Positions

Overview

  • As an immunologist by training, my ongoing research focuses on immunogenetic factors in several infectious diseases, especially HIV/AIDS.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 HLA-DQB1*06 is a risk marker for chlamydia reinfection in African American womenGenes and Immunity.  20:69-73. 2019
    2018 Fc-gamma receptor IIA and IIIA variants in two African cohorts: Lack of consistent impact on heterosexual HIV acquisition, viral control, and disease progressionVirology.  525:132-142. 2018
    2018 Immunogenetic factors in early immune control of human immunodeficiency virus type 1 (HIV-1) infection: Evaluation of HLA class I amino acid variants in two African populationsHuman Immunology.  79:166-171. 2018
    2018 Herpes Zoster in Persons Living with HIV-1 Infection: Viremia and Immunological Defects Are Strong Risk Factors in the Era of Combination Antiretroviral Therapy.Frontiers in Public Health.  6:70. 2018
    2016 Enhanced allogeneic cellular responses to mismatched HLA-B antigens results in more efficient killing of HIV infected cellsJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology.  71:493-497. 2016
    2016 Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progressionJournal of Experimental Medicine.  213:2049-2063. 2016
    2016 Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection CohortPLoS Pathogens.  12. 2016
    2016 Dynamics and correlates of CD8 T-cell counts in Africans with primary human immunodeficiency virus type 1 infectionJournal of Virology.  90:10423-10430. 2016
    2015 Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progressionProceedings of the National Academy of Sciences.  112:E1480-E1489. 2015
    2015 CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: Findings from an African cohort with prospective dataFrontiers in Microbiology.  6. 2015
    2015 HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell ResponsesPLoS Pathogens.  11. 2015
    2015 Immunogenetic influences on acquisition of HIV-1 infection: Consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2)Genes and Immunity.  16:213-220. 2015
    2015 Imputation of class I and II HLA loci using high-density SNPs from ImmunoChip and their associations with Kawasaki disease in family-based studyEuropean Journal of Immunogenetics.  42:140-146. 2015
    2015 Transmitted Virus Fitness and Host T Cell Responses Collectively Define Divergent Infection Outcomes in Two HIV-1 RecipientsPLoS Pathogens.  11:1-21. 2015
    2014 Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactionsHuman Genetics.  133:1187-1197. 2014
    2014 Mitochondrial DNA variation and virologic and immunological HIV outcomes in African AmericansAIDS.  28:1871-1878. 2014
    2014 KIR2DS4 promotes HIV-1 pathogenesis: New evidence from analyses of immunogenetic data and natural killer cell functionPLoS ONE.  9. 2014
    2014 Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlatesVirology.  449:254-262. 2014
    2014 Host genetics and immune control of HIV-1 infection: Fine mapping for the extended human MHC region in an African cohortGenes and Immunity.  15:275-281. 2014
    2014 Selection bias at the heterosexual HIV-1 transmission bottleneckScience.  345. 2014
    2013 Genetic associations with 25-hydroxyvitamin D deficiency in HIV-1-infected youth: Fine-mapping for the GC/DBP gene that encodes the vitamin D-binding proteinFrontiers in Genetics.  4. 2013
    2013 Dimorphic HLA-B signal peptides differentially influence HLA-E- and natural killer cell-mediated cytolysis of HIV-1-infected target cellsClinical and Experimental Immunology.  174:414-423. 2013
    2013 Variants in interleukin family of cytokines genes influence clearance of high risk HPV in HIV-1 coinfected African-American adolescentsHuman Immunology.  74:1696-1700. 2013
    2013 Genomic Copy Number Variants: Evidence for Association with Antibody Response to Anthrax Vaccine AdsorbedPLoS ONE.  8. 2013
    2013 HLA-B*57 versus HLA-B*81 in HIV-1 infection: Slow and steady wins the race?Journal of Virology.  87:4043-4051. 2013
    2013 Recent advances in research of HIV infection: Implications of viral and host genetics on treatment and preventionCommunity Genetics.  16:31-36. 2013
    2013 Cumulative impact of host and viral factors on HIV-1 viral-load control during early infectionJournal of Virology.  87:708-715. 2013
    2012 Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescentsJournal of Reproductive Immunology.  96:84-89. 2012
    2012 Role of Transmitted Gag CTL Polymorphisms in Defining Replicative Capacity and Early HIV-1 PathogenesisPLoS Pathogens.  8. 2012
    2012 HIV-1 Dynamics: A reappraisal of host and viral factors, as well as methodological issuesViruses.  4:2080-2096. 2012
    2012 Protocol for analyzing human leukocyte antigen variants and sexually transmitted infections: From genotyping to immunoassaysMethods in Molecular Biology.  903:359-380. 2012
    2012 A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine AdsorbedVaccine.  30:4778-4784. 2012
    2012 Erratum: Genetic variations and heterosexual HIV-1 infection: Analysis of clustered genes encoding CC-motif chemokine ligands (Genes and Immunity (2012) 13 (202-205) DOI:10.1038/gene.2011.70)Genes and Immunity.  13:444. 2012
    2012 HLA-B signal peptide polymorphism influences the rate of HIV-1 acquisition but not viral loadJournal of Infectious Diseases.  205:1797-1805. 2012
    2012 Genetic variations and heterosexual HIV-1 infection: Analysis of clustered genes encoding CC-motif chemokine ligandsGenes and Immunity.  13:202-205. 2012
    2011 Human leukocyte antigen variants B*44 and B*57 are consistently favorable during two distinct phases of primary HIV-1 infection in sub-Saharan Africans with several viral subtypesJournal of Virology.  85:8894-8902. 2011
    2011 The role of HLA-DR-DQ haplotypes in variable antibody responses to Anthrax Vaccine AdsorbedGenes and Immunity.  12:457-465. 2011
    2011 Disparate associations of HLA class I markers with HIV-1 acquisition and control of viremia in an African populationPLoS ONE.  6. 2011
    2011 Identification of three immunologic correlates for HIV type 1 pathogenesis in YouthAIDS Research and Human Retroviruses.  27:639-646. 2011
    2011 The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African AmericansHuman Immunology.  72:312-318. 2011
    2011 Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in ZambiansRetrovirology.  8. 2011
    2011 Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersJournal of Virology.  85:2316-2324. 2011
    2011 Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couplesJournal of Infectious Diseases.  203:487-495. 2011
    2010 Interleukin-10 (IL-10) pathway: Genetic variants and outcomes of HIV-1 infection in African American adolescentsPLoS ONE.  5. 2010
    2010 Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: Predominance of evolving relationshipsPLoS ONE.  5. 2010
    2010 Human leukocyte antigen class I supertypes and HIV-1 control in African AmericansJournal of Virology.  84:2610-2617. 2010
    2010 CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcriptionJournal of Experimental Medicine.  207:51-59. 2010
    2009 Predictors of suboptimal virologic response to highly active antiretroviral therapy among human immunodeficiency virus-infected adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) ProjectArchives of Pediatrics and Adolescent Medicine.  163:1100-1105. 2009
    2009 Gene copy number: Learning to count past twoNature Medicine.  15:1127-1129. 2009
    2009 OA06-03. Dynamics of CTL epitope escape and reversion in an African subtype C cohortRetrovirology.  6. 2009
    2009 The major histocompatibility complex conserved extended haplotype 8.1 in aids-related non-hodgkin lymphomaJournal of Acquired Immune Deficiency Syndromes.  52:170-179. 2009
    2009 Genetic epidemiology of glioblastoma multiforme: Confirmatory and new findings from analyses of human leukocyte antigen alleles and motifsPLoS ONE.  4. 2009
    2009 Clear and independent associations of several HLA-DRB1 alleles with diVerential antibody responses to hepatitis B vaccination in youthHuman Genetics.  126:685-696. 2009
    2009 Evolution of HLA-B 5703 hiv-1 escape mutations in HLA-B 5703-positive individuals and their transmission recipientsJournal of Experimental Medicine.  206:909-921. 2009
    2009 Adaptation of HIV-1 to human leukocyte antigen class INature.  458:641-645. 2009
    2009 Host genetics and HIV-1 viral load set-point in African-AmericansAIDS.  23:673-677. 2009
    2008 Human leukocyte antigen class I genotypes in relation to heterosexual HIV type 1 transmission within discordant couplesJournal of Immunology.  181:2626-2635. 2008
    2008 Immunogenetic correlates of neisseria gonorrhoeae infection in adolescentsSexually Transmitted Diseases.  35:656-661. 2008
    2008 Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipientsJournal of Experimental Medicine.  205:1009-1017. 2008
    2007 Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescentsAIDS.  21:2387-2397. 2007
    2007 Haplotype inference for present-absent genotype data using previously identified haplotypes and haplotype patternsComputer applications in the biosciences : CABIOS.  23:2399-2406. 2007
    2007 Interleukin-10 gene (IL10) polymorphisms and human papillomavirus clearance among immunosuppressed adolescentsCancer Epidemiology, Biomarkers and Prevention.  16:1626-1632. 2007
    2007 CCL3L1 and CCL4L1: Variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infectionGenes and Immunity.  8:224-231. 2007
    2006 Conserved extended haplotypes of the major histocompatibility complex: Further characterizationGenes and Immunity.  7:450-467. 2006
    2006 Cohort- and time-specific associations of CTLA4 genotypes with HIV-1 disease progressionAIDS.  20:1583-1590. 2006
    2006 Human leukocyte antigen B58 supertype and human immunodeficiency virus type 1 infection in native AfricansJournal of Virology.  80:6056-6060. 2006
    2006 Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adultsClinical and Experimental Immunology.  144:117-124. 2006
    2005 Association between human leukocyte antigen class II alleles and genotype of Borrelia burgdorferi in patients with early Lyme diseaseJournal of Infectious Diseases.  192:2020-2026. 2005
    2005 Interleukin (IL)-2 and IL-12 responses to Chlamydia trachomatis infection in adolescentsClinical and Experimental Immunology.  142:548-554. 2005
    2005 A case-control study to examine HLA haplotype associations in patients with posttreatment chronic lyme diseaseJournal of Infectious Diseases.  192:1010-1013. 2005
    2005 Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiformeCancer Epidemiology, Biomarkers and Prevention.  14:2040-2044. 2005
    2005 HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcomaJournal of Medical Virology.  76:302-310. 2005
    2005 Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescentsJournal of Infectious Diseases.  191:1084-1092. 2005
    2005 Influence of host genetic variation on susceptibility to HIV type 1 infectionJournal of Infectious Diseases.  191. 2005
    2004 Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescentsJournal of Infectious Diseases.  190:1723-1729. 2004
    2004 Molecular typing of human leukocyte antigen and related polymorphisms following whole genome amplificationTissue Antigens.  64:286-292. 2004
    2004 Pharmacogenomic perspectives of chronic hepatitis C virus (HCV) infectionPharmacogenomics Journal.  4:171-174. 2004
    2004 Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couplesLancet.  363:2137-2139. 2004
    2004 HLA-DRB1 and -DQB1 alleles and haplotypes in Zambian couples and their associations with heterosexual transmission of HIV type 1Journal of Infectious Diseases.  189:1696-1704. 2004
    2004 Cytokine and Chemokine Gene Polymorphisms among Ethnically Diverse North Americans with HIV-1 InfectionJournal of Acquired Immune Deficiency Syndromes.  35:446-454. 2004
    2004 HLA and Cytokine Gene Polymorphisms Are independently Associated with Responses to Hepatitis B VaccinationHepatology.  39:978-988. 2004
    2004 HLA Allele Sharing and HIV Type 1 Viremia in Seroconverting Zambians with Known Transmitting PartnersAIDS Research and Human Retroviruses.  20:19-25. 2004
    2003 T Cell Responses in HIV Type 1-Infected Adolescent Minorities Share Similar Epitope Specificities with Whites Despite Significant Differences in HLA Class I AllelesAIDS Research and Human Retroviruses.  19:1017-1026. 2003
    2003 Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in 3 cohorts of white menJournal of Infectious Diseases.  188:856-863. 2003
    2003 Cross-reactive CD8+ T cell epitopes identified in US adolescent minoritiesJournal of Acquired Immune Deficiency Syndromes.  33:426-438. 2003
    2003 The complexity of HLA class II (DRB1, DQB1, DM) associations with disseminated Mycobacterium avium complex infection among HIV-1-seropositive whitesJournal of Acquired Immune Deficiency Syndromes.  33:140-145. 2003
    2003 Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infectionJournal of Infectious Diseases.  187:1264-1271. 2003
    2003 The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy.AIDS.  17 Suppl 4. 2003
    2002 Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescentsAIDS.  16:2275-2284. 2002
    2002 C-C chemokine receptor 2 and C-C chemokine receptor 5 genotypes in patients treated for chronic hepatitis C virus infectionImmunologic Research.  26:167-175. 2002
    2002 Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1Journal of Virology.  76:8276-8284. 2002
    2002 Distribution of chemokine receptor ccr2 and ccr5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progressionJournal of Virology.  76:662-672. 2002
    2002 CCR2 and CCR5 genotypes in HIV type 1-infected adolescents: Limited contributions to variability in plasma HIV type 1 RNA concentration in the absence of antiretroviral therapyAIDS Research and Human Retroviruses.  18:403-412. 2002
    2001 Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccinesJournal of Virology.  75:8681-8689. 2001
    2001 Novel alleles at the lymphotoxin alpha (LTĪ±) locus mark extended HLA haplotypes in native AfricansHuman Immunology.  62:269-278. 2001
    2001 TAP1 polymorphisms in several human ethnic groups: Characteristics, evolution, and genotyping strategiesHuman Immunology.  62:256-268. 2001
    2001 Genotyping TAP2 variants in North American Caucasians, Brazilians, and AfricansGenes and Immunity.  2:32-40. 2001
    2001 Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infectionHepatology.  33:708-712. 2001
    2001 Is protection in HIV infection due to Bw4 or not to Bw4?Lancet Infectious Diseases.  1:221-222. 2001
    2000 Characteristics of HLA class I and class II polymorphisms in Rwandan womenExperimental and Clinical Immunogenetics.  17:185-189. 2000
    2000 Tumor necrosis factor gene polymorphisms in patients with cirrhosis from chronic hepatitis C virus infectionGenes and Immunity.  1:386-390. 2000
    1999 Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual menJournal of Infectious Diseases.  180:299-309. 1999
    1999 Identification of bloodmeals in haematophagous Diptera by cytochrome B heteroduplex analysisMedical and Veterinary Entomology.  13:282-287. 1999
    1999 HLA class I homozygosity accelerates disease progression in human immunodeficiency virus type 1 infectionAIDS Research and Human Retroviruses.  15:317-324. 1999
    1999 Biased TCR repertoire in infiltrating lesional T cells in human bancroftian filariasisJournal of Immunology.  162:1756-1764. 1999
    1999 Allelic variants of human beta-chemokine receptor 5 (CCR5) promoter: Evolutionary relationships and predictable associations with HIV-1 disease progressionGenes and Immunity.  1:20-27. 1999
    1999 HLA-B*5703 independently associated with slower HIV-1 disease progression in Rwandan women [10]AIDS.  13:1990-1991. 1999
    1998 Genetic variation in North American black flies in the subgenus Psilopelmia (Simulium: Diptera: Simuliidae)Canadian Journal of Zoology.  76:205-211. 1998
    1998 New TAP2 polymorphisms in AfricansTissue Antigens.  51:556-562. 1998
    1997 Onchocerca volvulus: Comparison of field collection methods for the preservation of parasite and vector samples for PCR analysisBulletin of the World Health Organization.  75:443-447. 1997
    1997 Vector-parasite transmission complexes for onchocerciasis in West AfricaLancet.  349:163-166. 1997
    1997 Heteroduplex analysis in medical entomology: A rapid and sensitive sequence-based tool for population and phylogenetic studiesParasitology Today.  13:271-274. 1997
    1996 Genotyping North American black flies by means of mitochondrial ribosomal RNA sequencesCanadian Journal of Zoology.  74:39-46. 1996
    1996 Intra-specific heterogeneity of the rDNA internal transcribed spacer in the Simulium damnosum (Diptera: Simuliidae) complexMolecular Biology and Evolution.  13:244-252. 1996
    1996 Molecular phylogeny and typing of blackflies (Diptera: Simuliidae) that serve as vectors of human or bovine onchocerciasisMedical and Veterinary Entomology.  10:228-234. 1996
    1995 Phenotypes of Heligmosomoides polygyrus selected to survive protective immunity in Quackenbush miceJournal of Parasitology.  81:900-904. 1995
    1995 Antigens in phenotypes of Heligmosomoides polygyrus raised selectively from different strains of miceInternational Journal for Parasitology.  25:847-852. 1995
    1995 Discriminating PCR artifacts using directed heteroduplex analysis (DHDA)BioTechniques.  19:902-905. 1995
    1995 Mitochondrial alleles of Simulium damnosum sensu lato infected with Onchocerca volvulusInternational Journal for Parasitology.  25:1251-1254. 1995
    1995 Optimizing probe selection in directed heteroduplex analysis using HDProbe 1.1BioTechniques.  19:972-977. 1995
    1995 The Simulium damnosum species complex: phylogenetic analysis and molecular identification based upon mitochondrially encoded gene sequencesInsect Molecular Biology.  4:79-88. 1995

    Chapter

    Year Title Altmetric
    2008 Susceptibility to Human Infectious Diseases, Genetics of. 2008
    2004 The Role of Host Genetic Variation in HIV Infection and its Manifestations.  285-302. 2004

    Research Overview

  • Aging
    HIV/AIDS
    Immunogenetics
    Immunologic Health
  • Teaching Overview

  • Guest lecturer for CLS518 (MSc in Clinical Laboratory Science: Immunology)
  • Education And Training

  • Doctor of Philosophy Level Degree in Parasitology, 1993
  • Doctor of Dental Surgery, 1986
  • Full Name

  • Jianming Tang