• Dr. James Donahue is an associate professor of surgery and the section chief of thoracic surgery at the University of Alabama at Birmingham. Dr. Donahue comes to UAB from the University of Maryland School of Medicine where he had an active clinical practice focused on thoracic surgical oncology and served as chief of thoracic surgery at the Baltimore VA Medical Center. He is committed to resident education and served as the associate program director for the University of Maryland cardiothoracic surgical residency program. Dr. Donahue is a former Navy reservist and was deployed with a forward surgical team in Afghanistan in 2013. In addition to his clinical interests, Dr. Donahue also runs a basic science research laboratory.

    Dr. Donahue is certified by the American Board of Surgery and the American Board of Thoracic Surgery. He is a fellow in the American College of Surgeons. He is also a member of the American Association of Cancer Research and the Society of Thoracic Surgeons.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Morbidity and 30-day mortality after decortication for parapneumonic empyema and pleural effusion among patients in the Society of Thoracic Surgeons' General Thoracic Surgery Database 2019
    2019 Lymph Node Size Predicts for Asymptomatic Brain Metastases in Patients With Non–small-cell Lung Cancer at Diagnosis 2019
    2018 MiR-199a-3p decreases esophageal cancer cell proliferation by targeting p21 activated kinase 4 2018
    2018 Implications of Pathologic Complete Response Beyond Mediastinal Nodal Clearance With High-Dose Neoadjuvant Chemoradiation Therapy in Locally Advanced, Non-Small Cell Lung Cancer 2018
    2018 Restrictive Transfusion Practices after Esophagectomy Are Associated with Improved Outcome: A Review of the Society of Thoracic Surgeons General Thoracic Database 2018
    2018 Corrigendum to “Clinical outcomes of black vs. non-black patients with locally advanced non–small cell lung cancer” [Lung Cancer 114, (December 2017) 44–49] (S016950021730555X) (10.1016/j.lungcan.2017.10.016)) 2018
    2018 Editorial for economic impact of an enhanced recovery pathway for lung resection 2018
    2017 Clinical outcomes of black vs. non-black patients with locally advanced non–small cell lung cancer 2017
    2017 The Society of Thoracic Surgeons General Thoracic Surgery Database: 2017 Update on Research 2017
    2017 Oncological outcomes from trimodality therapy receiving definitive doses of neoadjuvant chemoradiation (≥60 Gy) and factors influencing consideration for surgery in stage III non-small cell lung cancer 2017
    2016 The Society of Thoracic Surgeons General Thoracic Surgery Database: 2016 Update on Research 2016
    2016 Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1 2016
    2016 Overexpression of miR-199a-5p decreases esophageal cancer cell proliferation through repression of mitogen-activated protein kinase kinase kinase-11 (MAP3K11) 2016
    2015 Competition between RNA-binding proteins CELF1 and HuR modulates MYC translation and intestinal epithelium renewal 2015
    2014 Src-mediated caveolin-1 phosphorylation regulates intestinal epithelial restitution by altering Ca2+ influx after wounding 2014
    2014 Invited commentary 2014
    2014 Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer 2014
    2014 Role of p53 and EGFR as prognostic biomarkers in stage i non-small cell lung cancer 2014
    2013 Predictors of anastomotic leak after esophagectomy: An analysis of the society of thoracic surgeons general thoracic database 2013
    2013 Sphingosine kinase 1 overexpression stimulates intestinal epithelial cell proliferation through increased c-Myc translation 2013
    2013 Concurrent chemotherapy inhibits herpes simplex virus-1 replication and oncolysis 2013
    2012 The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stability 2012
    2012 Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis 2012
    2012 Oncologic efficacy of anatomic segmentectomy in stage IA lung cancer patients with T1a tumors 2012
    2011 The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cells 2011
    2010 Loss of p53, rather than beta-catenin overexpression, induces survivin-mediated resistance to apoptosis in an esophageal cancer cell line 2010
    2010 Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletion 2010
    2010 The prognostic importance of pathologically involved celiac node metastases in node-positive patients with carcinoma of the distal esophagus or gastroesophageal junction: A surgical series from the Mayo Clinic 2010
    2009 Lung Volume Reduction Surgery for Patients with Alpha-1 Antitrypsin Deficiency Emphysema 2009
    2009 Complete Pathologic Response After Neoadjuvant Chemoradiotherapy for Esophageal Cancer Is Associated With Enhanced Survival 2009
    2008 Extra-adrenal pheochromocytoma involving the organ of Zuckerkandl 2008
    2005 Mouse models of subcutaneous spleen reservoir for multiple portal venous injections to treat liver malignancies 2005
    2004 Oncolysis by viral replication and inhibition of angiogenesis by a replication-conditional herpes simplex virus that expresses mouse endostatin 2004
    2004 Selectivity of an Oncolytic Herpes Simplex Virus for Cells Expressing the DF3/MUC1 Antigen 2004
    2002 Regulation of herpes simplex virus 1 replication using tumor-associated promoters 2002
    2002 Viral oncolysis 2002
    2002 Regulation of herpes simplex virus γ134.5 expression and oncolysis of diffuse liver metastases by Myb34.5 2002


    Year Title Altmetric
    2012 Complications of thoracoscopy 2012
    2011 Primary mediastinal tumors and cysts and diagnostic investigation of mediastinal masses.  5841-5854. 2011

    Research Overview

  • post-transcriptional gene regulation in esophageal cancer cells as a way of identifying new therapeutic targets for management of this disease
  • Principal Investigator On

    Education And Training

  • Massachusetts General Hospital, Residency 2008
  • Mayo Clinic, Postdoctoral Fellowship 2008
  • Full Name

  • James Donahue