Selected Publications

Academic Article

Year Title Altmetric
2018 Optogenetic dissection of roles of specific cortical interneuron subtypes in GABAergic network synchronizationJournal of Physiology.  596:901-919. 2018
2018 Developmental changes in HCN channel modulation of neocortical layer 1 interneuronsFrontiers in Cellular Neuroscience.  12. 2018
2017 HCN channel modulation of synaptic integration in GABAergic interneurons in malformed rat NeocortexFrontiers in Cellular Neuroscience.  11. 2017
2016 Transcriptional dysregulation causes altered modulation of inhibition by haloperidolNeuropharmacology.  111:304-313. 2016
2016 Dynamic DNA methylation regulates neuronal intrinsic membrane excitabilityScience Signaling.  9. 2016
2015 Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K<sup>+</sup> channels and I<inf>h</inf>Frontiers in Cellular Neuroscience.  9. 2015
2015 DNA methylation regulates neuronal glutamatergic synaptic scalingScience Signaling.  8. 2015
2015 Interneuron transcriptional dysregulation causes frequency-dependent alterations in the balance of inhibition and excitation in hippocampusJournal of Neuroscience.  35:15276-15290. 2015
2015 Science signaling podcast: 23 June 2015Science Signaling.  8. 2015
2014 Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasiaFrontiers in Cellular Neuroscience.  8. 2014
2014 PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneuronsJournal of Neuroscience.  34:14375-14387. 2014
2014 Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortexNeuroscience.  271:137-148. 2014
2014 Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cellsNeurobiology of Disease.  62:160-171. 2014
2014 Transcriptional and epigenetic regulation of Hebbian and non-Hebbian plasticityNeuropharmacology.  80:3-17. 2014
2013 Regulation of epileptiform discharges in rat neocortex by HCN channelsJournal of Neurophysiology.  110:1733-1743. 2013
2013 Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampusNeuroscience.  248:602-619. 2013
2011 Decreased hyperpolarization-activated currents in layer 5 pyramidal neurons enhances excitability in focal cortical dysplasiaJournal of Neurophysiology.  106:2189-2200. 2011
2011 Baclofen and adenosine inhibition of synaptic transmission at CA3-CA1 synapses display differential sensitivity to K + channel blockadeCellular and Molecular Neurobiology.  31:587-596. 2011
2011 Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imagingJournal of Neurophysiology.  105:1768-1784. 2011
2011 Presynaptic NMDA receptors mediate IPSC potentiation at GABaergic synapses in developing rat neocortexPLoS ONE.  6. 2011
2010 Abnormal pyramidal cell morphology and HCN channel expression in cortical dysplasiaEpilepsia.  51:52-55. 2010
2009 GABA vesicles at synapses: Are there 2 distinct pools?Neuroscientist.  15:218-224. 2009
2008 Decreased glutamate transport enhances excitability in a rat model of cortical dysplasiaNeurobiology of Disease.  32:254-261. 2008
2008 Calcium release via activation of presynaptic IP3 receptors contributes to kainate-induced IPSC facilitation in rat neocortexNeuropharmacology.  55:106-116. 2008
2008 Kainate modulates presynaptic GABA release from two vesicle poolsJournal of Neuroscience.  28:725-731. 2008
2007 Pre- and postsynaptic effects of kainate on layer II/III pyramidal cells in rat neocortexNeuropharmacology.  53:37-47. 2007
2007 Dopaminergic modulation of local network activity in rat prefrontal cortexJournal of Neurophysiology.  97:4120-4128. 2007
2006 NR2B antagonists restrict spatiotemporal spread of activity in a rat model of cortical dysplasiaEpilepsy Research.  72:127-139. 2006
2006 Functional expression of Kir4.1 channels in spinal cord astrocytesGlia.  53:516-528. 2006
2006 Endogenous acetylcholine enhances synchronized interneuron activity in rat neocortexJournal of Neurophysiology.  95:1908-1916. 2006
2005 Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortexJournal of Neurophysiology.  94:2073-2085. 2005
2005 Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneuronsJournal of Neuroscience.  25:6322-6328. 2005
2005 Modification of epileptiform discharges in neocortical neurons following glutamate uptake inhibitionEpilepsia.  46:129-133. 2005
2005 Horizontal spread of activity in neocortical inhibitory networksDevelopmental Brain Research.  157:83-92. 2005
2005 Dopamine enhances spatiotemporal spread of activity in rat prefrontal cortexJournal of Neurophysiology.  93:864-872. 2005
2005 Ectopic action potential generation in cortical interneurons during synchronized GABA responsesNeuroscience.  131:833-842. 2005
2004 Glutamate transporters regulate excitability in local networks in rat neocortexNeuroscience.  127:625-635. 2004
2004 Regulation of circuits and excitability: implications for epileptogenesis.Epilepsy Currents.  4:151-153. 2004
2003 Dopamine enhances EPSCs in layer II-III pyramidal neurons in rat prefrontal cortexJournal of Neuroscience.  23:867-875. 2003
2003 GABAB receptor-mediated heterosynaptic depression of excitatory synaptic transmission in rat frontal neocortexBrain Research.  959:39-49. 2003
2001 Dopamine inhibition of evoked IPSCs in rat prefrontal cortexJournal of Neurophysiology.  86:2911-2918. 2001
2001 Chloride accumulation and depletion during GABAAreceptor activation in neocortexNeuroReport.  12:2537-2541. 2001
2001 Electrophysiological characteristics of reactive astrocytes in experimental cortical dysplasiaJournal of Neurophysiology.  85:1719-1731. 2001
2000 Nicotinic acetylcholine receptor-mediated synaptic potentials in rat neocortexBrain Research.  887:399-405. 2000
2000 Cellular abnormalities and synaptic plasticity in seizure disorders of the immature nervous systemMental Retardation and Developmental Disabilities Research Reviews.  6:258-267. 2000
2000 Potassium-coupled chloride cotransport controls intracellular chloride in rat neocortical pyramidal neuronsJournal of Neuroscience.  20:8069-8076. 2000
2000 Reactive astrocytes show enhanced inwardly rectifying K+currents in situNeuroReport.  11:3151-3155. 2000
2000 Quisqualate induces an inward current via mGluR activation in neocortical pyramidal neuronsBrain Research.  879:88-92. 2000
2000 Altered receptor subunit expression in rat neocortical malformationsEpilepsia.  41. 2000
2000 Alterations in NMDA receptors in a rat model of cortical dysplasiaJournal of Neurophysiology.  83:315-321. 2000
2000 Cellular abnormalities and synaptic plasticity in seizure disorders of the immature nervous system.Mental Retardation and Developmental Disabilities Research Reviews.  6:258-267. 2000
2000 Modulation of intrinsic circuits in developing neocortexEpilepsia.  41:1082-1084. 2000
1999 Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortexJournal of Neurophysiology.  82:2989-2999. 1999
1999 Dopamine modulation of membrane and synaptic properties of interneurons in rat cerebral cortexJournal of Neurophysiology.  81:967-976. 1999
1999 Reduction of zolpidem sensitivity in a freeze lesion model of neocortical dysgenesisJournal of Neurophysiology.  81:404-407. 1999
1998 Excitability changes in freeze-induced neocortical microgyriaEpilepsy Research.  32:75-82. 1998
1998 Depletion of intracellular CA2+ stores or lowering extracellular calcium alters intracellular Ca2+ changes during cerebral energy deprivationBrain Research.  796:125-131. 1998
1998 AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kineticsBrain Research.  780:166-169. 1998
1998 AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kineticsBrain Research.  780:164-167. 1998
1998 Activation of group I mGluRs increases spontaneous IPSC frequency in rat frontal cortexJournal of Neurophysiology.  80:621-627. 1998
1998 Zinc and zolpidem modulate mIPSCs in rat neocortical pyramidal neuronsJournal of Neurophysiology.  80:1670-1677. 1998
1997 Metabotropic glutamate receptor enhancement of spontaneous IPSCs in neocortical interneuronsJournal of Neurophysiology.  78:2287-2295. 1997
1997 Rapid kinetics and inward rectification of miniature EPSCs in layer I neurons of rat neocortexJournal of Neurophysiology.  77:2416-2426. 1997
1996 Morphological properties of intracellularly labeled layer I neurons in rat neocortexJournal of Comparative Neurology.  376:198-213. 1996
1996 Morphological properties of intracellularly labeled layer I neurons in rat neocortex.Journal of Comparative Neurology.  376:198-213. 1996
1996 Tetraethylammonium-induced synaptic plasticity in rat neocortexCerebral Cortex.  6:771-780. 1996
1996 G-protein activation by metabotropic glutamate receptors reduces spike frequency adaptation in neocortical neuronsNeuroscience.  75:123-131. 1996
1996 Postnatal development of membrane properties of layer I neurons in rat neocortexJournal of Neuroscience.  16:1131-1139. 1996
1996 Layer I neurons of rat neocortex. I. Action potential and repetitive firing propertiesJournal of Neurophysiology.  76:651-667. 1996
1996 Layer I neurons of the rat neocortex. II. Voltage-dependent outward currentsJournal of Neurophysiology.  76:668-682. 1996
1996 NMDA and non-NMDA synaptic currents in rat neocortex during early postnatal development.Epilepsy Research -Supplement-.  12:45-52. 1996
1995 Modulation of epileptiform activity by metabotropic glutamate receptors in immature rat neocortexJournal of Neurophysiology.  73:205-217. 1995
1995 N-methyl-d-aspartate receptor-mediated calcium accumulation in neocortical neuronsNeuroscience.  69:351-362. 1995
1994 Presynaptic depression of synaptic transmission mediated by activation of metabotropic glutamate receptors in rat neocortexJournal of Neuroscience.  14:5120-5130. 1994
1994 Developmental changes in the voltage-dependence of neocortical NMDA responsesDevelopmental Brain Research.  80:275-278. 1994
1994 Metabortropic glutamate receptor activation decreases epileptiform activity in rat neocortexNeuroscience Letters.  174:29-33. 1994
1994 Altered desensitization produces enhancement of EPSPs in neocortical neuronsJournal of Neurophysiology.  72:1032-1036. 1994
1994 Paired-pulse facilitation in the dentate gyrus: A patch-clamp study in rat hippocampus in vitroJournal of Neurophysiology.  72:326-336. 1994
1994 Spread of epileptiform activity in the immature rat neocortex studied with voltage-sensitive dyes and laser scanning microscopyJournal of Neurophysiology.  72:1756-1768. 1994
1993 Influence of barium on rectification in rat neocortical neuronsNeuroscience Letters.  157:62-66. 1993
1993 Developmental changes in NMDA and non-NMDA receptor-mediated synaptic potentials in rat neocortexJournal of Neurophysiology.  69:230-240. 1993
1993 Local anesthetics block transient outward potassium currents in rat neocortical neuronsJournal of Neurophysiology.  69:1966-1975. 1993
1993 NMDA receptor-mediated components of miniature excitatory synaptic currents in developing rat neocortexJournal of Neurophysiology.  70:1841-1852. 1993
1993 Zinc enhances GABAergic transmission in rat neocortical neuronsJournal of Neurophysiology.  70:1264-1269. 1993
1992 Kinetic properties of a transient outward current in rat neocortical neuronsJournal of Neurophysiology.  68:1133-1142. 1992
1992 NMDA receptor involvement in epileptogenesis in the immature neocortex.Epilepsy Research -Supplement-.  8:139-145. 1992
1992 Voltage‐dependence of GABAA‐receptor desensitization in cultured chick cerebral neuronsSynapse.  12:169-171. 1992
1991 Excitatory synaptic involvement in epileptiform bursting in the immature rat neocortexJournal of Neurophysiology.  66:1894-1901. 1991
1991 Initiation of epileptiform activity by excitatory amino acid receptors in the disinhibited rat neocortexJournal of Neurophysiology.  65:87-95. 1991
1990 Nystatin-perforated patch recordings disclose NMDA-induced outward currents in cultured neocortical neuronsBrain Research.  535:318-322. 1990
1990 Activation of subconductance states by γ-aminobutyric acid and its analogs in chick cerebral neuronsPflügers Archiv European Journal of Physiology.  416:454-461. 1990
1990 Effect of APV and ketamine on epileptiform acitivity in the CA1 and CA3 regions of the hippocampusEpilepsy Research.  6:87-94. 1990
1990 Excitatory postsynaptic potentials in rat neocortical neurons in vitro. III. Effects of a quinoxalinedione non-NMDA receptor antagonistJournal of Neurophysiology.  64:1282-1290. 1990
1989 Involvement of non-NMDA receptors in picrotoxin-induced epileptiform activity in the hippocampusNeuroscience Letters.  107:129-134. 1989
1989 Chronic exposure of developing cortical neurons to GABA down-regulates GABA/benzodiazepine receptors and GABA-gated chloride currentsBrain Research.  501:332-338. 1989
1989 Alterations in the microenvironment during spreading depression associated with epileptiform activity in the immature neocortexDevelopmental Brain Research.  46:243-252. 1989
1989 Cholinergic modulation of epileptiform activity in the developing rat neocortexDevelopmental Brain Research.  46:155-160. 1989
1989 Long-term potentiation in frontal cortex: Role of NMDA-modulated polysynaptic excitatory pathwaysNeuroscience Letters.  97:111-117. 1989
1989 EPSPs in rat neocortical neurons in vitro II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPsJournal of Neurophysiology.  61:621-634. 1989
1989 EPSPs in rat neocortical neurons in vitro. I. Electrophysiological evidence for two distinct EPSPsJournal of Neurophysiology.  61:607-620. 1989
1989 Zinc and glycine do not modify low-magnesium-induced epileptiform activity in the immature neocortex in vitroEpilepsy Research.  3:174-177. 1989
1989 cAMP increases the rate of GABAA receptor desensitization in chick cortical neuronsSynapse.  4:126-131. 1989
1988 Whole-cell and single-channel recordings of GABA-gated currents in cultured chick cerebral neuronsJournal of Neurophysiology.  59:495-513. 1988
1987 Extracellular K+ and Ca2+ changes during epileptiform discharges in the immature rat neocortexDevelopmental Brain Research.  36:299-303. 1987
1987 Glutamate-induced ionic currents in cultured neurons from the rat superior colliculusBrain Research.  420:182-187. 1987
1987 Conductance changes underlying a late synaptic hyperpolarization in hippocampal CA3 neuronsJournal of Neurophysiology.  58:160-179. 1987
1987 Extracellular K+ and Ca2+ changes during epileptiform discharges in the immature rat neocortex.Brain Research.  433:299-303. 1987
1987 Spontaneous ictal-like discharges and sustained potential shifts in the developing rat neocortexJournal of Neurophysiology.  58:1052-1065. 1987
1986 N-methyl-D-aspartate receptor antagonists reduce synaptic excitation in the hippocampusJournal of Neuroscience.  6:102-106. 1986
1986 Prenatal exposure to alcohol alters short-term plasticity in hippocampusExperimental Neurology.  93:423-427. 1986
1986 Step reductions in extracellular Ca2+ activate a transient inward current in chick dorsal root ganglion cellsBiophysical Journal.  50:753-757. 1986
1985 Action of excitatory amino acids and their antagonists on hippocampal neuronsCellular and Molecular Neurobiology.  5:389-405. 1985
1985 Role of uptake in γ-aminobutyric acid (GABA)-mediated responses in guinea pig hippocampal neuronsCellular and Molecular Neurobiology.  5:353-371. 1985
1984 Interaction of penicillin and pentobarbital with inhibitory synaptic mechanisms in neocortexCellular and Molecular Neurobiology.  4:301-317. 1984
1984 Picrotoxin-induced epileptiform activity in hippocampus: Role of endogenous versus synaptic factorsJournal of Neurophysiology.  51:1011-1027. 1984
1982 Conductance changes induced by DL-homocysteic acid and N-methyl-DL-aspartic acid in hippocampal neuronsBrain Research.  247:149-153. 1982
1982 Effect of sodium ions on penicillin-induced epileptiform activity in vitroExperimental Brain Research.  47:154-157. 1982
1982 Excitation of hippocampal pyramidal cells by glutamate in the guinea‐pig and rat.Journal of Physiology.  325:317-331. 1982
1982 Antagonism of GABA-mediated responses by d-tubocurarine in hippocampal neuronsJournal of Neurophysiology.  48:622-632. 1982
1981 Endogenous nature of spontaneous bursting in hippocampal pyramidal neuronsCellular and Molecular Neurobiology.  1:325-334. 1981
1981 Altered burst responses in hippocampal CA3 neurons injected with EGTAExperimental Brain Research.  42:483-485. 1981
1981 Reversal potential for glutamate responses in hippocampal pyramidal cellsNeuroscience Letters.  23:61-65. 1981
1981 Effects of intracellular injections of chloride and EGTA on postepileptiform-burst hyperpolarizations in hippocampal neuronsNeuroscience Letters.  22:159-163. 1981
1981 Hippocampal excitability and changes in extracellular potassiumExperimental Neurology.  71:410-420. 1981
1981 Synaptic triggering of epileptiform discharges in CA1 pyramidal cells in vitroActa Physiologica Scandinavica.  113:245-252. 1981
1980 Voltage clamp discloses slow inward current in hippocampal burst-firing neuronesNature.  286:391-393. 1980
1980 Pathological behavior of pyramidal cell dentrites as a major epileptogenic mechanismEpilepsia.  21:191-192. 1980
1978 Selective amplitude histograms: A statistical approach to EEG-single unit relationships in generalized epilepsyBrain Research.  154:317-329. 1978
1978 Chronically Isolated Cerebral Hemisphere in the Cat: Effects of Parenteral Administration of PenicillinEpilepsia.  19:637-642. 1978
1978 Focal penicillin epilepsy in an isolated cerebral hemisphereExperimental Neurology.  62:463-474. 1978
1977 Alterations in cerebellar unit activity during intramuscular penicillin epilepsyEpilepsia.  18:287. 1977
1977 Cerebellar unit activity during generalized penicillin epilepsy in the awake catExperimental Neurology.  56:189-199. 1977
1977 Modulation of cerebellar electrical and unit activity by low-frequency stimulation of caudate nucleus in chronic catsExperimental Neurology.  55:289-294. 1977
1977 Neuronal firing patterns during generalized penicillin epilepsy in the awake catBrain Research Bulletin.  2:317-321. 1977
1976 Cerebellar inhibition of intramuscular penicillin epilepsy in the catElectroencephalography and clinical neurophysiology.  40:310-311. 1976
1976 Cerebellar nuclear stimulation in generalized penicillin epilepsyBrain Research Bulletin.  1:599-601. 1976
1976 Intramuscular penicillin epilepsy in the cat: Effects of chronic cerebellar stimulationExperimental Neurology.  50:505-514. 1976
1975 Cortical seizures following cerebellar stimulation in primatesElectroencephalography and clinical neurophysiology.  38:423-426. 1975
1974 Electroencephalographic changes induced by cerebellar stimulation in freely moving primatesBrain Research.  75:305-308. 1974
1974 A technique for recording the electroretinogram (ERG) from chronically implanted electrodes in animalsVision Research.  14. 1974
1973 Operant conditioning and slow potential changes from monkey cortexElectroencephalography and clinical neurophysiology.  34:399-408. 1973
1973 Use of a simple visual display to reduce eye movement artifacts in CNV recordingsElectroencephalography and clinical neurophysiology.  34:433-436. 1973
1972 Adrenalin, sodium amobarbital, and the kamin effect in the albino ratLearning and Motivation.  3:51-58. 1972

Education And Training

  • Doctor of Philosophy in Psychology, University of Houston System : Clear Lake 1972
  • Full Name

  • John Hablitz