Positions

Overview

  • My major research interest is the neurobiological regulation of reward-related memory systems in the brain and the role of these systems in drug addiction. My laboratory approaches this broad topic at diverse levels of analysis that integrate molecular, genetic, and epigenetic tools with techniques that probe the function of single neurons and entire neuronal circuits. My ultimate goal is to understand epigenetic regulation in normal and disease states, and to use tools that manipulate the epigenome to treat addiction-related diseases. My lab has broad experience with reward circuitry, transcriptional and epigenetic analyses, whole-genome sequencing, and CRISPR/Cas9 genome editing tools to understand the role of specific genes and epigenetic modifications at these genes in neuronal function and behavior.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Genomic Enhancers in Brain Health and Disease.Genes.  10. 2019
    2018 Cell-Specific Deletion of PGC-1α from Medium Spiny Neurons Causes Transcriptional Alterations and Age-Related Motor Impairment.Journal of Neuroscience.  38:3273-3286. 2018
    2018 Enhancer RNAs are necessary and sufficient for activity-dependent neuronal gene transcription 2018
    2018 Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse Hippocampus.Cell Reports.  22:1124-1131. 2018
    2017 Applications of CRISPR/Cas9 in the Mammalian Central Nervous System.Yale Journal of Biology and Medicine.  90:567-581. 2017
    2017 Experience-dependent epigenomic reorganization in the hippocampus.Learning and Memory.  24:278-288. 2017
    2017 Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala.Behavioural Brain Research.  320:165-178. 2017
    2017 Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment.Frontiers in Aging Neuroscience.  9:383. 2017
    2016 Neonatal maternal separation stress elicits lasting DNA methylation changes in the hippocampus of stress-reactive Wistar Kyoto rats.European Journal of Neuroscience.  44:2829-2845. 2016
    2016 Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.Cell Reports.  16:2666-2685. 2016
    2016 Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds.eLife.  5. 2016
    2016 Extra-coding RNAs regulate neuronal DNA methylation dynamics.Nature Communications.  7:12091. 2016
    2015 DNA methylation regulates neuronal glutamatergic synaptic scaling.Science Signaling.  8:ra61. 2015
    2015 DNA methylation and its implications and accessibility for neuropsychiatric therapeutics.Annual review of pharmacology.  55:591-611. 2015
    2014 Histone H2A.Z subunit exchange controls consolidation of recent and remote memory.Nature.  515:582-586. 2014
    2014 New approaches to manipulating the epigenome.Dialogues in Clinical Neuroscience.  16:345-357. 2014
    2013 DNA methylation regulates associative reward learning.Nature Neuroscience.  16:1445-1452. 2013
    2013 Development of behavioral preferences for the optimal choice following unexpected reward omission is mediated by a reduction of D2-like receptor tone in the nucleus accumbens.European Journal of Neuroscience.  38:2572-2588. 2013
    2012 Direct bisulfite sequencing for examination of DNA methylation with gene and nucleotide resolution from brain tissues.Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.].  Chapter 7:Unit-7.24. 2012
    2012 Phasic nucleus accumbens dopamine encodes risk-based decision-making behavior.Biological Psychiatry.  71:199-205. 2012
    2012 Epigenetic treatments for cognitive impairments.Neuropsychopharmacology.  37:247-260. 2012
    2011 Cognitive neuroepigenetics: a role for epigenetic mechanisms in learning and memory.Neurobiology of Learning and Memory.  96:2-12. 2011
    2011 Epigenetic mechanisms in cognition.Neuron.  70:813-829. 2011
    2011 Cocaine cues drive opposing context-dependent shifts in reward processing and emotional state.Biological Psychiatry.  69:1067-1074. 2011
    2011 Epigenetic mechanisms in memory and synaptic function.Epigenomics.  3:157-181. 2011
    2011 Epigenetic modifications in neurons are essential for formation and storage of behavioral memory.Neuropsychopharmacology.  36:357-358. 2011
    2011 Nucleus accumbens neurons encode predicted and ongoing reward costs in rats.European Journal of Neuroscience.  33:308-321. 2011
    2010 DNA methylation and memory formation.Nature Neuroscience.  13:1319-1323. 2010
    2010 The basolateral amygdala differentially regulates conditioned neural responses within the nucleus accumbens core and shell.Neuroscience.  169:1186-1198. 2010
    2010 Phasic nucleus accumbens dopamine release encodes effort- and delay-related costs.Biological Psychiatry.  68:306-309. 2010
    2010 Basolateral amygdala modulates terminal dopamine release in the nucleus accumbens and conditioned responding.Biological Psychiatry.  67:737-744. 2010
    2009 Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats.European Journal of Neuroscience.  30:1889-1899. 2009
    2008 Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events.Journal of Neuroscience.  28:8821-8831. 2008
    2008 Extracellular signal-related kinase activation during natural reward learning: a physiological role for phasic nucleus accumbens dopamine?Journal of Neuroscience.  28:4295-4297. 2008
    2008 Methamphetamine induces chronic corticostriatal depression: too much of a bad thing.Neuron.  58:6-7. 2008
    2007 Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens.Nature Neuroscience.  10:1020-1028. 2007
    2007 Spatial and visual discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n-3 polyunsaturated fatty acids.NeuroToxicology.  28:707-719. 2007
    2007 The nucleus accumbens and Pavlovian reward learning.Neuroscientist.  13:148-159. 2007
    2006 Nucleus accumbens neurons encode Pavlovian approach behaviors: evidence from an autoshaping paradigm.European Journal of Neuroscience.  23:1341-1351. 2006
    2005 Neuromotor deficits and mercury concentrations in rats exposed to methyl mercury and fish oil.Neurotoxicology and Teratology.  27:629-641. 2005

    Chapter

    Year Title Altmetric
    2017 DNA Modifications and Memory.  95-111. 2017
    2013 Epigenetic Mechanisms in Learning and Memory.  121-170. 2013

    Full Name

  • Jeremy Day