Browse
Browse
Home
People
Organizations
Research
Events
Capability Map
Journal of Medicinal Chemistry
Journal
Overview
Identity
Overview
Publication Venue For
Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β-Cell Apoptosis
. 63:12666-12681.
2020
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties
. 63:10984-11011.
2020
Molecule Property Analyses of Active Compounds for Mycobacterium tuberculosis
. 63:8917-8955.
2020
Structural Effect on Adjuvanticity of Saponins
. 63:3290-3297.
2020
Vaccine Adjuvants Derivatized from Momordica Saponins i and II
. 62:9976-9982.
2019
β-Lactones: A Novel Class of Ca
2+
-Independent Phospholipase A
2
(Group VIA iPLA
2
) Inhibitors with the Ability To Inhibit β-Cell Apoptosis
. 62:2916-2927.
2019
Synthesis and Evaluation of a QS-17/18-Based Vaccine Adjuvant
. 62:1669-1676.
2019
Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.
. 62:987-992.
2019
Proline- and arginine-rich peptides as flexible allosteric modulators of human proteasome activity
2018
A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions
. 61:4720-4738.
2018
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
. 60:9184-9204.
2017
Retraction of "Design and Synthesis of Novel Cyclic Amine Benzimidazoles for the Treatment of Pancreatic Cancer".
. 60:7615.
2017
Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification
. 59:10470-10478.
2016
Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer
. 59:5102-5108.
2016
Effect of α-Methyl versus α-Hydrogen Substitution on Brain Availability and Tumor Imaging Properties of Heptanoic [F-18]Fluoroalkyl Amino Acids for Positron Emission Tomography (PET)
. 59:3515-3531.
2016
Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives
. 58:7881-7887.
2015
Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers
. 58:7763-7774.
2015
Synthesis and Biological Evaluation of (S)-Amino-2-methyl-4-[
76
Br]bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor Imaging
. 58:8542-8552.
2015
Synthesis, Radiolabeling, and Biological Evaluation of (R)- and (S)-2-Amino-5-[(18)F]fluoro-2-methylpentanoic Acid ((R)-, (S)-[(18)F]FAMPe) as Potential Positron Emission Tomography Tracers for Brain Tumors.
. 58:3817-3829.
2015
Discovery of potent inhibitors of Schistosoma mansoni NAD
+
catabolizing enzyme
. 58:3582-3592.
2015
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: Synthesis and biological evaluation
. 58:1228-1243.
2015
Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity
. 57:5370-5380.
2014
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1
. 57:2611-2622.
2014
Design and in vitro activities of N -alkyl- N -[(8- R -2,2-dimethyl-2 H -chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents
. 55:6738-6750.
2012
Design, synthesis, and biological action of 20 R -hydroxyvitamin D3
. 55:3573-3577.
2012
Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells
. 55:2427-2436.
2012
Design and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathway
. 54:8471-8489.
2011
Identification of inhibitors that block vaccinia virus infection by targeting the DNA synthesis processivity factor D4
. 54:3260-3267.
2011
Acyloxy nitroso compounds as nitroxyl (HNO) donors: Kinetics, reactions with thiols, and vasodilation properties
. 54:1059-1070.
2011
A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.
. 53:8274-8286.
2010
Synthesis and biological evaluation of apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins
. 53:8000-8011.
2010
BI-97C1, an optically pure apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/Leukemia-2 (Bcl-2) family proteins
. 53:4166-4176.
2010
Synthesis and preliminary biological evaluation of high-drug-load paclitaxel-antibody conjugates for tumor-targeted chemotherapy
. 53:586-594.
2010
Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-3-[(18)F]fluoro-2-methylpropanoic acid (FAMP) and (R)- and (S)-3-[(18)F]fluoro-2-methyl-2-N-(methylamino)propanoic acid (NMeFAMP) as potential PET radioligands for imaging brain tumors.
. 53:876-886.
2010
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C
8
substitution in structural analogues of S-adenosylmethionine
. 52:1388-1407.
2009
Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase
. 51:3934-3945.
2008
Design and development of water-soluble curcumin conjugates as potential anticancer agents
. 50:6284-6288.
2007
Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging
. 50:4759-4765.
2007
Novel boron-containing, nonclassical antifolates: Synthesis and preliminary biological and structural evaluation
. 50:3283-3289.
2007
Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: Amide- and ether-linked tethered dimers with α-amino acid end groups
. 50:2612-2621.
2007
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase
. 49:5939-5946.
2006
Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET.
. 49:942-946.
2006
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety
. 48:5543-5550.
2005
Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands.
. 48:4254-4265.
2005
Identification and characterization of novel benzil (diphenylethane-1,2- dione) analogues as inhibitors of mammalian carboxylesterases
. 48:2906-2915.
2005
Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophophorylation
. 48:2526-2533.
2005
Synthesis and structure-activity relationship studies for hydantoins and analogues as voltage-gated sodium channel ligands
. 47:6519-6528.
2004
Syntheses and Neuraminidase Inhibitory Activity of Multisubstituted Cyclopentane Amide Derivatives
. 47:1919-1929.
2004
Synthesis, Biological Activity and Molecular Modeling of 6-Benzylthioinosine Analogues as Subversive Substrates of Toxoplasma gondii Adenosine Kinase
. 47:1987-1996.
2004
Synthesis, radiosynthesis, and biological evaluation of carbon-11 and iodine-123 labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-haloethenyl)phenyl]tropanes: candidate radioligands for in vivo imaging of the serotonin transporter.
. 47:1122-1135.
2004
Antimycobacterial Agents. 1. Thio Analogues of Purine
. 47:273-276.
2004
Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3′,4′-dihydro-1′(2′H) -naphthalen-1′-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30)
. 46:3766-3769.
2003
Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone
. 46:3865-3876.
2003
Tethered dimers as NAD synthetase inhibitors with antibacterial activity
. 46:3371-3381.
2003
Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.
. 46:925-935.
2003
Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives
. 45:5604-5606.
2002
Enhancement of nucleoside cytotoxicity through nucleotide prodrugs
. 45:4505-4512.
2002
Radiolabeled amino acids for tumor imaging with PET: radiosynthesis and biological evaluation of 2-amino-3-[18F]fluoro-2-methylpropanoic acid and 3-[18F]fluoro-2-methyl-2-(methylamino)propanoic acid.
. 45:2240-2249.
2002
Synthesis of syn- and anti-1-amino-3-[18F]fluoromethyl-cyclobutane-1-carboxylic acid (FMACBC), potential PET ligands for tumor detection.
. 45:2250-2259.
2002
Synthesis and evaluation of several new (2-chloroethyl)nitrosocarbamates as potential anticancer agents
. 43:1484-1488.
2000
Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2β-carbo-1'-fluoro-2-propoxy-3β-(4-chlorophenyl)tropanes. Ligands for the imaging of dopamine transporters by positron emission tomography
. 43:639-648.
2000
Paclitaxel derivatives for targeted therapy of cancer: Toward the development of smart taxanes
. 42:4919-4924.
1999
Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent
. 42:2332-2343.
1999
Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel
. 42:1537-1545.
1999
Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y
1
receptor antagonists and partial agonists
. 42:1625-1638.
1999
Synthesis and biological activity of certain 4'-thio-D- arabinofuranosylpurine nucleosides
. 41:3865-3871.
1998
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias
. 41:1679-1687.
1998
Effects of log P and phenyl ring conformation on the binding of 5- phenylhydantoins to the voltage-dependent sodium channel
. 40:602-607.
1997
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure- activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity
. 39:3625-3635.
1996
Structure-Based Inhibitors of Inñuenza Virus Sialidase. A Benzoic Acid Lead with Novel Interaction
. 38:3217-3225.
1995
Conformationally Defined 6-s-trans-Retinoic Acid Analogs. 2. Selective Agonists for Nuclear Receptor Binding and Transcriptional Activity
. 38:2302-2310.
1995
Search for New Purine- and Ribose-Modified Adenosine Analogues as Selective Agonists and Antagonists at Adenosine Receptors
. 38:1174-1188.
1995
A Conformationally Defined 6-s-trans-Retinoic Acid Isomer: Synthesis, Chemopreventive Activity, and Toxicity
. 37:4499-4507.
1994
3-Amino-5,5-dimethylhexanoic Acid. Synthesis, Resolution, and Effects on Carnitine Acyltransferases
. 37:3247-3251.
1994
Bicyclic Hydantoins with a Bridgehead Nitrogen. Comparison of Anticonvulsant Activities with Binding to the Neuronal Voltage-Dependent Sodium Channel
. 37:3289-3293.
1994
Additions and Corrections: Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 3. 9-Arylmethyl Derivatives of 9-Deazaguanine Substituted on the Methylene Group ((J. Med. Chem. (1993) 36(24) (3771–3783) (10.1021/jm00076a004))
. 37:1034.
1994
Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 4. A Study of Phosphate Mimics
. 37:1109-1114.
1994
Phosphonate Analogs of Carbocyclic Nucleotides
. 37:739-744.
1994
Phenylselenenyl- and Phenylthio-Substituted Pyrimidines as Inhibitors of Dihydrouracil Dehydrogenase and Uridine Phosphorylase
. 36:4250-4254.
1993
Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 1. 9-(Arylmethyl) Derivatives of 9-Deazaguanine
. 36:55-69.
1993
Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 2. 9-Alicyclic and 9-Heteroalicyclic Derivatives of 9-Deazaguanine
. 36:1847-1854.
1993
Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 3. 9-Arylmethyl Derivatives of 9-Deazaguanine Substituted on the Methylene Group
. 36:3771-3783.
1993
Syntheses of 5′-Substituted Analogues of Carbocyclic 3-Deazaadenosine as Potential Antivirals
. 36:2102-2106.
1993
5,5-Disubstituted Hydantoins: Syntheses and Anti-HIV Activity
. 35:3567-3572.
1992
Synthesis and Antiviral Evaluation of N-Carboxamidine-Substituted Analogs of 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamidine Hydrochloride
. 35:3231-3238.
1992
Small Atrial Natriuretic Peptide Analogs: Design, Synthesis, and Structural Requirements for Guanylate Cyclase Activation
. 35:808-816.
1992
Synthesis and Anti-HIV Activity of 4′-Thio-2′,3′-dideoxynucleosides
. 35:533-538.
1992
Synthesis and Biological Activity of 2′-Fluoro-2-halo Derivatives of 9-β-d-Arabinofuranosyladenine
. 35:397-401.
1992
Synthesis and Biological Activity of 2′-Deoxy-4′-thio Pyrimidine Nucleosides
. 34:2361-2366.
1991
Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids.
. 32:1504-1517.
1989
Sodium Channel Binding and Anticonvulsant Activities for the Enantiomers of t Bicyclic 2,4-Oxazolidinedione and Monocyclic Models
. 32:1577-1580.
1989
Anticonvulsant Activities of Phenyl-Substituted Bicyclic 2,4-Oxazolidinediones and Monocyclic Models. Comparison with Binding to the Neuronal Voltage-Dependent Sodium Channel
. 31:2218-2221.
1988
Synthesis and Biological Evaluations of Certain 2-Halo-2'-Substituted Derivatives of 9-β-D-Arabinofuranosyladenine
. 31:405-410.
1988
Resolution of Racemic Carbocyclic Analogues of Purine Nucleosides through the Action of Adenosine Deaminase. Antiviral Activity of the Carbocyclic 2′-Deoxyguanosine Enantiomers
. 30:746-749.
1987
9-(2-Deoxy-2-fluoro-3-D-arabinofuranosy1)guanine: A Metabolically Stable Cytotoxic Analogue of 2’-Deoxyguanosine
. 29:2389-2392.
1986
Synthesis and Biochemical Properties of 8-Amino-6-fluoro-9-β-D-ribofuranosyl-9H-purine
. 29:2069-2074.
1986
2-Fluoroformycin and 2-Aminoformycin. Synthesis and Biological Activity
. 28:1740-1742.
1985
(±)-3-(4-Amino-lif-pyrrolo[2,3-d]pyrimidin-l-yl)-5-(hydroxymethyl)-(lα,2α,3β,5β)-1,2-cyclopentanediol, the Carbocyclic Analogue of Tubercidin
. 27:534-536.
1984
Identification of an Acridine Photoaffinity Probe for Trypanocidal Action
. 27:865-870.
1984
Improved Synthesis And Antitumor Activity Of 2-Bromo-2'-Deoxyadenosine
. 27:800-802.
1984
Synthesis and Anticonvulsant Activity of Some Substituted Lactams and Amides
. 27:202-206.
1984
Synthesis and Biological Evaluation of 2-Fluoro-8-azaadenosine and Related Compounds
. 26:1483-1489.
1983
Identity
International Standard Serial Number (issn)
0022-2623
Electronic International Standard Serial Number (eissn)
1520-4804