Positions

Selected Publications

Academic Article

Year Title Altmetric
2016 Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies 2016
2016 Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145-149 2016
2012 Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles. 2012
2010 Pathway modulators and inhibitors 2010
2010 Analysis of proteins: Introduction 2010
2010 Current Protocols in Molecular Biology: Preface 2010
2009 Pathway modulators and inhibitors. 2009
2008 Diagnosis of thrombotic thrombocytopenic purpura with normal ADAMTS13 activity and absence of its inhibitor (anti-ADAMTS13 antibodies) 2008
2007 Performance of the Sebia CAPILLARYS 2 for detection and immunotyping of serum monoclonal paraproteins 2007
2007 Bio*Medical informatics and genomic medicine: Research and training 2007
2007 Electrospray ionisation-cleavable tandem nucleic acid mass tag-peptide nucleic acid conjugates: Synthesis and applications to quantitative genomic analysis using electrospray ionisation-MS/MS 2007
2006 Timing of plasma exchange and rituximab for the treatment of thrombotic thrombocytopenic purpura [1] 2006
2006 Solution radioimmunoassay of proteins and peptides. 2006
2006 Spectrophotometric and colorimetric determination of protein concentration. 2006
2002 Electroelution of proteins from stained gels. 2002
2001 Column chromatography of antibodies and fragments. 2001
1999 Continuous quality improvement for point-of-care testing using background monitoring of duplicate specimens 1999
1999 Cost analysis for decision support: The case of comparing centralized versus distributed methods for blood gas testing 1999
1999 Curbing overutilization: the silver lining to HCFA compliance. 1999
1999 Estimating costs and turnaround times: presenting a user-friendly tool for analyzing costs and performance. 1999
1998 Evaluating stat testing options in an academic health center: Therapeutic turnaround time and staff satisfaction 1998
1998 Stark choices for AHCs 1998
1997 A N(alpha)-acetyltransferase selectively transfers an acetyl group to NH2-terminal methionine residues: purification and partial characterization. 1997
1997 A N(α)-acetyltransferase selectively transfers an acetyl group to NH2-terminal methionine residues: Purification and partial characterization 1997
1997 Streptococcus pyogenes type 5 M protein is an antigen, not a superantigen, for human T cells 1997
1997 Training of doctors in the UK. 1997
1997 Using patient satisfaction as an indicator of the quality of laboratory services. Applying social science methods to evaluate outcomes in laboratory medicine. 1997
1996 Acetyl-CoA hydrolase involved in acetate utilization in Saccharomyces cerevisiae 1996
1996 Automating clinical practice guidelines: A corporate-academic partnership 1996
1995 Different forms of Streptolysin O produced by Streptococcus pyogenes and by Escherichia coli expressing recombinant toxin: Cleavage by streptococcal cysteine protease 1995
1993 Immunodominance: A single amino acid substitution within an antigenic site alters intramolecular selection of T cell determinants 1993
1993 Isolation of a membrane-associated cathepsin D-like enzyme from the model antigen presenting cell, A20, and its ability to generate antigenic fragments from a protein antigen in a cell-free system 1993
1993 Mapping of the glycoprotein 330 (gp330) gene to mouse chromosome 2 1993
1992 Immunodominance: Intermolecular competition between MHC class II molecules by covalently linked T cell epitopes 1992
1992 Molecular cloning, sequencing, deletion, and overexpression of a methionine aminopeptidase gene from Saccharomyces cerevisiae 1992
1992 Silencing of immunodominant epitopes by contiguous sequences in complex synthetic peptides 1992
1991 Optimization of the Fragmentation in a Frit-Fast Atom Bombardment Ion Source for the Sequencing of Peptides at the Picomole Level 1991
1991 Comparison of class I‐ and II‐restricted T cell recognition of the identical peptide 1991
1991 Immunodominance: Intramolecular competition between T cell epitopes 1991
1991 Primary Structure Determination of Peptides and Enzymatically Digested Proteins Using Capillary Liquid Chromatography/Mass Spectrometry and Rapid Linked-Scan Techniques 1991
1991 Single amino acid substitution alters T cell determinant selection during antigen processing of Staphylococcus aureus nuclease 1991
1990 Purification and characterization of a methionine aminopeptidase from Saccharomyces cerevisiae 1990
1990 Model peptides reveal specificity of N(α)-acetyltransferase from Saccharomyces cerevisiae 1990
1990 A glucose-repressible gene encodes acetyl-CoA hydrolase from Saccharomyces cerevisiae 1990
1990 Identification of methionine N(α)-acetyltransferase from Saccharomyces cerevisiae 1990
1990 Freshly isolated Thy-1+ dendritic epidermal cells express T cell receptor γδ-CD3 1990
1990 Immunological activity of covalently linked T-cell epitopes 1990
1989 N alpha acetylation is required for normal growth and mating of Saccharomyces cerevisiae. 1989
1989 Nα-acetyltransferase deficiency alters protein synthesis in Saccharomyces cerevisiae 1989
1989 Structural organization of the rat acyl-peptide hydrolase gene. 1989
1989 Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor 1989
1989 Cloning and sequence analysis of a rat liver cDNA encoding acyl-peptide hydrolase 1989
1989 High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons 1989
1989 Identical peptides recognized by MHC class I- and II-restricted T cells 1989
1989 Molecular cloning and sequencing of a cDNA encoding N(α)-acetyltransferase from Saccharomyces cerevisiae 1989
1989 Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae 1989
1989 Murine MHC polymorphism and T cell specificities 1989
1989 N(α) acetylation is required for normal growth and mating of Saccharomyces cerevisiae 1989
1989 Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis 1989
1989 Purification and characterization of an acetyl‐CoA hydrolase from Saccharomyces cerevisiae 1989
1989 Relative contribution of 'determinant selection' and 'holes in the T-cell repertoire' to T-cell responses 1989
1988 Rapid separation of DNA restriction fragments using capillary electrophoresis 1988
1988 Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells 1988
1988 Identification of distinct C3B and C4B recognition sites in the human C3B/C4B receptor (Cri, Cd35) by deletion mutagenesis 1988
1988 T cell receptor gene usage in the response to γ repressor cI protein: An apparent bias in the usage of a Vα gene element 1988
1988 Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1 1988
1988 Characterization of the catalytic domain of bovine adrenal tyrosine hydroxylase 1988
1988 Structure of the human B lymphocyte receptor for C3d and the epstein-barr virus and relatedness to other members of the family of C3/C4 binding proteins 1988
1988 Eosinophil granule cationic proteins: Major basic protein is distinct from the smaller subunit of eosinophil peroxidase 1988
1988 Eosinophilic Chemotactic Factors of Anaphylaxis 1988
1988 Purification and characterization of an N alpha-acetyltransferase from Saccharomyces cerevisiae. 1988
1988 Rapid separation and purification of oligonucleotides by high-performance capillary gel electrophoresis 1988
1988 Sequence determination of the mumps virus HN gene 1988
1987 T lymphocyte response to bacteriophage λ repressor cI protein. Recognition of the same peptide presented by Ia molecules of different haplotypes 1987
1987 Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction. 1987
1987 Human C3B/C4B receptor (CR1): Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristic of C3/C4 binding proteins 1987
1987 A peptide binding protein which plays a role in antigen presentation. 1987
1987 A rat histone H4 gene closely associated with the testis-specific H1t gene 1987
1987 Complete Amino Acid Sequences of the Heavy and Light Chain Variable Regions from Two A/J Mouse Antigen Nonbinding Monoclonal Antibodies Bearing the Predominant p-Azophenyl Arsonate Idiotype 1987
1987 High-Performance Capillary Electrophoretic Separation of Bases, Nucleosides, and Oligonucleotides: Retention Manipulation via Micellar Solutions and Metal Additives 1987
1987 Immune recognition of proteins: Conclusions, dilemmas and enigmas 1987
1987 Immunological self, nonself discrimination 1987
1987 Reactive sulfhydryl groups of α39, a guanine nucleotide-binding protein from brain. Location and function 1987
1987 Site-directed mutagenesis of stahphylococcal nuclease: Role of tyrosine residues in substrate binding and catalysis 1987
1987 T cell activation by processed antigen is equally blocked by I‐E and I‐A‐restricted immunodominant peptides 1987
1986 Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: Homology with the receptor for fragments C3b and C4b of the third and fourth components of complement 1986
1986 Identification of a putative second T-cell receptor 1986
1986 Interaction of peptide antigens and class II major histocompatibility complex antigens 1986
1986 Molecular cloning and characterization of cDNA encoding the GTP-binding protein α(i) and identification of a related protein, α(h) 1986
1986 The T cell repertoire for recognition of a phylogenetically distant protein antigen: Peptide specificity and mhc restriction of staphylococcal nuclease-specific T cell clones 1986
1986 Purification of the B lymphocyte receptor for the C3d fragment of complement and the Epstein-Barr virus by monoclonal antibody affinity chromatography, and assessment of its functional capacities 1986
1986 Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains) 1986
1986 Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor 1986
1986 Identification of functional regions on the I-Ab molecule by site-directed mutagenesis 1986
1986 Molecular cartography of globular proteins with application to antigenic sites 1986
1985 Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Y1 adrenocortical tumor cells 1985
1985 Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b 1985
1985 Purification and amino-terminal protein sequence analysis of the mumps virus fusion protein 1985
1985 Combinational diversity within variable regions bearing the predominant anti-ρ-azophenylarsonate idiotype of strain a mice 1985
1985 Conformation of the eosinophil chemotactic tetrapeptides and analogues in dimethyl sulfoxide. 1H n.m.r. studies 1985
1985 Molecular studies of the atrial natriuretic factor gene 1985
1985 Rapid purification of the human C3b/C4b receptor (CR1) by monoclonal antibody affinity chromatography 1985
1985 Rat epidermal growth factor: complete amino acid sequence: Homology with the correspondence murine and human proteins; isolation of a form truncated at both ends with full in vitro biological activity 1985
1985 Turns in Peptides and Proteins 1985
1984 Complete Amino Acid Sequence of the Heavy-Chain Variable Region from an A/J Mouse Antigen-Nonbinding Monoclonal Antibody Bearing the Predominant Arsonate ldiotype 1984
1984 Nucleotide sequences of the human and mouse atrial natriuretic factor genes 1984
1984 The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone 1984
1983 Structural Correlates of Idiotypy in the Arsonate System 1983
1982 Hollow visceral myopathy. A light- and electron-microscopic study 1982
1981 CONFORMATIONAL CHARACTERISTICS OF THE N‐ACETYL‐N‘‐METHYLAMIDES OF THE FOUR (LYS, TYR) DIPEPTIDES 1981
1980 Polydispersity of rat mast cell heparin. Implications for proteoglycan assembly 1980
1979 The red blood cell lithium/plasma lithium ratio. Significance in recurrent affective illness. 1979
1978 Elimination of nonspecific adsorption of serum proteins by Sepharose-bound antigens 1978
1978 Aspects of Membrane Structure: Updated for the Clinician 1978
1978 The detection of five antigenically reactive regions in the soybean leghemoglobin a molecule 1978
1977 A controlled comparative trial of clorazepate (Tranxene) and diazepam (Valium) for anxiety 1977
1977 A novel method for delineating antigenic determinants: Peptide synthesis and radioimmunoassay using the same solid support 1977
1977 Conformational integrity of myoglobin after immunization with Freund's adjuvant 1977
1977 Cross-reactivity between mammalian myoglobins: Linear vs spatial antigenic determinants 1977
1977 Immunological Measurements of Conformational Motility in Regions of the Myoglobin Molecule 1977
1976 Evaluation of the fluorescamine test for monitoring completion of coupling on nitrochloromethylated resin 1976
1972 THERMAL PERTURBATION DIFFERENCE SPECTROSCOPY OF PROTEINS 1972

Education And Training

  • Master of Science in Health / Health Care Administration / Management, Tulane University 1998
  • Doctor of Philosophy in Biochemistry, University of Melbourne 1978
  • Doctor of Medicine, University of Missouri System : Columbia 1974
  • Brigham & Women's Hospital, Internship 1981
  • Massachusetts General Hospital, Residency 1983
  • Brigham & Women's Hospital, Residency 1982
  • Brigham & Women's Hospital, Residency 1980
  • Full Name

  • John Smith