1:386-390. 2000
    2000 Characteristics of HLA class I and class II polymorphisms in Rwandan women.Experimental and Clinical Immunogenetics.  17:185-198. 2000
    1999 HLA-B*5703 independently associated with slower HIV-1 disease progression in Rwandan women.AIDS.  13:1990-1991. 1999
    1999 Allelic variants of human beta-chemokine receptor 5 (CCR5) promoter: evolutionary relationships and predictable associations with HIV-1 disease progression.Genes and Immunity.  1:20-27. 1999
    1999 Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men.Journal of Infectious Diseases.  180:299-309. 1999
    1999 Identification of bloodmeals in haematophagous Diptera by cytochrome B heteroduplex analysis.Medical and Veterinary Entomology.  13:282-287. 1999
    1999 HLA class I homozygosity accelerates disease progression in human immunodeficiency virus type 1 infection.AIDS Research and Human Retroviruses.  15:317-324. 1999
    1999 Biased TCR repertoire in infiltrating lesional T cells in human Bancroftian filariasis.Journal of Immunology.  162:1756-1764. 1999
    1998 New TAP2 polymorphisms in Africans.Tissue Antigens.  51:556-562. 1998
    1998 Genetic variation in North American black flies in the subgenus Psilopelmia (Simulium: Diptera: Simuliidae)Canadian Journal of Zoology.  76:205-211. 1998
    1997 Heteroduplex analysis in medical entomology: A rapid and sensitive sequence-based tool for population and phylogenetic studies.Parasitology Today.  13:271-274. 1997
    1997 Vector-parasite transmission complexes for onchocerciasis in West Africa.Lancet.  349:163-166. 1997
    1997 Onchocerca volvulus: comparison of field collection methods for the preservation of parasite and vector samples for PCR analysis.Bulletin of the World Health Organization.  75:443-447. 1997
    1996 Molecular phylogeny and typing of blackflies (Diptera: Simuliidae) that serve as vectors of human or bovine onchocerciasis.Medical and Veterinary Entomology.  10:228-234. 1996
    1996 Genotyping North American black flies by means of mitochondrial ribosomal RNA sequencesCanadian Journal of Zoology.  74:39-46. 1996
    1996 Intra-specific heterogeneity of the rDNA internal transcribed spacer in the Simulium damnosum (Diptera: Simuliidae) complex.Molecular Biology and Evolution.  13:244-252. 1996
    1995 Discriminating PCR artifacts using directed heteroduplex analysis (DHDA).BioTechniques.  19:902-905. 1995
    1995 Phenotypes of Heligmosomoides polygyrus selected to survive protective immunity in quackenbush mice.Journal of Parasitology.  81:900-904. 1995
    1995 Technical report. Optimizing probe selection in directed heteroduplex analysis using HDprobe 1.1.BioTechniques.  19:972-977. 1995
    1995 Mitochondrial alleles of Simulium damnosum sensu lato infected with Onchocerca volvulus.International Journal for Parasitology.  25:1251-1254. 1995
    1995 Antigens in phenotypes of Heligmosomoides polygyrus raised selectively from different strains of mice.International Journal for Parasitology.  25:847-852. 1995
    1995 The Simulium damnosum species complex: phylogenetic analysis and molecular identification based upon mitochondrially encoded gene sequences.Insect Molecular Biology.  4:79-88. 1995

    Chapter

    Year Title Altmetric
    2008 Susceptibility to Human Infectious Diseases, Genetics of. 2008
    2004 The Role of Host Genetic Variation in HIV Infection and its Manifestations.  285-302. 2004

    Research Overview

  • Aging
    HIV/AIDS
    Immunogenetics
    Immunologic Health
  • Teaching Overview

  • Guest lecturer for CLS518 (MSc in Clinical Laboratory Science: Immunology)
  • Education And Training

  • Doctor of Dental Surgery, Foreign University
  • Doctor of Philosophy Level Degree in Parasitology, Foreign University
  • Full Name

  • Jianming Tang