Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Congenital bilateral eyelid eversion and chemosis: A case studyNeonatal Network.  37:137-140. 2018
2018 A case report of chromosome 17q22-qter trisomy with distinct clinical presentation and review of the literature.Clinical Case Reports.  6:612-616. 2018
2018 Early-Onset Neonatal Sepsis with Extended Spectrum Beta-Lactamase Producing Escherichia Coli in Infants Born to South and South East Asian Immigrants: A Case SeriesAmerican Journal of Perinatology Reports.  8:e277-e279. 2018
2016 Trisomy 18: A survey of opinions, attitudes, and practices of neonatologistsAmerican Journal of Medical Genetics.  170:2638-2643. 2016
2016 Trisomy 18: A single-center evaluation of management trends and experience with aggressive obstetric or neonatal interventionAmerican Journal of Medical Genetics.  170:838-846. 2016
2015 Topical nystatin for the prevention of catheter-associated candidiasis in ELBW infantsAdvances in Neonatal Care.  15:220-224. 2015
2014 Extremely early onset IPEX syndrome caused by a novel small exonic deletion in FOXP3Journal of Pediatric Gastroenterology and Nutrition2014
2010 Vitamin A and retinoic acid act synergistically to increase lung retinyl esters during normoxia and reduce hyperoxic lung injury in newborn micePediatric Research.  67:591-597. 2010
2009 A pumpless lung assist device reduces mechanical ventilation-induced lung injury in juvenile pigletsPediatric Research.  66:671-676. 2009
2009 Evaluation of a pumpless lung assist device in hypoxia-induced pulmonary hypertension in juvenile pigletsPediatric Research.  66:677-681. 2009
2009 The Role of Patent Ductus Arteriosus Ligation in Bronchopulmonary Dysplasia: Reexamining a Randomized Controlled TrialJournal of Pediatrics.  154:873-876. 2009
2008 Population structure of invasive and colonizing strains of Streptococcus agalactiae from neonates of six U.S. academic centers from 1995 to 1999Journal of Clinical Microbiology.  46:1285-1291. 2008
2006 Phylogenetic lineages of invasive and colonizing strains of serotype III group B streptococci from neonates: A multicenter prospective studyJournal of Clinical Microbiology.  44:1257-1261. 2006
2005 Doxycycline inhibits matrix metalloproteinase-2 (MMP-2) production by neonatal pulmonary artery endothelial cellsEthnicity and Disease.  15. 2005
2004 Level of maternal IgG anti-group B streptococcus type III antibody correlated with protection of neonates against early-onset disease caused by this pathogenJournal of Infectious Diseases.  190:928-934. 2004
2002 Endothelin-A receptor blockade in porcine pulmonary hypertensionPediatric Research.  52:913-921. 2002
2002 Endothelin-A receptor blockade in porcine pulmonary hypertension.Pediatric Research.  52:913-921. 2002
2002 Feasibility of nitric oxide administration by oxygen hood in neonatal pulmonary hypertensionJournal of Perinatology.  22:50-56. 2002
2002 Feasibility of nitric oxide administration by oxygen hood in neonatal pulmonary hypertension.Journal of Perinatology.  22:50-56. 2002
2001 Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal lifeBlood.  98:2745-2751. 2001
2001 Level of maternal antibody required to protect neonates against early-onset disease caused by group B streptococcus type Ia: A multicenter, seroepidemiology studyJournal of Infectious Diseases.  184:1022-1028. 2001
2001 Hemodynamic effects of levcromakalim in neonatal porcine pulmonary hypertensionBiology of the Neonate.  80:74-80. 2001
2001 Effect of cigarette smoke extract on neonatal porcine vascular smooth muscle cellsToxicology and Applied Pharmacology.  170:130-136. 2001
2001 The effectiveness of risk-based intrapartum chemoprophylaxis for the prevention of early-onset neonatal group B streptococcal diseaseAmerican Journal of Obstetrics and Gynecology.  184:1204-1210. 2001
2000 Antibiotic susceptibility profiles for group B streptococci isolated from neonates, 1995-1998Clinical Infectious Diseases.  31:76-79. 2000
2000 Early expression of Iε, CD23 (FcεRII), IL-4Rα, and IgE in the human fetusJournal of Allergy and Clinical Immunology.  106:911-917. 2000
1999 Role of nitric oxide in regulating neonatal porcine pulmonary artery smooth muscle cell proliferationBiology of the Neonate.  76:291-300. 1999
1999 Hypoxia-induced release of peptide growth factors from neonatal porcine pulmonary artery smooth muscle cellsBiology of the Neonate.  76:311-319. 1999
1998 Antibiotic susceptibility profile of group B streptococcus acquired verticallyObstetrics and Gynecology.  92:931-934. 1998
1998 Capsular polysaccharide types of group B streptococcal isolates from neonates with early-onset systemic infectionJournal of Infectious Diseases.  177:790-792. 1998
1998 Incidence, presenting features, risk factors and significance of late onset septicemia in very low birth weight infantsPediatric Infectious Disease Journal.  17:593-598. 1998
1997 Capsular polysaccharide types of group b streptococcal isolates from neonates wtth early-onset systemic infectionClinical Infectious Diseases.  25:439. 1997
1997 Changing frequency of early-onset group B streptococcal disease(EOGBS) in neonates from 1992 to 1996Clinical Infectious Diseases.  25:409. 1997
1996 Endotoxin induces biphasic alterations in small intestinal myoelectric activity in fasted newborn pigletsPediatric Research.  40:822-826. 1996
1996 Hyaluronidase promotes gbs invasion in newborn ratsJournal of Investigative Medicine.  44. 1996
1996 Inhaled nitric oxide in term infants with hypoxemic respiratory failureJournal of Pediatrics.  129:279-286. 1996
1995 Delayed thromboxane or tumor necrosis factor-α, but not leukotriene inhibition, attenuates prolonged pulmonary hypertension in endotoxemiaAmerican Journal of the Medical Sciences.  310:103-110. 1995
1994 A controlled trial of intravenous immune globulin to reduce nosocomial infections in very-low-birth-weight infantsNew England Journal of Medicine.  330:1107-1113. 1994
1994 Comparison of the effect of three doses of a synthetic surfactant on the alveolar-arterial oxygen gradient in infants weighing ≥1250 grams with respiratory distress syndromeJournal of Pediatrics.  124:294-301. 1994
1994 Effects of cholinergic blockade on hemodynamic disturbances and intestinal lesions in endotoxic shockin newborn pigletsShock.  2:98-105. 1994
1994 Thromboxane and pulmonary morphometry in the development of the pulmonary hypertensive response to group B streptococcusCritical Care Medicine.  22:506-514. 1994
1993 A multicenter randomized trial comparing two surfactants for the treatment of neonatal respiratory distress syndromeJournal of Pediatrics.  123:757-766. 1993
1993 Age-related differences in responses to endotoxin infusion in unanesthetized pigletsCirculatory shock.  41:40-47. 1993
1993 Capsular type-specific polysaccharide partially inhibits group B streptococcus-induced pulmonary hypertensionThe American review of respiratory disease.  148:152-157. 1993
1993 Decreasing mortality associated with the introduction of surfactant therapy: An observational study of neonates weighing 601 to 1300 grams at birthPediatrics.  92:191-196. 1993
1993 Diabetes insipidus associated with symptomatic congenital cytomegalovirus infectionJournal of Pediatrics.  122:911-913. 1993
1993 Low-dose aspirin therapy to prevent preeclampsiaAmerican Journal of Obstetrics and Gynecology.  168:1083-1093. 1993
1993 Predicting mortality risk for infants weighing 501 to 1500 grams at birth: A National Institutes of Health Neonatal Research Network reportCritical Care Medicine.  21:12-18. 1993
1992 Delayed thromboxane synthesis inhibition, but not cholinergic blockade, reverses group B streptococcus-induced pulmonary hypertensionDevelopmental pharmacology and therapeutics.  19:40-49. 1992
1992 Role of capsule in pulmonary hypertension induced by Group B streptococcusPediatric Research.  31:386-390. 1992
1991 Fused eyelids, airway anomalies, ovarian cysts, and digital abnormalities in siblings: A new autosomal recessive syndrome or a variant of Fraser syndrome?American Journal of Medical Genetics.  40:377-382. 1991
1990 Routine use of intraoperative epicardial echocardiography and Doppler color flow imaging to guide and evaluate repair of congenital heart lesions. A prospective study.Journal of Thoracic and Cardiovascular Surgery.  100:297-309. 1990
1990 Effects of position changes on transcutaneous carbon dioxide tension in neonates with respiratory distress.Journal of Perinatology.  10:35-37. 1990
1989 A Randomized, Controlled Trial of Very Early Prophylactic Ligation of the Ductus Arteriosus in Babies Who Weighed 1000 g or Less at BirthNew England Journal of Medicine.  320:1511-1516. 1989
1989 Intraventricular haemorrhage and the renin-angiotensin-aldosterone system in very low birthweight infantsEarly Human Development.  20:101-107. 1989
1989 The stability and short-term fluctuation in serum oxytocinase activity in pregnancyJournal of the International Federation of Gynaecology and Obstetrics.  28:331-335. 1989
1989 Ureaplasmal pneumonia and sepsis associated with persistent pulmonary hypertension of the newbornPediatrics.  83:79-85. 1989
1988 Hemodynamic responses of chronically instrumented piglets to bolus injections of group B streptococciPediatric Research.  23:81-85. 1988
1987 Capillary and Venous Bilirubin Values: Are They Really Different?American journal of diseases of children (1960).  141:1199-1200. 1987
1987 Low colloid osmotic pressure in very low birthweight infants receiving assisted ventilationJournal of Paediatrics and Child Health.  23:189-192. 1987
1987 Thromboxane synthesis inhibition reverses group B Streptococcus-induced pulmonary hypertensionCritical Care Medicine.  15:644-647. 1987
1986 Effect of application pressure and gestational age on transfontanel pressure in healthy neonatesBiology of the Neonate.  50:136-140. 1986
1986 Influence of prostaglandin D2on hemodynamic effects of group B streptococcus in neonatal lambsDevelopmental pharmacology and therapeutics.  9:260-265. 1986
1986 The effect of assisted ventilation on creatinine clearance and hormonal control of electrolyte balance in very low birth weight infantsPediatric Research.  20:447-452. 1986
1985 ReplyAmerican Journal of Obstetrics and Gynecology.  153:594-595. 1985
1985 Hemodynamic effects of nifedipine in normoxic and hypoxic newborn lambsPediatric pharmacology (New York, N.Y.).  5:23-30. 1985
1985 Fatal meconium aspiration syndrome occurring despite airway management considered appropriateAmerican Journal of Obstetrics and Gynecology.  151:731-736. 1985
1985 Alkalosis attenuates hypoxic pulmonary vasoconstriction in neonatal lambsPediatric Research.  19:1268-1271. 1985
1985 Surgical closure of patent ductus arteriosus does notincrease the risk of intraventricular hemorrhage in the preterm infantJournal of Pediatrics.  107:602-604. 1985
1984 Pharmacokinetics of cefoperazone in newborn infantsPediatric pharmacology (New York, N.Y.).  4:193-197. 1984
1984 Characteristics, mortality, and outcome of higher-birth weight infants who require intensive careAmerican Journal of Obstetrics and Gynecology.  149:875-879. 1984
1984 Control of pulmonary vascular resistance in the fetus and newbornClinics in Perinatology.  11:551-564. 1984
1984 Prostaglandins and related compounds in the perinatal pulmonary circulationPediatric pharmacology (New York, N.Y.).  4:129-142. 1984
1983 The accuracy of amikacin administration in neonatesPediatric pharmacology (New York, N.Y.).  3:127-130. 1983
1983 Prostaglandin D2inhibits hypoxic pulmonary vasoconstriction in neonatal lambsJournal of applied physiology: respiratory, environmental and exercise physiology.  54:1585-1589. 1983
1983 ReplyJournal of Pediatrics.  103:173-174. 1983
1982 Recommended amikacin doses in newborns often produce excessive serum levelsPediatric pharmacology (New York, N.Y.).  2:121-125. 1982
1982 Amikacin: Pharmacology, indications and cautions for use, and dose recommendationsSeminars in Perinatology.  6:166-171. 1982
1982 Prostaglandin D2prevents hypoxic pulmonary vasoconstriction in neonatal lambsPediatric Research.  16. 1982
1982 Radionuclide angiography in the evaluation of ductal shunts in preterm infantsJournal of Pediatrics.  101:264-268. 1982
1982 Subspecialty training in pediatrics: An academic modelJournal of medical education.  57:720-721. 1982
1982 Subspecialty training in pediatrics: An academic modelAcademic Medicine.  57:720-721. 1982
1981 Effects of prostacyclin on the fetal pulmonary circulationPediatric pharmacology (New York, N.Y.).  1:197-207. 1981
1981 Effects of prostaglandin D2 on perinatal circulation.American Journal of Physiology.  240. 1981
1981 Coronary sinus thrombosis: A central venous catheter complicationJournal of Pediatric Surgery.  16:733-734. 1981
1981 Effects of prostaglandin D2on perinatal circulationAJP - Heart and Circulatory Physiology.  9. 1981
1981 Recommended amikacin doses in newborns often produce excessive serum levelsPediatric Research.  15:355. 1981
1980 Effect of positive end-expiratory pressure on dynamic respiratory compliance in neonatesBiology of the Neonate.  38:270-275. 1980
1980 Fetal vascular responses to prostaglandin I2(PGI2) and D2(PGD2)Pediatric Research.  14. 1980
1979 USE OF PROSTACYCLIN IN PERSISTENT FETAL CIRCULATIONLancet.  314:638. 1979
1979 HYPOXÆMIA IN VENTILATED NEONATES AFTER PANCURONIUM PARALYSISLancet.  313:877. 1979
1979 Fetal vascular responses to prostaglandin I2(PGI2)Clinical research.  27. 1979
1979 Hypoxaemia in ventilated neonates after pancuronium paralysisLancet.  1:1095. 1979
1979 The response of the perinatal pulmonary circulation to prostaglandinD2Physiologist.  22:124. 1979

Research Overview

  • Primary laboratory research interests concern the regulation of fetal and neonatal pulmonary vascular tone and remodeling during normal development and in the pathophysiology of major diseases of neonates, such as persistent pulmonary hypertension, bronchopulmonary dysplasia, and sepsis. Whole animal models are used to elucidate the mechanisms of Group B streptococcus and hypoxia-induced pulmonary hypertension and to test potential remedies. Tissue culture is used to explore the role of oxygen tension, pH, and peptide growth factors and other signaling molecules in pulmonary vascular smooth muscle cell growth and remodeling. Clinical research interests include persistent pulmonary hypertension of the newborn, bronchopulmonary dysplasia, sepsis, neonatal immunity, necrotizing enterocolitis, and controlled clinical trials.
  • Education And Training

  • Doctor of Medicine, University of North Carolina System : Chapel Hill 1975
  • Mount Sinai Hospital, Internship 1976
  • Duke University Medical Center, Residency 1978
  • Mount Sinai Hospital, Residency 1977
  • University of Florida/Shands Hospital, Postdoctoral Fellowship 1980
  • Full Name

  • Joseph Philips