JCI insight

Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection.  7. 2022

Immunoglobulin A nephropathy is characterized by anticommensal humoral immune responses.  7. 2022

An in vivo model for extracellular vesicle–induced emphysema.  7. 2022

Islet transplantation into brown adipose tissue can delay immune rejection.  7. 2022

Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models.  7. 2022

A congenital CMV infection model for follow-up studies of neurodevelopmental disorders, neuroimaging abnormalities, and treatment.  7. 2022

The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer.  6. 2021

TT-10–loaded nanoparticles promote cardiomyocyte proliferation and cardiac repair in a mouse model of myocardial infarction.  6. 2021

HLA-C and KIR permutations influence chronic obstructive pulmonary disease risk.  6. 2021

Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease.  6. 2021

Duration of post-COVID-19 symptoms is associated with sustained SARS-CoV-2-specific immune responses.  6. 2021

Leveraging copper import by yersiniabactin siderophore system for targeted PET imaging of bacteria.  6. 2021

NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns.  6. 2021

A mechanism for matrikine regulation in acute inflammatory lung injury.  6. 2021

Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease.  6. 2021

Prolyl endopeptidase contributes to early neutrophilic inflammation in acute myocardial transplant rejection.  6. 2021

Glucagon receptor signaling regulates weight loss via central KLB receptor complexes.  6. 2021

Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10.  5. 2020

Canagliflozin extends life span in genetically heterogeneous male but not female mice.  5. 2020

IL-10 provides cardioprotection in diabetic myocardial infarction via upregulation of Heme clearance pathways.  5. 2020

Fluid-electrolyte homeostasis requires histone deacetylase function.  5. 2020

Lipid mediators and biomarkers associated with type 1 diabetes development.  5. 2020

Synchronization of mothers and offspring promotes tolerance and limits allergy.  5. 2020

The value of genotypic and imaging information to predict functional and structural outcomes in ADPKD.  5. 2020

Deep neural network analyses of spirometry for structural phenotyping of chronic obstructive pulmonary disease.  5. 2020

Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes.  5. 2020

Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice.  5. 2020

Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis.  5. 2020

Myocardial protection by nanomaterials formulated with CHIR99021 and FGF1.  5. 2020

Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling.  5. 2020

Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis.  5. 2020

Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution.  5. 2020

Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort.  5. 2020

LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target.  5. 2020

Neutrophil-Targeted, protease-Activated pulmonary drug delivery blocks airway and systemic inflammation.  4. 2019

IL-1RA regulates immunopathogenesis during fungal-Associated allergic airway inflammation.  4. 2019

Progenitor cell combination normalizes retinal vascular development in the oxygen-induced retinopathy (OIR) model.  4. 2019

Cadherin-11 blockade reduces inflammation-driven fibrotic remodeling and improves outcomes after myocardial infarction.  4. 2019

NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis.  4. 2019

Virus-induced cochlear inflammation in newborn mice alters auditory function.  4. 2019

Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by an RORγt inverse agonist.  4. 2019

Soluble membrane attack complex is diagnostic for intraventricular shunt infection in children.  1. 2019

Exogenous sickle erythrocytes combined with vascular disruption trigger disseminated tumor vaso-occlusion and lung tumor regression.  4. 2019

Vimentin intermediate filament assembly regulates fibroblast invasion in fibrogenic lung injury.  4. 2019

Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury.  4. 2019

Resident macrophages reprogram toward a developmental state after acute kidney injury.  4. 2019

Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts.  4. 2019

SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury.  4. 2019

A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus.  4. 2019

Deficiency of Socs3 leads to brain-targeted experimental autoimmune encephalomyelitis via enhanced neutrophil activation and ROS production.  4. 2019

Differential transcriptome and development of human peripheral plasma cell subsets.  4. 2019

Racial differences in the association of NT-proBNP with risk of incident heart failure in REGARDS.  4. 2019

Effect of ivacaftor on mucociliary clearance and clinical outcomes in cystic fibrosis patients with G551D-CFTR.  3. 2018

Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection.  3. 2018

Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement.  3. 2018

Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.  3. 2018

Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema.  3. 2018

Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis.  3. 2018

Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS.  3. 2018

Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury.  3. 2018

A limb-girdle muscular dystrophy 2I model of muscular dystrophy identifies corrective drug compounds for dystroglycanopathies.  3. 2018

Exosomal microRNA predicts and protects against severe bronchopulmonary dysplasia in extremely premature infants.  3. 2018

Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury.  3. 2018

Development of an airway mucus defect in the cystic fibrosis rat.  3. 2018

Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.  2. 2017

Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.  2. 2017

Nasospheroids permit measurements of CFTR-dependent fluid transport.  2. 2017

Dietary potassium regulates vascular calcification and arterial stiffness.  2. 2017

Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.  2. 2017

Sustained immune tolerance induction in enzyme replacement therapy–treated CRIM-negative patients with infantile Pompe disease.  2. 2017

Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD.  2. 2017

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys.  2. 2017

Erratum: 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs (JCI Insight. (2017) 2:2 (e91377) DOI: 10.1172/jci.insight.91377).  2. 2017

Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography.  2. 2017

Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.  2. 2017

3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs..  2:e91377. 2017

A ferret model of COPD-related chronic bronchitis.  1:e87536. 2016

Analysis of cystic fibrosis-associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases..  1. 2016

Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis.  1. 2016

Heme oxygenase-1 regulates mitochondrial quality control in the heart..  1:e85817. 2016