Positions

Overview

  • CEO of Southern Research Institute (retired)
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2016 6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylasesBioorganic Chemistry.  65:9-16. 2016
    2016 6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylaseChimica therapeutica.  108:616-622. 2016
    2016 The synthesis and biological evaluation of alkyl and benzyl naphthyridinium analogs of eupolauridine as potential antimicrobial and cytotoxic agentsBioorganic and Medicinal Chemistry.  24:6119-6130. 2016
    2015 Thiarabine, 1-(4-Thio-β-D-arabinofuranosyl)cytosine. A deoxycytidine analog with excellent anticancer activityCurrent Medicinal Chemistry.  22:3881-3896. 2015
    2012 Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitorsBioorganic and Medicinal Chemistry Letters.  22:6967-6973. 2012
    2012 Preclinical antitumor activity of thiarabine in human leukemia and lymphoma xenograft modelsNucleosides and Nucleotides.  31:647-660. 2012
    2012 Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitorsBioorganic and Medicinal Chemistry Letters.  22:5652-5657. 2012
    2012 Preclinical combination therapy of thiarabine plus various clinical anticancer agentsNucleosides and Nucleotides.  31:632-646. 2012
    2012 Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitorsBioorganic and Medicinal Chemistry Letters.  22:5144-5149. 2012
    2012 Preparation of 1,4-disubstituted-1,2,3-triazolo ribonucleosides by Na 2CuP2O7 catalyzed azide-alkyne 1,3-dipolar cycloadditionARKIVOC : Online Journal of Organic Chemistry.  2012:76-89. 2012
    2012 5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitorsBioorganic and Medicinal Chemistry Letters.  22:3229-3234. 2012
    2012 Novel substituted pyrimidines as HCV replication (replicase) inhibitorsBioorganic and Medicinal Chemistry Letters.  22:1160-1164. 2012
    2012 High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37RvTuberculosis.  92:72-83. 2012
    2012 Isolation and characterization of a murine P388 leukemia line resistant to thiarabineNucleosides and Nucleotides.  31:14-27. 2012
    2012 Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: Palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides [1]Chimica therapeutica.  47:167-174. 2012
    2011 Isolation and characterization of a murine P388 leukemia line resistant to clofarabineNucleosides and Nucleotides.  30:826-838. 2011
    2011 Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteineProtein Science.  20:1836-1844. 2011
    2011 Lack of in vivo cross-resistance with 4′-thio-ara-C against drug-resistant murine P388 and L1210 leukemiasCancer Chemotherapy and Pharmacology.  68:399-403. 2011
    2011 The Alabama drug discovery alliance: A collaborative partnership to facilitate academic drug discoveryPharmaceutical Research.  28:1454-1459. 2011
    2010 Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicityMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  684:1-10. 2010
    2009 Inhibition of herpesvirus replication by 5-substituted 4′- thiopyrimidine nucleosidesAntimicrobial Agents and Chemotherapy.  53:5251-5258. 2009
    2009 Antituberculosis activity of the molecular libraries screening center network libraryTuberculosis.  89:354-363. 2009
    2009 High-throughput screening for inhibitors of Mycobacterium tuberculosis H37RvTuberculosis.  89:334-353. 2009
    2009 Regioselective metalation of 6-methylpurines: Synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancerNucleosides and Nucleotides.  28:642-656. 2009
    2009 Synthesis and anticancer evaluation of 4'-C-methyl-2'-fluoro arabino nucleosidesNucleosides and Nucleotides.  28:657-677. 2009
    2009 New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C 8 substitution in structural analogues of S-adenosylmethionineJournal of Medicinal Chemistry.  52:1388-1407. 2009
    2009 Activities of certain 5-substituted 4′-thiopyrimidine nucleosides against orthopoxvirus infectionsAntimicrobial Agents and Chemotherapy.  53:572-579. 2009
    2009 Synthesis of certain 2′-Deoxy-3′,5′-di-O-benzyl-4′- thio-nucleosides using natural phosphate doped with trifluoromethanesulfonic acid as catalystPhosphorus, Sulfur, and Silicon and the Related Elements.  184:76-81. 2009
    2008 Clofarabine Acts as Radiosensitizer In Vitro and In Vivo by Interfering With DNA Damage ResponseInternational Journal of Radiation Oncology - Biology - Physics.  70:213-220. 2008
    2007 In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylaseJournal of Chemical Information and Computer Sciences.  47:1897-1905. 2007
    2007 Programs to facilitate tuberculosis drug discovery: The tuberculosis antimicrobial acquisition and coordinating facilityInfectious Disorders - Drug Targets.  7:92-104. 2007
    2006 Discovery and development of clofarabine: A nucleoside analogue for treating cancerNature Reviews Drug Discovery.  5:855-863. 2006
    2006 Antiangiogenic activity of 4′-thio-β-D-arabinofuranosylcytosineMolecular Cancer Therapeutics.  5:2218-2224. 2006
    2006 Recent development of therapeutics for chronic HCV infectionAntiviral Research.  71:351-362. 2006
    2006 Synthesis and biological evaluation of some 4′-C-(hydroxymethyl)- α- and -β-D-arabinofuranosyl pyrimidine and adenine nucleosidesCollection of Czechoslovak Chemical Communications.  71:1063-1087. 2006
    2006 The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activationActa Crystallographica Section D: Biological Crystallography.  62:133-139. 2006
    2005 Chemical and enzymatic synthesis of 4′-thio-β-D- arabinofuranosylcytosine monophosphate and triphosphateNucleosides and Nucleotides.  24:533-537. 2005
    2005 Design and evaluation of 5′-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutantNucleosides and Nucleotides.  24:387-392. 2005
    2005 Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancerNucleosides and Nucleotides.  24:881-885. 2005
    2005 Synthesis and biological activity of 2′-deoxy-4′-thio- pyrazolo[3,4-d]pyrimidine nucleosidesNucleosides and Nucleotides.  24:911-914. 2005
    2005 Synthesis of some 2′-fluoro-2′-deoxy-3′-C-ethynyl and 3′-C-vinyl-β-D-lyxofuranosyl nucleosidesNucleosides and Nucleotides.  24:713-715. 2005
    2005 bis(tBuSATE) phosphotriester prodrugs of 8-azaguanosine and 6-methylpurine riboside; bis(POM) phosphotriester prodrugs of 2′-deoxy-4′- thioadenosine and its corresponding 9α anomerNucleosides and Nucleotides.  24:809-813. 2005
    2005 Synthesis and biological activity of 4′-thio-L-xylofuranosyl purine nucleosidesNucleosides and Nucleotides.  24:1895-1906. 2005
    2005 Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapyHuman Gene Therapy.  16:339-347. 2005
    2005 Nucleosides as anticancer agents: from concept to the clinic.Nucleic Acids Symposium Series.  15-16. 2005
    2004 Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the Escherichia coli purine nucleoside phosphorylase geneCancer Research.  64:6610-6615. 2004
    2004 Purine nucleoside antimetabolites in development for the treatnment of cancerCurrent Opinion in Investigational Drugs.  5:592-596. 2004
    2004 Synthesis and cytotoxicity of 9-(2-deoxy-2-alkyldithio-β-D-arabinofuranosyl)purine nucleosides which are stable precursors to potential mechanistic probes of ribonucleotide reductasesJournal of the Chemical Society, Perkin Transactions 1.  2:120-126. 2004
    2003 Synthesis and Anti-cancer Activity of Some Novel 5-Azacytosine NucleosidesNucleosides and Nucleotides.  22:2161-2170. 2003
    2003 Selective metalation of 6-methylpurines: Synthesis of 6-fluoromethylpurines and related nucleosidesNucleosides and Nucleotides.  22:747-749. 2003
    2003 The novel nucleoside transport system exhibited by NB4 cells, csg, transports deoxyguanosine analogues, including ara-GBiochemical Pharmacology.  66:733-737. 2003
    2003 Preclinical antitumor activity of 4′-thio-β-D-arabinofuranosylcytosine (4′-thio-ara-C)Cancer Chemotherapy and Pharmacology.  51:422-426. 2003
    2003 Phosphorylation of 4′-thio-β-D-arabinofuranosylcytosine and its analogs by human deoxycytidine kinaseJournal of Pharmacology and Experimental Therapeutics.  304:1314-1322. 2003
    2003 Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylaseCancer Gene Therapy.  10:23-29. 2003
    2003 Designer Gene Therapy Using an Escherichia coli Purine Nucleoside Phosphorylase/Prodrug SystemCell Chemistry Biology.  10:1173-1181. 2003
    2002 Enhancement of nucleoside cytotoxicity through nucleotide prodrugsJournal of Medicinal Chemistry.  45:4505-4512. 2002
    2002 Multi-log cytotoxicity of carbocyclic 2′-deoxyguanosine in HSV-TK-expressing human tumor cellsHuman Gene Therapy.  13:543-551. 2002
    2001 The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylaseBiochemistry.  40:9484-9494. 2001
    2001 Nucleoside and nucleotide nomenclature.Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.].  Appendix 1. 2001
    2001 Synthesis and antiproliferative activity of some 4′-C-hydroxymethyl α- and -β-D-arabino-pentofuranosyl pyrimidine nucleosidesNucleosides and Nucleotides.  20:649-652. 2001
    2001 Synthesis and biological activity of 4′-C-hydroxymethyl-2′ fluoro-D-arabinofuranosylpurine nucleosidesNucleosides and Nucleotides.  20:747-750. 2001
    2001 Synthesis and biological activity of 4′-C-hydroxymethyl-2′-fluoro-D-arabinofuranosylpurine nucleosidesNucleosides and Nucleotides.  20:1583-1598. 2001
    2001 Synthesis and biological activity of 4′-thio-L-xylofuranosyl nucleosidesNucleosides and Nucleotides.  20:743-746. 2001
    2000 Metabolism of 4'-thio-β-d-arabinofuranosylcytosine in CEM cellsBiochemical Pharmacology.  60:1925-1932. 2000
    2000 A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapyNucleosides and Nucleotides.  19:559-565. 2000
    2000 Convenient syntheses of 6-methylpurine and related nucleosidesNucleosides and Nucleotides.  19:1123-1134. 2000
    2000 Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D- arabinofuranosyl)adenine (Cl-F-ara-A)Nucleosides and Nucleotides.  19:447-460. 2000
    2000 Synthesis and structure activity relationships of 5-substituted-4′-thio-β-D-arabinofuranosylcytosinesNucleosides and Nucleotides.  19:2005-2017. 2000
    2000 Synthesis of 4'-thio-β-D-arabinofuranosylcytosine (4'-thio-ara-C) and comparison of its anticancer activity with that of ara-CNucleosides and Nucleotides.  19:329-340. 2000
    1999 Synthesis and biological activity of 2'-fluoro- darabinofuranosylpyrazolo[3,4-d]pyrimidine nucleosidesHelvetica Chimica Acta.  82:2240-2245. 1999
    1999 Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y 1 receptor antagonists and partial agonistsJournal of Medicinal Chemistry.  42:1625-1638. 1999
    1999 Comparison of the mechanism of cytotoxicity of 2-chloro-9,(2-deoxy-2- fluoro-β-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro-β-D- ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro-β-D- ribofuranosyl)adenine in CEM cellsMolecular Pharmacology.  55:515-520. 1999
    1999 Certain 3,9-dideazapurines as inhibitors of purine nucleoside phosphorylaseNucleosides and Nucleotides.  18:2443-2461. 1999
    1999 Gene therapy of cancer: Activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylaseNucleosides and Nucleotides.  18:745-757. 1999
    1999 Kinetics for the acid-catalyzed hydrolysis of purine and cytosine 2'- deoxy-4'-thionucleosidesNucleosides and Nucleotides.  18:181-186. 1999
    1999 Synthesis and biological activity of 4'-thio-2'-deoxy purine nucleosidesNucleosides and Nucleotides.  18:683-685. 1999
    1999 Synthesis and biological activity of 5-azacytosine nucleosides derived from 4-thio-2-deoxy-L-threopentofuranose and 4-thio-2-deoxy-D-erythro- pentofuranoseNucleosides and Nucleotides.  18:613-614. 1999
    1998 Synthesis and biological activity of certain 4'-thio-D- arabinofuranosylpurine nucleosidesJournal of Medicinal Chemistry.  41:3865-3871. 1998
    1998 Polyamine pools in HIV-infected cellsJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology.  17:101-103. 1998
    1998 Synthesis and antiviral evaluation of analogs of adenosine-N1-oxide and 1-(benzyloxy)adenosineNucleosides and Nucleotides.  17:1409-1443. 1998
    1997 In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylaseHuman Gene Therapy.  8:1637-1644. 1997
    1995 Metabolism and metabolic actions of 4′-thiothymidine in L1210 cellsBiochemical Pharmacology.  50:687-695. 1995
    1995 The synthesis and biological activity of certain 4’-thionucleosidesNucleosides and Nucleotides.  14:675-686. 1995
    1995 Search for New Purine- and Ribose-Modified Adenosine Analogues as Selective Agonists and Antagonists at Adenosine ReceptorsJournal of Medicinal Chemistry.  38:1174-1188. 1995
    1995 Nucleosides & NucleotidesNucleosides and Nucleotides.  14:a. 1995
    1994 α-(1 → 2)-, α-(1 → 3)-, and α-(1 → 6)-Linked thioglycosidic disaccharides: syntheses and anti-HIV testing of thiokojibiose octaacetate, thionigerose, and thioisomaltoseCarbohydrate Research.  262:245-255. 1994
    1994 Synthesis and biological activity of 4,-thionucleosides of 2-chloroadenineNucleosides and Nucleotides.  13:1819-1828. 1994
    1994 PNP inhibitorsJournal of Computer-Aided Molecular Design.  2:205-220. 1994
    1994 synthesis and biologic evaluation of 8-substituted derivatives of nebularine (9/3-d-ribofuranosylpurine)Nucleosides and Nucleotides.  13:1017-1029. 1994
    1994 Additions and Corrections: Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 3. 9-Arylmethyl Derivatives of 9-Deazaguanine Substituted on the Methylene Group ((J. Med. Chem. (1993) 36(24) (3771–3783) (10.1021/jm00076a004))Journal of Medicinal Chemistry.  37:1034. 1994
    1994 Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 4. A Study of Phosphate MimicsJournal of Medicinal Chemistry.  37:1109-1114. 1994
    1994 Phosphonate Analogs of Carbocyclic NucleotidesJournal of Medicinal Chemistry.  37:739-744. 1994
    1994 Synthesis and biologic activity of purine 2'-deoxy-2’-fluoro-ni&>nucleosidesNucleosides and Nucleotides.  13:309-323. 1994
    1994 Characterization of S-adenosylmethionine decarboxylase induced by human cytomegalovirus infectionVirus Research.  31:255-263. 1994
    1994 In vitro and in vivo antiviral (RNA) evaluation of orotidine 5'- monophosphate decarboxylase inhibitors and analogues including 6-azauridine- 5'-(ethyl methoxyalaninyl)phosphate (a 5'-monophosphate prodrug)Antiviral Chemistry and Chemotherapy.  5:209-220. 1994
    1994 Seaborgium: Name not yet approved by ACS [7]Science.  265:303. 1994
    1993 Phosphorylation of the enantiomers of the carbocyclic analog of 2'- deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinaseMolecular Pharmacology.  44:1258-1266. 1993
    1993 Nucleosides & NucleotidesNucleosides and Nucleotides.  12:a. 1993
    1993 THE SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-(2-DEOXY-4-THIO-α-L-7HREO-PENTOFURANOSYL)THYMINENucleosides and Nucleotides.  12:841-846. 1993
    1993 Nucleosides & NucleotidesNucleosides and Nucleotides.  12:a-b. 1993
    1993 Nucleosides & nucleotidesNucleosides and Nucleotides.  12:a-b. 1993
    1993 Conformational studies of thymidine dimers containing sulfonate and sulfonamide linkages by NMR spectroscopyTetrahedron.  49:2287-2298. 1993
    1993 Nucleosides & nucleotidesNucleosides and Nucleotides.  12:a. 1993
    1993 Application of X‐Ray Crystallographic Methods in the Design of Purine Nucleoside Phosphorylase InhibitorsAnnals of the New York Academy of Sciences.  685:237-247. 1993
    1993 Nucleosides & NucleotidesNucleosides and Nucleotides.  12:a. 1993
    1993 Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 1. 9-(Arylmethyl) Derivatives of 9-DeazaguanineJournal of Medicinal Chemistry.  36:55-69. 1993
    1993 Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 2. 9-Alicyclic and 9-Heteroalicyclic Derivatives of 9-DeazaguanineJournal of Medicinal Chemistry.  36:1847-1854. 1993
    1993 Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 3. 9-Arylmethyl Derivatives of 9-Deazaguanine Substituted on the Methylene GroupJournal of Medicinal Chemistry.  36:3771-3783. 1993
    1993 Syntheses of 5′-Substituted Analogues of Carbocyclic 3-Deazaadenosine as Potential AntiviralsJournal of Medicinal Chemistry.  36:2102-2106. 1993
    1993 Synthesis and antiviral evaluation of some novel [1,2,4]triazolo[4,3‐β][1,2,4]triazole nucleoside analogsJournal of Heterocyclic Chemistry.  30:1289-1292. 1993
    1992 Nucleosides & NucleotidesNucleosides and Nucleotides.  11:a. 1992
    1992 Nucleosides & nucleotidesNucleosides and Nucleotides.  11:a. 1992
    1992 Interference with HIV-1 reverse transcriptase-catalyzed DNA chain elongation by the 5′-triphosphate of the carbocyclic analog of 2′-deoxyguanosineAntiviral Research.  19:325-332. 1992
    1992 Acyclic analogues of pyrazofurin: syntheses and antiviral evaluationCarbohydrate Research.  216:441-452. 1992
    1992 5,5-Disubstituted Hydantoins: Syntheses and Anti-HIV ActivityJournal of Medicinal Chemistry.  35:3567-3572. 1992
    1992 Irreversible inhibition of S-adenosylmethionine decarboxylase of trypanosoma bru cei bru cei by S-adenosylmethionine analoguesBiochemical Pharmacology.  44:905-911. 1992
    1992 Nucleosides & nucleotidesNucleosides and Nucleotides.  11:a. 1992
    1992 Nucleosides & NucleotidesNucleosides and Nucleotides.  11:a-b. 1992
    1992 Synthesis and Antiviral Evaluation of N-Carboxamidine-Substituted Analogs of 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamidine HydrochlorideJournal of Medicinal Chemistry.  35:3231-3238. 1992
    1992 Nucleosides & NucleotidesNucleosides and Nucleotides.  11:a-b. 1992
    1992 Nucleosides & NucleotidesNucleosides and Nucleotides.  11:a. 1992
    1992 Nucleoside Sultones: Synthons for the Preparation of Novel Nucleotide Analogsues. 1. Synthesis and Ring-Opening ReactionsJournal of Organic Chemistry.  57:2830-2835. 1992
    1992 Synthesis of Thymidine Dimers Containing Internucleoside Sulfonate and Sulfonamide LinkagesJournal of Organic Chemistry.  57:2983-2985. 1992
    1992 Nucleosides and nucleotidesNucleosides and Nucleotides.  11:a. 1992
    1992 Purification of Human S-Adenosylmethionine Decarboxylase Expressed in Escherichia coli and Use of This Protein To Investigate the Mechanism of Inhibition by the Irreversible Inhibitors, 5ʹ-Deoxy-5ʹ-[(3-hydrazinopropyl)methylamino] adenosine and 5ʹ-{[(Z)-4-Amino-2-butenyl]methylamino}-5ʹ-deoxyadenosineBiochemistry.  31:6848-6855. 1992
    1992 Syntheses of phosphonate analogues of dideoxyadenosine (dda)-, dideoxycytidine (ddc)-, dideoxyinosine (ddi)-, and deoxythymidine (ddt)-51-MoriophosphatesNucleosides and Nucleotides.  11:947-956. 1992
    1992 Synthesis and Anti-HIV Activity of 4′-Thio-2′,3′-dideoxynucleosidesJournal of Medicinal Chemistry.  35:533-538. 1992
    1992 Erratum: Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors (Proc. Natl. Acad. Sci. USA (December 15, 1991) 88:24 (11540-11544))Proceedings of the National Academy of Sciences.  89:9974. 1992
    1992 Incorporation of the carbocyclic analog of 2'-deoxyguanosine into the DNA of herpes simplex virus and of HEp-2 cells infected with herpes simplex virusMolecular Pharmacology.  41:245-251. 1992
    1992 Nucleosides & NucleotidesNucleosides and Nucleotides.  11:a-b. 1992
    1992 Synthesis and Biological Activity of 2′-Fluoro-2-halo Derivatives of 9-β-d-ArabinofuranosyladenineJournal of Medicinal Chemistry.  35:397-401. 1992
    1991 Nucleosides & nucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Nucleosides & NucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Nucleosides & nucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Synthesis and Biological Activity of 2′-Deoxy-4′-thio Pyrimidine NucleosidesJournal of Medicinal Chemistry.  34:2361-2366. 1991
    1991 Nucleosides & NucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Nucleosides & NucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases α, β, and γ by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine, and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugsJournal of Biological Chemistry.  266:1754-1762. 1991
    1991 Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitorsProceedings of the National Academy of Sciences.  88:11540-11544. 1991
    1991 Nucleosides & NucleotidesNucleosides and Nucleotides.  10:a. 1991
    1991 Progress toward the synthesis of nonionic oligonucleotide analogues with sulfonate and sulfonamide internucleotide linkages.Nucleic Acids Symposium Series.  5-8. 1991
    1990 Metabolism of the Carbocyclic Nucleoside Analogue Carbovir, an Inhibitor of Human Immunodeficiency Virus, in Human Lymphoid CellsBiochemistry.  29:9839-9843. 1990
    1990 Nucleosides & nucleotidesNucleosides and Nucleotides.  9:a. 1990
    1990 5-C-chain-extended adenosine derivatives related to sinefungin. synthesis and biological activity.Nucleosides and Nucleotides.  9:619-627. 1990
    1990 Nucleosides & NucleotidesNucleosides and Nucleotides.  9:a. 1990
    1990 Nucleosides & NucleotidesNucleosides and Nucleotides.  9:a. 1990
    1990 Nucleosides & nucleotidesNucleosides and Nucleotides.  9:a. 1990
    1989 Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerasesBiochemical and Biophysical Research Communications.  161:393-398. 1989
    1989 8-Substituted Purine Ribosides: Synthesis And Biological ActivityNucleosides and Nucleotides.  8:911-913. 1989
    1989 Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cellsBiochemical Journal.  263:215-221. 1989
    1989 Nucleosides & NucleotidesNucleosides and Nucleotides.  8:a. 1989
    1989 Nucleosides & NucleotidesNucleosides and Nucleotides.  8:a. 1989
    1989 Nucleosides & nucleotidesNucleosides and Nucleotides.  8:a. 1989
    1989 Nudeosides & NucleotidesNucleosides and Nucleotides.  8:a. 1989
    1989 Nudeosides & NucleotidesNucleosides and Nucleotides.  8:a. 1989
    1989 Phosphate modified analogues of 5'O-phosphorylated 2', 3'-dldeoxynucleosides: Synthesis and Anti-HIV activityNucleosides and Nucleotides.  8:1119-1120. 1989
    1989 Progress in the synthesis of a potential PNP transition state inhibitorNucleosides and Nucleotides.  8:1103-1105. 1989
    1989 Syn'Thesis And Antiviral Evaluation Of Adenosine-N1-Oxide And I-(Benzyloxy) AdenosinesNucleosides and Nucleotides.  8:915-917. 1989
    1989 Synthesis of 5'-substituted analogues of carbocyclic 3-deazaadenosine as potential antiviralsNucleosides and Nucleotides.  8:1153-1154. 1989
    1988 Nucleosides & NucleotidesNucleosides and Nucleotides.  7:a. 1988
    1988 Nucleosides & NucleotidesNucleosides and Nucleotides.  7:a. 1988
    1988 Nucleosides & NucleotidesNucleosides and Nucleotides.  7:a. 1988
    1988 Effect of Inhibitors of S-Adenosylmethionine Decarboxylase on Polyamine Content and Growth of L1210 CellsBiochemistry.  27:1408-1415. 1988
    1988 Synthesis and Biological Evaluations of Certain 2-Halo-2'-Substituted Derivatives of 9-β-D-ArabinofuranosyladenineJournal of Medicinal Chemistry.  31:405-410. 1988
    1988 Nucleosides & NucleotidesNucleosides and Nucleotides.  7:a. 1988
    1988 Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cellsBiochemical Journal.  254:45-50. 1988
    1988 Properties of L1210 Cells Resistant to α-Difluoro Methyl Or NithineCancer Research.  48:2678-2682. 1988
    1987 Nucleosides & NucleotidesNucleosides and Nucleotides.  6:a. 1987
    1987 Nucleosides & NucleotidesNucleosides and Nucleotides.  6:a. 1987
    1987 5′-Deoxy-5′-methylthioadenosine phosphorylase-IV. Biological activity of 2-fluoroadenine-substituted 5′-deoxy-5′ -methylthioadenosine analogsBiochemical Pharmacology.  36:1881-1893. 1987
    1987 Nucleosides & NucleotidesNucleosides and Nucleotides.  6:a. 1987
    1987 Resolution of Racemic Carbocyclic Analogues of Purine Nucleosides through the Action of Adenosine Deaminase. Antiviral Activity of the Carbocyclic 2′-Deoxyguanosine EnantiomersJournal of Medicinal Chemistry.  30:746-749. 1987
    1987 New substrate analogues as inhibitors of s-adenosylmethionine decarboxylaseNucleosides and Nucleotides.  6:73-83. 1987
    1987 Nucleosides & NucleotidesNucleosides and Nucleotides.  6:a. 1987
    1987 Synthesis of terminal nucleoside phosphates and thiophosphates via phosphoramidite chemistryNucleosides and Nucleotides.  6:537-539. 1987
    1986 Nucleosides & NucleotidesNucleosides and Nucleotides.  5:a. 1986
    1986 Differences in the metabolism and metabolic effects of carbocyclic adenosine analogs, neplanocin A and aristeromycinMolecular Pharmacology.  29:383-390. 1986
    1986 Nucleosides & NucleotidesNucleosides and Nucleotides.  5:a. 1986
    1986 Nucleosides & NucleotidesNucleosides and Nucleotides.  5:a. 1986
    1986 Nucleosides & NucleotidesNucleosides and Nucleotides.  5:a. 1986
    1986 Nucleosides & NucleotidesNucleosides and Nucleotides.  5:a. 1986
    1986 9-(2-Deoxy-2-fluoro-3-D-arabinofuranosy1)guanine: A Metabolically Stable Cytotoxic Analogue of 2’-DeoxyguanosineJournal of Medicinal Chemistry.  29:2389-2392. 1986
    1986 Effects of Certain 5'-Substituted Adenosines on Polyarnine Synthesis: Selective Inhibitors of Spermine SynthaseBiochemistry.  25:4091-4097. 1986
    1986 Synthesis and Biochemical Properties of 8-Amino-6-fluoro-9-β-D-ribofuranosyl-9H-purineJournal of Medicinal Chemistry.  29:2069-2074. 1986
    1985 Nudeosides & NucleotidesNucleosides and Nucleotides.  4:a. 1985
    1985 Acyclic Nucleosides Other Than Acyclovir as Potential Antiviral AgentsNucleosides and Nucleotides.  4:411-427. 1985
    1985 Nudeosides & NucleotidesNucleosides and Nucleotides.  4:a. 1985
    1985 Metabolism and metabolic effects of halopurine nucleosides in tumor cells in cultureNucleosides and Nucleotides.  4:107-116. 1985
    1985 Nucleosides & NudeotidesNucleosides and Nucleotides.  4:a. 1985
    1985 2-Fluoroformycin and 2-Aminoformycin. Synthesis and Biological ActivityJournal of Medicinal Chemistry.  28:1740-1742. 1985
    1985 Inosine Analogs as Anti-Leishmanial AgentsPharmaceutical Research.  2:217-220. 1985
    1984 (±)-3-(4-Amino-lif-pyrrolo[2,3-d]pyrimidin-l-yl)-5-(hydroxymethyl)-(lα,2α,3β,5β)-1,2-cyclopentanediol, the Carbocyclic Analogue of TubercidinJournal of Medicinal Chemistry.  27:534-536. 1984
    1984 Improved Synthesis And Antitumor Activity Of 2-Bromo-2'-DeoxyadenosineJournal of Medicinal Chemistry.  27:800-802. 1984
    1984 Nucleosides & NucleotidesNucleosides and Nucleotides.  3:a. 1984
    1984 Nucleosides & NucleotidesNucleosides and Nucleotides.  3. 1984
    1984 Nucleosides & NucleotidesNucleosides and Nucleotides.  3:a. 1984
    1984 Nucleosides & NucleotidesNucleosides and Nucleotides.  3:a. 1984
    1984 Nucleosides & NucleotidesNucleosides and Nucleotides.  3:a. 1984
    1983 Formation of 3-(2′-deoxyribofuranosyl) and 9-(2′-deoxyribofuranosyl) nucleosides of 8-substituted purines by nucleoside deoxyribosyltransferaseArchives of Biochemistry and Biophysics.  222:133-144. 1983
    1983 Nucleosides & NucleotidesNucleosides and Nucleotides.  2:a. 1983
    1983 Nucleosides & NucleotidesNucleosides and Nucleotides.  2:a. 1983
    1983 Nucleosides & NucleotidesNucleosides and Nucleotides.  2. 1983
    1983 Nucleosides & NucleotidesNucleosides and Nucleotides.  2. 1983
    1983 Nucleosides & NucleotidesNucleosides and Nucleotides.  2. 1983
    1983 Synthesis and Biological Evaluation of 2-Fluoro-8-azaadenosine and Related CompoundsJournal of Medicinal Chemistry.  26:1483-1489. 1983
    1983 Synthesis of C-β-D-Ribofuranosyl Derivatives with a Highly Functionalized Two-Carbon Unit. Conversion to Certain Blocked Thiazole C-NucleosidesJournal of Organic Chemistry.  48:3141-3145. 1983
    1983 Synthesis of Chain-Extended and C-6’ Functionalized Precursors of the Nucleoside Antibiotic SinefunginJournal of Organic Chemistry.  48:1982-1988. 1983
    1982 Nucleosides & NucleotidesNucleosides and Nucleotides.  1:a. 1982
    1982 Nucleosides & NucleotidesNucleosides and Nucleotides.  1:a-b. 1982
    1982 Nucleosides & NucleotidesNucleosides and Nucleotides.  1:a. 1982
    1980 Synthesis of Methyl Peracetyl α-Hikosaminide, the Undecose Portion of the Nucleoside Antibiotic HikizimycinJournal of Organic Chemistry.  45:4526-4528. 1980
    1979 Comparative Tumor-initiating Activity of Methylated Benzo(a)pyrene Derivatives in Mouse Skin 1Cancer Research.  40:1073-1076. 1979
    1979 Convenient Synthesis of 9-MethylbenzotalpyreneJournal of Organic Chemistry.  44:2941-2943. 1979
    1979 Nucleoside 4ʹ,5ʹ-Enol Acetates. Synthesis and Chemistry of a Unique Uridine O2,4ʹ-AnhydronucleosideJournal of the American Chemical Society.  101:1554-1564. 1979
    1979 A convenient procedure for the formation of enol acetates under basic conditionsSynthetic Communications.  9:157-163. 1979
    1979 Construction of Long-Chain Carbohydrates. Synthesis and Chemistry of a Galactose 6-PhosphoraneJournal of Organic Chemistry.  44:1434-1438. 1979
    1979 Synthesis of Certain β-D-Ribofuranosyl Thiazole C-Nucleosides from a Versatile PrecursorJournal of Organic Chemistry.  44:4351-4358. 1979
    1978 Carbon-Carbon Bond Formation at C4' of a Nucleoside. Synthesis and Utilization of a Uridine 4',5'-EnamineJournal of the American Chemical Society.  100:2554-2555. 1978
    1978 Homo-C-nucleosides. The Synthesis of Certain 6-Substituted 4-Pyrimidinones1Journal of Organic Chemistry.  43:2925-2927. 1978
    1978 Studies Directed Toward a Total Synthesis of Nucleoside Q. Annulation of 2,6-Diaminopyrimidin-4-one with α-Halo Carbonyls to form Pyrrolo[2,3-d]pyrimidines and furo[2,3-d]pyrimidinesJournal of Organic Chemistry.  43:3937-3941. 1978
    1978 Total Synthesis of Erythromycins. 3. Stereoselective Routes to Intermediates Corresponding to C(1) to C(9) and C(10) to C(13) Fragments of Erythronolide BJournal of the American Chemical Society.  100:4618-4620. 1978
    1977 Generation and Reactivity of an Unstabilized Carbohydrate PhosphoraneJournal of Organic Chemistry.  42:4084-4088. 1977
    1977 A Convenient Total Synthesis of (±)-(7E, 9E)-Trisporic Acid B Methyl EsterJournal of Organic Chemistry.  42:525-527. 1977
    1976 Crystalline methyl 2,3 O isopropylidene 5 O trityl β D ribofuranosylacetateJournal of Carbohydrates Nucleosides Nucleotides.  3:185-189. 1976
    1976 Enol acetates of nucleoside-5′-aldehydes: potential intermediates for substituent incorporation at C-4′Carbohydrate Research.  52. 1976
    1975 A convenient procedure for formation of certain uracil and thymine anhydronucleosidesCarbohydrate Research.  42:379-381. 1975
    1973 Interactions of fluorescent analogs of adenine nucleotides with pyruvate kinaseFEBS Letters.  29:215-218. 1973
    1972 Erratum: Synthetic spectroscopic models related to coenzymes and base pairs. An "abbreviated" nicotinamide adenine dinucleotide (Journal of the American Chemical Society (1972) 94 (1702))Journal of the American Chemical Society.  94:4400. 1972
    1972 Fluorescent Modification of Adenosine-Containing Coenzymes. Biological Activities and Spectroscopic PropertiesBiochemistry.  11:3499-3506. 1972
    1972 A spray reagent for adenine-containing residues: Detection by fluorescenceBiochimica et Biophysica Acta - Section Nucleic Acids And Protein Synthesis.  269:531-532. 1972
    1972 Fluorescent adenosine and cytidine derivativesBiochemical and Biophysical Research Communications.  46:597-604. 1972
    1972 A Fluorescent modification of adenosine triphosphate with activity in enzyme systems: 1,N 6 -ethenoadenosine triphosphateScience.  175:646-647. 1972
    1972 A fluorescent analog of nicotinamide adenine dinucleotide.Proceedings of the National Academy of Sciences.  69:2039-2042. 1972
    1972 Amine Hydrochlorides by Reduction in the Presence of ChloroformJournal of Organic Chemistry.  37:335-336. 1972
    1972 Fluorescent modification of adenosine 3′,5′-monophosphate: Spectroscopic properties and activity in enzyme systemsScience.  177:279-280. 1972
    1971 Attachment of a fluorescent label to 4-thiouracil and 4-thiouridineBiochemical and Biophysical Research Communications.  45:1262-1270. 1971

    Chapter

    Year Title Altmetric
    2009 Other Imidazoles with Fused Six-membered Rings.  607-668. 2009
    2008 Clofarabine: From Design to Approval.  631-646. 2008

    Research Overview

  • Keywords - Drug Discovery
  • Education And Training

  • Doctor of Philosophy, University of Michigan System : Ann Arbor 1972
  • Bachelor of Science or Mathematics, University of Illinois System : Chicago 1968
  • Full Name

  • John Secrist