Positions

Overview

  • Wegener's granulomatosis, an anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic small vessel vasculitide, is characterized by inflammatory lesions with granuloma formation in the upper and lower airways, pauci-immune glomerulonephritis, and anti-proteinase 3 autoantibodies. Although Wegener's granulomatosis is considered idiopathic, there has been substantial interest in environmental factors as either etiologic or accelerating risk factors, with Staphylococcus aureus having attracted substantial attention as one such environmental factor. Although consensus about etiology remains elusive, the nature of the host response has emerged as an important determinant for disease phenotype and severity. Although Wegener's granulomatosis occurs sporadically, and does not show classical familial clustering and transmission characteristic of some autoimmune diseases, the identification of important genetic factors in Wegener's granulomatosis is not only feasible but also potentially very fruitful in providing insights into pathogenesis and potential therapeutic targets. Building on the clinical trial of etanercept in Wegener's granulomatosis, Dr. Edberg, in collaboration with Drs. Kimberly and Kaslow, is developing a renewable genetic repository to explore the relationship between the Wegener's granulomatosis diathesis and genetic polymorphisms in candidate molecules, selected for their role in pathophysiology. These studies also will involve identification of new polymorphisms in such molecules and application of these to this cohort.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Ifnγ induces epigenetic programming of human t-bethi b cells and promotes tlr7/8 and il-21 induced differentiationeLife.  8. 2019
    2019 Type 1 diabetes risk in African-ancestry participants and utility of an ancestry-specific genetic risk scoreDiabetes Care.  42:406-415. 2019
    2019 Genetic influences on susceptibility to rheumatoid arthritis in African-AmericansHuman Molecular Genetics.  28:858-874. 2019
    2018 Optimism and Psychological Resilience are Beneficially Associated with Measures of Clinical and Experimental Pain in Adults with or at Risk for Knee OsteoarthritisClinical Journal of Pain.  34:1164-1172. 2018
    2018 Role of Macrophage Migration Inhibitory Factor in Granulomatosis With PolyangiitisArthritis and Rheumatology.  70:2077-2086. 2018
    2018 Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1–second gene interactionsKidney International.  94:599-607. 2018
    2018 A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locusHuman Molecular Genetics.  27:2392-2404. 2018
    2018 Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African AmericansHuman Molecular Genetics.  27:3813-3824. 2018
    2018 Omega-6:Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults with Knee PainClinical Journal of Pain.  34:182-189. 2018
    2017 Transancestral mapping and genetic load in systemic lupus erythematosusNature Communications.  8. 2017
    2017 Accelerated aging in adults with knee osteoarthritis pain: Consideration for frequency, intensity, time, and total pain sitesPAIN Reports.  2. 2017
    2017 Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody–Associated VasculitisArthritis and Rheumatology.  69:1054-1066. 2017
    2017 Regulation of FcRγ function by site-specific serine phosphorylationJournal of Leukocyte Biology.  101:421-428. 2017
    2017 Ethnicity, cortisol, and experimental pain responses among persons with symptomatic knee osteoarthritisClinical Journal of Pain.  33:820-826. 2017
    2017 Single Nucleotide Polymorphism in the COL11A2 Gene Associated with Heat Pain Sensitivity in Knee OsteoarthritisMolecular Pain.  13. 2017
    2016 Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody productionAnnals of the Rheumatic Diseases.  75:2007-2013. 2016
    2016 X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's SyndromeArthritis and Rheumatology.  68:1290-1300. 2016
    2016 Estimation of cell-type composition including T and B cell subtypes for whole blood methylation microarray dataFrontiers in Genetics.  7. 2016
    2016 Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNAAnnals of the Rheumatic Diseases.  75:242-252. 2016
    2015 Genetic associations of leptin-related polymorphisms with systemic lupus erythematosusClinical Immunology.  161:157-162. 2015
    2015 The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably shareHuman Molecular Genetics.  24:582-596. 2015
    2014 Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcriptionAmerican Journal of Human Genetics.  94:586-598. 2014
    2014 Brief report: A polymorphism in TLR2 is associated with arterial thrombosis in a multiethnic population of patients with systemic lupus erythematosusArthritis and Rheumatology.  66:1882-1887. 2014
    2014 End-stage renal disease in African Americans with lupus nephritis is associated with APOL1Arthritis and Rheumatology.  66:390-396. 2014
    2014 Fcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African AmericansArthritis and Rheumatology.  66:1291-1299. 2014
    2014 Folate and vitamin B12 may play a critical role in lowering the HPV 16 methylation - Associated risk of developing higher grades of CINCancer Prevention Research.  7:1128-1137. 2014
    2014 Human neutrophil flow chamber adhesion assayJournal of Visualized Experiments2014
    2014 Lupus nephritis susceptibility loci in women with systemic lupus erythematosusJournal of the American Society of Nephrology.  25:2859-2870. 2014
    2013 FcγRIIIa SNPs and haplotypes affect human IgG binding and association with lupus nephritis in African Americans.Arthritis and Rheumatism2013
    2013 Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responsesScience Translational Medicine.  5. 2013
    2013 ABIN1 dysfunction as a genetic basis for lupus nephritisJournal of the American Society of Nephrology.  24:1743-1754. 2013
    2013 Multiple lupus-associated ITGAM variants alter mac-1 functions on neutrophilsArthritis and Rheumatism.  65:2907-2916. 2013
    2013 Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 ExpressionPLoS Genetics.  9. 2013
    2013 FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment responsePharmacogenetics -London-.  23:455-462. 2013
    2013 PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-PhenotypesPLoS ONE.  8. 2013
    2013 Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: Evidence grom genome-wide analysisArthritis and Rheumatism.  65:2457-2468. 2013
    2013 Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell PopulationsPLoS Genetics.  9. 2013
    2013 Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4PLoS Genetics.  9. 2013
    2013 Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestryJournal of Rheumatology.  40:842-849. 2013
    2013 Genomic Copy Number Variants: Evidence for Association with Antibody Response to Anthrax Vaccine AdsorbedPLoS ONE.  8. 2013
    2013 Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groupsAnnals of the Rheumatic Diseases.  72:437-444. 2013
    2013 Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody ProductionPLoS Genetics.  9. 2013
    2013 MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus ErythematosusPLoS Genetics.  9. 2013
    2013 Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in AsiansArthritis and Rheumatism.  65:211-215. 2013
    2012 Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosusArthritis and Rheumatism.  64:3695-3705. 2012
    2012 Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populationsArthritis and Rheumatism.  64:3687-3694. 2012
    2012 The unique cytoplasmic domain of human FcγRIIIA regulates receptor-mediated functionJournal of Immunology.  189:4284-4294. 2012
    2012 Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestriesAnnals of the Rheumatic Diseases.  71:1809-1814. 2012
    2012 Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritisArthritis and Rheumatism.  64:3463-3471. 2012
    2012 Genetic risk factors for thrombosis in systemic lupus erythematosusJournal of Rheumatology.  39:1603-1610. 2012
    2012 A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine AdsorbedVaccine.  30:4778-4784. 2012
    2012 A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosusGenes and Immunity.  13:380-387. 2012
    2012 Evaluation of TRAF6 in a large multiancestral lupus cohortArthritis and Rheumatism.  64:1960-1969. 2012
    2012 Role of activating FcγR gene polymorphisms in kawasaki disease susceptibility and intravenous immunoglobulin responseCirculation: Cardiovascular Genetics.  5:309-316. 2012
    2012 Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosusAnnals of the Rheumatic Diseases.  71:694-699. 2012
    2012 Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African AmericansArthritis and Rheumatism.  64:1355-1358. 2012
    2012 Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication studyAmerican Journal of Human Genetics.  90:648-660. 2012
    2012 Role of MYH9 and APOL1 in African and non-African populations with lupus nephritisGenes and Immunity.  13:232-238. 2012
    2012 IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosusAnnals of the Rheumatic Diseases.  71:463-468. 2012
    2012 Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosusArthritis and Rheumatism.  64:485-492. 2012
    2012 Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1GJournal of Leukocyte Biology.  91:97-103. 2012
    2011 IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitisProceedings of the National Academy of Sciences.  108:20736-20741. 2011
    2011 FAS mRNA editing in human systemic lupus erythematosusHuman Mutation.  32:1268-1277. 2011
    2011 Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association studyArthritis and Rheumatism.  63:3493-3501. 2011
    2011 Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functionsPLoS ONE.  6. 2011
    2011 Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosusAnnals of the Rheumatic Diseases.  70:1752-1757. 2011
    2011 Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groupsArthritis and Rheumatism.  63:2755-2763. 2011
    2011 The role of HLA-DR-DQ haplotypes in variable antibody responses to Anthrax Vaccine AdsorbedGenes and Immunity.  12:457-465. 2011
    2011 Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosusArthritis and Rheumatism.  63:2049-2057. 2011
    2011 Evaluation of the TREX1 gene in a large multi-ancestral lupus cohortGenes and Immunity.  12:270-279. 2011
    2011 Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21Arthritis and Rheumatism.  63:1689-1697. 2011
    2011 A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasiaNutrition.  27:513-519. 2011
    2011 Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibilityPLoS Genetics.  7. 2011
    2011 Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.PLoS Genetics.  7:e1002079. 2011
    2011 A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasiaCancer.  117:957-963. 2011
    2011 Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosusNature Genetics.  43:253-258. 2011
    2011 The functional polymorphism 844 A>G in Fc αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibilityJournal of Rheumatology.  38:446-449. 2011
    2011 Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic studyAmerican Journal of Human Genetics.  88:83-91. 2011
    2011 Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki diseaseJournal of Allergy and Clinical Immunology.  128. 2011
    2010 Alpha 1-antitrypsin deficiency-related alleles Z and S and the risk of Wegener's granulomatosisArthritis Care and Research.  62:3760-3767. 2010
    2010 Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African AmericansArthritis and Rheumatism.  62:3547-3553. 2010
    2010 The role of genetic variation near interferon-kappa in systemic lupus erythematosusJournal of Biomedicine and Biotechnology.  2010. 2010
    2010 ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestryAnnals of the Rheumatic Diseases.  69:1329-1332. 2010
    2010 The non-muscle myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African AmericansAmerican Journal of Nephrology.  32:66-72. 2010
    2010 Pathways: Strategies for susceptibility genes in SLEAutoimmunity Reviews.  9:473-476. 2010
    2010 Variations in CCL3L gene cluster sequence and non-specific gene copy numbersBMC Research Notes.  3. 2010
    2010 Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African AmericansAnnals of the Rheumatic Diseases.  69:625-626. 2010
    2010 Wegener's granulomatosis: A model of auto-antibodies in mucosal autoimmunityClinical Immunology.  134:104-112. 2010
    2010 Erratum: Genetic associations of LYN with systemic lupus erythematosus (Genes and Immunity (2009) 10 (397-403) DOI: 10.1038/gene.2009.19)Genes and Immunity.  11:98. 2010
    2009 A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosusNature Genetics.  41:1228-1233. 2009
    2009 The FCRL3 -169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cellsArthritis and Rheumatism.  60:3510-3512. 2009
    2009 Factors associated with arterial vascular events in PROFILE: A multiethnic lupus cohortLupus.  18:958-965. 2009
    2009 Erratum: Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing (Genes and Immunity (2009) vol. 10 (457-469) 10.1038/gene.2009.27)Genes and Immunity.  10:606. 2009
    2009 A polymorphism within IL21R confers risk for systemic lupus erythematosusArthritis and Rheumatism.  60:2402-2407. 2009
    2009 Identification of new SLE-associated genes with a two-step Bayesian study designGenes and Immunity.  10:446-456. 2009
    2009 Fcγ receptors: Structure, function and role as genetic risk factors in SLEGenes and Immunity.  10:380-389. 2009
    2009 Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived populationGenes and Immunity.  10:531-538. 2009
    2009 Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosusArthritis and Rheumatism.  60:1076-1084. 2009
    2009 Copy number variants in genetic susceptibility and severity of systemic lupus erythematosusCytogenetics and Cell Genetics.  123:142-147. 2009
    2009 Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicingGenes and Immunity.  10:457-469. 2009
    2009 Genetic associations of LYN with systemic lupus erythematosusGenes and Immunity.  10:397-403. 2009
    2008 Functional expression of IgA receptor FcαRI on human plateletsJournal of Leukocyte Biology.  84:1492-1500. 2008
    2008 Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohortArthritis Care and Research.  59:1332-1340. 2008
    2008 Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashionJournal of Immunology.  181:1012-1018. 2008
    2008 Time to seizure occurrence and damage in PROFILE, a multi-ethnic systemic lupus erythematosus cohortLupus.  17:177-184. 2008
    2008 Genetic variation in the CRP promoter: Association with systemic lupus erythematosusHuman Molecular Genetics.  17:1147-1155. 2008
    2008 Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African AmericansGenes and Immunity.  9:187-194. 2008
    2008 Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other lociNature Genetics.  40:204-210. 2008
    2008 IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1Journal of Clinical Investigation.  118:629-639. 2008
    2007 Fc receptor genes and the systemic lupus erythematosus diathesisAutoimmunity.  40:567-581. 2007
    2007 Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjectsArthritis and Rheumatism.  56:3375-3378. 2007
    2007 Clinical and genetic risk factors for pneumonia in systemic lupus erythematosusArthritis and Rheumatism.  56:2679-2686. 2007
    2007 FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA.Journal of Immunology.  178:3973-3982. 2007
    2007 FcαRI (CD89) alleles determine the proinflammatory potential of serum IgAJournal of Immunology.  178:3973-3982. 2007
    2007 Expression profile of FcγRIIb on leukocytes and its dysregulation in systemic lupus erythematosusJournal of Immunology.  178:3272-3280. 2007
    2006 Anti-GD3 monoclonal antibody effects on lymphocytes and antibody-dependent cellular cytotoxicityCancer Biotherapy and Radiopharmaceuticals.  21:553-560. 2006
    2006 Association of a transmembrane polymorphism of Fcγ receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patientsArthritis and Rheumatism.  54:3908-3917. 2006
    2006 Time to renal disease and end-stage renal disease in PROFILE: A multiethnic lupus cohortPLoS Medicine.  3:1949-1956. 2006
    2005 Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: Association between C-reactive protein (CRP) gene polymorphisms and vascular eventsRheumatology.  44:864-868. 2005
    2005 Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP levelThe Clinical investigator.  83:440-447. 2005
    2004 Genetic risk factors for infection in patients with early rheumatoid arthritisGenes and Immunity.  5:641-647. 2004
    2004 Differential gene expression modulated by the cytoplasmic domain of FcγRIa (CD64) α-chainJournal of Immunology.  173:6211-6219. 2004
    2004 The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanerceptArthritis and Rheumatism.  50:2750-2756. 2004
    2004 A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcγRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosusJournal of Immunology.  172:7186-7191. 2004
    2004 A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcγRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and functionJournal of Immunology.  172:7192-7199. 2004
    2003 Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins.Journal of Immunology.  171:6090-6096. 2003
    2003 FcγRIIIb Allele-Sensitive Release of α-Defensins: Anti-Neutrophil Cytoplasmic Antibody-Induced Release of ChemotaxinsJournal of Immunology.  171:6090-6096. 2003
    2003 A Novel Polymorphism in the Fcγ Receptor IIB (CD32B) Transmembrane Region Alters Receptor SignalingArthritis and Rheumatism.  48:3242-3252. 2003
    2003 The FcγRIIIA-F158 allele is a risk factor for the development of lupus nephritis: A meta-analysisKidney International.  63:1475-1482. 2003
    2003 A novel polymorphic CAAT/enhancer-binding protein β element in the FasL gene promoter alters Fas ligand expression: A candidate background gene in African American systemic lupus erythematosus patientsJournal of Immunology.  170:132-138. 2003
    2002 Diversity and duplicity: Human Fcγ receptors in host defense and autoimmunityImmunologic Research.  26:177-189. 2002
    2002 The CY domain of the FcγRIa α-chain (CD64) alters γ-chain tyrosine-based signaling and phagocytosisJournal of Biological Chemistry.  277:41287-41293. 2002
    2002 Genetic linkage and association of Fcγ receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosusArthritis and Rheumatism.  46:2132-2140. 2002
    2002 Conservation of FcεRI gamma chain coding region in normals and in SLE patientsLupus.  11:42-45. 2002
    2002 Genomic organization of classical human low-affinity Fcγ receptor genesGenes and Immunity.  3:S51-S56. 2002
    2001 The Influence of Genetic Variation in Fcγ RIIIb (NA1/NA2) on Neutrophil Specific Granule ReleaseKitasato medicine.  31:70-77. 2001
    2001 Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosusJournal of Immunology.  166:3915-3922. 2001
    2000 C-reactive protein binding to FcγRIIa on human monocytes and neutrophils is allele-specificJournal of Clinical Investigation.  105:369-376. 2000
    1999 Single-nucleotide polymorphisms of T cell receptor zeta chain in patients with systemic lupus erythematosus.Arthritis and Rheumatism.  42:2601-2605. 1999
    1999 Single-nucleotide polymorphisms of T cell receptor ζ chain in patients with systemic lupus erythematosusArthritis and Rheumatism.  42:2601-2605. 1999
    1999 The cytoplasmic domain of human FcγRIa alters the functional properties of the FcγRI·γ-chain receptor complexJournal of Biological Chemistry.  274:30328-30333. 1999
    1999 Differential expression of integrin subunits in canine knee ligament fibroblastsJournal of Orthopaedic Research.  17:748-754. 1999
    1998 Antineutrophil cytoplasmic antibodies preferentially engage FcγrIIIb on human neutrophilsJournal of Immunology.  161:6909-6914. 1998
    1998 Differential regulation of human neutrophil FcγRIIa (CD32) and FcγRIIIb (CD16)-induced Ca2+ transientsJournal of Biological Chemistry.  273:8071-8079. 1998
    1998 Analysis of FcγRII gene polymorphisms in Wegener's granulomatosisExperimental and Clinical Immunogenetics.  14:183-195. 1998
    1997 Cell Type-Specific Glycoforms of FcγRIIIa (CD16): Differential Ligand BindingJournal of Immunology.  159:3849-3857. 1997
    1997 Cross-Linking of Fcγ Receptor IIa and Fcγ Receptor IIIb Induces Different Proadhesive Phenotypes on Human NeutrophilsJournal of Immunology.  159:3940-3948. 1997
    1997 A novel polymorphism of FcγRIIIa (CD16) alters receptor function and predisposes to autoimmune diseaseJournal of Clinical Investigation.  100:1059-1070. 1997
    1997 Flow cytometric quantitation of attachment and phagocytosis in phenotypically-defined subpopulations of cells using PKH26-labeled FcγR- specific probesJournal of Immunological Methods.  205:55-65. 1997
    1995 Differential Regulation of Fcgamma Receptor Isoforms: Implications for Therapeutic Intervention.American Journal of Therapeutics.  2:777-781. 1995
    1995 B cell differentiation factor-induced human B cell maturation: Stimulation of intracellular calcium releaseCellular Immunology.  164:227-233. 1995
    1995 Receptors for immunoglobulin g molecular diversity and implications for diseaseArthritis and Rheumatism.  38:306-314. 1995
    1995 The Ca2+ dependence of human Fcγ receptor-initiated phagocytosisJournal of Biological Chemistry.  270:22301-22307. 1995
    1994 Modulation of Fcγ and complement receptor function by the glycosyl- phosphatidylinositol-anchored form of FcγRIIIJournal of Immunology.  152:5826-5835. 1994
    1993 Human mononuclear phagocytes express adenosine A1 receptors: A novel mechanism for differential regulation of Fcγ receptor functionJournal of Immunology.  151:2775-2785. 1993
    1992 Functional capacity of Fcγ receptor III (CD16) on human neutrophilsImmunologic Research.  11:239-251. 1992
    1992 Allelic polymorphisms of human Fcγ receptor IIA and Fcγ receptor IIIB: Independent mechanisms for differences in human phagocyte functionJournal of Clinical Investigation.  89:1274-1281. 1992
    1992 Functional characterization of non‐human primate erythrocyte immune adherence receptors: implications for the uptake of immune complexes by the cells of the mononuclear phagocytic systemEuropean Journal of Immunology.  22:1333-1339. 1992
    1992 Receptor specific probes for the study of Fcγ receptor specific functionJournal of Immunological Methods.  148:179-187. 1992
    1991 Fc gamma receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fc gamma receptor II.Journal of Immunology.  146:997-1004. 1991
    1991 Fcγ receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fcγ receptor IIJournal of Immunology.  146:997-1004. 1991
    1991 Preferential expression of human FcγRIII(PMN) (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteinsJournal of Clinical Investigation.  87:58-67. 1991
    1991 Regulation of phagocytosis and [Ca2+]i flux by distinct regions of an Fc receptorScience.  254:1785-1788. 1991
    1990 Fc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cells.Journal of Immunology.  144:4729-4734. 1990
    1990 Fc gamma receptor III on human neutrophils. Allelic variants have functionally distinct capacities.Journal of Clinical Investigation.  85:1287-1295. 1990
    1990 The glycosyl phosphatidylinositol-linked fcγRIIIPMN mediates transmembrane signaling events distinct from FCγRIIJournal of Experimental Medicine.  171:1239-1255. 1990
    1990 Fcγ receptor III on human neutrophils: Allelic variants have functionally distinct capacitiesJournal of Clinical Investigation.  85:1287-1295. 1990
    1990 FcγRIII expressed on cultured monocytes is an N-glycosylated transmembrane protein distinct from FcγRIII expressed on natural killer cellsJournal of Immunology.  144:4729-4734. 1990
    1989 The role of Fcγ receptors in mononuclear phagocyte system functionClinical and Experimental Rheumatology.  7. 1989
    1989 Preparation of monoclonal antibodies to C3b by immunization with C3b(i)-SepharoseJournal of Immunological Methods.  120:241-249. 1989
    1989 Carbohydrates on human Fcγ receptors. Interdependence of the classical IgG and nonclassical lectin-binding sites on human FcγRIII expressed on neutrophilsJournal of Immunology.  142:3923-3930. 1989
    1989 Human FcγRIII (CD16). Isoforms with distinct allelic expression, extracellular domains, and membrane linkages on polymorphonuclear and natural killer cellsJournal of Immunology.  143:1642-1649. 1989
    1989 Immune adherence and the processing of soluble complement-fixing antibody/DNA immune complexes in miceClinical immunology and immunopathology.  51:118-132. 1989
    1989 In vivo handling of soluble complement fixing Ab/dsDNA immune complexes in chimpanzeesJournal of Clinical Investigation.  84:962-970. 1989
    1988 Quantitative analyses of the relationship between C3 consumption, C3b capture, and immune adherence of complement-fixing antibody/DNA immune complexesJournal of Immunology.  141:4258-4265. 1988
    1987 Cross-reactivity of anti-dsDNA antibodiesImmunology Today.  8:75. 1987
    1987 Quantitative analyses of the binding of soluble complement-fixing antibody/dsDNA immune complexes to CR1 on human red blood cellsJournal of Immunology.  139:3739-3747. 1987
    1987 Clearance kinetics and immunochemistry in rabbits of soluble antibody/DNA immune complexes. Effects of antibody class and DNA conformationJournal of Immunology.  139:180-187. 1987
    1987 Clearance of human antibody/DNA immune complexes and free DNA from the circulation of the nonhuman primateClinical immunology and immunopathology.  42:1-9. 1987
    1987 Cross-reactivity of anti-dsDNA antibodiesImmunology Today.  8:75. 1987
    1987 Rapid immune adherence reactivity of nascent, soluble antibody/DNA immune complexes in the circulationJournal of Immunology.  139:1240-1244. 1987
    1987 The interaction of antibody/dna immune complexes with complementArthritis and Rheumatism.  30:176-185. 1987
    1986 The kinetics of clearance of human antibody/dsDNA immune complexes from rabbit circulation. Effects of dsDNA size, rheumatoid factor, and reduction and alkylation of the antibodiesJournal of Immunology.  136:3785-3792. 1986
    1986 Quantitative aspects of lupus anti-DNA autoantibody specificityJournal of Immunology.  136:4581-4587. 1986
    1985 Determination of nitrate in soil extracts by dual-wavelength ultraviolet spectrophotometry.Soil Science Society of America Journal.  49:1182-1185. 1985
    1973 Interaction of virulent and avirulent Listeria monocytogenes with cultured mouse peritoneal macrophages.Infection and Immunity.  7:409-415. 1973

    Investigator On

  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2019 - 2024
  • Effects of ITGAM Genetic Variation on Mac-1 Mediated Functions of B Cells  awarded by DOD - Department of Defense 2018 - 2021
  • Private Grant  awarded by REGENERON GENETICS CENTER 2017 - 2020
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core D: Analytical Genomics and Transgenics Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Impact of SLE-Associated ITGAM Variants on Dendritic Cell Function  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2016 - 2019
  • Association of Genetic and Autoantibody Signatures with SLE Clinical Course  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2014 - 2019
  • Ethnic Differences in Response to Painful Stimuli  awarded by University of Florida 2018 - 2019
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2016 - 2018
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2015 - 2018
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2014 - 2018
  • UAB Center for Clinical and Translational Science (CCTS) (3 linked awards: UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2014 - 2015
  • Population Genetics Analysis Program: Immunity to Vaccines/Infections II  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2015
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2009 - 2014
  • Genomics of Lupus  awarded by Oklahoma Medical Research Foundation (OMRF) 2009 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) UL1  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • Program Project in the Genetics of SLE  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Program Project in the Genetics of SLE - Project 1 (Copy Number Variation in Genetic Susceptibility and Severity of SLE)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Biological Mechanisms of ITGAM Variants for Genetic Risk in SLE  awarded by LUPUS RESEARCH ALLIANCE 2009 - 2013
  • FcgRIIB Links CRP Signals with ITGAM Functions: a G x G x G Model of SLE.  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2012
  • Mononuclear Phagocyte Function in Immunologic Diseases  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2006 - 2012
  • Education And Training

  • Doctor of Philosophy in Biochemistry, University of Virginia 1988
  • Full Name

  • Jeffrey Edberg