Laboratory Investigation

Hedgehog blockade remodels the gut microbiota and the intestinal effector CD8⁺ T cells in a mouse model of mammary carcinoma.  102:1236-1244. 2022

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning.  101:1585-1596. 2021

Novel role of the dietary flavonoid fisetin in suppressing rRNA biogenesis.  101:1439-1448. 2021

ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppression.  101:1467-1474. 2021

Early infiltrating macrophage subtype correlates with late-stage phenotypic outcome in a mouse model of hepatorenal fibrocystic disease.  101:1382-1393. 2021

Quantitative 3-dimensional imaging and tissue cytometry reveals lymphatic expansion in acute kidney injury.  101:1186-1196. 2021

A novel tree shrew model of pulmonary fibrosis.  101:116-124. 2021

Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment.  100:1503-1516. 2020

Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory.  100:1238-1251. 2020

Regulation of pancreatic cancer TRAIL resistance by protein O-GlcNAcylation.  100:777-785. 2020

Autophagy-related 7 modulates tumor progression in triple-negative breast cancer.  99:1266-1274. 2019

Dynamic signature of lymphangiogenesis during acute kidney injury and chronic kidney disease.  99:1376-1388. 2019

Lipoprotein modulation of proteinuric renal injury.  99:1107-1116. 2019

Let’s go swimming.  99:450-451. 2019

Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure.  99:371-386. 2019

O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity.  99:260-270. 2019

Parabiosis reveals leukocyte dynamics in the kidney.  98:391-402. 2018

Vitamin D signaling and melanoma: Role of Vitamin D and its receptors in melanoma progression and management.  97:706-724. 2017

Cancer cell chemokines direct chemotaxis of activated stellate cells in pancreatic ductal adenocarcinoma..  97:302-317. 2017

In Memorium: Nathan Kaufman..  96:1142-1143. 2016

Laboratory Investigation web focus on China.  96:1144-1146. 2016

Gastric adenocarcinoma microRNA profiles in fixed tissue and in plasma reveal cancer-associated and Epstein-Barr virus-related expression patterns.  96:661-671. 2016

Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974.  96:249-259. 2016

Intra-tumor genetic heterogeneity in rectal cancer.  96:4-15. 2016

Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patients.  95:132-141. 2015

Dermatopathology.  95:115-128. 2015

Regulation of autophagy by protein post-translational modification.  95:14-25. 2015

Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.  94:1312-1325. 2014

Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase.  93:868-879. 2013

Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood.  93:690-700. 2013

Expression of osteoprotegerin from a replicating adenovirus inhibits the progression of prostate cancer bone metastases in a murine model.  93:268-278. 2013

Finding a new generation of spies and manuscript reviewers.  93:1262-1264. 2013

Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria.  92:1541-1552. 2012

Micro-RNA-632 downregulates DNAJB6 in breast cancer.  92:1310-1317. 2012

Reduced CaM/FLIP binding by a single point mutation in c-FLIP L modulates Fas-mediated apoptosis and decreases tumorigenesis.  92:82-90. 2012

Absence of Thy-1 results in TGF-Β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts.  91:1206-1218. 2011

The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: A complementary concept to Mendelian genetics.  91:1122-1135. 2011

C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice.  91:837-851. 2011

Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesis.  91:896-904. 2011

Laboratory Investigation editorial internship program.  91:646. 2011

Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine.  90:128-139. 2010

What editors want in an abstract.  90:4-5. 2010

Cardiac hypertrophy in mice with long-chain acyl-CoA dehydrogenase or very long-chain acyl-CoA dehydrogenase deficiency.  89:1348-1354. 2009

Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4.  89:1221-1228. 2009

Navigating interpersonal conflict and peer review.  89:256-258. 2009

High levels of Epstein-Barr virus DNA in latently infected gastric adenocarcinoma.  89:80-90. 2009

Who's on first?.  89:4-5. 2009

α-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression.  87:938-950. 2007

Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma.  86:748-766. 2006

Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension.  86:62-71. 2006

Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737^orpk mutant mice.  85:45-64. 2005

CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion.  84:1666-1676. 2004

Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages.  84:29-40. 2004

Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma.  84:397-405. 2004

Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages.  84:29-40. 2004

Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies.  82:1755-1764. 2002

Fibroblast growth factor-2 in remodeling of the developing basement membrane zone in the trachea of infant rhesus monkeys sensitized and challenged with allergen.  82:1747-1754. 2002

Cytogenetics and molecular biology of osteosarcoma.  82:365-373. 2002

Guanylin mRNA expression in human intestine and colorectal adenocarcinoma.  78:101-108. 1998

Increased expression of placenta growth factor in proliferative diabetic retinopathy.  78:109-116. 1998

Neutrophils and reactive oxygen intermediates mediate glucan-induced pulmonary granuloma formation through the local induction of monocyte chemoattractant protein-1.  76:191-201. 1997

Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis.  76:37-51. 1997

Mitogen-activated protein kinase and mitogen-activated kinase phosphatase-1 expression in the noble rat model of sex hormone-induced prostatic dysplasia and carcinoma.  75:361-370. 1996

In vitro AL-amyloid formation by rat and human mesangial cells.  74:290-302. 1996

Biochemical interaction between Tamm-Horsfall glycoprotein and Ig light chains in the pathogenesis of cast nephropathy.  73:810-817. 1995

Developmental analysis of bone tumors in polyomavirus transgenic mice.  70:86-94. 1994

Methods in laboratory investigation. Cytomegalovirus infection of human retinal tissue: An in vivo model.  71:141-148. 1994

Ultrastructural localization of a fluorinated bile salt in hepatocytes.  71:42-51. 1994

Hypertensive nephrosclerosis in the Dahl/Rapp rat: Initial sites of injury and effect of dietary L-arginine supplementation.  68:174-184. 1993

Spectrum of glomerular and tubulointerstitial renal lesions associated with monotypical immunoglobulin light chain deposition.  64:527-537. 1991

Glomerular development in intraocular and intrarenal grafts of fetal kidneys.  64:629-639. 1991

Tenascin expression in the human endometrium and in endometrial adenocarcinomas.  62:725-730. 1990

Retinoids, growth factors, and the tracheobronchial epithelium.  59:1-4. 1988

The differentiation potential of tracheal basal cells.  58:706-717. 1988

Retinoic acid and substratum regulate the differentiation of rabbit tracheal epithelial cells into squamous and secretory phenotype. Morphological and biochemical characterization.  56:654-664. 1987

Myocardial cell growth and blood pressure development in neonatal spontaneously hypertensive rats.  56. 1987

The differentiation capacity of Clara cells isolated from the lungs of rabbits.  57:219-229. 1987

Loss of basement membrane components by invasive tumors but not by their benign counterparts.  49:140-147. 1983

Human diabetic perineurial cell basement membrane thickening.  44:265-270. 1981

Peripheral couplings in human skeletal muscle.  39:17-20. 1978