Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Chemical Synthesis and Application of Biotinylated Oligo-α-(1 → 3)- d -Glucosides to Study the Antibody and Cytokine Response against the Cell Wall α-(1 → 3)- d -Glucan of Aspergillus fumigatusJournal of Organic Chemistry.  83:12965-12976. 2018
2018 Terminal deoxynucleotidyl transferase is not required for antibody response to polysaccharide vaccines against Streptococcus pneumoniae and Salmonella enterica serovar TyphiInfection and Immunity.  86. 2018
2018 IL-7 enables antibody responses to bacterial polysaccharides by promoting B cell receptor diversityJournal of Immunology.  201:1229-1240. 2018
2018 Myeloid-derived suppressor cells impair B cell responses in lung cancer through IL-7 and STAT5Journal of Immunology.  201:278-295. 2018
2017 Accelerated systemic autoimmunity in the absence of somatic hypermutation in 564Igi: A mouse model of systemic lupus with knocked-in heavy and light chain genesFrontiers in Immunology.  8. 2017
2017 Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfacesJCI insight.  2. 2017
2017 CD36 and platelet-activating factor receptor promote house dust mite allergy developmentJournal of Immunology.  199:1184-1195. 2017
2017 Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10Nature Immunology.  18:313-320. 2017
2016 Immunological outcomes of antibody binding to glycans shared between microorganisms and mammalsJournal of Immunology.  197:4201-4209. 2016
2016 Pulmonary α-1,3-glucan-specific iga-secreting b cells suppress the development of cockroach allergyJournal of Immunology.  197:3175-3187. 2016
2016 Manipulation of the glycan-specific natural antibody repertoire for immunotherapyImmunological Reviews.  270:32-50. 2016
2015 Antibodies generated against streptococci protect in a mouse model of disseminated aspergillosisJournal of Immunology.  194:4387-4396. 2015
2015 B cell autophagy mediates TLR7-dependent autoimmunity and inflammationAutophagy.  11:1010-1024. 2015
2015 Natural antibody repertoires: Development and functional role in inhibiting allergic airway diseaseAnnual Review of Immunology.  33:475-504. 2015
2015 Neonatal exposure to pneumococcal phosphorylcholine modulates the development of house dust mite allergy during adult lifeJournal of Immunology.  194:5838-5850. 2015
2015 Unique ligand-binding property of the human IgM Fc receptorJournal of Immunology.  194:1975-1982. 2015
2014 Microbicidal power of alpha radiation in sterilizing germinating Bacillus anthracis sporesAntimicrobial Agents and Chemotherapy.  58:1813-1815. 2014
2014 Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosusEuropean Journal of Immunology.  44:1503-1516. 2014
2013 Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survivalProceedings of the National Academy of Sciences.  110. 2013
2013 The link between antibodies to oxldl and natural protection against pneumococci depends on dh gene conservationJournal of Experimental Medicine.  210:875-890. 2013
2013 The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammationJournal of Investigative Dermatology.  133:2714-2721. 2013
2012 Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (FcμR)Proceedings of the National Academy of Sciences.  109:15882-15887. 2012
2012 Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway diseaseJournal of Immunology.  189:2246-2256. 2012
2012 Long-term maintenance of polysaccharide-specific antibodies by IgM-secreting cellsJournal of Immunology.  188:57-67. 2012
2011 Cathelin-related antimicrobial peptide differentially regulates T- and B-cell functionEuropean Journal of Immunology.  41:3006-3016. 2011
2011 Limiting CDR-H3 diversity abrogates the antibody response to the bacterial polysaccharide α 1→3 dextranJournal of Immunology.  187:879-886. 2011
2011 Marginal zone B cells regulate antigen capture by marginal zone macrophagesJournal of Immunology.  186:2172-2181. 2011
2010 Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide α-1,3 dextranJournal of Immunology.  184:851-858. 2010
2010 ExsB, an unusually highly phosphorylated protein required for the stable attachment of the exosporium of Bacillus anthracisMicrobiological sciences.  76:1527-1538. 2010
2009 Generation of B cell memory to the bacterial polysaccharide α-1,3 dextranJournal of Immunology.  183:6359-6368. 2009
2009 PI3 Kinase Signals BCR-Dependent Mature B Cell SurvivalCell.  139:573-586. 2009
2009 CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophagesProceedings of the National Academy of Sciences.  106:13957-13962. 2009
2008 Cathelicidin administration protects mice from Bacillus anthracis spore challengeJournal of Immunology.  181:4989-5000. 2008
2008 PIR-B-deficient mice are susceptible to Salmonella infectionJournal of Immunology.  181:4229-4239. 2008
2008 B cell subpopulations and secondary lymphoid organ architectureSeminars in Immunology.  20:1-3. 2008
2008 The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytesProceedings of the National Academy of Sciences.  105:1261-1266. 2008
2008 CD36 is differentially expressed on B cell subsets during development and in responses to antigenJournal of Immunology.  180:230-237. 2008
2008 DNA microarray gene expression profile of marginal zone versus follicular B cells and idiotype positive marginal zone B cells before and after immunization with Streptococcus pneumoniaeJournal of Immunology.  180:6663-6674. 2008
2007 Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cellsJournal of Immunology.  179:1340-1352. 2007
2007 Non-uniform assembly of the Bacillus anthracis exosporium and a bottle cap model for spore germination and outgrowthMicrobiological sciences.  64:359-367. 2007
2006 Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cellsJournal of Immunology.  177:6815-6823. 2006
2006 The ExsY protein is required for complete formation of the exosporium of Bacillus anthracisJournal of Bacteriology.  188:7440-7448. 2006
2006 Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin MiceImmunity.  25:429-440. 2006
2006 Erratum: Monoclonal antibodies for Bacillus anthracis spore detection and functional analyses of spore germination and outgrowth (Journal of Immunology (2006) 176 (6076-6084))Journal of Immunology.  177:2024. 2006
2006 Monoclonal antibodies for Bacillus anthracis spore detection and functional analyses of spore germination and outgrowthJournal of Immunology.  176:6076-6084. 2006
2006 Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigenProceedings of the National Academy of Sciences.  103:3734-3739. 2006
2005 Characterization of the exosporium basal layer protein BxpB of Bacillus anthracisJournal of Bacteriology.  187:5868-5876. 2005
2005 Marginal zone B cells in lymphocyte activation and regulationCurrent Opinion in Immunology.  17:244-250. 2005
2005 Innate-like B cellsSpringer Seminars in Immunopathology.  26:377-383. 2005
2005 Isoforms of terminal deoxynucleotidyltransferase: Developmental aspects and functionAdvances in Immunology.  86:113-136. 2005
2005 Marginal zone B cell physiology and disease.Current Directions in Autoimmunity.  8:91-123. 2005
2004 Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variantsJournal of Immunology.  173:4009-4019. 2004
2004 B cell positive selection: Road map to the primary repertoire?Journal of Immunology.  173:15-19. 2004
2004 Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T CellsJournal of Immunology.  172:803-811. 2004
2004 Development and selection of marginal zone B cellsImmunological Reviews.  197:192-205. 2004
2003 Peptide Ligands that Bind Selectively to Spores of Bacillus subtilis and Closely Related SpeciesApplied and Environmental Microbiology.  69:6841-6847. 2003
2003 Delayed lupus onset in (NZB × NZW)F1 mice expressing a human C-reactive protein transgeneArthritis and Rheumatism.  48:1602-1611. 2003
2003 Identification of the immunodominant protein and other proteins of the Bacillus anthracis exosporiumJournal of Bacteriology.  185:1903-1910. 2003
2002 Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responsesImmunity.  17:341-352. 2002
2002 Activated α4 integrins are preferentially expressed on immature thymocytes and activated T cellsAutoimmunity.  9:73-84. 2002
2002 CD9 is a unique marker for marginal zone B cells, B1 cells, and plasma cells in miceJournal of Immunology.  168:5605-5611. 2002
2002 Distinct and opposite diversifying activities of terminal transferase splice variantsNature Immunology.  3:457-462. 2002
2002 Marginal-zone B cellsNature Reviews Immunology.  2:323-335. 2002
2001 Bacillus Spore Inactivation Methods Affect Detection AssaysApplied and Environmental Microbiology.  67:3665-3670. 2001
2001 B1 cells: Similarities and differences with other B cell subsetsCurrent Opinion in Immunology.  13:195-201. 2001
2001 Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferaseNucleic Acids Research.  29:1638-1646. 2001
2001 Antigen receptor proximal signaling in splenic B-2 cell subsetsJournal of Immunology.  166:3122-3129. 2001
2001 Autoreactivity by design: Innate B and T lymphocytesNature Reviews Immunology.  1:177-186. 2001
2001 Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigensImmunity.  14:617-629. 2001
2001 The long isoform of terminal deoxynucleotidyl transferase enters the nucleus and, rather than catalyzing nontemplated nucleotide addition, modulates the catalytic activity of the short isoformJournal of Experimental Medicine.  193:89-99. 2001
2000 Selection in the mature B cell repertoireCurrent Topics in Microbiology and Immunology.  252:97-105. 2000
2000 B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a ″natural immune memory″Immunological Reviews.  175:70-79. 2000
2000 Terminal deoxynucleotidyl transferase and repertoire developmentImmunological Reviews.  175:150-157. 2000
2000 Immune recognition of OxLDL in atherosclerosisJournal of Clinical Investigation.  105:1683-1685. 2000
2000 Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btkImmunity.  12:39-49. 2000
2000 The arthus reaction in rodents: Species-specific requirement of complementJournal of Immunology.  164:463-468. 2000
1999 Partial IgA-deficiency with increased Th2-type cytokines in TGF-β1 knockout miceJournal of Immunology.  163:1951-1957. 1999
1999 IgM(high)CD21(high) lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cellsJournal of Immunology.  162:7198-7207. 1999
1999 CD21(high) IgM(High) splenic B cells enriched in the marginal zone: Distinct phenotypes and functionsCurrent Topics in Microbiology and Immunology.  246:45-52. 1999
1999 A developmental bias in reading frame usage by human fetal thymic TCRBDJ transcripts is not present in genomic TCRBDJ rearrangementsAutoimmunity.  7:9-15. 1999
1999 Ab 93 antigen: Mouse FcγRII and FcγRIIIHybridoma.  18:211. 1999
1999 Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult miceImmunity.  10:607-617. 1999
1999 Independently ligating CD38 and FcγRIIB relays a dominant negative signal to B cellsHybridoma.  18:113-119. 1999
1998 T and B cell development in BP-1/6C3/aminopeptidase A-deficient miceJournal of Immunology.  160:4681-4687. 1998
1998 Generation of the germline peripheral B cell repertoire: VH81X-λ B cells are unable to complete all developmental programsJournal of Immunology.  160:3748-3758. 1998
1998 In vivo generation and function of CD21high IGMHIGH (MZ) B cells is BTK dependent and T independentFederation proceedings.  12. 1998
1998 Ontogeny of the autoreactive and anti-Streptococcus sanguis antibody repertoire in human infantsFederation proceedings.  12. 1998
1998 Repertoire changes and loss of B lineage cells in TDT transgenic miceFederation proceedings.  12. 1998
1998 Splenic CD21high IGMhigh (MZ) B cells can quickly generate into plasma cells after in-vivo T-independent antigen stimulationFederation proceedings.  12. 1998
1997 Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responsesEuropean Journal of Immunology.  27:2366-2374. 1997
1997 Development of V(H)81X transgene-bearing B cells in fetus and adult: Sites for expansion and deletion in conventional and CD5/B1 cellsInternational Immunology.  9:493-505. 1997
1997 Isolation and purification of CD14-negative mucosal macrophages from normal human small intestineJournal of Immunological Methods.  202:1-11. 1997
1997 Evidence for selection of a population of multi-reactive B cells into the splenic marginal zoneInternational Immunology.  9:27-41. 1997
1997 Mouse CD38 Is Down-Regulated on Germinal Center B Cells and Mature Plasma CellsJournal of Immunology.  158:1108-1115. 1997
1997 B cell development in miceInternational Reviews of Immunology.  15:207-241. 1997
1996 A novel murine integrin β subunit associates with α4 and is involved in lymphocyte traffickingFederation proceedings.  10. 1996
1996 Loss of fetal and neonatal B cells in TDT transgenic miceFederation proceedings.  10. 1996
1996 Lymphoid precursors in the human fetal mesenteryFederation proceedings.  10. 1996
1996 Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motifInternational Immunology.  8:1195-1203. 1996
1996 Generation and function of natural self-reactive B lymphocytesSeminars in Immunology.  8:19-27. 1996
1995 Sequence analysis and antigen binding characteristics of Ig SCID Ig+; miceInternational Immunology.  7:807-819. 1995
1995 Development of the Mouse B‐Cell RepertoireAnnals of the New York Academy of Sciences.  764:207-221. 1995
1995 Do CD5 B cells respond to oral antigens?Advances in Experimental Medicine and Biology.  371:1439-1444. 1995
1995 T cell activation through Thy-1 is associated with the expression of a surface protein(p100) on a subset of CD4 cellsInternational Immunology.  7:607-616. 1995
1994 Immunofluorescence analysis of B-1 cell ontogeny in the mouseInternational Immunology.  6:355-361. 1994
1994 CD5 transgenic miceCurrent Topics in Microbiology and Immunology.  194:209-217. 1994
1994 Effects of Igm Allotype Suppression on Serum Igm Levels, B-L and B-2 Cells, and Antibody Responses Ir Allotype Heterozygous Fi MiceAutoimmunity.  4:27-41. 1994
1994 Formation of Autoantibodies, Including Anti-Cytokine Antibodies, Is a Hallmark of the Immune Response of Early B CellsJournal of interferon research.  14:151-152. 1994
1994 Lymphopoiesis todayImmunology Today.  15:255-257. 1994
1994 Synergistic induction of thermotolerance in murine natural killer cells by interferon α and mild heat shockRadiation Research.  139:364-369. 1994
1993 Normal B lymphocyte differentiation.Baillieres Clinical Haematology.  6:785-806. 1993
1993 3 Normal B lymphocyte differentiationBaillieres Clinical Haematology.  6:785-806. 1993
1993 CD5+ B-cell networksCurrent Opinion in Immunology.  5:223-226. 1993
1993 Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide: V. In vivo expression of individual antibody clones is dependent on Ig C(H) haplotypes and the categories of antigenJournal of Immunology.  151:4352-4361. 1993
1992 Early B-cell repertoiresCurrent Topics in Microbiology and Immunology.  182:81-84. 1992
1992 Characterization, specificity, and lgV gene usage of anti-lymphocyte monoclonal antibodies from perinatal miceInternational Immunology.  4:1073-1084. 1992
1992 The expression of the mouse VpreB/λ5 locus in transformed cell lines and tumors of the B lineage differentiation pathwayInternational Immunology.  4:831-840. 1992
1992 Continuous anti-interleukin 10 antibody administration depletes mice of ly-1 b cells but not conventional b cellsJournal of Experimental Medicine.  175:1213-1220. 1992
1992 The human fetal omentum: A site of B cell generationJournal of Experimental Medicine.  175:397-404. 1992
1992 Development and function of the early b cell repertoireInternational Reviews of Immunology.  8:247-257. 1992
1992 Effect of a VH81X‐Expressing IgM Antibody on Early B‐Cell DevelopmentAnnals of the New York Academy of Sciences.  651:160-161. 1992
1992 Identification of a surface protein (p100) associated with two glycosyl‐phosphatidylinositol‐linked molecules (Thy‐1 and ThB) by natural anti‐lymphocyte autoantibodiesEuropean Journal of Immunology.  22:2373-2380. 1992
1992 Idiotypic Regulation of Development of the B‐Cell RepertoireAnnals of the New York Academy of Sciences.  651:336-345. 1992
1992 Perinatally Derived Antiidiotypic Antibodies from the Antipolyfructosan Immune Response: Molecular Analysis of Idiotype RegulationAnnals of the New York Academy of Sciences.  651:316-318. 1992
1992 The Fetal Omentum in Mice and Humans: A Site Enriched for Precursors of CD5 B Cells Early in DevelopmentAnnals of the New York Academy of Sciences.  651:10-20. 1992
1991 An embryonic source of Ly1 but not conventional B cellsInternational Immunology.  3:543-550. 1991
1991 Antigen-Independent Selection of T15 Idiotype During B-Cell Ontogeny in MiceAutoimmunity.  1:203-212. 1991
1991 Functional Relationship between T15 and J558 Idiotypes in Balb/C MiceAutoimmunity.  1:213-224. 1991
1991 Thymus-dependent network responses to a monoclonal cross-reactive antiidiotypic antibodyJournal of Immunology.  147:1849-1855. 1991
1990 Association of transport-defective light chains with immunoglobulin heavy chain binding proteinMolecular Immunology.  27:623-630. 1990
1990 Thymus-dependent antiidiotype and anti-antiidiotype responses to a dinitrophenyl-specific monoclonal antibodyJournal of Immunology.  145:202-208. 1990
1989 Idiotypes and B cell developmentChemical Immunology.  48:1-13. 1989
1989 The role of idiotypic interactions and B-cell subsets in development of the B-cell repertoireCold Spring Harbor Symposia on Quantitative Biology.  54:203-207. 1989
1989 Early rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus.Proceedings of the National Academy of Sciences.  86:6744-6747. 1989
1989 Immune status of a μ, χ transgenic mouse line. Deficient response to bacterially related antigensEuropean Journal of Immunology.  19:459-468. 1989
1989 Pauciclonal B cell involvement in production of immunoglobulin in scid Ig+ mice.Current Topics in Microbiology and Immunology.  152:137-147. 1989
1989 Reconstitution of lymphocyte subsets in scid mice by transplantation of fetal primordia.Current Topics in Microbiology and Immunology.  152:161-168. 1989
1988 A role for human heavy chain binding protein in the developmental regulation of immunoglobin transportMolecular Immunology.  25:585-595. 1988
1988 Activation of a functional idiotype network response by monoclonal antibody specific for a virus (M-MuLV)-induced tumor antigenJournal of Immunology.  140:3266-3272. 1988
1988 Regulatory influences of neonatal multispecific antibodies on the developing b cell repertoireInternational Reviews of Immunology.  3:117-131. 1988
1987 Analysis with antiidiotype antibody of a patient with chronic lymphocytic leukemia and a large cell lymphoma (Richter's syndrome)Blood.  70:45-50. 1987
1987 Monoclonal anti-Id antibodies react with varying proportions of human B lineage cellsJournal of Immunology.  138:4150-4158. 1987
1987 Monoclonal IgM antibodies that inhibit primary Moloney murine sarcoma growthJNCI: Journal of the National Cancer Institute.  78:547-556. 1987
1987 A Possible Cause of Myasthenia Gravis: Idiotypic Networks Involving Bacterial AntigensAnnals of the New York Academy of Sciences.  505:461-471. 1987
1987 Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding proteinJournal of Cell Biology.  104:761-767. 1987
1987 Idiotypes and autoimmunity.Ciba Foundation symposium.  129:109-122. 1987
1987 Probing functional sites on complement protein B with monoclonal antibodies: Evidence for C3b-binding sites on BaJournal of Immunology.  138:1143-1149. 1987
1987 The role of immunoglobulin heavy chain binding protein. in immunoglobulin transportImmunology Today.  8:111-114. 1987
1987 The role of immunoglobulin heavy chain binding protein. in immunoglobulin transportImmunology Today.  8:111-114. 1987
1986 Mouse monoclonal antibodies against bromelain-treated mouse erythrocytes: Reactivity with erythrocytes of various species of animals and idiotypesCellular Immunology.  102:241-250. 1986
1986 Idiotypic network connectivity and a possible cause of myasthenia gravisJournal of Experimental Medicine.  164:1310-1318. 1986
1986 Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiencyCell.  46:963-972. 1986
1986 In Vitro Effect of Monoclonal Anti-ldiotype Antibodies (Anti-M104E) on MOPC 104E Myeloma CellsCancer Research.  46:1250-1254. 1986
1986 Analysis of the hepatobiliary transport of IgA with monoclonal anti-idiotype and anti-allotype antibodiesMolecular Immunology.  23:339-346. 1986
1986 Clonotypic analysis of the fetal B cell repertoire: Evidence for an early and predominant expression of idiotypes associated with the V(H) 36-60 familyThe Journal of molecular and cellular immunology : JMCI.  2:283-292. 1986
1986 Functional characterization of monoclonal auto‐antiidiotype antibodies isolated from the early B cell repertoire of BALB/c miceEuropean Journal of Immunology.  16:1151-1158. 1986
1986 Functional idiotype networks during B-cell ontogenyAnnales de l'Institut Pasteur. Immunology.  137:77-82. 1986
1986 Idiotype‐Directed Interactions during Ontogeny Play a Major Role in the Establishment of the Adult B Cell RepertoireImmunological Reviews.  94:39-50. 1986
1986 In vivo suppression of perinatal multispecific B cells results in a distortion of the adult B cell repertoireEuropean Journal of Immunology.  16:1159-1165. 1986
1986 Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomasJournal of Cell Biology.  102:1558-1566. 1986
1985 Induction of germ-line anti-α1-3 dextran antibody responses in mice by members of the enterobacteriaceae familyJournal of Immunology.  135:3468-3472. 1985
1985 Analysis of V region diversity and specificities of neonatal B cellsFederation proceedings.  44. 1985
1985 Analysis of the hepatobiliary transport of polymeric IgA with monoclonal anti-allotypic antibodiesFederation proceedings.  44. 1985
1985 Antiidiotypic antibodiesMethods in Enzymology.  VOL. 116:174-189. 1985
1985 Developmentally controlled expression of immunoglobulin VH genesScience.  227:1597-1601. 1985
1985 Differential effects of monoclonal anti-idiotype antibodies on MOPC 104E myelomaFederation proceedings.  44. 1985
1985 Isolation and characterization of hybridomas with auto-anti-idiotype activity from newborn Balb/c miceFederation proceedings.  44. 1985
1985 The association of immunoglobulin heavy chain binding protein with unassembled immunoglobulin heavy chains occurs within the rough endoplasmic reticulumFederation proceedings.  44. 1985
1984 A biological consequence of variation in the site of D-JH gene rearrangementNature.  311:376-379. 1984
1984 Ontogeny of B cell precursors responding to α1->3 dextran in BALB/c miceJournal of Immunology.  133:2323-2326. 1984
1984 Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell linesNature.  311:727-733. 1984
1984 Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus PneumoniaeJournal of Experimental Medicine.  160:386-397. 1984
1984 Quantitation of complement factor D in human serum by a solid-phase radioimmunoassayJournal of Immunological Methods.  67:303-309. 1984
1984 Isotype specificity of helper T cell clones peyer’s patch Th cells preferentially collaborate with mature IgA B cells for IgA responsesJournal of Experimental Medicine.  159:798-811. 1984
1984 A role for immunoglobulin heavy chain binding protein in the intracellular transport or processing of immunoglobulin in heavy chainsFederation proceedings.  43. 1984
1984 Analysis of the reactivity of four anti-mouse IgM allotype antibodies with μ+ B lineage cells at various stages of differentiationJournal of Immunology.  133:2098-2103. 1984
1984 Cellular expression of idiotopes defined by monoclonal antibodiesEuropean Journal of Immunology.  14:623-628. 1984
1984 Identification and characterization of an apparent germline set of auto-anti-idiotypic regulatory B lymphocytesJournal of Immunology.  132:44-121. 1984
1984 Ontogeny of 1->3 dextran positive B cell precursors in miceFederation proceedings.  43. 1984
1984 Programmed expression of immunoglobulin V(H) genes during murine developmentFederation proceedings.  43. 1984
1984 The use of monoclonal antibodies as probes of the three-dimensional structure of human complement factor DJournal of Immunology.  132:809-815. 1984
1983 Fine idiotype analysis of b cell precursors in the t-dependent and t-independent responses to αl→3 dextran in balb/c miceJournal of Experimental Medicine.  158:2081-2094. 1983
1983 Localization of the phosphocholine-binding sites on C-reactive protein by immunoelectron microscopyJournal of Immunology.  131:2411-2415. 1983
1983 Naturally occurring anti-idiotypic antibodies in myasthenia gravis patientsNature.  301:611-614. 1983
1983 Nonrandom Escape of Tumor Cells from Immune Lysis Due to Intraclonal Fluctuations in Antigen ExpressionCancer Research.  43:4050-4056. 1983
1983 An enzyme-linked immunoabsorbent assay for measuring antibodies against muscle acetylcholine receptorJournal of Immunological Methods.  57:111-119. 1983
1983 Analysis of Idiotypic Heterogeneity in the Anti‐α1–3 Dextran and Anti‐Phosphorylcholine Responses Using Monoclonal Anti‐Idiotype AntibodiesAnnals of the New York Academy of Sciences.  418:151-169. 1983
1983 Analysis of the anti-α1→3 dextran response with monoclonal anti-idiotype antibodiesJournal of Immunology.  131:1375-1379. 1983
1983 Ten percent of normal B cells and plasma cells share A V(H) determinants) (J606-GAC) with a distinct subset of murine V(H)III plasmacytomasJournal of Immunology.  130:2423-2428. 1983
1982 CRP-associated determinant expressed by human monocytesImmunological communications.  11:275-282. 1982
1982 Structural and biological properties of a monoclonal auto-anti-(anti- idiotype) antibodyNature.  299:447-449. 1982
1982 Studies on the clonal origin of human B cell leukemia using monoclonal anti-idiotype antibodiesJournal of Immunology.  129:904-910. 1982
1982 Immunoglobulin VH determinants defined by monoclonal antibodiesJournal of Experimental Medicine.  156:1010-1024. 1982
1982 Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescenceJournal of Clinical Immunology.  2:264-269. 1982
1982 Murine peyer’s patch T cell clones: Characterization of antigen-specific helper T cells for immunoglobulin a responsesJournal of Experimental Medicine.  156:1115-1130. 1982
1982 A monoclonal antibody (MMA) thet identifies a differentiation antigen on human myelomonocytic cellsClinical immunology and immunopathology.  23:172-188. 1982
1982 Anti-DNA autoantibodies in (NZB x NZW)F1 mice are clonally heterogeneous, but the majority share a common idiotypeJournal of Immunology.  128:668-674. 1982
1982 CRP-associated determinant expressed by human monocytesImmunological communications.  11:275-282. 1982
1982 Demonstration of calcium-induced conformational change(s) in C-reactive protein by using monoclonal antibodiesMolecular Immunology.  19:1159-1165. 1982
1982 Enhancement of in Vitro Immune Responses of Murine Peyer's Patch Cultures by Concanavalin A, Muramyl Dipeptide and LipopolysaccharideScandinavian Journal of Immunology.  15:329-339. 1982
1982 Estimate of the light chain repertoire size of fetal and adult BALB/cJ and CBA/J miceJournal of Immunology.  129:673-677. 1982
1982 Human blood monocytes and platelets share a cell surface componentBlood.  60:767-771. 1982
1981 Light chain isotypes selectively associate with heavy chain idiotypes in T-dependent and T-independent dextran-specific precursorsNature.  292:629-631. 1981
1981 Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniaeJournal of Experimental Medicine.  153:694-705. 1981
1981 Structural analysis of the μ-chains synthesized by fetal liver hybridomasJournal of Immunology.  126:1346-1350. 1981
1981 Anti-immunoglobulin antibodies. II. Expression of individual and cross-reactive idiotypes on syngeneic and homologous anti-idiotype antibodiesJournal of Immunology.  127:491-495. 1981
1981 Cross-reactivity between C-reactive protein and idiotypic determinants on a phosphocholine-binding murine myeloma proteinJournal of Experimental Medicine.  153:1604-1614. 1981
1981 INTERACTION OF HUMAN ANTIBODY AND MURINE MONOCLONAL ANTIBODY WITH MUSCLE ACETYLCHOLINE RECEPTORAnnals of the New York Academy of Sciences.  377:143-157. 1981
1981 Monoclonal vs. heterogeneous anti‐H‐8 antibodies in the analysis of the anti‐phosphorylcholine response in BALB/c miceEuropean Journal of Immunology.  11:877-883. 1981
1981 Organization and expression of immunoglobulin genes in fetal liver hybridomasProceedings of the National Academy of Sciences.  78:247-251. 1981
1980 Differentiation of human B cells expressing the IgA subclasses as demonstrated by monoclonal hybridoma antibodiesJournal of Immunology.  125:2311-2316. 1980
1980 Effects of Anti‐Ig Antibodies on the Development and Differentiation of B CellsImmunological Reviews.  52:29-53. 1980
1980 Immunoglobulin gene rearrangement in immature B cellsScience.  209:1366-1369. 1980
1980 Studies on phosphorylcholine-specific T cell idiotypes and idiotype-specific immunityMolecular Immunology.  17:823-831. 1980
1979 A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell linesJournal of Immunology.  123:1548-1550. 1979
1979 Evidence that murine pre-B cells synthesise mu; heavy chains but no light chains [11]Nature.  280:838-841. 1979
1978 B cell differentiation induced by lipopolysaccharide. V. Suppression of plasma cell maturation by anti-μ: mode of action and characteristics of suppressed cellsJournal of Immunology.  120:158-166. 1978
1978 Generation of clonal and isotype diversity.Advances in Experimental Medicine and Biology.  107:9-17. 1978
1978 Pre-B cells: Bone marrow persistence in anti-μ-suppressed mice, conversion to B lymphocytes, and recovery after destruction by cyclophosphamideJournal of Immunology.  120:1526-1531. 1978
1978 Sequential expression of immunoglobulin on developing mouse B lymphocytes: a systematic survey that suggests a model for the generation of immunoglobulin isotype diversityJournal of Immunology.  120:2041-2049. 1978
1978 Immunoglobulin isotype expression.Contemporary topics in immunobiology.  8:245-265. 1978
1977 Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice*Journal of Experimental Medicine.  146:297-301. 1977
1976 B cell differentiation induced by lipopolysaccharide. IV. Development of immunoglobulin class restriction in precursors of IgG synthesizing cellsJournal of Immunology.  117. 1976
1976 B lymphocyte differentiation induced by lipopolysaccharide. III. Suppression of B cell maturation by anti mouse immunoglobulin antibodiesJournal of Immunology.  116:1664-1668. 1976
1976 Generation of immunoglobulin class diversity in B cells: a discussion with emphasis on IgD developmentCOLLECT.ANN.INST.PASTEUR.  127 C:573-581. 1976
1976 Studies of generation of B cell diversity in mouse, man, and chicken Origins of Lymphocyte DiversityCold Spring Harbor Symposia on Quantitative Biology.  41:139-146. 1976
1976 Relationship between β2 microglobulin and cell surface alloantigens of the mouseJournal of Immunology.  117:1532-1537. 1976
1975 B lymphocyte differentiation induced by lipopolysaccharide. I. Generation of cells synthesizing four major immunoglobulin classesJournal of Immunology.  115:671-676. 1975
1975 B lymphocyte differentiation induced by lipopolysaccharide. II. Response of fetal lymphocytesJournal of Immunology.  115:677-681. 1975
1975 Ontogeny of B lymphocytes in mice: induction of polyclonal immunoglobulin synthesis by lipopolysaccharideFederation proceedings.  34. 1975
1974 T and B lymphocytesJournal of Oral Pathology and Medicine.  3:151-166. 1974

Chapter

Year Title Altmetric
2015 Development and Function of B Cell Subsets.  99-119. 2015
2004 Development and Function of B Cell Subsets.  155-160. 2004

Principal Investigator On

  • Tissue and Organ Specific Human B Cell Immunity - Project 1: Development and Maintenance of Human Glycan and Phospholipid Antibody Repertoires  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • Effects of Neonatal Microbial Exposure on Anti-Polysaccharide B Cell Development  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2017 - 2022
  • Regulation of B Cell Clonal Diversity and Its Role in Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2021
  • Natural Antibody Idiotopes as Biomarkers for Progression in The At-risk Setting for Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International 2016 - 2018
  • Commensal-Dependent Maturation of the Natural IgM Repertoire  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2015 - 2018
  • Antibody Induction by Group B Streptococcal Vaccines for Protection against Fungal Infections  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2018
  • Characterization of B-Lymphocytes in the Cutaneous Immune System  awarded by ALABAMA LYME DISEASE ASSOCIATION 2016 - 2017
  • Effects of Neonatal Microbial Exposure on Anti-polysaccharide B Cell Development  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2017
  • Role of Aryl Hydrocarbon Receptor in B Cell Development and Function  awarded by American Heart Association (Southeast Affiliate) 2015 - 2016
  • Analysis of Human and Mouse Antibodies to Beta Cell Antigens Bearing N-Acetyl Glucosamine Post-Translation Modifications and their Potential to Prevent Human Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International 2014 - 2016
  • Regulation of B Cell Clonal Diversity and Its Role in Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2016
  • Protective Effects of Anti-BclA Antibodies in Bacillus Anthracis Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2015
  • Antibodies to Beta Cell GlcNAc - Modified Autoantigens Blocks T1D in NOD Mice  awarded by Juvenile Diabetes Research Foundation International 2012 - 2014
  • Immunobiology of Bacillus Anthracis Spore-Host Interactions  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Modulation of Allergic Asthma by B Cells and Antibodies  awarded by Sandler Program for Asthma Research 2008 - 2012
  • Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B Cells  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2011
  • The Influence of Anti-N-Acetyl-D-Glucosamine B Cells on Type One Diabetes in Mice  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2010 - 2011
  • Regulation of B Cell Clonal Diversity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2006 - 2011
  • The Role of IL-10 Secreting MZ B Cells in Response to a Bacterial Challenge  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2011
  • Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of Melbourne 1973
  • Bachelor's Degree in Dental Clinical Sciences, The University of Adelaide 1969
  • Full Name

  • John Kearney