Positions

Overview

  • Wegener's granulomatosis, an anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic small vessel vasculitide, is characterized by inflammatory lesions with granuloma formation in the upper and lower airways, pauci-immune glomerulonephritis, and anti-proteinase 3 autoantibodies. Although Wegener's granulomatosis is considered idiopathic, there has been substantial interest in environmental factors as either etiologic or accelerating risk factors, with Staphylococcus aureus having attracted substantial attention as one such environmental factor. Although consensus about etiology remains elusive, the nature of the host response has emerged as an important determinant for disease phenotype and severity. Although Wegener's granulomatosis occurs sporadically, and does not show classical familial clustering and transmission characteristic of some autoimmune diseases, the identification of important genetic factors in Wegener's granulomatosis is not only feasible but also potentially very fruitful in providing insights into pathogenesis and potential therapeutic targets. Building on the clinical trial of etanercept in Wegener's granulomatosis, Dr. Edberg, in collaboration with Drs. Kimberly and Kaslow, is developing a renewable genetic repository to explore the relationship between the Wegener's granulomatosis diathesis and genetic polymorphisms in candidate molecules, selected for their role in pathophysiology. These studies also will involve identification of new polymorphisms in such molecules and application of these to this cohort.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Ifnγ induces epigenetic programming of human t-bethi b cells and promotes tlr7/8 and il-21 induced differentiation 2019
    2019 Type 1 diabetes risk in African-ancestry participants and utility of an ancestry-specific genetic risk score 2019
    2019 At the Intersection of Ethnicity/Race and Poverty: Knee Pain and Physical Function 2019
    2019 Genetic influences on susceptibility to rheumatoid arthritis in African-Americans 2019
    2018 Optimism and Psychological Resilience are Beneficially Associated with Measures of Clinical and Experimental Pain in Adults with or at Risk for Knee Osteoarthritis 2018
    2018 Role of Macrophage Migration Inhibitory Factor in Granulomatosis With Polyangiitis 2018
    2018 Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1–second gene interactions 2018
    2018 A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus 2018
    2018 Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans 2018
    2018 Omega-6:Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults with Knee Pain 2018
    2017 Transancestral mapping and genetic load in systemic lupus erythematosus 2017
    2017 Accelerated aging in adults with knee osteoarthritis pain: Consideration for frequency, intensity, time, and total pain sites 2017
    2017 Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis 2017
    2017 Regulation of FcRγ function by site-specific serine phosphorylation 2017
    2017 Ethnicity, cortisol, and experimental pain responses among persons with symptomatic knee osteoarthritis 2017
    2017 Single Nucleotide Polymorphism in the COL11A2 Gene Associated with Heat Pain Sensitivity in Knee Osteoarthritis 2017
    2016 Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production 2016
    2016 X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome 2016
    2016 Estimation of cell-type composition including T and B cell subtypes for whole blood methylation microarray data 2016
    2016 Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA 2016
    2015 Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus 2015
    2015 The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share 2015
    2014 Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription 2014
    2014 Brief report: A polymorphism in TLR2 is associated with arterial thrombosis in a multiethnic population of patients with systemic lupus erythematosus 2014
    2014 End-stage renal disease in African Americans with lupus nephritis is associated with APOL1 2014
    2014 Fcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African Americans 2014
    2014 Folate and vitamin B12 may play a critical role in lowering the HPV 16 methylation - Associated risk of developing higher grades of CIN 2014
    2014 Human neutrophil flow chamber adhesion assay 2014
    2014 Lupus nephritis susceptibility loci in women with systemic lupus erythematosus 2014
    2013 FcγRIIIa SNPs and haplotypes affect human IgG binding and association with lupus nephritis in African Americans. 2013
    2013 Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses 2013
    2013 ABIN1 dysfunction as a genetic basis for lupus nephritis 2013
    2013 Multiple lupus-associated ITGAM variants alter mac-1 functions on neutrophils 2013
    2013 Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression 2013
    2013 FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response 2013
    2013 PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes 2013
    2013 Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: Evidence grom genome-wide analysis 2013
    2013 Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations 2013
    2013 Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4 2013
    2013 Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry 2013
    2013 Genomic Copy Number Variants: Evidence for Association with Antibody Response to Anthrax Vaccine Adsorbed 2013
    2013 Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups 2013
    2013 Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production 2013
    2013 MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus 2013
    2013 Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians 2013
    2012 Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus 2012
    2012 Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations 2012
    2012 The unique cytoplasmic domain of human FcγRIIIA regulates receptor-mediated function 2012
    2012 Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries 2012
    2012 Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis 2012
    2012 Genetic risk factors for thrombosis in systemic lupus erythematosus 2012
    2012 A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed 2012
    2012 A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus 2012
    2012 Evaluation of TRAF6 in a large multiancestral lupus cohort 2012
    2012 Role of activating FcγR gene polymorphisms in kawasaki disease susceptibility and intravenous immunoglobulin response 2012
    2012 Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus 2012
    2012 Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans 2012
    2012 Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study 2012
    2012 Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis 2012
    2012 IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus 2012
    2012 Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus 2012
    2012 Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G 2012
    2011 IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis 2011
    2011 FAS mRNA editing in human systemic lupus erythematosus 2011
    2011 Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study 2011
    2011 Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions 2011
    2011 Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus 2011
    2011 Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups 2011
    2011 The role of HLA-DR-DQ haplotypes in variable antibody responses to Anthrax Vaccine Adsorbed 2011
    2011 Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus 2011
    2011 Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort 2011
    2011 Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21 2011
    2011 A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia 2011
    2011 Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility 2011
    2011 Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. 2011
    2011 A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia 2011
    2011 Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus 2011
    2011 The functional polymorphism 844 A>G in Fc αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility 2011
    2011 Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study 2011
    2011 Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease 2011
    2010 Alpha 1-antitrypsin deficiency-related alleles Z and S and the risk of Wegener's granulomatosis 2010
    2010 Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans 2010
    2010 The role of genetic variation near interferon-kappa in systemic lupus erythematosus 2010
    2010 ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry 2010
    2010 The non-muscle myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans 2010
    2010 Pathways: Strategies for susceptibility genes in SLE 2010
    2010 Variations in CCL3L gene cluster sequence and non-specific gene copy numbers 2010
    2010 Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans 2010
    2010 Wegener's granulomatosis: A model of auto-antibodies in mucosal autoimmunity 2010
    2010 Erratum: Genetic associations of LYN with systemic lupus erythematosus (Genes and Immunity (2009) 10 (397-403) DOI: 10.1038/gene.2009.19) 2010
    2009 A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus 2009
    2009 The FCRL3 -169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells 2009
    2009 Factors associated with arterial vascular events in PROFILE: A multiethnic lupus cohort 2009
    2009 Erratum: Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing (Genes and Immunity (2009) vol. 10 (457-469) 10.1038/gene.2009.27) 2009
    2009 A polymorphism within IL21R confers risk for systemic lupus erythematosus 2009
    2009 Identification of new SLE-associated genes with a two-step Bayesian study design 2009
    2009 Fcγ receptors: Structure, function and role as genetic risk factors in SLE 2009
    2009 Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population 2009
    2009 Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus 2009
    2009 Copy number variants in genetic susceptibility and severity of systemic lupus erythematosus 2009
    2009 Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing 2009
    2009 Genetic associations of LYN with systemic lupus erythematosus 2009
    2008 Functional expression of IgA receptor FcαRI on human platelets 2008
    2008 Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort 2008
    2008 Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion 2008
    2008 Time to seizure occurrence and damage in PROFILE, a multi-ethnic systemic lupus erythematosus cohort 2008
    2008 Genetic variation in the CRP promoter: Association with systemic lupus erythematosus 2008
    2008 Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans 2008
    2008 Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci 2008
    2008 IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1 2008
    2007 Fc receptor genes and the systemic lupus erythematosus diathesis 2007
    2007 Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects 2007
    2007 Clinical and genetic risk factors for pneumonia in systemic lupus erythematosus 2007
    2007 FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA. 2007
    2007 FcαRI (CD89) alleles determine the proinflammatory potential of serum IgA 2007
    2007 Expression profile of FcγRIIb on leukocytes and its dysregulation in systemic lupus erythematosus 2007
    2006 Anti-GD3 monoclonal antibody effects on lymphocytes and antibody-dependent cellular cytotoxicity 2006
    2006 Association of a transmembrane polymorphism of Fcγ receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients 2006
    2006 Time to renal disease and end-stage renal disease in PROFILE: A multiethnic lupus cohort 2006
    2005 Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: Association between C-reactive protein (CRP) gene polymorphisms and vascular events 2005
    2005 Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level 2005
    2004 Genetic risk factors for infection in patients with early rheumatoid arthritis 2004
    2004 Differential gene expression modulated by the cytoplasmic domain of FcγRIa (CD64) α-chain 2004
    2004 The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept 2004
    2004 A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcγRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus 2004
    2004 A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcγRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function 2004
    2003 Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins. 2003
    2003 FcγRIIIb Allele-Sensitive Release of α-Defensins: Anti-Neutrophil Cytoplasmic Antibody-Induced Release of Chemotaxins 2003
    2003 A Novel Polymorphism in the Fcγ Receptor IIB (CD32B) Transmembrane Region Alters Receptor Signaling 2003
    2003 The FcγRIIIA-F158 allele is a risk factor for the development of lupus nephritis: A meta-analysis 2003
    2003 A novel polymorphic CAAT/enhancer-binding protein β element in the FasL gene promoter alters Fas ligand expression: A candidate background gene in African American systemic lupus erythematosus patients 2003
    2002 Diversity and duplicity: Human Fcγ receptors in host defense and autoimmunity 2002
    2002 The CY domain of the FcγRIa α-chain (CD64) alters γ-chain tyrosine-based signaling and phagocytosis 2002
    2002 Genetic linkage and association of Fcγ receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus 2002
    2002 Conservation of FcεRI gamma chain coding region in normals and in SLE patients 2002
    2002 Genomic organization of classical human low-affinity Fcγ receptor genes 2002
    2001 The Influence of Genetic Variation in Fcγ RIIIb (NA1/NA2) on Neutrophil Specific Granule Release 2001
    2001 Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus 2001
    2000 C-reactive protein binding to FcγRIIa on human monocytes and neutrophils is allele-specific 2000
    1999 Single-nucleotide polymorphisms of T cell receptor zeta chain in patients with systemic lupus erythematosus. 1999
    1999 Single-nucleotide polymorphisms of T cell receptor ζ chain in patients with systemic lupus erythematosus 1999
    1999 The cytoplasmic domain of human FcγRIa alters the functional properties of the FcγRI·γ-chain receptor complex 1999
    1999 Differential expression of integrin subunits in canine knee ligament fibroblasts 1999
    1998 Antineutrophil cytoplasmic antibodies preferentially engage FcγrIIIb on human neutrophils 1998
    1998 Differential regulation of human neutrophil FcγRIIa (CD32) and FcγRIIIb (CD16)-induced Ca2+ transients 1998
    1998 Analysis of FcγRII gene polymorphisms in Wegener's granulomatosis 1998
    1997 Cell Type-Specific Glycoforms of FcγRIIIa (CD16): Differential Ligand Binding 1997
    1997 Cross-Linking of Fcγ Receptor IIa and Fcγ Receptor IIIb Induces Different Proadhesive Phenotypes on Human Neutrophils 1997
    1997 A novel polymorphism of FcγRIIIa (CD16) alters receptor function and predisposes to autoimmune disease 1997
    1997 Flow cytometric quantitation of attachment and phagocytosis in phenotypically-defined subpopulations of cells using PKH26-labeled FcγR- specific probes 1997
    1995 Differential Regulation of Fcgamma Receptor Isoforms: Implications for Therapeutic Intervention. 1995
    1995 B cell differentiation factor-induced human B cell maturation: Stimulation of intracellular calcium release 1995
    1995 Receptors for immunoglobulin g molecular diversity and implications for disease 1995
    1995 The Ca 2+ dependence of human Fcγ receptor-initiated phagocytosis 1995
    1994 Modulation of Fcγ and complement receptor function by the glycosyl- phosphatidylinositol-anchored form of FcγRIII 1994
    1993 Human mononuclear phagocytes express adenosine A1 receptors: A novel mechanism for differential regulation of Fcγ receptor function 1993
    1992 Functional capacity of Fcγ receptor III (CD16) on human neutrophils 1992
    1992 Allelic polymorphisms of human Fcγ receptor IIA and Fcγ receptor IIIB: Independent mechanisms for differences in human phagocyte function 1992
    1992 Functional characterization of non‐human primate erythrocyte immune adherence receptors: implications for the uptake of immune complexes by the cells of the mononuclear phagocytic system 1992
    1992 Receptor specific probes for the study of Fcγ receptor specific function 1992
    1991 Fc gamma receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fc gamma receptor II. 1991
    1991 Fcγ receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fcγ receptor II 1991
    1991 Preferential expression of human FcγRIII(PMN) (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins 1991
    1991 Regulation of phagocytosis and [Ca2+]i flux by distinct regions of an Fc receptor 1991
    1990 Fc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cells. 1990
    1990 Fc gamma receptor III on human neutrophils. Allelic variants have functionally distinct capacities. 1990
    1990 The glycosyl phosphatidylinositol-linked fcγRIIIPMN mediates transmembrane signaling events distinct from FCγRII 1990
    1990 Fcγ receptor III on human neutrophils: Allelic variants have functionally distinct capacities 1990
    1990 FcγRIII expressed on cultured monocytes is an N-glycosylated transmembrane protein distinct from FcγRIII expressed on natural killer cells 1990
    1989 The role of Fcγ receptors in mononuclear phagocyte system function 1989
    1989 Preparation of monoclonal antibodies to C3b by immunization with C3b(i)-Sepharose 1989
    1989 Carbohydrates on human Fcγ receptors. Interdependence of the classical IgG and nonclassical lectin-binding sites on human FcγRIII expressed on neutrophils 1989
    1989 Human FcγRIII (CD16). Isoforms with distinct allelic expression, extracellular domains, and membrane linkages on polymorphonuclear and natural killer cells 1989
    1989 Immune adherence and the processing of soluble complement-fixing antibody/DNA immune complexes in mice 1989
    1989 In vivo handling of soluble complement fixing Ab/dsDNA immune complexes in chimpanzees 1989
    1988 Quantitative analyses of the relationship between C3 consumption, C3b capture, and immune adherence of complement-fixing antibody/DNA immune complexes 1988
    1987 Cross-reactivity of anti-dsDNA antibodies 1987
    1987 Quantitative analyses of the binding of soluble complement-fixing antibody/dsDNA immune complexes to CR1 on human red blood cells 1987
    1987 Clearance kinetics and immunochemistry in rabbits of soluble antibody/DNA immune complexes. Effects of antibody class and DNA conformation 1987
    1987 Clearance of human antibody/DNA immune complexes and free DNA from the circulation of the nonhuman primate 1987
    1987 Cross-reactivity of anti-dsDNA antibodies 1987
    1987 Rapid immune adherence reactivity of nascent, soluble antibody/DNA immune complexes in the circulation 1987
    1987 The interaction of antibody/dna immune complexes with complement 1987
    1986 The kinetics of clearance of human antibody/dsDNA immune complexes from rabbit circulation. Effects of dsDNA size, rheumatoid factor, and reduction and alkylation of the antibodies 1986
    1986 Quantitative aspects of lupus anti-DNA autoantibody specificity 1986
    1985 Determination of nitrate in soil extracts by dual-wavelength ultraviolet spectrophotometry. 1985
    1973 Interaction of virulent and avirulent Listeria monocytogenes with cultured mouse peritoneal macrophages. 1973

    Investigator On

  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2019 - 2024
  • Effects of ITGAM Genetic Variation on Mac-1 Mediated Functions of B Cells  awarded by DOD - Department of Defense 2018 - 2021
  • Private Grant  awarded by REGENERON GENETICS CENTER 2017 - 2020
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core D: Analytical Genomics and Transgenics Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Impact of SLE-Associated ITGAM Variants on Dendritic Cell Function  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2016 - 2019
  • Association of Genetic and Autoantibody Signatures with SLE Clinical Course  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2014 - 2019
  • Ethnic Differences in Response to Painful Stimuli  awarded by University of Florida 2018 - 2019
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2016 - 2018
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2015 - 2018
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2014 - 2018
  • UAB Center for Clinical and Translational Science (CCTS) (3 linked awards: UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2014 - 2015
  • Population Genetics Analysis Program: Immunity to Vaccines/Infections II  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2015
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2009 - 2014
  • Genomics of Lupus  awarded by Oklahoma Medical Research Foundation (OMRF) 2009 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) UL1  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • Program Project in the Genetics of SLE  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Program Project in the Genetics of SLE - Project 1 (Copy Number Variation in Genetic Susceptibility and Severity of SLE)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Biological Mechanisms of ITGAM Variants for Genetic Risk in SLE  awarded by LUPUS RESEARCH ALLIANCE 2009 - 2013
  • FcgRIIB Links CRP Signals with ITGAM Functions: a G x G x G Model of SLE.  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2012
  • Mononuclear Phagocyte Function in Immunologic Diseases  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2006 - 2012
  • Full Name

  • Jeffrey Edberg