Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire DevelopmentImmunity.  53:172-186.e6. 2020
2018 Terminal deoxynucleotidyl transferase is not required for antibody response to polysaccharide vaccines against Streptococcus pneumoniae and Salmonella enterica serovar TyphiInfection and Immunity.  86. 2018
2017 Accelerated systemic autoimmunity in the absence of somatic hypermutation in 564Igi: A mouse model of systemic lupus with knocked-in heavy and light chain genesFrontiers in Immunology.  8. 2017
2016 Manipulation of the glycan-specific natural antibody repertoire for immunotherapyImmunological Reviews.  270:32-50. 2016
2015 B cell autophagy mediates TLR7-dependent autoimmunity and inflammationAutophagy.  11:1010-1024. 2015
2015 Natural antibody repertoires: Development and functional role in inhibiting allergic airway diseaseAnnual Review of Immunology.  33:475-504. 2015
2014 Microbicidal power of alpha radiation in sterilizing germinating Bacillus anthracis sporesAntimicrobial Agents and Chemotherapy.  58:1813-1815. 2014
2014 Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosusEuropean Journal of Immunology.  44:1503-1516. 2014
2011 Cathelin-related antimicrobial peptide differentially regulates T- and B-cell functionEuropean Journal of Immunology.  41:3006-3016. 2011
2009 PI3 Kinase Signals BCR-Dependent Mature B Cell SurvivalCell.  139:573-586. 2009
2006 Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin MiceImmunity.  25:429-440. 2006
2005 Marginal zone B cells in lymphocyte activation and regulationCurrent Opinion in Immunology.  17:244-250. 2005
2005 Isoforms of terminal deoxynucleotidyltransferase: Developmental aspects and functionAdvances in Immunology.  86:113-136. 2005
2005 Marginal zone B cell physiology and disease.Current Directions in Autoimmunity.  8:91-123. 2005
2004 Development and selection of marginal zone B cellsImmunological Reviews.  197:192-205. 2004
2003 Peptide Ligands that Bind Selectively to Spores of Bacillus subtilis and Closely Related SpeciesApplied and Environmental Microbiology.  69:6841-6847. 2003
2003 Delayed lupus onset in (NZB × NZW)F1 mice expressing a human C-reactive protein transgeneArthritis and Rheumatism.  48:1602-1611. 2003
2002 Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responsesImmunity.  17:341-352. 2002
2002 Activated α4 integrins are preferentially expressed on immature thymocytes and activated T cellsAutoimmunity.  9:73-84. 2002
2001 Bacillus Spore Inactivation Methods Affect Detection AssaysApplied and Environmental Microbiology.  67:3665-3670. 2001
2001 B1 cells: Similarities and differences with other B cell subsetsCurrent Opinion in Immunology.  13:195-201. 2001
2001 Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigensImmunity.  14:617-629. 2001
2000 B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a ″natural immune memory″Immunological Reviews.  175:70-79. 2000
2000 Terminal deoxynucleotidyl transferase and repertoire developmentImmunological Reviews.  175:150-157. 2000
2000 Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btkImmunity.  12:39-49. 2000
2000 Selection in the mature B cell repertoireCurrent Topics in Microbiology and Immunology.  252:97-105. 2000
1999 A developmental bias in reading frame usage by human fetal thymic TCRBDJ transcripts is not present in genomic TCRBDJ rearrangementsAutoimmunity.  7:9-15. 1999
1999 Ab 93 antigen: Mouse FcγRII and FcγRIIIHybridoma.  18:211. 1999
1999 CD21(high) IgM(High) splenic B cells enriched in the marginal zone: Distinct phenotypes and functionsCurrent Topics in Microbiology and Immunology.  246:45-52. 1999
1999 Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult miceImmunity.  10:607-617. 1999
1999 Independently ligating CD38 and FcγRIIB relays a dominant negative signal to B cellsHybridoma.  18:113-119. 1999
1997 Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responsesEuropean Journal of Immunology.  27:2366-2374. 1997
1997 Development of V(H)81X transgene-bearing B cells in fetus and adult: Sites for expansion and deletion in conventional and CD5/B1 cellsInternational Immunology.  9:493-505. 1997
1997 Evidence for selection of a population of multi-reactive B cells into the splenic marginal zoneInternational Immunology.  9:27-41. 1997
1997 B cell development in miceInternational Reviews of Immunology.  15:207-241. 1997
1996 Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motifInternational Immunology.  8:1195-1203. 1996
1995 Sequence analysis and antigen binding characteristics of Ig SCID Ig+; miceInternational Immunology.  7:807-819. 1995
1995 Development of the Mouse B‐Cell RepertoireAnnals of the New York Academy of Sciences.  764:207-221. 1995
1995 Do CD5 B cells respond to oral antigens?Advances in Experimental Medicine and Biology.  371:1439-1444. 1995
1995 T cell activation through Thy-1 is associated with the expression of a surface protein(p100) on a subset of CD4 cellsInternational Immunology.  7:607-616. 1995
1994 Immunofluorescence analysis of B-1 cell ontogeny in the mouseInternational Immunology.  6:355-361. 1994
1994 CD5 transgenic miceCurrent Topics in Microbiology and Immunology.  194:209-217. 1994
1994 Effects of Igm Allotype Suppression on Serum Igm Levels, B-L and B-2 Cells, and Antibody Responses Ir Allotype Heterozygous Fi MiceAutoimmunity.  4:27-41. 1994
1993 Normal B lymphocyte differentiation. 1993
1993 3 Normal B lymphocyte differentiation 1993
1993 CD5+ B-cell networksCurrent Opinion in Immunology.  5:223-226. 1993
1992 Characterization, specificity, and lgV gene usage of anti-lymphocyte monoclonal antibodies from perinatal miceInternational Immunology.  4:1073-1084. 1992
1992 The expression of the mouse VpreB/λ5 locus in transformed cell lines and tumors of the B lineage differentiation pathwayInternational Immunology.  4:831-840. 1992
1992 Development and function of the early b cell repertoireInternational Reviews of Immunology.  8:247-257. 1992
1992 Early B-cell repertoiresCurrent Topics in Microbiology and Immunology.  182:81-84. 1992
1992 Effect of a VH81X‐Expressing IgM Antibody on Early B‐Cell DevelopmentAnnals of the New York Academy of Sciences.  651:160-161. 1992
1992 Identification of a surface protein (p100) associated with two glycosyl‐phosphatidylinositol‐linked molecules (Thy‐1 and ThB) by natural anti‐lymphocyte autoantibodiesEuropean Journal of Immunology.  22:2373-2380. 1992
1992 Idiotypic Regulation of Development of the B‐Cell RepertoireAnnals of the New York Academy of Sciences.  651:336-345. 1992
1992 Perinatally Derived Antiidiotypic Antibodies from the Antipolyfructosan Immune Response: Molecular Analysis of Idiotype RegulationAnnals of the New York Academy of Sciences.  651:316-318. 1992
1992 The Fetal Omentum in Mice and Humans: A Site Enriched for Precursors of CD5 B Cells Early in DevelopmentAnnals of the New York Academy of Sciences.  651:10-20. 1992
1991 An embryonic source of Ly1 but not conventional B cellsInternational Immunology.  3:543-550. 1991
1991 Antigen-Independent Selection of T15 Idiotype During B-Cell Ontogeny in MiceAutoimmunity.  1:203-212. 1991
1991 Functional Relationship between T15 and J558 Idiotypes in Balb/C MiceAutoimmunity.  1:213-224. 1991
1989 Idiotypes and B cell developmentChemical Immunology.  48:1-13. 1989
1989 Immune status of a μ, χ transgenic mouse line. Deficient response to bacterially related antigensEuropean Journal of Immunology.  19:459-468. 1989
1989 Pauciclonal B cell involvement in production of immunoglobulin in scid Ig+ mice.Current Topics in Microbiology and Immunology.  152:137-147. 1989
1989 Reconstitution of lymphocyte subsets in scid mice by transplantation of fetal primordia.Current Topics in Microbiology and Immunology.  152:161-168. 1989
1989 The role of idiotypic interactions and B-cell subsets in development of the B-cell repertoire 1989
1988 Regulatory influences of neonatal multispecific antibodies on the developing b cell repertoireInternational Reviews of Immunology.  3:117-131. 1988
1987 A Possible Cause of Myasthenia Gravis: Idiotypic Networks Involving Bacterial AntigensAnnals of the New York Academy of Sciences.  505:461-471. 1987
1987 Analysis with antiidiotype antibody of a patient with chronic lymphocytic leukemia and a large cell lymphoma (Richter's syndrome)Blood.  70:45-50. 1987
1987 Idiotypes and autoimmunity.Ciba Foundation symposium.  129:109-122. 1987
1986 Mouse monoclonal antibodies against bromelain-treated mouse erythrocytes: Reactivity with erythrocytes of various species of animals and idiotypesCellular Immunology.  102:241-250. 1986
1986 Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiencyCell.  46:963-972. 1986
1986 In Vitro Effect of Monoclonal Anti-ldiotype Antibodies (Anti-M104E) on MOPC 104E Myeloma CellsCancer Research.  46:1250-1254. 1986
1986 Functional characterization of monoclonal auto‐antiidiotype antibodies isolated from the early B cell repertoire of BALB/c miceEuropean Journal of Immunology.  16:1151-1158. 1986
1986 Functional idiotype networks during B-cell ontogenyAnnales de l'Institut Pasteur. Immunology.  137:77-82. 1986
1986 Idiotype‐Directed Interactions during Ontogeny Play a Major Role in the Establishment of the Adult B Cell RepertoireImmunological Reviews.  94:39-50. 1986
1986 In vivo suppression of perinatal multispecific B cells results in a distortion of the adult B cell repertoireEuropean Journal of Immunology.  16:1159-1165. 1986
1984 Cellular expression of idiotopes defined by monoclonal antibodiesEuropean Journal of Immunology.  14:623-628. 1984
1983 Nonrandom Escape of Tumor Cells from Immune Lysis Due to Intraclonal Fluctuations in Antigen ExpressionCancer Research.  43:4050-4056. 1983
1983 Analysis of Idiotypic Heterogeneity in the Anti‐α1–3 Dextran and Anti‐Phosphorylcholine Responses Using Monoclonal Anti‐Idiotype AntibodiesAnnals of the New York Academy of Sciences.  418:151-169. 1983
1982 CRP-associated determinant expressed by human monocytes 1982
1982 A monoclonal antibody (MMA) thet identifies a differentiation antigen on human myelomonocytic cellsClinical immunology and immunopathology.  23:172-188. 1982
1982 CRP-associated determinant expressed by human monocytes 1982
1982 Human blood monocytes and platelets share a cell surface componentBlood.  60:767-771. 1982
1981 INTERACTION OF HUMAN ANTIBODY AND MURINE MONOCLONAL ANTIBODY WITH MUSCLE ACETYLCHOLINE RECEPTORAnnals of the New York Academy of Sciences.  377:143-157. 1981
1981 Monoclonal vs. heterogeneous anti‐H‐8 antibodies in the analysis of the anti‐phosphorylcholine response in BALB/c miceEuropean Journal of Immunology.  11:877-883. 1981
1980 Effects of Anti‐Ig Antibodies on the Development and Differentiation of B CellsImmunological Reviews.  52:29-53. 1980
1978 Generation of clonal and isotype diversity.Advances in Experimental Medicine and Biology.  107:9-17. 1978
1978 Immunoglobulin isotype expression.Contemporary topics in immunobiology.  8:245-265. 1978
1976 Generation of immunoglobulin class diversity in B cells: a discussion with emphasis on IgD developmentCOLLECT.ANN.INST.PASTEUR.  127 C:573-581. 1976
1976 Studies of generation of B cell diversity in mouse, man, and chicken Origins of Lymphocyte Diversity 1976

Chapter

Year Title Altmetric
2015 Development and Function of B Cell Subsets.  99-119. 2015
2004 Development and Function of B Cell Subsets.  155-160. 2004

Principal Investigator On

  • Tissue and Organ Specific Human B Cell Immunity - Project 1: Development and Maintenance of Human Glycan and Phospholipid Antibody Repertoires  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • Effects of Neonatal Microbial Exposure on Anti-Polysaccharide B Cell Development  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2017 - 2022
  • Regulation of B Cell Clonal Diversity and Its Role in Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2021
  • Natural Antibody Idiotopes as Biomarkers for Progression in The At-risk Setting for Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International 2016 - 2018
  • Commensal-Dependent Maturation of the Natural IgM Repertoire  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2015 - 2018
  • Antibody Induction by Group B Streptococcal Vaccines for Protection against Fungal Infections  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2018
  • Characterization of B-Lymphocytes in the Cutaneous Immune System  awarded by ALABAMA LYME DISEASE ASSOCIATION 2016 - 2017
  • Effects of Neonatal Microbial Exposure on Anti-polysaccharide B Cell Development  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2017
  • Role of Aryl Hydrocarbon Receptor in B Cell Development and Function  awarded by American Heart Association (Southeast Affiliate) 2015 - 2016
  • Analysis of Human and Mouse Antibodies to Beta Cell Antigens Bearing N-Acetyl Glucosamine Post-Translation Modifications and their Potential to Prevent Human Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International 2014 - 2016
  • Regulation of B Cell Clonal Diversity and Its Role in Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2016
  • Protective Effects of Anti-BclA Antibodies in Bacillus Anthracis Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2015
  • Antibodies to Beta Cell GlcNAc - Modified Autoantigens Blocks T1D in NOD Mice  awarded by Juvenile Diabetes Research Foundation International 2012 - 2014
  • Immunobiology of Bacillus Anthracis Spore-Host Interactions  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Modulation of Allergic Asthma by B Cells and Antibodies  awarded by Sandler Program for Asthma Research 2008 - 2012
  • Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B Cells  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2011
  • The Influence of Anti-N-Acetyl-D-Glucosamine B Cells on Type One Diabetes in Mice  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2010 - 2011
  • Regulation of B Cell Clonal Diversity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2006 - 2011
  • The Role of IL-10 Secreting MZ B Cells in Response to a Bacterial Challenge  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2011
  • Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of Melbourne 1973
  • Bachelor's Degree in Dental Clinical Sciences, The University of Adelaide 1969
  • Full Name

  • John Kearney