• Jennifer Larson-Casey received her doctorate at the University of North Dakota. Her postdoctoral training was completed at the University of Iowa in the Free Radical and Radiation Biology Program and the University of Alabama in the Pulmonary, Allergy, and Critical Care Division. She is now an Assistant Professor of Pulmonary, Allergy and Critical Care in the Department of Medicine. She is a recent awardee of the Parker B. Francis Pulmonary Research Fellowship. Jennifer was awarded the 2022 Recognition of Early Academic Achievement (REAAch) Award from the Assembly of Respiratory Cell and Molecular Biology (RCMB) of the American Thoracic Society. This recognition is awarded to Early Stage Investigators who demonstrate an outstanding commitment to develop a productive academic career.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosisAging Cell.  21. 2022
    2022 Does UCP2 Couple Hyperoxia to Lung Injury?American Journal of Respiratory Cell and Molecular Biology.  66:250-251. 2022
    2022 Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodelingCell Death and Differentiation.  29:118-132. 2022
    2021 NOX4 regulates macrophage apoptosis resistance to induce fibrotic progressionJournal of Biological Chemistry.  297. 2021
    2021 Post-translational regulation of PGC-1α modulates fibrotic repair 2021
    2021 Auranofin-mediated nrf2 induction attenuates interleukin 1 beta expression in alveolar macrophagesAntioxidants.  10. 2021
    2021 A novel tree shrew model of pulmonary fibrosisLaboratory Investigation.  101:116-124. 2021
    2020 Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophagesJournal of Biological Chemistry.  295:15754-15766. 2020
    2020 Technical advance: The use of tree shrews as a model of pulmonary fibrosisPLoS One.  15. 2020
    2020 Mitochondrial quality control in pulmonary fibrosisRedox Biology.  33. 2020
    2019 Increased flux through the mevalonate pathway mediates fibrotic repair without injuryJournal of Clinical Investigation.  129:4962-4978. 2019
    2019 Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosisRedox Biology.  26. 2019
    2019 NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosisJCI Insight.  4. 2019
    2019 Reply to Eapen et al.: Dysfunctional immunity and microbial adhesion molecules in smoking-induced pneumoniaAmerican Journal of Respiratory and Critical Care Medicine.  199:251-252. 2019
    2018 Macrophage Rac2 is required to reduce the severity of cigarette smoke-induced pneumoniaAmerican Journal of Respiratory and Critical Care Medicine.  198:1288-1301. 2018
    2017 Macrophages utilize the mitochondrial calcium uniporter for profibrotic polarization 2017
    2016 Assay to evaluate BAL Fluid regulation of Fibroblast α-SMA Expression.Bio-protocol.  6. 2016
    2016 Determination of H2O2 Generation by pHPA Assay.Bio-protocol.  6. 2016
    2016 Cu,Zn-superoxide dismutase-mediated redox regulation of Jumonji domain containing 3 modulates macrophage polarization and pulmonary fibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  55:58-71. 2016
    2016 Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary FibrosisImmunity.  44:582-596. 2016
    2016 SPARC Expression Is Selectively Suppressed in Tumor Initiating Urospheres Isolated from As+3- and Cd+2-Transformed Human Urothelial Cells (UROtsa) Stably Transfected with SPARCPLoS One.  11. 2016
    2015 Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure 2015
    2015 Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosisFree Radical Biology and Medicine.  86:47-56. 2015
    2014 Modulation of the mevalonate pathway by AKT regulates macrophage survival and development of pulmonary fibrosisJournal of Biological Chemistry.  289:36204-36219. 2014
    2014 3 Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophagesJournal of Biological Chemistry.  289:33391-33403. 2014
    2011 Comparison of expression patterns of keratin 6, 7, 16, 17, and 19 within multiple independent isolates of As +3- and Cd +2-induced bladder cancer: Keratin 6, 7, 16, 17, and 19 in bladder cancer 2011
    2010 SPARC gene expression is repressed in human urothelial cells (UROtsa) exposed to or malignantly transformed by cadmium or arseniteToxicology Letters.  199:166-172. 2010
    2010 Beclin-1 expression in normal bladder and in Cd2+ and As3+ exposed and transformed human urothelial cells (UROtsa)Toxicology Letters.  195:15-22. 2010

    Research Overview

  • Dr. Larson-Casey research interests focus on environmental toxins and the critical role of lung monocytes and macrophages within chronic pulmonary diseases. Dr. Larson-Casey studies include investigating the macrophage subset and mechanism(s) by which environmental toxins (fine particulate matter, cadmium, asbestos) regulate the development and progression of chronic lung diseases by focusing on macrophage/monocyte redox signaling, mitochondrial bioenergetics, and immunometabolism.
  • Education And Training

  • University of Iowa Medicine, Postdoctoral Research
  • Doctor of Philosophy in Cell Biology and Anatomy, University of North Dakota 2012
  • Full Name

  • Jennifer Casey