Positions

Overview

  • Dr. Wells’ research and clinical interest focuses on COPD, including COPD-associated pulmonary vascular disease. He is currently exploring the mechanism by which a tri-peptide extracellular matrix collagen fragment causes pulmonary hypertension in COPD through a translational research project that incorporates his interest in proteomics and imaging. Dr. Wells received his Internal Medicine and Pulmonary / Critical Care post-graduate training at the University of Alabama at Birmingham (UAB). He also served as Chief Medical Resident from 2008-2009. During his pulmonary fellowship, Dr. Wells was the first post-doctoral fellow at UAB selected to the T32 Training Grant in Lung Biology and Translational Medicine under the mentorship of Drs. Blalock and Dransfield in 2010.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Arterial vascular pruning, right ventricular size, and clinical outcomes in chronic obstructive pulmonary disease a longitudinal observational studyAmerican Journal of Respiratory and Critical Care Medicine.  200:454-461. 2019
    2019 Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene StudyChest.  156:228-238. 2019
    2019 Fibroblast growth factor 23 is associated with a frequent exacerbator phenotype in COPD: A cross-sectional pilot studyInternational Journal of Molecular Sciences.  20. 2019
    2019 Safety and tolerability of comprehensive research bronchoscopy in chronic obstructive pulmonary disease results from the SPIROMICS bronchoscopy substudyAnnals of the American Thoracic Society.  16:439-446. 2019
    2019 Aspirin Use and Respiratory Morbidity in COPD: A Propensity Score-Matched Analysis in Subpopulations and Intermediate Outcome Measures in COPD StudyChest.  155:519-527. 2019
    2019 Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the LungCell.  176:113-126.e15. 2019
    2019 An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroupJournal of Clinical Investigation.  129. 2019
    2019 Acquired cystic fibrosis transmembrane conductance regulator dysfunction and radiographic bronchiectasis in current and former smokers: A cross-sectional studyAnnals of the American Thoracic Society.  16:150-153. 2019
    2019 Association of e-cigarette use with oral health: A populationbased cross-sectional questionnaire studyJournal of Public Health Medicine.  41:354-361. 2019
    2019 Induced pluripotent stem cell-derived endothelial cells attenuate lipopolysaccharide-induced acute lung injuryJournal of applied physiology: respiratory, environmental and exercise physiology.  127:444-456. 2019
    2019 Inflammation and endothelial activation in early adulthood are associated with future emphysema: the CARDIA Lung StudyEuropean Respiratory Journal.  53. 2019
    2019 Proline-glycine-proline peptides are critical in the development of smoke-induced emphysemaAmerican Journal of Respiratory Cell and Molecular Biology.  61:560-566. 2019
    2018 Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGeneJCI insight.  3. 2018
    2018 Macrophage Rac2 is required to reduce the severity of cigarette smoke-induced pneumoniaAmerican Journal of Respiratory and Critical Care Medicine.  198:1288-1301. 2018
    2018 Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysemaJCI insight.  3. 2018
    2018 COPD ground zero: small airways rather than alveoli as the initial site of injuryLancet Respiratory Medicine.  6:568-569. 2018
    2018 Interstitial features at chest CT enhance the deleterious effects of emphysema in the COPDGene cohortRadiology.  288:600-609. 2018
    2018 Fibroblast growth factor 23 and Klotho contribute to airway inflammationEuropean Respiratory Journal.  52. 2018
    2018 NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohortRespiratory Medicine.  140:87-93. 2018
    2018 Rural residence and chronic obstructive pulmonary disease exacerbations: Analysis of the SPIROMICS cohortAnnals of the American Thoracic Society.  15:808-815. 2018
    2018 Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS.Annals of the American Thoracic Society.  15:710-717. 2018
    2018 Deciphering COPD and associated cardiovascular impairmentLancet Respiratory Medicine.  6:320-322. 2018
    2018 Sleep disruption as a predictor of quality of life among patients in the subpopulations and intermediate outcome measures in COPD study (SPIROMICS)SLEEP.  41. 2018
    2018 Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-yearsThorax.  73:414-421. 2018
    2018 Paratracheal paraseptal emphysema and expiratory central airway collapse in smokersAnnals of the American Thoracic Society.  15:479-484. 2018
    2018 Association of thrombocytosis with COPD morbidity: The SPIROMICS and COPDGene cohortsRespiratory Research.  19. 2018
    2018 CT measurements of central pulmonary vasculature as predictors of severe exacerbation in COPDMedicine.  97. 2018
    2018 Life-space mobility and clinical outcomes in COPDInternational Journal of COPD.  13:2731-2738. 2018
    2018 Phenotype Detection Registry System (PheDRS) - Implementation of a Generalizable Single Institution Clinical Registry ArchitectureAMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium.  2018:847-856. 2018
    2018 The use of a standardized order set reduces systemic corticosteroid dose and length of stay for individuals hospitalized with acute exacerbations of COPD: A cohort studyInternational Journal of COPD.  13:2147-2156. 2018
    2017 Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohortLancet Respiratory Medicine.  5:956-967. 2017
    2017 Cardiac morphometry on computed tomography and exacerbation reduction with β-blocker therapy in chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  196:1484-1488. 2017
    2017 Implications of DRG Classification in a Bundled Payment Initiative for COPD.Am J Accountable Care.  5:12-18. 2017
    2017 The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac RejectionScientific Reports.  7. 2017
    2017 Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohortLancet Respiratory Medicine.  5:619-626. 2017
    2017 In Rotterdam, size really does matter: implications of pulmonary artery enlargement on mortalityEuropean Respiratory Journal.  49. 2017
    2017 Results of a Medicare Bundled Payments for care Improvement initiative for chronic obstructive pulmonary disease readmissionsAnnals of the American Thoracic Society.  14:643-648. 2017
    2017 Ventricular Geometry From Non-contrast Non-ECG-gated CT Scans: An Imaging Marker of Cardiopulmonary Disease in SmokersAcademic Radiology.  24:594-602. 2017
    2017 Bringing Stability to the Chronic Obstructive Pulmonary Disease Patient: Clinical and Pharmacological Considerations for Frequent ExacerbatorsDrugs.  77:651-670. 2017
    2017 Doxycycline improves clinical outcomes during cystic fibrosis exacerbationsEuropean Respiratory Journal.  49. 2017
    2017 GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery diseaseRespiratory Research.  18. 2017
    2017 Acute exacerbations and lung function loss in smokers with and without chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  195:324-330. 2017
    2017 Pulmonary rehabilitation improves outcomes in chronic obstructive pulmonary disease independent of disease burdenAnnals of the American Thoracic Society.  14:26-32. 2017
    2016 Evaluation of Galleria mellonella larvae for studying the virulence of Streptococcus suisBMC Microbiology.  16:1-9. 2016
    2016 Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: A cohort studyBMC Pulmonary Medicine.  16. 2016
    2016 A ferret model of COPD-related chronic bronchitisJCI insight.  1:e87536. 2016
    2016 Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPDPLoS Genetics.  12. 2016
    2016 Pulmonary artery enlargement and cystic fibrosis pulmonary exacerbations: a cohort studyLancet Respiratory Medicine.  4:636-645. 2016
    2016 Association between functional small airway disease and FEV1 decline in chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  194:178-184. 2016
    2016 β-Blockers for the prevention of acute exacerbations of chronic obstructive pulmonary disease (βLOCK COPD): A randomised controlled study protocolBMJ Open.  6. 2016
    2016 Pulmonary artery enlargement is associated with cardiac injury during severe exacerbations of COPDChest.  149:1197-1204. 2016
    2016 Disease phenotyping in chronic obstructive pulmonary disease: The neutrophilic endotypeCurrent Opinion in Pulmonary Medicine.  22:91-99. 2016
    2016 Determinants of successful completion of pulmonary rehabilitation in COPDInternational Journal of COPD.  11:391-397. 2016
    2016 Risk factors for COPD exacerbations in inhaled medication users: The COPDGene study biannual longitudinal follow-up prospective cohortBMC Pulmonary Medicine.  16. 2016
    2016 Depression is associated with readmission for acute exacerbation of chronic obstructive pulmonary diseaseAnnals of the American Thoracic Society.  13:197-203. 2016
    2016 Arterial and venous pulmonary vascular morphology and their relationship to findings in cardiac magnetic resonance imaging in smokersJournal of Computer Assisted Tomography.  40:948-952. 2016
    2016 β-Blockers are associated with a reduction in COPD exacerbationsThorax.  71:8-14. 2016
    2015 A fragment in time: Elastin peptides and progression of emphysemaAmerican Journal of Respiratory and Critical Care Medicine.  192:1141-1143. 2015
    2015 Benefits of completing pulmonary rehabilitation in patients with asthmaThe Journal of asthma research.  52:969-973. 2015
    2015 MMP generated matrikinesCollagen and related research.  44-46:122-129. 2015
    2015 The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeabilityScience Advances.  1. 2015
    2015 A randomised trial of lung sealant versus medical therapy for advanced emphysemaEuropean Respiratory Journal.  46:651-662. 2015
    2015 A randomized, placebo-controlled trial of roflumilast effect on proline-glycine-proline and neutrophilic inflammation in chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  192:934-942. 2015
    2015 Clinical and radiologic disease in smokers with normal spirometryJAMA Internal Medicine.  175:1539-1549. 2015
    2015 IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary diseaseAmerican Journal of Respiratory Cell and Molecular Biology.  52:365-376. 2015
    2015 Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary diseaseCirculation: Cardiovascular Imaging.  8. 2015
    2014 Radiological correlates and clinical implications of the paradoxical lung function response to β2 agonists: An observational studyLancet Respiratory Medicine.  2:911-918. 2014
    2014 Prediction of acute respiratory disease in current and former smokers with and without COPDChest.  146:941-950. 2014
    2014 An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary diseaseAmerican Journal of Respiratory and Critical Care Medicine.  190:51-61. 2014
    2014 Determinants of arterial stiffness in COPDBMC Pulmonary Medicine.  14. 2014
    2014 CT scan-measured pulmonary artery to aorta ratio and echocardiography for detecting pulmonary hypertension in severe COPDChest.  145:824-832. 2014
    2014 Cardiovascular disease in COPD: A call for actionLancet Respiratory Medicine.  2:783-785. 2014
    2014 FEV1/FEV6to diagnose airflow obstruction: Comparisons with computed tomography and morbidity indicesAnnals of the American Thoracic Society.  11:335-341. 2014
    2013 Sputum PGP is reduced by azithromycin treatment in patients with COPD and correlates with exacerbationsBMJ Open.  3. 2013
    2013 Pathophysiology and clinical implications of pulmonary arterial enlargement in COPDInternational Journal of COPD.  8:509-521. 2013
    2013 Bullous Lesions After Use of a Commercial Therapeutic Hypothermia Temperature Management System: A Possible Burn Injury?Therapeutic Hypothermia and Temperature Management.  3:147-150. 2013
    2013 Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implicationsAmerican Journal of Respiratory and Critical Care Medicine.  188:231-239. 2013
    2012 The authors replyNew England Journal of Medicine.  367:2254-2255. 2012
    2012 Pulmonary arterial enlargement and acute exacerbations of COPDNew England Journal of Medicine.  367:913-921. 2012
    2011 Recommended Reading from the University of Alabama Fellows: J. Allen Cooper, Program Director.American Journal of Respiratory and Critical Care Medicine.  183:411-412. 2011
    2010 In search of...New England Journal of Medicine.  363:2249-2254. 2010

    Research Overview

  • Dr. Wells joined the Pulmonary Division in 2012 as an Assistant Professor. His research productivity has been recognized through publications, presentations at national meetings, and receipt of awards including the Sreedhar Nair Early Stage Investigator Award in COPD from the American Thoracic Society in 2015 and he was named one of the first Pittman Scholars at UAB in 2015. His research has been funded through intramural and extramural awards including a NIH/NHLBI K08 Mentored Scientist Career Development Award, a Cystic Fibrosis Research Development Grant, the Walter B. Frommeyer Jr. Fellowship in Investigational Medicine from UAB, the NIH/NHLBI Loan Repayment Program, as well as through clinical trials in COPD.
  • Investigator On

  • A Novel Exosomal Inflammatory Pathway  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2023
  • Private Grant  awarded by ARROWHEAD PHARMACEUTICALS INC. 2019 - 2023
  • Combined Cardiopulmonary Failure in COPD: SPIROMICS II - HF  awarded by Columbia University 2019 - 2023
  • Private Grant  awarded by LUNG BIOTECHNOLOGY PBC 2018 - 2022
  • Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)  awarded by COPD FOUNDATION 2016 - 2022
  • Private Grant  awarded by GlaxoSmithKline 2018 - 2022
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2016 - 2021
  • Private Grant  awarded by MEREO BIOPHARMA 4 LIMITED 2017 - 2021
  • Private Grant  awarded by PNEUMRX, INC. 2016 - 2021
  • Beta Blockers for the Prevention of Acute Exacerbations of COPD  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2015 - 2020
  • AZD9688: A First in Class Disease Modifying Therapy to Treat Alpha-1 Antitrypsin Deficiency a Genetically Linked Orphan Disease  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2018 - 2020
  • SPIROMICS GIC Support  awarded by University of North Carolina at Chapel Hill 2018 - 2020
  • Fibroblast Growth Factor 23/Klotho Crosstalk and Airway Epithelial Senescence in COPD  awarded by National Institute on Aging/NIH/DHHS 2018 - 2020
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) (RETHINC)  awarded by COPD FOUNDATION 2017 - 2020
  • Network Management Cote (NEMO) for the Pulmonary Trials Cooperative (PTC) (INSIGHT)  awarded by COPD FOUNDATION 2017 - 2020
  • Private Grant  awarded by PULMONX 2013 - 2020
  • Private Grant  awarded by PNEUMRX, INC. 2014 - 2020
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) (RETHINC)  awarded by COPD FOUNDATION 2018 - 2019
  • Private Grant  awarded by GlaxoSmithKline 2017 - 2019
  • Prostaglandin Inhibition for Emphysema  awarded by UNIVERSITY OF NEBRASKA 2015 - 2019
  • Research Development Program  awarded by Cystic Fibrosis Foundation 2015 - 2019
  • Private Grant  awarded by BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2016 - 2019
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) LEEP (Losartan Effects on Emphysema Progression) Trial  awarded by American Lung Association 2017 - 2019
  • Private Grant  awarded by PEARL THERAPEUTICS 2018
  • Private Grant  awarded by PROTERIXBIO, INC. 2016 - 2018
  • Reliability of a Portable Device to Measure Respiratory and Step Rates  awarded by UNIVERSITY OF NEBRASKA, OMAHA 2017 - 2018
  • Private Grant  awarded by Gilead Sciences 2015 - 2017
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) RETHINC (Redefining Therapy in Early COPD)  awarded by University of Pittsburgh 2017
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) INSIGHT (Intervention Study in Overweight Patients with COPD)  awarded by University of Pittsburgh 2016 - 2017
  • Private Grant  awarded by PNEUMRX, INC. 2016 - 2017
  • Private Grant  awarded by ASTRAZENECA PHARMACEUTICALS LP 2014 - 2017
  • Airways Clinical Research Center (ACRC)  awarded by American Lung Association 2016 - 2017
  • Private Grant  awarded by YUNGJIN PHARM. CO.,LTD. 2015 - 2017
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION 2015 - 2016
  • Private Grant  awarded by SPECTRAL MEDICAL, INC. 2010 - 2016
  • Age Related Differences in Parametrics Response Mapping in COPD (Martinez Supplement)  awarded by University of Michigan 2015 - 2016
  • (Spiromics) SubPopulations and InteRmediate Outcome Measures in COPD Study  awarded by WAKE FOREST UNIVERSITY 2012 - 2016
  • (Spiromics) SubPopulations and InteRmediate Outcome Measures in COPD Study - Administrative Core  awarded by WAKE FOREST UNIVERSITY 2012 - 2016
  • (Spiromics) SubPopulations and InteRmediate Outcome Measures in COPD Study - Bronchoscopy - Project 1  awarded by WAKE FOREST UNIVERSITY 2012 - 2016
  • (Spiromics) SubPopulations and InteRmediate Outcome Measures in COPD Study - Exacerbation - Project 2  awarded by WAKE FOREST UNIVERSITY 2012 - 2016
  • Private Grant  awarded by GlaxoSmithKline 2015 - 2016
  • Private Grant  awarded by GlaxoSmithKline 2014 - 2016
  • Symbicort in HRCT-Defined Airway Predominant COPD  awarded by NATIONAL JEWISH MEDICAL RESEARCH CENTER 2014 - 2016
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION 2015
  • Pharmacogenomics of Inhaled Corticosteroids to Reduce COPD Exacerbations  awarded by Brigham and Women's Hospital 2013 - 2015
  • UAB Research Development Program Component II - Overall Program  awarded by Cystic Fibrosis Foundation 2015
  • Private Grant  awarded by GlaxoSmithKline 2011 - 2015
  • Kit Inhibition in Asthma (KIA)  awarded by Brigham and Women's Hospital 2012 - 2015
  • Private Grant  awarded by PEARL THERAPEUTICS 2013 - 2015
  • Private Grant  awarded by FOREST LABORATORIES, INC. 2012 - 2014
  • Private Grant  awarded by PEARL THERAPEUTICS 2014
  • Private Grant  awarded by BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2013 - 2014
  • Private Grant  awarded by MedImmune 2012 - 2014
  • Private Grant  awarded by JANSSEN RESEARCH & DEVELOPMENT, LLC 2010 - 2014
  • Private Grant  awarded by AERIS THERAPEUTICS, INC. 2012 - 2013
  • Private Grant  awarded by Pfizer Pharmaceuticals 2012 - 2013
  • Private Grant  awarded by GlaxoSmithKline 2012 - 2013
  • Education And Training

  • Master of Science in Health Professions and Related Programs, University of Alabama at Birmingham 2018
  • Doctor of Medicine, The University of Texas Health Science Center at Houston 2005
  • UAB Hospital, Internship 2006
  • UAB Hospital, Residency 2008
  • UAB Hospital, Postdoctoral Fellowship 2012
  • Full Name

  • James Wells