Selected Publications

Academic Article

Year Title Altmetric
2018 Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.Blood Adv.  2:2829-2836. 2018
2018 Bone Marrow Transplantation after Nonmyeloablative Treosulfan Conditioning Is Curative in a Murine Model of Sickle Cell DiseaseBiology of Blood and Marrow Transplantation.  24:1554-1562. 2018
2017 Sickle cells produce functional immune modulators and cytotoxicsAmerican Journal of Hematology.  92:981-988. 2017
2017 Induced pluripotent stem cell-derived endothelial cells overexpressing interleukin-8 receptors a/b and/or c-c chemokine receptors 2/5 inhibit vascular injury responseStem Cells Translational Medicine.  6:1168-1177. 2017
2016 Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene CorrectionScientific Reports.  6. 2016
2016 Sickle cells abolish melanoma tumorigenesis in hemoglobin SS knockin mice and augment the tumoricidal effect of oncolytic virus in vivoFrontiers in Oncology.  6. 2016
2015 Peroxiredoxin-2 recycling is inhibited during erythrocyte storageAntioxidants and Redox Signaling.  22:294-307. 2015
2013 Role of the b93cys, ATP and adenosine in red cell dependent hypoxic vasorelaxationInternational Journal of Physiology, Pathophysiology and Pharmacology.  5:21-31. 2013
2013 Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivoFree Radical Biology and Medicine.  55:119-129. 2013
2012 Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesisBlood.  119:5276-5284. 2012
2012 Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cellsCell Stem Cell.  10:570-582. 2012
2011 PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramingSTEM CELLS.  29:229-240. 2011
2011 Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responsesJournal of Immunology.  186:1001-1010. 2011
2010 KLF1 regulates BCL11A expression and γ- to β-globin gene switchingNature Genetics.  42:742-744. 2010
2009 Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cellsSTEM CELLS.  27:1042-1049. 2009
2009 Humanized mouse model of Cooley's anemiaJournal of Biological Chemistry.  284:4889-4896. 2009
2008 SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilationNature Medicine.  14:773-777. 2008
2008 ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivoJournal of Experimental Medicine.  205:1227-1242. 2008
2007 Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skinScience.  318:1920-1923. 2007
2006 Correction of sickle cell disease by homologous recombination in embryonic stem cellsBlood.  108:1183-1188. 2006
2006 Differential binding of erythroid krupple-like factor to embryonic/fetal globin gene promoters during developmentJournal of Biological Chemistry.  281:16052-16057. 2006
2004 Homocysteine Increases the Expression of Vascular Endothelial Growth Factor by a Mechanism Involving Endoplasmic Reticulum Stress and Transcription Factor ATF4Journal of Biological Chemistry.  279:14844-14852. 2004
2000 Human β-globin gene promoter element regulates human β-globin gene developmental specificityNucleic Acids Research.  28:2736-2740. 2000
1997 The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse developmentGenes and Development.  11:786-798. 1997
1995 End joining of genomic DNA and transgene DNA in fertilized mouse eggsGene.  165:173-181. 1995
1994 Cloning and functional characterization of LCR-F1: A bZIP transcription factor that activates erythroid-specific, human globin gene expressionNucleic Acids Research.  22:2383-2391. 1994

Education And Training

  • Doctor of Philosophy in Biochemistry, University of Alabama at Birmingham 1998
  • Full Name

  • Chiao-Wang Sun