• Dr. Johnston specializes in pediatric neurosurgery. His practice includes all aspects of patient care related to neurological surgery, including neurosurgical oncology (brain and spine tumors), complex spinal surgery, craniosynostosis, vascular neurosurgery (including revascularization for moyamoya), radiosurgery, neurocritical care and trauma, and congenital disorders.
    Dr. Johnston is an active researcher, and is currently the co-investigator at Children’s in a trial of intratumoral viral therapy for the treatment of recurrent malignant brain tumors in children. He is also working with colleagues on the development and FDA-approval of a rapid complement-based diagnostic device for bacterial meningitis and shunt infection.
    Dr. Johnston received his M.D. degree from Washington University School of Medicine in Saint Louis in 2002. He completed an internship in General Surgery at Washington University in 2003 and residency in the Washington University Department of Neurosurgery from 2003-2006. He pursued post-doctoral training in functional and diffusion tensor MR imaging at the Mallinckrodt Institute of Radiology Neuro-Imaging Laboratories from 2006-2008. During this time, he also served as neurosurgical registrar at the National Referral Centre for Neurosurgery, Beaumont Hospital in Dublin, Ireland from July to December 2007. He was then named Chief Resident in Neurosurgery at Washington University/Barnes Hospital from 2008-2009 and went on to complete fellowship training in pediatric neurosurgery at Saint Louis Children's Hospital in 2010.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Functional outcomes at 2 years of age following treatment for posthemorrhagic hydrocephalus of prematurity: What do we know at the time of consult? 2020
    2020 Incidence of delayed intracranial hypertension in children with isolated sagittal synostosis following open calvarial vault reconstruction 2020
    2020 The initial experience of InterSurgeon: An online platform to facilitate global neurosurgical partnerships 2020
    2020 Treatment of pediatric high-grade central nervous system tumors with high-dose methotrexate in combination with multiagent chemotherapy: A single-institution experience 2020
    2019 A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition 2019
    2019 Soluble membrane attack complex is diagnostic for intraventricular shunt infection in children 2019
    2019 Stereotactic Placement of Intratumoral Catheters for Continuous Infusion Delivery of Herpes Simplex Virus -1 G207 in Pediatric Malignant Supratentorial Brain Tumors 2019
    2019 Treatment-induced remission of medulloblastoma using a chemotherapeutic regimen devoid of vincristine in a child with charcot–marie–tooth disease 2019
    2018 Surgical treatment of epilepsy in Vietnam: Program development and international collaboration 2018
    2018 Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile 2018
    2018 De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus 2018
    2017 Extremely large sinus pericranii with involvement of the torcular and associated with Crouzon’s syndrome 2017
    2017 A review of the literature on pediatric concussions and Return-to-Learn (RTL): Implications for RTL policy, research, and practice 2017
    2017 Extreme aplasia cutis congenita involving the skull 2017
    2017 State of global pediatric neurosurgery outreach: Survey by the International Education Subcommittee 2017
    2017 A never before reported variant of the sacrum 2017
    2017 Risk factors for surgical site infection following nonshunt pediatric neurosurgery: A review of 9296 procedures from a national database and comparison with a single-center experience 2017
    2017 Rationale and Design of a Phase 1 Clinical Trial to Evaluate HSV G207 Alone or with a Single Radiation Dose in Children with Progressive or Recurrent Malignant Supratentorial Brain Tumors 2017
    2017 Youth helmet design in sports with repetitive low- and medium-energy impacts: a systematic review 2017
    2017 Rationale and Design of a Phase I Clinical Trial to Evaluate HSV G207 Alone or with a Single Radiation Dose in Children with Progressive or Recurrent Malignant Supratentorial Brain Tumors. 2017
    2017 Endoscopic third ventriculostomy: A historical review 2017
    2017 Academic Difficulty and Vision Symptoms in Children with Concussion 2017
    2017 Classification and Management of Pediatric Subaxial Cervical Spine Injuries 2017
    2017 Molecular analyses reveal inflammatory mediators in the solid component and cyst fluid of human adamantinomatous craniopharyngioma 2017
    2016 Radiographic markers of clinical outcomes after endoscopic third ventriculostomy with choroid plexus cauterization: Cerebrospinal fluid turbulence and choroid plexus visualization 2016
    2016 Risk factors for unplanned readmission within 30 days after pediatric neurosurgery: A nationwide analysis of 9799 procedures from the American College of Surgeons National Surgical Quality Improvement Program 2016
    2016 Predictors of delayed recovery following pediatric sports-related concussion: A case-control study 2016
    2016 Virtual Interactive Presence in Global Surgical Education: International Collaboration Through Augmented Reality 2016
    2016 Gynecomastia and hyperprolactinemia secondary to advanced allergic fungal rhinosinusitis in a pediatric patient 2016
    2016 Rate of shunt revision as a function of age in patients with shunted hydrocephalus due to myelomeningocele 2016
    2016 Two-stage surgical resection of an atypical teratoid rhabdoid tumor occupying the infratentorial and supratentorial compartment in children under two years: Report of two cases 2016
    2015 Chiari malformation Type 1 and atlantoaxial instability: A letter from the Pediatric Craniocervical Society 2015
    2015 The Sport Concussion Assessment Tool-Second Edition and its Relationship with Attention and Verbal Learning in a Pediatric Population 2015
    2015 Clinical Presentation of Chiari I Malformation and Syringomyelia in Children 2015
    2015 Encephaloduroarteriosynangiosis and encephalomyoarteriosynangiosis for treatment of moyamoya syndrome in pediatric patients with sickle cell disease 2015
    2015 Identification of targets for rational pharmacological therapy in childhood craniopharyngioma 2015
    2015 Simulation, fabrication and impact testing of a novel football helmet padding system that decreases rotational acceleration 2015
    2014 Endoscopic third ventriculostomy with/without choroid plexus cauterization for hydrocephalus due to hemorrhage, infection, Dandy-Walker malformation, and neural tube defect: A meta-analysis 2014
    2014 Establishment of a multidisciplinary concussion program: Impact of standardization on patient care and resource utilization: Clinical article 2014
    2014 Fast-sequence MRI studies for surveillance imaging in pediatric hydrocephalus 2014
    2014 Lambdoidal synostosis in dizygotic twins with a family history of an undiagnosed connective tissue disorder 2014
    2013 Technology preferences among caregivers of children with hydrocephalus: Clinical article 2013
    2012 Clinical evaluation and surveillance imaging in children with spina bifida aperta and shunt-treated hydrocephalus: Clinical article 2012
    2011 Massive pediatric neurosurgical injuries and lessons learned following a tornado disaster in Alabama: Clinical article 2011
    2011 Extratemporal, nonlesional epilepsy in children: Postsurgical clinical and neurocognitive outcomes 2011
    2010 Complete versus anterior two-thirds corpus callosotomy in children: analysis of outcome 2010
    2010 Neurosurgical treatment of progressive posthemorrhagic ventricular dilation in preterm infants: A 10-year single-institution study 2010
    2010 Response 2010
    2010 Passive real-time identification of speech and motor cortex during an awake craniotomy 2010
    2009 Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with functional magnetic resonance imaging: Initial experience 2009
    2009 Isolated cerebellar Rosai-Dorfman granuloma mimicking Lhermitte-Duclos disease: Case report 2009
    2009 Resting-state Spontaneous Fluctuations in Brain Activity. A New Paradigm for Presurgical Planning Using fMRI 2009
    2008 Aneurysmal subarachnoid hemorrhage, hydrocephalus, and acute paraparesis 2008
    2008 Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum 2008
    2007 Prolonged target deprivation reduces the capacity of injured motoneurons to regenerate: Commentary 2007
    2007 Giant intracranial teratoma with epignathus in a neonate. Case report and review of the literature. 2007
    2007 Giant intracranial teratoma with epignathus in a neonate: Case report and review of the literature 2007
    2006 Depressed skull fracture. 2006
    2006 Depressed skull fracture. 2006
    2006 Complications of invasive subdural electrode monitoring at St. Louis Children's Hospital, 1994-2005 2006
    2006 Complications of invasive subdural electrode monitoring at St. Louis Children's Hospital, 1994-2005. 2006
    2006 Surgical techniques of selective dorsal rhizotomy for spastic cerebral palsy. Technical note. 2006


    Year Title Altmetric
    2013 The Chiari malformations and hydrocephalus.  273-282. 2013

    Education And Training

  • Doctor of Medicine, Washington University/St. Louis 2002
  • Bachelor of Arts in French Language and Literature, Washington & Lee University 1995
  • Washington University School of Medicine, Internship 2003
  • Washington University School of Medicine, Residency 2009
  • St. Louis Children's Hospital, Postdoctoral Fellowship 2010
  • Full Name

  • James Johnston