Positions

Overview

  • CEO of Southern Research Institute (retired)
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2016 The synthesis and biological evaluation of alkyl and benzyl naphthyridinium analogs of eupolauridine as potential antimicrobial and cytotoxic agents.Bioorganic and Medicinal Chemistry.  24:6119-6130. 2016
    2016 6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases.Bioorganic Chemistry.  65:9-16. 2016
    2016 6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase.Chimica therapeutica.  108:616-622. 2016
    2015 Thiarabine, 1-(4-Thio-β-D-arabinofuranosyl)cytosine. A Deoxycytidine Analog With Excellent Anticancer Activity.Current Medicinal Chemistry.  22:3881-3896. 2015
    2012 Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.Bioorganic and Medicinal Chemistry Letters.  22:6967-6973. 2012
    2012 Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.Bioorganic and Medicinal Chemistry Letters.  22:5652-5657. 2012
    2012 Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.Bioorganic and Medicinal Chemistry Letters.  22:5144-5149. 2012
    2012 Preparation of 1,4-disubstituted-1,2,3-triazolo ribonucleosides by Na 2CuP2O7 catalyzed azide-alkyne 1,3-dipolar cycloadditionARKIVOC : Online Journal of Organic Chemistry.  2012:76-89. 2012
    2012 5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.Bioorganic and Medicinal Chemistry Letters.  22:3229-3234. 2012
    2012 Novel substituted pyrimidines as HCV replication (replicase) inhibitors.Bioorganic and Medicinal Chemistry Letters.  22:1160-1164. 2012
    2012 High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.Tuberculosis.  92:72-83. 2012
    2012 Isolation and characterization of a murine P388 leukemia line resistant to thiarabine.Nucleosides and Nucleotides.  31:14-27. 2012
    2012 Preclinical antitumor activity of thiarabine in human leukemia and lymphoma xenograft models.Nucleosides and Nucleotides.  31:647-660. 2012
    2012 Preclinical combination therapy of thiarabine plus various clinical anticancer agents.Nucleosides and Nucleotides.  31:630-646. 2012
    2012 Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides.Chimica therapeutica.  47:167-174. 2012
    2011 Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine.Protein Science.  20:1836-1844. 2011
    2011 Isolation and characterization of a murine P388 leukemia line resistant to clofarabine.Nucleosides and Nucleotides.  30:826-838. 2011
    2011 Lack of in vivo cross-resistance with 4'-thio-ara-C against drug-resistant murine P388 and L1210 leukemias.Cancer Chemotherapy and Pharmacology.  68:399-403. 2011
    2011 The Alabama Drug Discovery Alliance: a collaborative partnership to facilitate academic drug discovery.Pharmaceutical Research.  28:1454-1459. 2011
    2010 Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity.Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  684:1-10. 2010
    2009 Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.Antimicrobial Agents and Chemotherapy.  53:5251-5258. 2009
    2009 Antituberculosis activity of the molecular libraries screening center network library.Tuberculosis.  89:354-363. 2009
    2009 High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.Tuberculosis.  89:334-353. 2009
    2009 Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer.Nucleosides and Nucleotides.  28:642-656. 2009
    2009 Synthesis and anticancer evaluation of 4'-C-methyl-2'-fluoro arabino nucleosides.Nucleosides and Nucleotides.  28:657-677. 2009
    2009 New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.Journal of Medicinal Chemistry.  52:1388-1407. 2009
    2009 Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.Antimicrobial Agents and Chemotherapy.  53:572-579. 2009
    2009 Synthesis of certain 2′-Deoxy-3′,5′-di-O-benzyl-4′- thio-nucleosides using natural phosphate doped with trifluoromethanesulfonic acid as catalystPhosphorus, Sulfur, and Silicon and the Related Elements.  184:76-81. 2009
    2008 Clofarabine acts as radiosensitizer in vitro and in vivo by interfering with DNA damage response.International Journal of Radiation Oncology - Biology - Physics.  70:213-220. 2008
    2007 In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase.Journal of Chemical Information and Computer Sciences.  47:1897-1905. 2007
    2007 Programs to facilitate tuberculosis drug discovery: the tuberculosis antimicrobial acquisition and coordinating facility.Infectious Disorders - Drug Targets.  7:92-104. 2007
    2006 Discovery and development of clofarabine: a nucleoside analogue for treating cancer.Nature Reviews Drug Discovery.  5:855-863. 2006
    2006 Antiangiogenic activity of 4'-thio-beta-D-arabinofuranosylcytosine.Molecular Cancer Therapeutics.  5:2218-2224. 2006
    2006 Recent development of therapeutics for chronic HCV infection.Antiviral Research.  71:351-362. 2006
    2006 Synthesis and biological evaluation of some 4′-C-(hydroxymethyl)- α- and -β-D-arabinofuranosyl pyrimidine and adenine nucleosidesCollection of Czechoslovak Chemical Communications.  71:1063-1087. 2006
    2006 The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.Acta Crystallographica Section D: Biological Crystallography.  62:133-139. 2006
    2005 Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy.Human Gene Therapy.  16:339-347. 2005
    2005 Bis(tBuSATE) phosphotriester prodrugs of 8-azaguanosine and 6-methylpurine riboside; bis(pom) phosphotriester prodrugs of 2'-deoxy-4'-thioadenosine and its corresponding 9alpha anomer.Nucleosides and Nucleotides.  24:809-813. 2005
    2005 Chemical and enzymatic synthesis of 4'-thio-beta-D-arabinofuranosylcytosine monophosphate and triphosphate.Nucleosides and Nucleotides.  24:533-537. 2005
    2005 Design and evaluation of 5'-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant.Nucleosides and Nucleotides.  24:387-392. 2005
    2005 Nucleosides as anticancer agents: from concept to the clinic.Nucleic Acids Symposium Series.  15-16. 2005
    2005 Synthesis and biological activity of 2'-deoxy-4'-thio-pyrazolo[3,4-d]pyrimidine nucleosides.Nucleosides and Nucleotides.  24:911-914. 2005
    2005 Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer.Nucleosides and Nucleotides.  24:881-885. 2005
    2005 Synthesis and biological activity of 4'-thio-L-xylofuranosyl purine nucleosides.Nucleosides and Nucleotides.  24:1895-1906. 2005
    2005 Synthesis of some 2'-fluoro-2'-deoxy-3'-C-ethynyl and 3'-C-vinyl-beta-D-lyxofuranosyl nucleosides.Nucleosides and Nucleotides.  24:713-715. 2005
    2004 Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the escherichia coli purine nucleoside phosphorylase gene.Cancer Research.  64:6610-6615. 2004
    2004 Purine nucleoside antimetabolites in development for the treatment of cancer.Current Opinion in Investigational Drugs.  5:592-596. 2004
    2004 Synthesis and cytotoxicity of 9-(2-deoxy-2-alkyldithio-beta-D-arabinofuranosyl)purine nucleosides which are stable precursors to potential mechanistic probes of ribonucleotide reductases.Journal of the Chemical Society, Perkin Transactions 1.  2:120-126. 2004
    2003 Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.Cell Chemistry Biology.  10:1173-1181. 2003
    2003 Synthesis and anti-cancer activity of some novel 5-azacytosine nucleosides.Nucleosides and Nucleotides.  22:2161-2170. 2003
    2003 The novel nucleoside transport system exhibited by NB4 cells, csg, transports deoxyguanosine analogues, including ara-G.Biochemical Pharmacology.  66:733-737. 2003
    2003 Preclinical antitumor activity of 4'-thio-beta-D-arabinofuranosylcytosine (4'-thio-ara-C).Cancer Chemotherapy and Pharmacology.  51:422-426. 2003
    2003 Selective metalation of 6-methylpurines: synthesis of 6-fluoromethylpurines and related nucleosides.Nucleosides and Nucleotides.  22:747-749. 2003
    2003 Phosphorylation of 4'-thio-beta-D-arabinofuranosylcytosine and its analogs by human deoxycytidine kinase.Journal of Pharmacology and Experimental Therapeutics.  304:1314-1322. 2003
    2003 Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase.Cancer Gene Therapy.  10:23-29. 2003
    2002 Enhancement of nucleoside cytotoxicity through nucleotide prodrugs.Journal of Medicinal Chemistry.  45:4505-4512. 2002
    2002 Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells.Human Gene Therapy.  13:543-551. 2002
    2001 The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.Biochemistry.  40:9484-9494. 2001
    2001 Synthesis and biological activity of 4'-C-hydroxymethyl-2'-fluro-D-arabinofuranosylpurine nucleosides.Nucleosides and Nucleotides.  20:1583-1598. 2001
    2001 Nucleoside and nucleotide nomenclature.Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.].  Appendix 1:Appendix-1D. 2001
    2001 Synthesis and antiproliferative activity of some 4'-C-hydroxymethyl-alpha- and -beta-D-arabino-pentofuranosyl pyrimidine nucleosides.Nucleosides and Nucleotides.  20:649-652. 2001
    2001 Synthesis and biological activity of 4'-C-hydroxymethyl-2'-fluoro-D-arabinofuranosylpurine nucleosides.Nucleosides and Nucleotides.  20:747-750. 2001
    2001 Synthesis and biological activity of 4'-thio-L-xylofuranosyl nucleosides.Nucleosides and Nucleotides.  20:743-746. 2001
    2000 Metabolism of 4'-thio-beta-D-arabinofuranosylcytosine in CEM cells.Biochemical Pharmacology.  60:1925-1932. 2000
    2000 Synthesis and structure activity relationships of 5-substituted-4'-thio-beta-D-arabinofuranosylcytosines.Nucleosides and Nucleotides.  19:2005-2017. 2000
    2000 Convenient syntheses of 6-methylpurine and related nucleosides.Nucleosides and Nucleotides.  19:1123-1134. 2000
    2000 A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy.Nucleosides and Nucleotides.  19:559-565. 2000
    2000 Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)adenine (Cl-F-ara-A).Nucleosides and Nucleotides.  19:447-460. 2000
    2000 Synthesis of 4'-thio-beta-D-arabinofuranosylcytosine (4'-thio-ara-C) and comparison of its anticancer activity with that of ara-C.Nucleosides and Nucleotides.  19:329-340. 2000
    1999 Synthesis and biological activity of 2'-fluoro- darabinofuranosylpyrazolo[3,4-d]pyrimidine nucleosidesHelvetica Chimica Acta.  82:2240-2245. 1999
    1999 Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.Journal of Medicinal Chemistry.  42:1625-1638. 1999
    1999 Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase.Nucleosides and Nucleotides.  18:745-757. 1999
    1999 Synthesis and biological activity of 4'-thio-2'-deoxy purine nucleosides.Nucleosides and Nucleotides.  18:683-685. 1999
    1999 Synthesis and biological activity of 5-azacytosine nucleosides derived from 4-thio-2-deoxy-L-threo-pentofuranose and 4-thio-2-deoxy-D-erythro-pentofuranose.Nucleosides and Nucleotides.  18:613-614. 1999
    1999 Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro- beta-D-ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro- beta-D-ribofuranosyl)adenine in CEM cells.Molecular Pharmacology.  55:515-520. 1999
    1999 Certain 3,9-dideazapurines as inhibitors of purine nucleoside phosphorylaseNucleosides and Nucleotides.  18:2443-2461. 1999
    1999 Kinetics for the acid-catalyzed hydrolysis of purine and cytosine 2'- deoxy-4'-thionucleosidesNucleosides and Nucleotides.  18:181-186. 1999
    1998 Synthesis and biological activity of certain 4'-thio-D-arabinofuranosylpurine nucleosides.Journal of Medicinal Chemistry.  41:3865-3871. 1998
    1998 Synthesis and antiviral evaluation of analogs of adenosine-N1-oxide and 1-(Benzyloxy)adenosine.Nucleosides and Nucleotides.  17:1409-1443. 1998
    1998 Polyamine pools in HIV-infected cells.Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology.  17:101-103. 1998
    1997 In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.Human Gene Therapy.  8:1637-1644. 1997
    1995 Metabolism and metabolic actions of 4'-thiothymidine in L1210 cells.Biochemical Pharmacology.  50:687-695. 1995
    1995 The synthesis and biological activity of certain 4’-thionucleosidesNucleosides and Nucleotides.  14:675-686. 1995
    1995 Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.Journal of Medicinal Chemistry.  38:1174-1188. 1995
    1995 Nucleosides & NucleotidesNucleosides and Nucleotides.  14:a. 1995
    1994 Alpha-(1-->2)-, and alpha-(1-->3)-, and alpha-(1-->6)-linked thioglycosidic disaccharides: syntheses and anti-HIV testing of thiokojibiose octaacetate, thionigerose, and thioisomaltose.Carbohydrate Research.  262:245-255. 1994
    1994 Synthesis and biological activity of 4,-thionucleosides of 2-chloroadenineNucleosides and Nucleotides.  13:1819-1828. 1994
    1994 PNP inhibitorsJournal of Computer-Aided Molecular Design.  2:205-220. 1994
    1994 synthesis and biologic evaluation of 8-substituted derivatives of nebularine (9/3-d-ribofuranosylpurine)Nucleosides and Nucleotides.  13:1017-1029. 1994
    1994 Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics.Journal of Medicinal Chemistry.  37:1109-1114. 1994
    1994 Additions and Corrections: Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 3. 9-Arylmethyl Derivatives of 9-Deazaguanine Substituted on the Methylene Group ((J. Med. Chem. (1993) 36(24) (3771–3783) (10.1021/jm00076a004))Journal of Medicinal Chemistry.  37:1034. 1994
    1994 Phosphonate analogs of carbocyclic nucleotides.Journal of Medicinal Chemistry.  37:739-744. 1994
    1994 Synthesis and biologic activity of purine 2'-deoxy-2’-fluoro-ni&>nucleosidesNucleosides and Nucleotides.  13:309-323. 1994
    1994 Characterization of S-adenosylmethionine decarboxylase induced by human cytomegalovirus infection.Virus Research.  31:255-263. 1994
    1994 In vitro and in vivo antiviral (RNA) evaluation of orotidine 5'- monophosphate decarboxylase inhibitors and analogues including 6-azauridine- 5'-(ethyl methoxyalaninyl)phosphate (a 5'-monophosphate prodrug)Antiviral Chemistry and Chemotherapy.  5:209-220. 1994
    1993 Phosphorylation of the enantiomers of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase.Molecular Pharmacology.  44:1258-1266. 1993
    1993 Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.Journal of Medicinal Chemistry.  36:3771-3783. 1993
    1993 Nucleosides & NucleotidesNucleosides and Nucleotides.  12:a. 1993
    1993 THE SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-(2-DEOXY-4-THIO-α-L-7HREO-PENTOFURANOSYL)THYMINENucleosides and Nucleotides.  12:841-846. 1993
    1993 Nucleosides & NucleotidesNucleosides and Nucleotides.  12:a-b. 1993
    1993 Syntheses of 5'-substituted analogues of carbocyclic 3-deazaadenosine as potential antivirals.Journal of Medicinal Chemistry.  36:2102-2106. 1993
    1993 Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine.Journal of Medicinal Chemistry.  36:1847-1854. 1993
    1993 Application of X-ray crystallographic methods in the design of purine nucleoside phosphorylase inhibitors.Annals of the New York Academy of Sciences.  685:237-247. 1993
    1993 Nucleosides & nucleotidesNucleosides and Nucleotides.  12:a-b. 1993
    1993 Conformational studies of thymidine dimers containing sulfonate and sulfonamide linkages by NMR spectroscopyTetrahedron.  49:2287-2298. 1993
    1993 Nucleosides & nucleotidesNucleosides and Nucleotides.  12:a. 1993
    1993 Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine.Journal of Medicinal Chemistry.  36:55-69. 1993
    1993 Nucleosides & NucleotidesNucleosides and Nucleotides.  12:a. 1993
    1993 Synthesis and antiviral evaluation of some novel [1,2,4]triazolo[4,3‐β][1,2,4]triazole nucleoside analogsJournal of Heterocyclic Chemistry.  30:1289-1292. 1993
    1992 Nucleosides & NucleotidesNucleosides and Nucleotides.  11:a. 1992
    1992 Nucleosides & nucleotidesNucleosides and Nucleotides.  11:a. 1992
    1992 Interference with HIV-1 reverse transcriptase-catalyzed DNA chain elongation by the 5'-triphosphate of the carbocyclic analog of 2'-deoxyguanosine.Antiviral Research.  19:325-332. 1992
    1992 5,5-disubstituted hydantoins: syntheses and anti-HIV activity.Journal of Medicinal Chemistry.  35:3567-3572. 1992
    1992 Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues.Biochemical Pharmacology.  44:905-911. 1992
    1992 Nucleosides & nucleotidesNucleosides and Nucleotides.  11:a. 1992
    1992 Synthesis and antiviral evaluation of N-carboxamidine-substituted analogues of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine hydrochloride.Journal of Medicinal Chemistry.  35:3231-3238. 1992
    1992 Nucleosides & NucleotidesNucleosides and Nucleotides.  11:a-b. 1992
    1992 Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine.Biochemistry.  31:6848-6855. 1992
    1992 Nucleosides & NucleotidesNucleosides and Nucleotides.  11:a-b. 1992
    1992 Nucleosides & NucleotidesNucleosides and Nucleotides.  11:a. 1992
    1992 Nucleoside Sultones: Synthons for the Preparation of Novel Nucleotide Analogsues. 1. Synthesis and Ring-Opening ReactionsJournal of Organic Chemistry.  57:2830-2835. 1992
    1992 Synthesis of Thymidine Dimers Containing Internucleoside Sulfonate and Sulfonamide LinkagesJournal of Organic Chemistry.  57:2983-2985. 1992
    1992 Synthesis and anti-HIV activity of 4'-thio-2',3'-dideoxynucleosides.Journal of Medicinal Chemistry.  35:533-538. 1992
    1992 Incorporation of the carbocyclic analog of 2'-deoxyguanosine into the DNA of herpes simplex virus and of HEp-2 cells infected with herpes simplex virus.Molecular Pharmacology.  41:245-251. 1992
    1992 Nucleosides and nucleotidesNucleosides and Nucleotides.  11:a. 1992
    1992 Syntheses of phosphonate analogues of dideoxyadenosine (dda)-, dideoxycytidine (ddc)-, dideoxyinosine (ddi)-, and deoxythymidine (ddt)-51-MoriophosphatesNucleosides and Nucleotides.  11:947-956. 1992
    1992 Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine.Journal of Medicinal Chemistry.  35:397-401. 1992
    1992 Erratum: Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors (Proc. Natl. Acad. Sci. USA (December 15, 1991) 88:24 (11540-11544))Proceedings of the National Academy of Sciences.  89:9974. 1992
    1992 Nucleosides & NucleotidesNucleosides and Nucleotides.  11:a-b. 1992
    1991 Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.Proceedings of the National Academy of Sciences.  88:11540-11544. 1991
    1991 Nucleosides & nucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Nucleosides & NucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Acyclic analogues of pyrazofurin: syntheses and antiviral evaluation.Carbohydrate Research.  216:441-452. 1991
    1991 Nucleosides & nucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides.Journal of Medicinal Chemistry.  34:2361-2366. 1991
    1991 Nucleosides & NucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Nucleosides & NucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs.Journal of Biological Chemistry.  266:1754-1762. 1991
    1991 Nucleosides & NucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Progress toward the synthesis of nonionic oligonucleotide analogues with sulfonate and sulfonamide internucleotide linkages.Nucleic Acids Symposium Series.  5-8. 1991
    1990 Metabolism of the carbocyclic nucleoside analogue carbovir, an inhibitor of human immunodeficiency virus, in human lymphoid cells.Biochemistry.  29:9839-9843. 1990
    1990 Nucleosides & nucleotidesNucleosides and Nucleotides.  9:a. 1990
    1990 5-C-chain-extended adenosine derivatives related to sinefungin. synthesis and biological activity.Nucleosides and Nucleotides.  9:619-627. 1990
    1990 Nucleosides & NucleotidesNucleosides and Nucleotides.  9:a. 1990
    1990 Nucleosides & NucleotidesNucleosides and Nucleotides.  9:a. 1990
    1990 Nucleosides & nucleotidesNucleosides and Nucleotides.  9:a. 1990
    1989 Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cells.Biochemical Journal.  263:215-221. 1989
    1989 Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases.Biochemical and Biophysical Research Communications.  161:393-398. 1989
    1989 8-Substituted Purine Ribosides: Synthesis And Biological ActivityNucleosides and Nucleotides.  8:911-913. 1989
    1989 Nucleosides & NucleotidesNucleosides and Nucleotides.  8:a. 1989
    1989 Nucleosides & NucleotidesNucleosides and Nucleotides.  8:a. 1989
    1989 Nucleosides & nucleotidesNucleosides and Nucleotides.  8:a. 1989
    1989 Nudeosides & NucleotidesNucleosides and Nucleotides.  8:a. 1989
    1989 Nudeosides & NucleotidesNucleosides and Nucleotides.  8:a. 1989
    1989 Phosphate modified analogues of 5'O-phosphorylated 2', 3'-dldeoxynucleosides: Synthesis and Anti-HIV activityNucleosides and Nucleotides.  8:1119-1120. 1989
    1989 Progress in the synthesis of a potential PNP transition state inhibitorNucleosides and Nucleotides.  8:1103-1105. 1989
    1989 Syn'Thesis And Antiviral Evaluation Of Adenosine-N1-Oxide And I-(Benzyloxy) AdenosinesNucleosides and Nucleotides.  8:915-917. 1989
    1989 Synthesis of 5'-substituted analogues of carbocyclic 3-deazaadenosine as potential antiviralsNucleosides and Nucleotides.  8:1153-1154. 1989
    1988 Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells.Biochemical Journal.  254:45-50. 1988
    1988 Nucleosides & NucleotidesNucleosides and Nucleotides.  7:a. 1988
    1988 Nucleosides & NucleotidesNucleosides and Nucleotides.  7:a. 1988
    1988 Properties of L1210 cells resistant to alpha-difluoromethylornithine.Cancer Research.  48:2678-2682. 1988
    1988 Nucleosides & NucleotidesNucleosides and Nucleotides.  7:a. 1988
    1988 Effect of inhibitors of S-adenosylmethionine decarboxylase on polyamine content and growth of L1210 cells.Biochemistry.  27:1408-1415. 1988
    1988 Synthesis and biological evaluations of certain 2-halo-2'-substituted derivatives of 9-beta-D-arabinofuranosyladenine.Journal of Medicinal Chemistry.  31:405-410. 1988
    1988 Nucleosides & NucleotidesNucleosides and Nucleotides.  7:a. 1988
    1987 Nucleosides & NucleotidesNucleosides and Nucleotides.  6:a. 1987
    1987 Nucleosides & NucleotidesNucleosides and Nucleotides.  6:a. 1987
    1987 5'-deoxy-5'-methylthioadenosine phosphorylase--IV. Biological activity of 2-fluoroadenine-substituted 5'-deoxy-5'-methylthioadenosine analogs.Biochemical Pharmacology.  36:1881-1893. 1987
    1987 Nucleosides & NucleotidesNucleosides and Nucleotides.  6:a. 1987
    1987 Resolution of racemic carbocyclic analogues of purine nucleosides through the action of adenosine deaminase. Antiviral activity of the carbocyclic 2'-deoxyguanosine enantiomers.Journal of Medicinal Chemistry.  30:746-749. 1987
    1987 New substrate analogues as inhibitors of s-adenosylmethionine decarboxylaseNucleosides and Nucleotides.  6:73-83. 1987
    1987 Nucleosides & NucleotidesNucleosides and Nucleotides.  6:a. 1987
    1987 Synthesis of terminal nucleoside phosphates and thiophosphates via phosphoramidite chemistryNucleosides and Nucleotides.  6:537-539. 1987
    1986 Nucleosides & NucleotidesNucleosides and Nucleotides.  5:a. 1986
    1986 9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)guanine: a metabolically stable cytotoxic analogue of 2'-deoxyguanosine.Journal of Medicinal Chemistry.  29:2389-2392. 1986
    1986 Synthesis and biochemical properties of 8-amino-6-fluoro-9-beta-D-ribofuranosyl-9H-purine.Journal of Medicinal Chemistry.  29:2069-2074. 1986
    1986 Nucleosides & NucleotidesNucleosides and Nucleotides.  5:a. 1986
    1986 Effects of certain 5'-substituted adenosines on polyamine synthesis: selective inhibitors of spermine synthase.Biochemistry.  25:4091-4097. 1986
    1986 Nucleosides & NucleotidesNucleosides and Nucleotides.  5:a. 1986
    1986 Nucleosides & NucleotidesNucleosides and Nucleotides.  5:a. 1986
    1986 Differences in the metabolism and metabolic effects of the carbocyclic adenosine analogs, neplanocin A and aristeromycin.Molecular Pharmacology.  29:383-390. 1986
    1986 Nucleosides & NucleotidesNucleosides and Nucleotides.  5:a. 1986
    1985 Nudeosides & NucleotidesNucleosides and Nucleotides.  4:a. 1985
    1985 2-Fluoroformycin and 2-aminoformycin. Synthesis and biological activity.Journal of Medicinal Chemistry.  28:1740-1742. 1985
    1985 Acyclic Nucleosides Other Than Acyclovir as Potential Antiviral AgentsNucleosides and Nucleotides.  4:411-427. 1985
    1985 Nudeosides & NucleotidesNucleosides and Nucleotides.  4:a. 1985
    1985 Metabolism and metabolic effects of halopurine nucleosides in tumor cells in cultureNucleosides and Nucleotides.  4:107-116. 1985
    1985 Nucleosides & NudeotidesNucleosides and Nucleotides.  4:a. 1985
    1985 Inosine Analogs as Anti-Leishmanial AgentsPharmaceutical Research.  2:217-220. 1985
    1984 (+/-)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)- (1 alpha,2 alpha,3 beta,5 beta)-1,2-cyclopentanediol, the carbocyclic analogue of tubercidin.Journal of Medicinal Chemistry.  27:534-536. 1984
    1984 Improved Synthesis And Antitumor Activity Of 2-Bromo-2'-DeoxyadenosineJournal of Medicinal Chemistry.  27:800-802. 1984
    1984 Nucleosides & NucleotidesNucleosides and Nucleotides.  3:a. 1984
    1984 Nucleosides & NucleotidesNucleosides and Nucleotides.  3. 1984
    1984 Nucleosides & NucleotidesNucleosides and Nucleotides.  3:a. 1984
    1984 Nucleosides & NucleotidesNucleosides and Nucleotides.  3:a. 1984
    1984 Nucleosides & NucleotidesNucleosides and Nucleotides.  3:a. 1984
    1983 Synthesis and biological evaluation of 2-fluoro-8-azaadenosine and related compounds.Journal of Medicinal Chemistry.  26:1483-1489. 1983
    1983 Formation of 3-(2'-deoxyribofuranosyl) and 9-(2'-deoxyribofuranosyl) nucleosides of 8-substituted purines by nucleoside deoxyribosyltransferase.Archives of Biochemistry and Biophysics.  222:133-144. 1983
    1983 Nucleosides & NucleotidesNucleosides and Nucleotides.  2:a. 1983
    1983 Nucleosides & NucleotidesNucleosides and Nucleotides.  2:a. 1983
    1983 Nucleosides & NucleotidesNucleosides and Nucleotides.  2. 1983
    1983 Nucleosides & NucleotidesNucleosides and Nucleotides.  2. 1983
    1983 Nucleosides & NucleotidesNucleosides and Nucleotides.  2. 1983
    1983 Synthesis of C-β-D-Ribofuranosyl Derivatives with a Highly Functionalized Two-Carbon Unit. Conversion to Certain Blocked Thiazole C-NucleosidesJournal of Organic Chemistry.  48:3141-3145. 1983
    1983 Synthesis of Chain-Extended and C-6’ Functionalized Precursors of the Nucleoside Antibiotic SinefunginJournal of Organic Chemistry.  48:1982-1988. 1983
    1982 Nucleosides & NucleotidesNucleosides and Nucleotides.  1:a. 1982
    1982 Nucleosides & NucleotidesNucleosides and Nucleotides.  1:a-b. 1982
    1982 Nucleosides & NucleotidesNucleosides and Nucleotides.  1:a. 1982
    1980 Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin.Cancer Research.  40:1073-1076. 1980
    1980 Synthesis of Methyl Peracetyl α-Hikosaminide, the Undecose Portion of the Nucleoside Antibiotic HikizimycinJournal of Organic Chemistry.  45:4526-4528. 1980
    1979 Convenient Synthesis of 9-MethylbenzotalpyreneJournal of Organic Chemistry.  44:2941-2943. 1979
    1979 Nucleoside 4ʹ,5ʹ-Enol Acetates. Synthesis and Chemistry of a Unique Uridine O2,4ʹ-AnhydronucleosideJournal of the American Chemical Society.  101:1554-1564. 1979
    1979 A convenient procedure for the formation of enol acetates under basic conditionsSynthetic Communications.  9:157-163. 1979
    1979 Construction of Long-Chain Carbohydrates. Synthesis and Chemistry of a Galactose 6-PhosphoraneJournal of Organic Chemistry.  44:1434-1438. 1979
    1979 Synthesis of Certain β-D-Ribofuranosyl Thiazole C-Nucleosides from a Versatile PrecursorJournal of Organic Chemistry.  44:4351-4358. 1979
    1978 Carbon-Carbon Bond Formation at C4' of a Nucleoside. Synthesis and Utilization of a Uridine 4',5'-EnamineJournal of the American Chemical Society.  100:2554-2555. 1978
    1978 Homo-C-nucleosides. The Synthesis of Certain 6-Substituted 4-Pyrimidinones1Journal of Organic Chemistry.  43:2925-2927. 1978
    1978 Studies Directed Toward a Total Synthesis of Nucleoside Q. Annulation of 2,6-Diaminopyrimidin-4-one with α-Halo Carbonyls to form Pyrrolo[2,3-d]pyrimidines and furo[2,3-d]pyrimidinesJournal of Organic Chemistry.  43:3937-3941. 1978
    1978 Total Synthesis of Erythromycins. 3. Stereoselective Routes to Intermediates Corresponding to C(1) to C(9) and C(10) to C(13) Fragments of Erythronolide BJournal of the American Chemical Society.  100:4618-4620. 1978
    1977 Generation and Reactivity of an Unstabilized Carbohydrate PhosphoraneJournal of Organic Chemistry.  42:4084-4088. 1977
    1977 A Convenient Total Synthesis of (±)-(7E, 9E)-Trisporic Acid B Methyl EsterJournal of Organic Chemistry.  42:525-527. 1977
    1976 Enol acetates of nucleoside-5'-aldehydes: potential intermediates for substituent incorporation at C-4'.Carbohydrate Research.  52:C3-C6. 1976
    1976 Crystalline methyl 2,3 O isopropylidene 5 O trityl β D ribofuranosylacetateJournal of Carbohydrates Nucleosides Nucleotides.  3:185-189. 1976
    1975 A convenient procedure for formation of certain uracil and thymine anhydronucleosides.Carbohydrate Research.  42:379-381. 1975
    1973 Interactions of fluorescent analogs of adenine nucleotides with pyruvate kinaseFEBS Letters.  29:215-218. 1973
    1972 Erratum: Synthetic spectroscopic models related to coenzymes and base pairs. An "abbreviated" nicotinamide adenine dinucleotide (Journal of the American Chemical Society (1972) 94 (1702))Journal of the American Chemical Society.  94:4400. 1972
    1972 Fluorescent modification of adenosine-containing coenzymes. Biological activities and spectroscopic properties.Biochemistry.  11:3499-3506. 1972
    1972 A fluorescent analog of nicotinamide adenine dinucleotide.Proceedings of the National Academy of Sciences.  69:2039-2042. 1972
    1972 Fluorescent modification of adenosine 3',5'-monophosphate: spectroscopic properties and activity in enzyme systems.Science.  177:279-280. 1972
    1972 A spray reagent for adenine-containing residues: detection by fluorescence.BBA - Biochimica et Biophysica Acta.  269:531-532. 1972
    1972 A fluorescent modification of adenosine triphosphate with activity in enzyme systems: 1,N 6 -ethenoadenosine triphosphate.Science.  175:646-647. 1972
    1972 Fluorescent adenosine and cytidine derivatives.Biochemical and Biophysical Research Communications.  46:597-604. 1972
    1972 Amine Hydrochlorides by Reduction in the Presence of ChloroformJournal of Organic Chemistry.  37:335-336. 1972
    1971 Attachment of a fluorescent label to 4-thiouracil and 4-thiouridine.Biochemical and Biophysical Research Communications.  45:1262-1270. 1971

    Chapter

    Year Title Altmetric
    2009 Other Imidazoles with Fused Six-membered Rings.  607-668. 2009
    2008 Clofarabine: From Design to Approval.  631-646. 2008

    Research Overview

  • Keywords - Drug Discovery
  • Education And Training

  • Bachelor of Science or Mathematics, University of Illinois System : Chicago
  • Doctor of Philosophy, University of Michigan System : Ann Arbor
  • Full Name

  • John Secrist
  • Blazerid

  • jsecrist