Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Early-Onset Neonatal Sepsis with Extended Spectrum Beta-Lactamase Producing Escherichia Coli in Infants Born to South and South East Asian Immigrants: A Case Series.American Journal of Perinatology Reports.  8:e277-e279. 2018
2018 Congenital Bilateral Eyelid Eversion and Chemosis: A Case Study.Neonatal Network.  37:137-140. 2018
2018 A case report of chromosome 17q22-qter trisomy with distinct clinical presentation and review of the literature.Clinical Case Reports.  6:612-616. 2018
2016 Trisomy 18: A single-center evaluation of management trends and experience with aggressive obstetric or neonatal intervention.American Journal of Medical Genetics.  170A:838-846. 2016
2016 Trisomy 18: A survey of opinions, attitudes, and practices of neonatologists.American Journal of Medical Genetics.  170:2638-2643. 2016
2015 Topical Nystatin for the Prevention of Catheter-Associated Candidiasis in ELBW Infants.Advances in Neonatal Care.  15:220-224. 2015
2014 Extremely Early Onset IPEX Syndrome Caused by a Novel Small Exonic Deletion in FOXP3.Journal of Pediatric Gastroenterology and Nutrition.  63:e119-e120. 2014
2010 Vitamin A and retinoic acid act synergistically to increase lung retinyl esters during normoxia and reduce hyperoxic lung injury in newborn mice.Pediatric Research.  67:591-597. 2010
2009 A pumpless lung assist device reduces mechanical ventilation-induced lung injury in juvenile piglets.Pediatric Research.  66:671-676. 2009
2009 Evaluation of a pumpless lung assist device in hypoxia-induced pulmonary hypertension in juvenile piglets.Pediatric Research.  66:677-681. 2009
2009 The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trial.Journal of Pediatrics.  154:873-876. 2009
2008 Population structure of invasive and colonizing strains of Streptococcus agalactiae from neonates of six U.S. Academic Centers from 1995 to 1999.Journal of Clinical Microbiology.  46:1285-1291. 2008
2006 Phylogenetic lineages of invasive and colonizing strains of serotype III group B Streptococci from neonates: a multicenter prospective study.Journal of Clinical Microbiology.  44:1257-1261. 2006
2005 Doxycycline inhibits matrix metalloproteinase-2 (MMP-2) production by neonatal pulmonary artery endothelial cellsEthnicity and Disease.  15. 2005
2004 Level of maternal IgG anti-group B streptococcus type III antibody correlated with protection of neonates against early-onset disease caused by this pathogen.Journal of Infectious Diseases.  190:928-934. 2004
2002 Endothelin-A receptor blockade in porcine pulmonary hypertension.Pediatric Research.  52:913-921. 2002
2002 Endothelin-A receptor blockade in porcine pulmonary hypertension.Pediatric Research.  52:913-921. 2002
2002 Feasibility of nitric oxide administration by oxygen hood in neonatal pulmonary hypertensionJournal of Perinatology.  22:50-56. 2002
2002 Feasibility of nitric oxide administration by oxygen hood in neonatal pulmonary hypertension.Journal of Perinatology.  22:50-56. 2002
2001 Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life.Blood.  98:2745-2751. 2001
2001 Level of maternal antibody required to protect neonates against early-onset disease caused by group B Streptococcus type Ia: a multicenter, seroepidemiology study.Journal of Infectious Diseases.  184:1022-1028. 2001
2001 Hemodynamic effects of levcromakalim in neonatal porcine pulmonary hypertension.Biology of the Neonate.  80:74-80. 2001
2001 The effectiveness of risk-based intrapartum chemoprophylaxis for the prevention of early-onset neonatal group B streptococcal disease.American Journal of Obstetrics and Gynecology.  184:1204-1210. 2001
2001 Effect of cigarette smoke extract on neonatal porcine vascular smooth muscle cells.Toxicology and Applied Pharmacology.  170:130-136. 2001
2000 Early expression of iepsilon, CD23 (FcepsilonRII), IL-4Ralpha, and IgE in the human fetus.Journal of Allergy and Clinical Immunology.  106:911-917. 2000
2000 Antibiotic susceptibility profiles for group B streptococci isolated from neonates, 1995-1998.Clinical Infectious Diseases.  31:76-79. 2000
1999 Hypoxia-induced release of peptide growth factors from neonatal porcine pulmonary artery smooth muscle cells.Biology of the Neonate.  76:311-319. 1999
1999 Role of nitric oxide in regulating neonatal porcine pulmonary artery smooth muscle cell proliferation.Biology of the Neonate.  76:291-300. 1999
1998 Antibiotic susceptibility profile of group B streptococcus acquired vertically.Obstetrics and Gynecology.  92:931-934. 1998
1998 Incidence, presenting features, risk factors and significance of late onset septicemia in very low birth weight infants. The National Institute of Child Health and Human Development Neonatal Research Network.Pediatric Infectious Disease Journal.  17:593-598. 1998
1998 Capsular polysaccharide types of group B streptococcal isolates from neonates with early-onset systemic infection.Journal of Infectious Diseases.  177:790-792. 1998
1997 Capsular polysaccharide types of group b streptococcal isolates from neonates wtth early-onset systemic infectionClinical Infectious Diseases.  25:439. 1997
1997 Changing frequency of early-onset group B streptococcal disease(EOGBS) in neonates from 1992 to 1996Clinical Infectious Diseases.  25:409. 1997
1996 Endotoxin induces biphasic alterations in small intestinal myoelectric activity in fasted newborn piglets.Pediatric Research.  40:822-826. 1996
1996 Inhaled nitric oxide in term infants with hypoxemic respiratory failure.Journal of Pediatrics.  129:279-286. 1996
1996 Hyaluronidase promotes gbs invasion in newborn ratsJournal of Investigative Medicine.  44. 1996
1995 Delayed thromboxane or tumor necrosis factor-alpha, but not leukotriene inhibition, attenuates prolonged pulmonary hypertension in endotoxemia.American Journal of the Medical Sciences.  310:103-110. 1995
1994 Effects of cholinergic blockade on hemodynamic disturbances and intestinal lesions in endotoxic shock in newborn piglets.Shock.  2:98-105. 1994
1994 A controlled trial of intravenous immune globulin to reduce nosocomial infections in very-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network.New England Journal of Medicine.  330:1107-1113. 1994
1994 Thromboxane and pulmonary morphometry in the development of the pulmonary hypertensive response to group B streptococcus.Critical Care Medicine.  22:506-514. 1994
1994 Comparison of the effect of three doses of a synthetic surfactant on the alveolar-arterial oxygen gradient in infants weighing > or = 1250 grams with respiratory distress syndrome. American Exosurf Neonatal Study Group II.Journal of Pediatrics.  124:294-301. 1994
1993 A multicenter randomized trial comparing two surfactants for the treatment of neonatal respiratory distress syndrome. National Institute of Child Health and Human Development Neonatal Research Network.Journal of Pediatrics.  123:757-766. 1993
1993 Age-related differences in responses to endotoxin infusion in unanesthetized piglets.Circulatory shock.  41:40-47. 1993
1993 Decreasing mortality associated with the introduction of surfactant therapy: an observational study of neonates weighing 601 to 1300 grams at birth. The Members of the National Institute of Child Health and Human Development Neonatal Research Network.Pediatrics.  92:191-196. 1993
1993 Capsular type-specific polysaccharide partially inhibits group B Streptococcus-induced pulmonary hypertension.The American review of respiratory disease.  148:152-157. 1993
1993 Diabetes insipidus associated with symptomatic congenital cytomegalovirus infection.Journal of Pediatrics.  122:911-913. 1993
1993 Low-dose aspirin therapy to prevent preeclampsia.American Journal of Obstetrics and Gynecology.  168:1083-1091. 1993
1993 Predicting mortality risk for infants weighing 501 to 1500 grams at birth: a National Institutes of Health Neonatal Research Network report.Critical Care Medicine.  21:12-18. 1993
1992 Role of capsule in pulmonary hypertension induced by group B streptococcus.Pediatric Research.  31:386-390. 1992
1992 Delayed thromboxane synthesis inhibition, but not cholinergic blockade, reverses group B streptococcus-induced pulmonary hypertension.Developmental pharmacology and therapeutics.  19:40-49. 1992
1991 Fused eyelids, airway anomalies, ovarian cysts, and digital abnormalities in siblings: a new autosomal recessive syndrome or a variant of Fraser syndrome?American Journal of Medical Genetics.  40:377-382. 1991
1990 Routine use of intraoperative epicardial echocardiography and Doppler color flow imaging to guide and evaluate repair of congenital heart lesions. A prospective study.Journal of Thoracic and Cardiovascular Surgery.  100:297-309. 1990
1990 Effects of position changes on transcutaneous carbon dioxide tension in neonates with respiratory distress.Journal of Perinatology.  10:35-37. 1990
1989 Intraventricular haemorrhage and the renin-angiotensin-aldosterone system in very low birthweight infants.Early Human Development.  20:101-107. 1989
1989 A randomized, controlled trial of very early prophylactic ligation of the ductus arteriosus in babies who weighed 1000 g or less at birth.New England Journal of Medicine.  320:1511-1516. 1989
1989 The stability and short-term fluctuation in serum oxytocinase activity in pregnancy.Journal of the International Federation of Gynaecology and Obstetrics.  28:331-335. 1989
1989 Ureaplasmal pneumonia and sepsis associated with persistent pulmonary hypertension of the newborn.Pediatrics.  83:79-85. 1989
1988 Hemodynamic responses of chronically instrumented piglets to bolus injections of group B streptococci.Pediatric Research.  23:81-85. 1988
1987 Capillary and venous bilirubin values. Are they really different?American journal of diseases of children (1960).  141:1199-1200. 1987
1987 Thromboxane synthesis inhibition reverses group B Streptococcus-induced pulmonary hypertension.Critical Care Medicine.  15:644-647. 1987
1987 Low colloid osmotic pressure in very low birthweight infants receiving assisted ventilation.Australian paediatric journal.  23:189-192. 1987
1986 The effect of assisted ventilation on creatinine clearance and hormonal control of electrolyte balance in very low birth weight infants.Pediatric Research.  20:447-452. 1986
1986 Effect of application pressure and gestational age on transfontanel pressure in healthy neonates.Biology of the Neonate.  50:136-140. 1986
1986 Influence of prostaglandin D2 on hemodynamic effects of group B streptococcus in neonatal lambs.Developmental pharmacology and therapeutics.  9:260-265. 1986
1985 Alkalosis attenuates hypoxic pulmonary vasoconstriction in neonatal lambs.Pediatric Research.  19:1268-1271. 1985
1985 ReplyAmerican Journal of Obstetrics and Gynecology.  153:594-595. 1985
1985 Surgical closure of patent ductus arteriosus does not increase the risk of intraventricular hemorrhage in the preterm infant.Journal of Pediatrics.  107:602-604. 1985
1985 Fatal meconium aspiration syndrome occurring despite airway management considered appropriate.American Journal of Obstetrics and Gynecology.  151:731-736. 1985
1985 Hemodynamic effects of nifedipine in normoxic and hypoxic newborn lambs.Pediatric pharmacology (New York, N.Y.).  5:23-30. 1985
1984 Control of pulmonary vascular resistance in the fetus and newborn.Clinics in Perinatology.  11:551-564. 1984
1984 Characteristics, mortality, and outcome of higher-birth weight infants who require intensive care.American Journal of Obstetrics and Gynecology.  149:875-879. 1984
1984 Pharmacokinetics of cefoperazone in newborn infants.Pediatric pharmacology (New York, N.Y.).  4:193-197. 1984
1984 Prostaglandins and related compounds in the perinatal pulmonary circulation.Pediatric pharmacology (New York, N.Y.).  4:129-142. 1984
1983 Prostaglandin D2 inhibits hypoxic pulmonary vasoconstriction in neonatal lambs.Journal of applied physiology: respiratory, environmental and exercise physiology.  54:1585-1589. 1983
1983 ReplyJournal of Pediatrics.  103:173-174. 1983
1983 The accuracy of amikacin administration in neonates.Pediatric pharmacology (New York, N.Y.).  3:127-130. 1983
1982 Subspecialty training in pediatrics: an academic model.Journal of medical education.  57:720-721. 1982
1982 Radionuclide angiography in the evaluation of ductal shunts in preterm infants.Journal of Pediatrics.  101:264-268. 1982
1982 Amikacin: pharmacology, indications and cautions for use, and dose recommendations.Seminars in Perinatology.  6:166-171. 1982
1982 Prostaglandin D2prevents hypoxic pulmonary vasoconstriction in neonatal lambsPediatric Research.  16. 1982
1982 Recommended amikacin doses in newborns often produce excessive serum levels.Pediatric pharmacology (New York, N.Y.).  2:121-125. 1982
1981 Coronary sinus thrombosis: a central venous catheter complication.Journal of Pediatric Surgery.  16:733-734. 1981
1981 Effects of prostaglandin D2 on perinatal circulation.American Journal of Physiology.  240:H755-H760. 1981
1981 Effects of prostacyclin on the fetal pulmonary circulation.Pediatric pharmacology (New York, N.Y.).  1:197-207. 1981
1981 Effects of prostaglandin D2on perinatal circulationAJP - Heart and Circulatory Physiology.  9. 1981
1981 Recommended amikacin doses in newborns often produce excessive serum levelsPediatric Research.  15:355. 1981
1980 Effect of positive end-expiratory pressure on dynamic respiratory compliance in neonates.Biology of the Neonate.  38:270-275. 1980
1980 Fetal vascular responses to prostaglandin I2(PGI2) and D2(PGD2)Pediatric Research.  14. 1980
1979 Use of prostacyclin in persistent fetal circulation.Lancet.  2:638. 1979
1979 Hypoxaemia in ventilated neonates after pancuronium paralysis.Lancet.  1:877. 1979
1979 Fetal vascular responses to prostaglandin I2(PGI2)Clinical research.  27. 1979
1979 Hypoxaemia in ventilated neonates after pancuronium paralysisLancet.  1:1095. 1979
1979 The response of the perinatal pulmonary circulation to prostaglandinD2Physiologist.  22:124. 1979

Research Overview

  • Primary laboratory research interests concern the regulation of fetal and neonatal pulmonary vascular tone and remodeling during normal development and in the pathophysiology of major diseases of neonates, such as persistent pulmonary hypertension, bronchopulmonary dysplasia, and sepsis. Whole animal models are used to elucidate the mechanisms of Group B streptococcus and hypoxia-induced pulmonary hypertension and to test potential remedies. Tissue culture is used to explore the role of oxygen tension, pH, and peptide growth factors and other signaling molecules in pulmonary vascular smooth muscle cell growth and remodeling. Clinical research interests include persistent pulmonary hypertension of the newborn, bronchopulmonary dysplasia, sepsis, neonatal immunity, necrotizing enterocolitis, and controlled clinical trials.
  • Principal Investigator On

  • Private Grant  awarded by IKARIA 2013
  • Education And Training

  • Doctor of Medicine, University of North Carolina System : Chapel Hill
  • Mount Sinai Hospital, Internship 1976
  • Duke University Medical Center, Residency 1978
  • Mount Sinai Hospital, Residency 1977
  • University of Florida/Shands Hospital, Postdoctoral Fellowship 1980
  • Full Name

  • Joseph Philips
  • Blazerid

  • jphilips