Positions

Overview

  • My major research interest is the neurobiological regulation of reward-related memory systems in the brain and the role of these systems in drug addiction. My laboratory approaches this broad topic at diverse levels of analysis that integrate molecular, genetic, and epigenetic tools with techniques that probe the function of single neurons and entire neuronal circuits. My ultimate goal is to understand epigenetic regulation in normal and disease states, and to use tools that manipulate the epigenome to treat addiction-related diseases. My lab has broad experience with reward circuitry, transcriptional and epigenetic analyses, whole-genome sequencing, and CRISPR/Cas9 genome editing tools to understand the role of specific genes and epigenetic modifications at these genes in neuronal function and behavior.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Blue light-induced gene expression alterations in cultured neurons are the result of phototoxic interactions with neuronal culture media 2019
    2019 A neuron-optimized CRISPR/dCas9 activation system for robust and specific gene regulationEnvironmental Science and Technology Letters.  6. 2019
    2019 Genomic enhancers in brain health and diseaseGenes.  10. 2019
    2019 Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloidScience Signaling.  12. 2019
    2018 Cell-specific deletion of PGC-1α from medium spiny neurons causes transcriptional alterations and age-related motor impairmentJournal of Neuroscience.  38:3273-3286. 2018
    2018 Enhancer RNAs are necessary and sufficient for activity-dependent neuronal gene transcription 2018
    2018 Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse HippocampusHuman Gene Therapy Clinical Development.  22:1124-1131. 2018
    2017 Hippocampal transcriptomic profiles: Subfield vulnerability to age and cognitive impairmentFrontiers in Aging Neuroscience.  9. 2017
    2017 Applications of CRISPR/CAS9 in the mammalian central nervous systemYale Journal of Biology and Medicine.  90:567-581. 2017
    2017 Experience-dependent epigenomic reorganization in the hippocampusLearning and Memory.  24:278-288. 2017
    2017 Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdalaApplied Neuropsychology Adult.  320:165-178. 2017
    2016 Neonatal maternal separation stress elicits lasting DNA methylation changes in the hippocampus of stress-reactive Wistar Kyoto ratsEuropean Journal of Neuroscience.  44:2829-2845. 2016
    2016 Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory FunctionHuman Gene Therapy Clinical Development.  16:2666-2685. 2016
    2016 Extra-coding RNAs regulate neuronal DNA methylation dynamicsNature Communications.  7. 2016
    2016 Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bondsOverview.  5. 2016
    2015 DNA methylation and its implications and accessibility for neuropsychiatric therapeuticsAddictive Behaviors.  55:591-611. 2015
    2015 DNA methylation regulates neuronal glutamatergic synaptic scalingScience Signaling.  8. 2015
    2015 DNA methylation slows effects of C9orf72 mutationsNeurology.  84:1616-1617. 2015
    2014 Histone H2A.Z subunit exchange controls consolidation of recent and remote memoryNature.  515:582-586. 2014
    2014 New approaches to manipulating the epigenomeResults and Problems in Cell Differentiation.  16:345-357. 2014
    2013 DNA methylation regulates associative reward learningNature Neuroscience.  16:1445-1452. 2013
    2013 Development of behavioral preferences for the optimal choice following unexpected reward omission is mediated by a reduction of D2-like receptor tone in the nucleus accumbensEuropean Journal of Neuroscience.  38:2572-2588. 2013
    2012 Direct bisulfite sequencing for examination of DNA methylation with gene and nucleotide resolution from brain tissuesJournal of tissue culture methods : Tissue Culture Association manual of cell, tissue, and organ culture procedures.  1. 2012
    2012 Phasic nucleus accumbens dopamine encodes risk-based decision-making behaviorRenaissance Quarterly.  71:199-205. 2012
    2012 Epigenetic treatments for cognitive impairmentsNeuropsychopharmacology.  37:247-260. 2012
    2011 Cognitive neuroepigenetics: A role for epigenetic mechanisms in learning and memoryNeurobiology of Learning and Memory.  96:2-12. 2011
    2011 Epigenetic Mechanisms in CognitionNeuron.  70:813-829. 2011
    2011 Cocaine cues drive opposing context-dependent shifts in reward processing and emotional stateRenaissance Quarterly.  69:1067-1074. 2011
    2011 Epigenetic mechanisms in memory and synaptic functionEpigenomics.  3:157-181. 2011
    2011 Epigenetic modifications in neurons are essential for formation and storage of behavioral memoryNeuropsychopharmacology.  36:357-358. 2011
    2011 Nucleus accumbens neurons encode predicted and ongoing reward costs in ratsEuropean Journal of Neuroscience.  33:308-321. 2011
    2010 DNA methylation and memory formationNature Neuroscience.  13:1319-1323. 2010
    2010 The basolateral amygdala differentially regulates conditioned neural responses within the nucleus accumbens core and shellNeuroscience.  169:1186-1198. 2010
    2010 Phasic nucleus accumbens dopamine release encodes effort- and delay-related costsRenaissance Quarterly.  68:306-309. 2010
    2010 Basolateral Amygdala Modulates Terminal Dopamine Release in the Nucleus Accumbens and Conditioned RespondingRenaissance Quarterly.  67:737-744. 2010
    2009 Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in ratsEuropean Journal of Neuroscience.  30:1889-1899. 2009
    2008 Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release eventsJournal of Neuroscience.  28:8821-8831. 2008
    2008 Extracellular signal-related kinase activation during natural reward learning: A physiological role for phasic nucleus accumbens dopamine?Journal of Neuroscience.  28:4295-4297. 2008
    2008 Methamphetamine Induces Chronic Corticostriatal Depression: Too Much of a Bad ThingNeuron.  58:6-7. 2008
    2007 Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbensNature Neuroscience.  10:1020-1028. 2007
    2007 Spatial and visual discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n - 3 polyunsaturated fatty acidsNeuroToxicology.  28:707-719. 2007
    2007 The nucleus accumbens and pavlovian reward learningNeuroscientist.  13:148-159. 2007
    2006 Nucleus accumbens neurons encode Pavlovian approach behaviors: Evidence from an autoshaping paradigmEuropean Journal of Neuroscience.  23:1341-1351. 2006
    2005 Neuromotor deficits and mercury concentrations in rats exposed to methyl mercury and fish oilNeurotoxicology and Teratology.  27:629-641. 2005

    Chapter

    Year Title Altmetric
    2017 DNA Modifications and Memory.  95-111. 2017
    2013 Epigenetic Mechanisms in Learning and Memory.  121-170. 2013

    Education And Training

  • Doctor of Philosophy in Psychology, University of North Carolina System : Chapel Hill 2009
  • University of Alabama at Birmingham, Birmingham Neurobiology, Postdoctoral Fellowship 2014
  • Full Name

  • Jeremy Day