Jennifer Casey

Jennifer Casey
Assistant Professor

Assistant Professor (P), Medicine - Pulmonary, Allergy, & Critical Care Medicine , Department of Medicine

Overview

Jennifer Larson-Casey received her doctorate at the University of North Dakota. Her postdoctoral training was completed at the University of Iowa in the Free Radical and Radiation Biology Program and the University of Alabama in the Pulmonary, Allergy, and Critical Care Division. She is now an Assistant Professor of Pulmonary, Allergy and Critical Care in the Department of Medicine. She is a recent awardee of the Parker B. Francis Pulmonary Research Fellowship.

Selected Publications

Academic Article

Year	Title	Altmetric
2021	NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression. Journal of Biological Chemistry. 297. 2021
2021	Post-translational regulation of PGC-1α modulates fibrotic repair. The FASEB Journal. 35. 2021
2021	Auranofin-mediated nrf2 induction attenuates interleukin 1 beta expression in alveolar macrophages. Antioxidants. 10. 2021
2021	A novel tree shrew model of pulmonary fibrosis. Laboratory Investigation. 101:116-124. 2021
2021	Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling. Cell Death and Differentiation. 2021
2020	Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages. Journal of Biological Chemistry. 295:15754-15766. 2020
2020	Technical advance: The use of tree shrews as a model of pulmonary fibrosis. PLoS ONE. 15. 2020
2020	Mitochondrial quality control in pulmonary fibrosis. Redox Biology. 33. 2020
2019	Increased flux through the mevalonate pathway mediates fibrotic repair without injury. Journal of Clinical Investigation. 129:4962-4978. 2019
2019	Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis. Redox Biology. 26. 2019
2019	NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis. JCI insight. 4. 2019
2019	Reply to Eapen et al.: Dysfunctional immunity and microbial adhesion molecules in smoking-induced pneumonia. American Journal of Respiratory and Critical Care Medicine. 199:251-252. 2019
2018	Macrophage Rac2 is required to reduce the severity of cigarette smoke-induced pneumonia. American Journal of Respiratory and Critical Care Medicine. 198:1288-1301. 2018
2017	Macrophages utilize the mitochondrial calcium uniporter for profibrotic polarization. The FASEB Journal. 31:3072-3083. 2017
2016	Assay to evaluate BAL Fluid regulation of Fibroblast α-SMA Expression.. Bio-protocol. 6. 2016
2016	Determination of H2O2 Generation by pHPA Assay.. Bio-protocol. 6. 2016
2016	Cu,Zn-superoxide dismutase-mediated redox regulation of Jumonji domain containing 3 modulates macrophage polarization and pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology. 55:58-71. 2016
2016	Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Immunity. 44:582-596. 2016
2016	SPARC Expression Is Selectively Suppressed in Tumor Initiating Urospheres Isolated from As⁺³- and Cd⁺²-Transformed Human Urothelial Cells (UROtsa) Stably Transfected with SPARC. PLoS ONE. 11. 2016
2015	Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure. The FASEB Journal. 29:3527-3536. 2015
2015	Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis. Free Radical Biology and Medicine. 86:47-56. 2015
2014	Modulation of the mevalonate pathway by AKT regulates macrophage survival and development of pulmonary fibrosis. Journal of Biological Chemistry. 289:36204-36219. 2014
2014	3 Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophages. Journal of Biological Chemistry. 289:33391-33403. 2014
2011	Comparison of expression patterns of keratin 6, 7, 16, 17, and 19 within multiple independent isolates of As ⁺³- and Cd ⁺²-induced bladder cancer: Keratin 6, 7, 16, 17, and 19 in bladder cancer 2011
2010	SPARC gene expression is repressed in human urothelial cells (UROtsa) exposed to or malignantly transformed by cadmium or arsenite. Toxicology Letters. 199:166-172. 2010
2010	Beclin-1 expression in normal bladder and in Cd²⁺ and As³⁺ exposed and transformed human urothelial cells (UROtsa). Toxicology Letters. 195:15-22. 2010

Research Overview

Dr. Larson-Casey research interests focus on environmental toxins and the critical role of lung monocytes and macrophages within chronic pulmonary diseases. Dr. Larson-Casey studies include investigating the macrophage subset and mechanism(s) by which environmental toxins (fine particulate matter, cadmium, asbestos) regulate the development and progression of chronic lung diseases by focusing on macrophage/monocyte redox signaling, mitochondrial bioenergetics, and immunometabolism.