Positions

Overview

  • As an immunologist by training, my ongoing research focuses on immunogenetic factors in several infectious diseases, especially HIV/AIDS.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis 2019
    2019 Control of the HIV-1 Load Varies by Viral Subtype in a Large Cohort of African Adults with Incident HIV-1 Infection 2019
    2019 HLA-DQB1*06 is a risk marker for chlamydia reinfection in African American women 2019
    2018 Fc-gamma receptor IIA and IIIA variants in two African cohorts: Lack of consistent impact on heterosexual HIV acquisition, viral control, and disease progression 2018
    2018 Immunogenetic factors in early immune control of human immunodeficiency virus type 1 (HIV-1) infection: Evaluation of HLA class I amino acid variants in two African populations 2018
    2018 Herpes Zoster in Persons Living with HIV-1 Infection: Viremia and Immunological Defects Are Strong Risk Factors in the Era of Combination Antiretroviral Therapy. 2018
    2016 Enhanced allogeneic cellular responses to mismatched HLA-B antigens results in more efficient killing of HIV infected cells 2016
    2016 Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression 2016
    2016 Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort 2016
    2016 Dynamics and correlates of CD8 T-cell counts in Africans with primary human immunodeficiency virus type 1 infection 2016
    2015 Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression 2015
    2015 CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: Findings from an African cohort with prospective data 2015
    2015 HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses 2015
    2015 Immunogenetic influences on acquisition of HIV-1 infection: Consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2) 2015
    2015 Imputation of class I and II HLA loci using high-density SNPs from ImmunoChip and their associations with Kawasaki disease in family-based study 2015
    2015 Transmitted Virus Fitness and Host T Cell Responses Collectively Define Divergent Infection Outcomes in Two HIV-1 Recipients 2015
    2014 Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions 2014
    2014 Mitochondrial DNA variation and virologic and immunological HIV outcomes in African Americans 2014
    2014 KIR2DS4 promotes HIV-1 pathogenesis: New evidence from analyses of immunogenetic data and natural killer cell function 2014
    2014 Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlates 2014
    2014 Host genetics and immune control of HIV-1 infection: Fine mapping for the extended human MHC region in an African cohort 2014
    2014 Selection bias at the heterosexual HIV-1 transmission bottleneck 2014
    2013 Genetic associations with 25-hydroxyvitamin D deficiency in HIV-1-infected youth: Fine-mapping for the GC/DBP gene that encodes the vitamin D-binding protein 2013
    2013 Dimorphic HLA-B signal peptides differentially influence HLA-E- and natural killer cell-mediated cytolysis of HIV-1-infected target cells 2013
    2013 Variants in interleukin family of cytokines genes influence clearance of high risk HPV in HIV-1 coinfected African-American adolescents 2013
    2013 Genomic Copy Number Variants: Evidence for Association with Antibody Response to Anthrax Vaccine Adsorbed 2013
    2013 HLA-B*57 versus HLA-B*81 in HIV-1 infection: Slow and steady wins the race? 2013
    2013 Recent advances in research of HIV infection: Implications of viral and host genetics on treatment and prevention 2013
    2013 Cumulative impact of host and viral factors on HIV-1 viral-load control during early infection 2013
    2012 Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents 2012
    2012 Role of Transmitted Gag CTL Polymorphisms in Defining Replicative Capacity and Early HIV-1 Pathogenesis 2012
    2012 HIV-1 Dynamics: A reappraisal of host and viral factors, as well as methodological issues 2012
    2012 Protocol for analyzing human leukocyte antigen variants and sexually transmitted infections: From genotyping to immunoassays 2012
    2012 A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed 2012
    2012 Erratum: Genetic variations and heterosexual HIV-1 infection: Analysis of clustered genes encoding CC-motif chemokine ligands (Genes and Immunity (2012) 13 (202-205) DOI:10.1038/gene.2011.70) 2012
    2012 HLA-B signal peptide polymorphism influences the rate of HIV-1 acquisition but not viral load 2012
    2012 Genetic variations and heterosexual HIV-1 infection: Analysis of clustered genes encoding CC-motif chemokine ligands 2012
    2011 Human leukocyte antigen variants B*44 and B*57 are consistently favorable during two distinct phases of primary HIV-1 infection in sub-Saharan Africans with several viral subtypes 2011
    2011 The role of HLA-DR-DQ haplotypes in variable antibody responses to Anthrax Vaccine Adsorbed 2011
    2011 Disparate associations of HLA class I markers with HIV-1 acquisition and control of viremia in an African population 2011
    2011 Identification of three immunologic correlates for HIV type 1 pathogenesis in Youth 2011
    2011 The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African Americans 2011
    2011 Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians 2011
    2011 Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers 2011
    2011 Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couples 2011
    2010 Interleukin-10 (IL-10) pathway: Genetic variants and outcomes of HIV-1 infection in African American adolescents 2010
    2010 Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: Predominance of evolving relationships 2010
    2010 Human leukocyte antigen class I supertypes and HIV-1 control in African Americans 2010
    2010 CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription 2010
    2009 Predictors of suboptimal virologic response to highly active antiretroviral therapy among human immunodeficiency virus-infected adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project 2009
    2009 Gene copy number: Learning to count past two 2009
    2009 OA06-03. Dynamics of CTL epitope escape and reversion in an African subtype C cohort 2009
    2009 The major histocompatibility complex conserved extended haplotype 8.1 in aids-related non-hodgkin lymphoma 2009
    2009 Genetic epidemiology of glioblastoma multiforme: Confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs 2009
    2009 Clear and independent associations of several HLA-DRB1 alleles with diVerential antibody responses to hepatitis B vaccination in youth 2009
    2009 Evolution of HLA-B 5703 hiv-1 escape mutations in HLA-B 5703-positive individuals and their transmission recipients 2009
    2009 Adaptation of HIV-1 to human leukocyte antigen class I 2009
    2009 Host genetics and HIV-1 viral load set-point in African-Americans 2009
    2008 Human leukocyte antigen class I genotypes in relation to heterosexual HIV type 1 transmission within discordant couples 2008
    2008 Immunogenetic correlates of neisseria gonorrhoeae infection in adolescents 2008
    2008 Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients 2008
    2007 Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents 2007
    2007 Haplotype inference for present-absent genotype data using previously identified haplotypes and haplotype patterns 2007
    2007 Interleukin-10 gene (IL10) polymorphisms and human papillomavirus clearance among immunosuppressed adolescents 2007
    2007 CCL3L1 and CCL4L1: Variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection 2007
    2006 Conserved extended haplotypes of the major histocompatibility complex: Further characterization 2006
    2006 Cohort- and time-specific associations of CTLA4 genotypes with HIV-1 disease progression 2006
    2006 Human leukocyte antigen B58 supertype and human immunodeficiency virus type 1 infection in native Africans 2006
    2006 Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults 2006
    2005 Association between human leukocyte antigen class II alleles and genotype of Borrelia burgdorferi in patients with early Lyme disease 2005
    2005 Interleukin (IL)-2 and IL-12 responses to Chlamydia trachomatis infection in adolescents 2005
    2005 A case-control study to examine HLA haplotype associations in patients with posttreatment chronic lyme disease 2005
    2005 Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme 2005
    2005 HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma 2005
    2005 Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents 2005
    2005 Influence of host genetic variation on susceptibility to HIV type 1 infection 2005
    2004 Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescents 2004
    2004 Molecular typing of human leukocyte antigen and related polymorphisms following whole genome amplification 2004
    2004 Pharmacogenomic perspectives of chronic hepatitis C virus (HCV) infection 2004
    2004 Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples 2004
    2004 HLA-DRB1 and -DQB1 alleles and haplotypes in Zambian couples and their associations with heterosexual transmission of HIV type 1 2004
    2004 Cytokine and Chemokine Gene Polymorphisms among Ethnically Diverse North Americans with HIV-1 Infection 2004
    2004 HLA and Cytokine Gene Polymorphisms Are independently Associated with Responses to Hepatitis B Vaccination 2004
    2004 HLA Allele Sharing and HIV Type 1 Viremia in Seroconverting Zambians with Known Transmitting Partners 2004
    2003 T Cell Responses in HIV Type 1-Infected Adolescent Minorities Share Similar Epitope Specificities with Whites Despite Significant Differences in HLA Class I Alleles 2003
    2003 Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in 3 cohorts of white men 2003
    2003 Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities 2003
    2003 The complexity of HLA class II (DRB1, DQB1, DM) associations with disseminated Mycobacterium avium complex infection among HIV-1-seropositive whites 2003
    2003 Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection 2003
    2003 The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy. 2003
    2002 Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents 2002
    2002 C-C chemokine receptor 2 and C-C chemokine receptor 5 genotypes in patients treated for chronic hepatitis C virus infection 2002
    2002 Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1 2002
    2002 CCR2 and CCR5 genotypes in HIV type 1-infected adolescents: Limited contributions to variability in plasma HIV type 1 RNA concentration in the absence of antiretroviral therapy 2002
    2002 Distribution of chemokine receptor ccr2 and ccr5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression 2002
    2001 Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines 2001
    2001 Novel alleles at the lymphotoxin alpha (LTĪ±) locus mark extended HLA haplotypes in native Africans 2001
    2001 TAP1 polymorphisms in several human ethnic groups: Characteristics, evolution, and genotyping strategies 2001
    2001 Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans 2001
    2001 Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection 2001
    2001 Is protection in HIV infection due to Bw4 or not to Bw4? 2001
    2000 Characteristics of HLA class I and class II polymorphisms in Rwandan women 2000
    2000 Tumor necrosis factor gene polymorphisms in patients with cirrhosis from chronic hepatitis C virus infection 2000
    1999 Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men 1999
    1999 Identification of bloodmeals in haematophagous Diptera by cytochrome B heteroduplex analysis 1999
    1999 HLA class I homozygosity accelerates disease progression in human immunodeficiency virus type 1 infection 1999
    1999 Biased TCR repertoire in infiltrating lesional T cells in human bancroftian filariasis 1999
    1999 Allelic variants of human beta-chemokine receptor 5 (CCR5) promoter: Evolutionary relationships and predictable associations with HIV-1 disease progression 1999
    1999 HLA-B*5703 independently associated with slower HIV-1 disease progression in Rwandan women [10] 1999
    1998 Genetic variation in North American black flies in the subgenus Psilopelmia (Simulium: Diptera: Simuliidae) 1998
    1998 New TAP2 polymorphisms in Africans 1998
    1997 Onchocerca volvulus: Comparison of field collection methods for the preservation of parasite and vector samples for PCR analysis 1997
    1997 Vector-parasite transmission complexes for onchocerciasis in West Africa 1997
    1997 Heteroduplex analysis in medical entomology: A rapid and sensitive sequence-based tool for population and phylogenetic studies 1997
    1996 Genotyping North American black flies by means of mitochondrial ribosomal RNA sequences 1996
    1996 Intra-specific heterogeneity of the rDNA internal transcribed spacer in the Simulium damnosum (Diptera: Simuliidae) complex 1996
    1996 Molecular phylogeny and typing of blackflies (Diptera: Simuliidae) that serve as vectors of human or bovine onchocerciasis 1996
    1995 Phenotypes of Heligmosomoides polygyrus selected to survive protective immunity in Quackenbush mice 1995
    1995 Antigens in phenotypes of Heligmosomoides polygyrus raised selectively from different strains of mice 1995
    1995 Discriminating PCR artifacts using directed heteroduplex analysis (DHDA) 1995
    1995 Mitochondrial alleles of Simulium damnosum sensu lato infected with Onchocerca volvulus 1995
    1995 Optimizing probe selection in directed heteroduplex analysis using HDProbe 1.1 1995
    1995 The Simulium damnosum species complex: phylogenetic analysis and molecular identification based upon mitochondrially encoded gene sequences 1995

    Chapter

    Year Title Altmetric
    2008 Susceptibility to Human Infectious Diseases, Genetics of. 2008
    2004 The Role of Host Genetic Variation in HIV Infection and its Manifestations.  285-302. 2004

    Research Overview

  • Aging
    HIV/AIDS
    Immunogenetics
    Immunologic Health
  • Teaching Overview

  • Guest lecturer for CLS518 (MSc in Clinical Laboratory Science: Immunology)
  • Full Name

  • Jianming Tang