Selected Publications

Academic Article

Year Title Altmetric
2022 CD206+ resident macrophages are a candidate biomarker for renal cystic disease in preclinical models and patients with ADPKD.Disease Models and Mechanisms2022
2022 Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutantsDisease Models and Mechanisms.  15. 2022
2022 Reduced sister chromatid cohesion acts as a tumor penetrance modifierPLoS Genetics.  18. 2022
2022 Evolutionarily conserved genetic interactions between nphp-4 and bbs-5 mutations exacerbate ciliopathy phenotypes 2022
2021 Genotype–phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders 2021
2021 Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosisCell Death and Disease.  12. 2021
2020 Human transcription factors responsive to initial reprogramming predominantly undergo legitimate reprogramming during fibroblast conversion to iPSCsScientific Reports.  10. 2020
2019 Truncating PKHD1 and PKD2 mutations alter energy metabolism 2019
2016 Observing mitotic division and dynamics in a live zebrafish embryoJournal of Visualized Experiments.  2016. 2016
2016 Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human DiseasePLoS Genetics.  12. 2016
2016 Approaches to inactivate genes in zebrafishAdvances in Experimental Medicine and Biology.  916:61-86. 2016
2015 Erratum: Activity suppression behavior phenotype in SULT4A1 frameshift mutant zebrafish (Drug Metabolism and Disposition (2015) 43 (1037-1044))Drug Metabolism and Disposition.  43:1284. 2015
2015 Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndromeDisease Models and Mechanisms.  8:941-955. 2015
2015 Activity suppression behavior phenotype in SULT4A1 frameshift mutant zebrafishDrug Metabolism and Disposition.  43:1037-1044. 2015
2014 High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysisPLoS One.  9. 2014
2014 Inhibition of sult4a1 expression induces up-regulation of phototransduction gene expression in 72-hour postfertilization zebrafish larvaeDrug Metabolism and Disposition.  42:947-953. 2014
2010 Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repairOncogene.  29:6125-6137. 2010
2010 Genetic modeling of Li-Fraumeni syndrome in zebrafishDisease Models and Mechanisms.  3:45-56. 2010
2009 A rapid and efficient method of genotyping zebrafish mutantsDevelopmental Dynamics.  238:3168-3174. 2009
2008 EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse modelCancer Research.  68:8968-8975. 2008
2008 Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethalityOncogene.  27:4122-4127. 2008
2008 Mtbp haploinsufficiency in mice increases tumor metastasisOncogene.  27:1813-1820. 2008
2007 The Tol2kit: A multisite gateway-based construction Kit for Tol2 transposon transgenesis constructsDevelopmental Dynamics.  236:3088-3099. 2007
2006 Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4Molecular and Cellular Biology.  26:192-198. 2006
2005 Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor 2005
2004 Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndromeCell.  119:861-872. 2004
2004 Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null miceOncogene.  23:7644-7650. 2004
2004 Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant miceNature Genetics.  36:63-68. 2004
2003 Switching Mechanisms of Cell Death in mdm2- and mdm4-null Mice by Deletion of p53 Downstream TargetsCancer Research.  63:8664-8669. 2003
2003 Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradationCell.  112:779-791. 2003
2003 Disrupting TP53 in mouse models of human cancersHuman Mutation.  21:321-326. 2003
2002 Mutual dependence of MDM2 and MDMX in their functional inactivation of p53Journal of Biological Chemistry.  277:19251-19254. 2002
2001 Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53Nature Genetics.  29:92-95. 2001
2001 Organization, expression, and localization of the murine mdmx gene and pseudogeneGene.  270:277-283. 2001
2001 Differential roles of p21Waf1 and p27Kip1 in modulating chemosensitivity and their possible application in drug discovery studiesMolecular Pharmacology.  60:900-906. 2001

Education And Training

  • Doctor of Philosophy in Biomedical Sciences, University of Texas System : Health Science Center-Houston 2001
  • Full Name

  • John Parant