Positions

Overview

  • Dr. James F. George is a Professor of Surgery for the Division of Cardiothoracic Surgery. He is a molecular and cellular biologist who has worked in the field of heart failure and transplantation for more than 20 years. He is actively involved in researching the basic biology of heart failure and transplant rejection, the development of new drugs, and clinical outcomes after cardiac surgery and transplantation.

    His studies are concentrated in transplantation immunobiology, particularly in relation to allograft vascular disease, immune regulation, and the role of heme oxygenase-1. As Director of the Transplantation Immunobiology Laboratory and the UAB Microsurgical Core Laboratory, Dr. George has pursued investigations in: The role of Heme oxygenase-1, in arterial thrombosis, and the development of post-transplant vascular disease, one of the largest limitations to long-term heart transplant survival. The mechanisms of clinical benefit from extracorporeal photopheresis, a clinical treatment involving the exposure of peripheral blood mononuclear cells to ultraviolet irradiation. The development of unique rodent-based animal models in acute kidney injury, including ischemia reperfusion and unilateral ureteral obstruction, and the molecular mechanisms of immunological tolerance. Dr. George also has a substantial interest in clinical outcomes research as it relates to transplantation and heart failure. As Director of Cardiothoracic Surgery Research, he oversees all clinical research efforts within the Division of Cardiothoracic Surgery in the Department of Surgery. Clinical research efforts in collaboration with heart failure physicians are concentrated on time-related analyses of outcomes with respect to patient demographic variables, clinical care, and post-treatment morbid events in patients undergoing heart failure, heart and lung transplantation, and those implanted with ventricular assist devices.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells.AJP - Renal Physiology.  314:F702-F714. 2018
    2018 Association of Pulsatility with Gastrointestinal Bleeding in a Cohort of HeartMate II Recipients.ASAIO Journal.  64:472-479. 2018
    2018 Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection.Frontiers in Immunology.  9:860. 2018
    2017 Parabiosis reveals leukocyte dynamics in the kidney.Laboratory Investigation.  98:391-402. 2017
    2017 Increased Inflammation in Pericardial Fluid Persists 48 Hours After Cardiac Surgery.Circulation.  136:2284-2286. 2017
    2017 Practical application of gene expression arrays in a clinical setting: The light at the end of a long tunnel.The Journal of heart transplantation.  36:1178-1179. 2017
    2017 Anticoagulation Control in Patients With Ventricular Assist Devices.ASAIO Journal.  63:759-765. 2017
    2017 Mononuclear phagocyte subpopulations in the mouse kidney.AJP - Renal Physiology.  312:F640-F646. 2017
    2016 Heme Oxygenase-1 in Kidney Health and Disease.Antioxidants and Redox Signaling.  25:165-183. 2016
    2016 Heme oxygenase-1 regulates mitochondrial quality control in the heart.JCI insight.  1:e85817. 2016
    2015 Predictors of thromboembolic events in patients with ventricular assist deviceASAIO Journal.  61:640-647. 2015
    2015 Predictors of Thromboembolic Events in Patients with Ventricular Assist Device.ASAIO Journal.  61:640-647. 2015
    2015 Clinical Characteristics and Outcomes of Intravenous Inotropic Therapy in Advanced Heart Failure.Circulation: Heart Failure.  8:880-886. 2015
    2015 Heme Oxygenase-1 Regulates Myeloid Cell Trafficking in AKI.Journal of the American Society of Nephrology.  26:2139-2151. 2015
    2015 Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.Human Molecular Genetics.  24:4078-4093. 2015
    2015 Decreased Bioenergetic Health Index in monocytes isolated from the pericardial fluid and blood of post-operative cardiac surgery patients.Bioscience Reports.  35. 2015
    2015 Macrophage and epithelial cell H-ferritin expression regulates renal inflammation.Kidney International.  88:95-108. 2015
    2015 A time-related parametric risk factor analysis for postoperative atrial fibrillation after heart surgery.Journal of Thoracic and Cardiovascular Surgery.  149:886-892. 2015
    2015 Effects of antegrade versus integrated blood cardioplegia on left ventricular function evaluated by echocardiographic real-time 3-dimensional speckle tracking.Journal of Thoracic and Cardiovascular Surgery.  149:877-84.e1-5. 2015
    2015 Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patients.Laboratory Investigation.  95:132-141. 2015
    2015 Transcatheter aortic valve replacement program in the post-food and drug administration approval era: early outcomes at an academic medical center.Innovations:Technology and Techniques in Cardiothoracic and Vascular Surgery.  10:48-51. 2015
    2014 Have risk factors for mortality after heart transplantation changed over time? Insights from 19 years of Cardiac Transplant Research Database study.The Journal of heart transplantation.  33:1304-1311. 2014
    2014 Utility of double-balloon enteroscopy in patients with left ventricular assist devices and obscure overt gastrointestinal bleeding.Endoscopy.  46:986-991. 2014
    2014 Infection and rejection risk after cardiac transplantation with induction vs. no induction: a multi-institutional study.Clinical Transplantation.  28:946-952. 2014
    2014 Single-center experience with extracorporeal photopheresis in pediatric heart transplantation.The Journal of heart transplantation.  33:624-628. 2014
    2014 A multi-institutional study of malignancies after heart transplantation and a comparison with the general United States population.The Journal of heart transplantation.  33:478-485. 2014
    2014 The mononuclear phagocyte system in homeostasis and disease: a role for heme oxygenase-1.Antioxidants and Redox Signaling.  20:1770-1788. 2014
    2014 Systemic effects of intracoronary nitroglycerin during coronary angiography in children after heart transplantation.Texas Heart Institute Journal.  41:21-25. 2014
    2014 A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy.Frontiers in Medicine.  1:45. 2014
    2013 Gastrointestinal bleeding in patients with ventricular assist devices is highest immediately after implantation.ASAIO Journal.  59:480-485. 2013
    2013 Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase.Laboratory Investigation.  93:868-879. 2013
    2013 Ganciclovir prophylaxis improves late murine cytomegalovirus-induced renal allograft damage.Transplantation.  95:48-53. 2013
    2012 A reproducible mouse model of chronic allograft nephropathy with vasculopathy.Kidney International.  82:1231-1235. 2012
    2012 Orthotopic aortic transplantation in mice for the study of vascular disease.Journal of Visualized Experiments.  e4338. 2012
    2012 A 16-year multi-institutional study of the role of age and EBV status on PTLD incidence among pediatric heart transplant recipients.American Journal of Transplantation.  12:3061-3068. 2012
    2012 In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice.Kidney International.  82:278-291. 2012
    2012 Opportunities for improvement in heart transplantation outcomes for young adults 18 to 35 years of age.The Journal of heart transplantation.  31:903-904. 2012
    2012 Comparison of observed survival after ventricular assist device placement versus predicted survival without assist device using the Seattle heart failure model.ASAIO Journal.  58:93-97. 2012
    2012 Pathologic features of dilated cardiomyopathy with localized noncompaction in a child with deletion 1p36 syndrome.Congenital Heart Disease.  7:59-61. 2012
    2011 Total lymphoid irradiation in heart transplantation: long-term efficacy and survival--an 18-year experience.Transplantation.  92:1159-1164. 2011
    2011 Allosensitization and outcomes in pediatric heart transplantation.The Journal of heart transplantation.  30:1221-1227. 2011
    2011 Ganciclovir transiently attenuates murine cytomegalovirus-associated renal allograft inflammation.Transplantation.  92:759-766. 2011
    2011 Improvement in 2-year survival for ventricular assist device patients after implementation of an intensive surveillance protocol.The Journal of heart transplantation.  30:879-887. 2011
    2011 The role of fibrinolytic genes and proteins in the development of allograft vascular disease.The Journal of heart transplantation.  30:935-944. 2011
    2011 Early therapy evaluation of combined cetuximab and irinotecan in orthotopic pancreatic tumor xenografts by dynamic contrast-enhanced magnetic resonance imaging.Molecular Imaging.  10:153-167. 2011
    2011 Carbon monoxide-releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in diluted plasma in vitro.Journal of Trauma.  70:939-947. 2011
    2011 DCE-MRI detects early vascular response in breast tumor xenografts following anti-DR5 therapy.Clinical Positron Imaging.  13:94-103. 2011
    2011 Minimizing infection and rejection death: clues acquired from 19 years of multi-institutional cardiac transplantation data.The Journal of heart transplantation.  30:151-157. 2011
    2011 Data quality in the study of the mechanisms of extracorporeal photochemotherapy.Blood.  117:366-367. 2011
    2011 Use of gated cardiac computed tomography angiography in the assessment of left ventricular assist device dysfunction.ASAIO Journal.  57:32-37. 2011
    2010 Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in plasma exposed to heparin or argatroban.Anesthesia and Analgesia.  111:1347-1352. 2010
    2010 On solid-phase antibody assays.The Journal of heart transplantation.  29:1207-1209. 2010
    2010 Balancing rejection and infection with respect to age, race, and gender: clues acquired from 17 years of cardiac transplantation data.The Journal of heart transplantation.  29:966-972. 2010
    2010 Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in subjects exposed to warfarin.Thrombosis Research.  126:68-73. 2010
    2010 Carbon monoxide releasing molecule-2 increases fibrinogen-dependent coagulation kinetics but does not enhance prothrombin activity.Blood Coagulation and Fibrinolysis.  21:349-353. 2010
    2010 Heme oxygenase-1 expression in murine dendritic cell subpopulations: effect on CD8+ dendritic cell differentiation in vivo.American Journal of Pathology.  176:2831-2839. 2010
    2010 Carbon monoxide releasing molecule-2 decreases thick diameter fibrin fibre formation in normal and Factor XIII deficient plasmas.Blood Coagulation and Fibrinolysis.  21:101-105. 2010
    2010 Carbon monoxide releasing molecule-2 increases the velocity of thrombus growth and strength in hemophilia A, hemophilia B and factor VII-deficient plasmas.Blood Coagulation and Fibrinolysis.  21:41-45. 2010
    2010 Hydrogen: another gas with therapeutic potential.Kidney International.  77:85-87. 2010
    2009 Carbon monoxide-releasing molecule-2 decreases fibrinolysis in human plasma.Blood Coagulation and Fibrinolysis.  20:448-455. 2009
    2009 Carbon monoxide releasing molecule-2 increases the velocity of thrombus growth and strength in human plasma.Blood Coagulation and Fibrinolysis.  20:377-380. 2009
    2009 Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantation.American Journal of Pathology.  175:422-429. 2009
    2008 Patient with hypofibrinolysis-mediated thromboembolism converted to a hypercoagulable/hyperfibrinolytic state via ventricular assist device placement.The Journal of heart transplantation.  27:1169-1171. 2008
    2008 Mechanical circulatory device thrombosis: a new paradigm linking hypercoagulation and hypofibrinolysis.ASAIO Journal.  54:351-358. 2008
    2008 Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.American Journal of Pathology.  173:154-160. 2008
    2008 Role for CD4(+)CD25(+) T cells in inhibition of graft rejection by extracorporeal photopheresis.The Journal of heart transplantation.  27:616-622. 2008
    2008 IL-10 and IL-4 in skin allograft survival induced by T-cell depletion plus deoxyspergualin.Cell Transplantation.  17:713-720. 2008
    2007 Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model.American Journal of Transplantation.  7:1112-1120. 2007
    2006 Rejection with hemodynamic compromise: objective evidence for efficacy of photopheresis.The Journal of heart transplantation.  25:283-288. 2006
    2006 Xenotransplantation: an ethical dilemma.Current Opinion in Cardiology.  21:138-141. 2006
    2005 Of mice and men: mouse models and the molecular mechanisms of post-transplant coronary artery disease.The Journal of heart transplantation.  24:2003-2014. 2005
    2005 Multi-organ transplantation: is there a protective effect against acute and chronic rejection?The Journal of heart transplantation.  24:1828-1833. 2005
    2003 Allogeneic bone marrow inhibits T-cell activation and clonal expansion in vitro.Transplantation.  76:237-243. 2003
    2003 Donor PAI-1 expression inhibits the intimal response of early allograft vascular disease.The Journal of heart transplantation.  22:515-518. 2003
    2002 Aortic graft transplantation in mice.The Journal of heart transplantation.  21:1319-1321. 2002
    2002 Molecular and cellular mechanisms of donor cell-induced tolerance.Immunologic Research.  26:119-129. 2002
    2001 Indefinite allograft survival mediated by donor bone marrow is dependent on the presence of a functional CD95 (Fas) gene in recipients.The Journal of heart transplantation.  20:1132-1135. 2001
    2001 An essential role for natural killer cells in augmentation of allograft survival mediated by donor spleen cells.Transplantation.  72:954-956. 2001
    2001 Peter Medawar and the science of transplantation: a parable.The Journal of heart transplantation.  20:927. 2001
    2001 Differential modulation of alloreactive T cell receptor expression induced by allogeneic bone marrow and splenocyte infusions.The Journal of heart transplantation.  20:172. 2001
    2001 Preclinical bridge to clinical toleranceCurrent Opinion in Organ Transplantation.  6:95-101. 2001
    2000 A differential requirement for CD8+ donor cells in the augmentation of allograft survival by posttransplantation administration of donor spleen cells and donor bone marrow cells.Transplantation.  70:1068-1073. 2000
    2000 Enhanced allograft survival induced by posttransplant donor spleen cell infusion occurs via a mechanism that is distinct from the mechanism of enhancement by donor bone marrow.Transplantation.  69:1020-1022. 2000
    1999 Donor bone marrow and transplantation tolerance: historical perspectives, molecular mechanisms and future directions (review).International Journal of Molecular Medicine.  4:475-482. 1999
    1999 The molecular mechanisms of veto mediated regulation of alloresponsiveness.The Clinical investigator.  77:519-526. 1999
    1999 An automated method for the analysis of T-cell receptor repertoires. Rapid RT-PCR fragment length analysis of the T-cell receptor beta chain complementarity-determining region 3.American Journal of Clinical Pathology.  111:683-690. 1999
    1999 Immunoregulatory role of CD8alpha in the veto effect.Transplantation.  67:372-380. 1999
    1999 Immunoregulatory role of CD8α in the veto effect: Transforming growth factor-b1 activationTransplantation.  67:372-380. 1999
    1999 A developmental bias in reading frame usage by human fetal thymic TCRBDJ transcripts is not present in genomic TCRBDJ rearrangements.Autoimmunity.  7:9-15. 1999
    1998 Gene polymorphisms for plasminogen activator inhibitor-1/tissue plasminogen activator and development of allograft coronary artery disease.Circulation.  98:2248-2254. 1998
    1998 Molecular cloning, expression and characterization of rhesus macaque Fas ligand cDNA.Human Immunology.  59:599-606. 1998
    1998 DR non-B1 mismatches influence allogeneic MLR-induced TH1- or TH2-like cytokine responses in rhesus monkeys.Human Immunology.  59:363-372. 1998
    1998 An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow.Nature Medicine.  4:333-335. 1998
    1997 Serial measurements of interleukin-6, interleukin-8, tumor necrosis factor-alpha, and soluble vascular cell adhesion molecule-1 in the peripheral blood plasma of human cardiac allograft recipients.The Journal of heart transplantation.  16:1046-1053. 1997
    1996 Semiquantitative measurement of cytokine messenger RNA in endomyocardium and peripheral blood mononuclear cells from human heart transplant recipients.The Journal of heart transplantation.  15:206-217. 1996
    1995 Utility of posttransplantation panel-reactive antibody measurements for the prediction of rejection frequency and survival of heart transplant recipients.The Journal of heart transplantation.  14:856-864. 1995
    1994 Arrested rearrangement of TCR V beta genes in thymocytes from children with X-linked severe combined immunodeficiency disease.Journal of Immunology.  153:442-448. 1994
    1994 Reply to the EditorJournal of Thoracic and Cardiovascular Surgery.  107:1366-1367. 1994
    1993 Total lymphoid irradiation: is there a role in pediatric heart transplantation?The Journal of heart transplantation.  12:S293-S300. 1993
    1993 Invited letter concerning: cytokines and mechanisms of capillary leakage after cardiopulmonary bypass.Journal of Thoracic and Cardiovascular Surgery.  106:566-567. 1993
    1993 Invited letter concerning: Transplantation tolerance and transplantation.Journal of Thoracic and Cardiovascular Surgery.  105:184-185. 1993
    1992 Methotrexate pulse therapy in the treatment of recurrent acute heart rejection.The Journal of heart transplantation.  11:1116-1124. 1992
    1992 Developmental regulation of D beta reading frame and junctional diversity in T cell receptor-beta transcripts from human thymus.Journal of Immunology.  148:1230-1239. 1992
    1990 Gamma/delta T cells and alpha/beta T cells differ in their developmental patterns of receptor expression and modulation requirements.European Journal of Immunology.  20:2177-2181. 1990
    1990 γ/δ T cells and α/β T cells differ in their developmental patterns of receptor expression and modulation requirementsEuropean Journal of Immunology.  20:2177-2181. 1990
    1989 T-cell development in birds.Cold Spring Harbor Symposia on Quantitative Biology.  54 Pt 1:69-73. 1989
    1987 Alteration of the protein composition in the haemolymph of American cockroaches immunized with soluble proteins.Immunology.  62:505-509. 1987
    1987 Primary integumentary allograft reactivity in the American cockroach, Periplaneta americana.Transplantation.  43:514-519. 1987
    1986 Recent progress in studies on cell-mediated immune responsiveness in insects.Experimental and Clinical Immunogenetics.  3:1-9. 1986
    1985 Primary integumentary allograft reactivity in the American cockroachFederation proceedings.  44. 1985
    1984 Primary integumentary xenograft reactivity in the American cockroach, Periplaneta americana.Transplantation.  37:478-484. 1984

    Chapter

    Year Title Altmetric
    1989 Lymphocyte Development and Receptor Selection - T Cells T-cell Development in Birds.  69-73. 1989

    Research Overview

  • immune regulation of post-transplant vascular disease and allograft rejection, transplantation and heart failure outcomes research
  • Investigator On

  • UAB-UCSD O'Brien Center For Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • TLR4 in the Regulation of Renal Microvascular Function  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • Injury Response Mediated Pathogenesis in Renal Ciliopathies  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2021
  • Human Heme Oxygenase-1 Gene Regulation in Renal Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2020
  • C-Reactive Protein in Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • Splenic Marginal Zone Macrophages in Chronic Ischemic Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2019
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • Innate Immunity and Viral Renal Allograft Injury  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2015
  • UAB -UCSD O'Brien Core Center for Acute Kidney Injury Research - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • Genomic Classification of the Heart Transplant Endomyocardial Biopsy  awarded by University of California, Los Angeles 2012 - 2013
  • Genomic Classification of the Heart Transplant Endomyocardial Biopsy  awarded by American Heart Association (Southeast Affiliate) 2011 - 2013
  • Full Name

  • James George