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Novel Therapy of Bicarbonate, Glutathione and Ascorbic Acid Improves Cystic Fibrosis Mucus Transport.
C(C)Learing the Role of Chemokines in Pulmonary Fibrosis..
Impaired Myofibroblast Dedifferentiation Contributes to Nonresolving Fibrosis in Aging..
CD70 Activation Decreases Pulmonary Fibroblast Production of Extracellular Matrix Proteins.
PAI-1 regulation of TGF-β1-induced alveolar Type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages.
Inhibition of glutaminase 1 attenuates experimental pulmonary fibrosis.
Vaporized e-cigarette liquids induce ion transport dysfunction in airway epithelia.
What lies beneath: Preformed autoantibodies and lung transplantation.
Fibronectin on the surface of extracellular vesicles mediates fibroblast invasion.
Impairment of fatty acid oxidation in alveolar epithelial cells mediates acute lung injury.
Betting on novel treatments for asthma: Bromodomain 4 inhibitors.
Beyond fibroblast heterogeneity: What single-cell RNA sequencing tells us.
Glutaminolysis epigenetically regulates antiapoptotic gene expression in idiopathic pulmonary fibrosis fibroblasts.
Modeling fibrosis in three-dimensional organoids reveals new epithelial restraints on fibroblasts.
Proline-glycine-proline peptides are critical in the development of smoke-induced emphysema.
Can a Vitamin A day keep tuberculosis away?.
Mechanisms of ventilator-induced lung injury: Is the elafin in the room?.
Whole-genome sequencing in severe chronic obstructive pulmonary disease.
Cellular senescence in chronic obstructive pulmonary disease: Multifaceted and multifunctional.
Collagen biosynthesis in pulmonary fibrosis: Unraveling the metabolic web.
LPS-induced acute lung injury involves NF-kB–mediated downregulation of SOX18.
Most good, least harm: Isoform-specific targeting of ROCK in pulmonary fibrosis.
Systemic markers of adaptive and innate immunity are associated with chronic obstructive pulmonary disease severity and spirometric disease progression.
Glutaminolysis promotes collagen translation and stability via a-ketoglutarate-mediated mTOR activation and proline hydroxylation.
The lung likes the little fella miR-29.
Multiomics approach to asthma: Navigating the network.
An official American thoracic society workshop report: Use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis.
Effect of prenatal versus postnatal Vitamin D deficiency on pulmonary structure and function in mice.
Sex-based genetic association study identifies celsr1 as a possible chronic obstructive pulmonary disease risk locus among women.
MIR-34a inhibits lung fibrosis by inducing lung fibroblast senescence.
Epigenetic regulation of caveolin-1 gene expression in lung fibroblasts.
Susceptibility to childhood pneumonia: A genome-wide analysis.
The cystic fibrosis transmembrane conductance regulator potentiator ivacaftor augments mucociliary clearance abrogating cystic fibrosis transmembrane conductance regulator inhibition by cigarette smoke.
Transplantation of airway epithelial stem/progenitor cells: A future for cell-based therapy.
Bone morphogenic protein type 2 receptor mutation-independent mechanisms of disrupted bone morphogenetic protein signaling in idiopathic pulmonary arterial hypertension.
Endothelial monocyte-activating polypeptide II mediates macrophage migration in the development of hyperoxia-induced lung disease of prematurity.
Airway progenitor clone formation is enhanced by Y-27632-dependent changes in the transcriptome.
Cu,Zn-superoxide dismutase-mediated redox regulation of Jumonji domain containing 3 modulates macrophage polarization and pulmonary fibrosis.
Matrix remodeling in pulmonary fibrosis and emphysema.
MicroRNA-27a-3p is a negative regulator of lung fibrosis by targeting myofibroblast differentiation.
Bik mediates caspase-dependent cleavage of viral proteins to promote influenza a virus infection.
Toll-like receptor 4 engagement mediates prolyl endopeptidase release from airway epithelia via exosomes.
Novel mechanisms for the antifibrotic action of nintedanib.
Alterations in gene expression and DNA methylation during murine and human lung alveolar septation.
Noninvasive imaging of experimental lung fibrosis.
Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs.
Early exposure to hyperoxia or hypoxia adversely impacts cardiopulmonary development.
IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.
Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model.
Sarcoendoplasmic Reticulum Ca21 ATPase A critical target in chlorine inhalation-induced cardiotoxicity.
Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.
Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury..
An autoregulatory mechanism governing mucociliary transport is sensitive to mucus load.
Antifibrinolytic mechanisms in acute airway injury after sulfur mustard analog inhalation.
Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis.
Inter-a-inhibitor blocks epithelial sodium channel activation and decreases nasal potential differences in DF508 mice.
Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor.
Human tracheobronchial basal cells: Normal versus remodeling/repairing phenotypes in vivo and in vitro.
In utero exposure to second-hand smoke aggravates the response to ovalbumin in adult mice.
Ephrin-B2 reverse signaling increases α5β1 integrin-mediated fibronectin deposition and reduces distal lung compliance.
Chlorine induces the unfolded protein response in murine lungs and skin.
Differential regulation of pulmonary vascular cell growth by hypoxia-inducible transcription factor-1a and hypoxia-inducible transcription factor-2α.
Defining lung injury in animals.
Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2.
In utero exposure to second-hand smoke aggravates adult responses to irritants adult second-hand smoke.
Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.
NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy.
Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice.
Thy-1 signals through PPARγ to promote lipofibroblast differentiation in the developing lung.
Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways.
Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation.
Regulation of alveolar epithelial Na + channels by ERK1/2 in chlorine-breathing mice.
Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis.
Hypoxia-inducible factor regulates expression of surfactant protein in alveolar type II cells in vitro.
Enhancement of Respiratory Mucosal Antiviral Defenses by the Oxidation of Iodide.
Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa - Induced lung injury in mice.
Ascorbate and deferoxamine administration after chlorine exposure decrease mortality and lung injury in mice.
Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling.
miR-29 is a major regulator of genes associated with pulmonary fibrosis.
Epigenetic regulation of Thy-1 by histone deacetylase inhibitor in rat lung fibroblasts.
Postexposure administration of a β2-agonist decreases chlorine-induced airway hyperreactivity in mice.
Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: Potential use as a biomarker of ΔF508 cystic fibrosis transmembrane conductance regulator rescue.
Characterization of the epithelial sodium channel δ-subunit in human nasal epithelium.
Respiratory syncytial virus impairs macrophage IFN-α/β- and IFN-γ-stimulated transcription by distinct mechanisms.
Functional stability of rescued ΔF508 cystic fibrosis transmembrane conductance regulator in airway epithelial cells.
Repeated bouts of moderate-intensity aerobic exercise reduce airway reactivity in a murine asthma model.
Highlights of the December issue.
Endothelin-1 and transforming growth factor-β1 independently induce fibroblast resistance to apoptosis via AKT activation.
Highlights of the October issue.
Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis.
α1-Antitrypsin inhibits epithelial Na+ transport in vitro and in vivo.
Highlights of the August issue.
Participation of mammalian target of rapamycin complex 1 in toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury.
Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity.
Highlights of the July issue.
Influenza exerts continued pressure in an era of modern medicine.
Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure.
Expression and regulation of epithelial Na+ channels by nucleotides in pleural mesothelial cells.
Inhibition of Na+ transport in lung epithelial cells by respiratory syncytial virus infection.
Oxygen in the evolution of complex life and the price we pay.
Search and rescue finding ways to correct ΔF508 CFTR.
Highlights of the march issue.
Acute exercise decreases airway inflammation, but not responsiveness, in an allergic asthma model.
α1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro.
Role of oxygen availability in CFTR expression and function.
Thy-1 promoter hypermethylation: A novel epigenetic pathogenic mechanism in pulmonary fibrosis.
Activation of the unfolded protein response by ΔF508 CFTR.
Activation of the unfolded protein response by F508 cystic fibrosis transmembrane conductance regulator.
Developmental regulation of NO-mediated VEGF-induced effects in the lung.
DETANO and nitrated lipids increase chloride secretion across lung airway cells.
Asbestos-induced MKP-3 expression augments TNF-α gene expression in human monocytes.
Human metapneumovirus inhibits IFN-α signaling through inhibition of STAT1 phosphorylation.
The role of red blood cells and hemoglobin-nitric oxide interactions on blood flow.
Decreased asbestos-induced lung inflammation and fibrosis after radiation and bone marrow transplant.
Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae.
Plasminogen activation-induced pericellular fibronectin proteolysis promotes fibroblast apoptosis.
Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection.
Differential expression and oxidation of MKP-1 modulates TNF-α gene expression.
Restoration of W1282X CFTR activity by enhanced expression.
No detectable improvements in cystic fibrosis transmembrane conductance regulator by nasal aminoglycosides in patients with cystic fibrosis with stop mutations.
VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator.
NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I.
Enhanced myofibroblastic differentiation and survival in thy-1(-) lung fibroblasts.
Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection.
Unlocking the mysteries of Na+-K+-ATPase endocytosis: Phosphorylation is the key.
Bactericidal function of alveolar macrophages in mechanically ventilated rabbits.
4-Hydroxynonenal induces rat γ-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.
Involvement of calpain-calpastatin in cigarette smoke-induced inhibition of lung endothelial nitric oxide synthase.
Thrombin increases lung water by decreasing Na,K-ATPase activity.
American Journal of Respiratory Cell and Molecular Biology: Editors' notes.
Role of hypoxia-inducible factor-1α in hypoxia-induced apoptosis of primary alveolar epithelial type II cells.
Altered airway responsiveness in CD38-deficient mice.
Surfactant proteins and inflammation: The Yin and the Yang.
Activation of airway Cl- secretion in human subjects by adenosine.
High levels of catalase and glutathione peroxidase activity dampen H 2O2 signaling in human alveolar macrophages.
Regulation of amiloride-sensitive Na+ transport by basal nitric oxide.
Role of Surfactant Protein-A in Nitric Oxide Production and Mycoplasma Killing in Congenic C57BL/6 Mice.
Trafficking of Th1 Cells to Lung: A Role for Selectins and a P-Selectin Glycoprotein-1-Independent Ligand.
Gene Expression Analysis in response to lung toxicants I. sequencing and microarray development.
Prostaglandin E2 Inhibits Fibroblast to Myofibroblast Transition via E. Prostanoid Receptor 2 Signaling and Cyclic Adenosine Monophosphate Elevation.
Hyperoxia impairs antibacterial function of macrophages through effects on actin.
Increased susceptibility to rsv infection by exposure to inhaled diesel engine emissions.
Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: Role of phosphatidylinositol 3-kinase.
Pseudomonas aeruginosa and tumor necrosis factor-α attenuate Clara cell secretory protein promoter function.
4-Hydroxy-2-nonenal increases γ-glutamylcysteine synthetase gene expression in alveolar epithelial cells.
Early events in naphthalene-induced acute Clara cell toxicity II. Comparison of glutathione depletion and histopathology by airway location.
GM-CSF increases AP-1 DNA binding and Ref-1 amounts in human alveolar macrophages.
Modification of sodium transport and alveolar fluid clearance by hypoxia: Mechanisms and physiological implications.
Na,K-ATPase gene transfer mitigates an oxidant-induced decrease of active sodium transport in rat fetal ATII cells.
A CD36 synthetic peptide inhibits bleomycin-induced pulmonary inflammation and connective tissue synthesis in the rat.
Could asthma be worsened by stimulating the T-helper type 1 immune response?.
Decreased expression of aquaporin (AQP)1 and AQP5 in mouse lung after acute viral infection.
Pulmonary fibrosis. Pathways are slowly coming into light.
Three-dimensional organization of the lamina reticularis in the rat tracheal basement membrane zone.
Both Erk and p38 kinases are necessary for cytokine gene transcription.
Cloning and characterization of KPL2, a novel gene induced during ciliogenesis of tracheal epithelial cells.
Components of human papillomavirus that activate transcription and support plasmid replication in human airway cells.
In vitro culture of microdissected rat nasal airway tissues.
Iron regulates hyperoxia-dependent human heme oxygenase 1 gene expression in pulmonary endothelial cells.
Restoration of the mucous phenotype by retinoic acid in retinoid-deficient human bronchial cell cultures: Changes in mucin gene expression.
Surfactant protein B deficiency worsens hyperoxic injury to the alveolar epithelium.
The attenuated fibroblast sheath of the respiratory tract epithelial-mesenchymal trophic unit.
Inhibition of cell proliferation and induction of apoptosis by the retinoid AHPN in human lung carcinoma cells.
Lipopolysaccharide-induced NF-κB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-PLC-dependent.
Modulation of monocyte chemotactic protein-1 production by hyperoxia: Importance of RNA stability in control of cytokine production.
Identification of Novel Inducible Genes in Airway Epithelium.
Modulation of Adenovirus-mediated Gene Transfer by Nitric Oxide.
Phenotyping and Cytokine Regulation of the BEAS-2B Human Bronchial Epithelial Cell: Demonstration of Inducible Expression of the Adhesion Molecules VCAM-1 and ICAM-1.
Pulmonary Cytochrome P450 Monooxygenase and Clara Cell Differentiation in Mice.
Characterization of a Neutrophil Inhibitor Peptide Harvested from Human Bronchial Lavage: Homology to Influenza A Nucleoprotein.
Differential Enhancement of γ-Glutamyl Transpeptidase and γ-Glutamylcysteine Synthetase by Tert-butylhydroquinone in Rat Lung Epithelial L2 Cells.
Increased γ-Glutamylcysteine Synthetase and γ-Glutamyl Transpeptidase Activities Enhance Resistance of Rat Lung Epithelial L2 Cells to Quinone Toxicity.
Quantitation of the Alveolar Distribution of Surfactant Mixtures in Normal and Injured Lungs.
erbB-2 Knockout Employing an Intracellular Single-chain Antibody (sFv) Accomplishes Specific Toxicity in erbB-2-expressing Lung Cancer Cells.
Pleural mesothelial cell expression of C-C (monocyte chemotactic peptide) and C-X-C (interleukin 8) chemokines..
Release of hydrogen peroxide in response to hypoxia-reoxygenation: role of an NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane..
Differential responsiveness of human bronchial epithelial cells, lung carcinoma cells, and bronchial fibroblasts to interferon-gamma in vitro..
Manganese superoxide dismutase expression in alveolar type II epithelial cells from nonventilated and hypoperfused lungs..
gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells..
Homeobox 1.3 expression: induction by retinoic acid in human bronchial fibroblasts..
Mesothelial cell response to pleural injury: thrombin-induced proliferation and chemotaxis of rat pleural mesothelial cells..
Regulation of type I and type II transglutaminase in normal human bronchial epithelial and lung carcinoma cells..
Production of tumor necrosis factor-alpha by blood and lung mononuclear phagocytes from patients with human immunodeficiency virus-related lung disease..
Human alveolar macrophages release a factor that inhibits phagocyte function..