• Dr. Mountz is a Professor of Medicine and Director of the UAB Recombinant Inbred Strain Facility. Dr. Mountz is the Co-Director of the UAB Bone Center, the UAB Center for Aging, Basic Biology Component, and is a Physician at the Birmingham Veterans Administration Medical Center. Dr. Mountz is the recipient of the J. W. & Virginia Goodwin-Warren D. Blackburn, Jr. Research Chair in Rheumatology (2002) and recipient of the Max Cooper Award for Excellence in Research (2003). Dr. Mountz was designated one of 50 Arthritis Foundation ¡§Heroes¡¨for outstanding contributions for research in Rheumatology (2002). Dr. Mountz was Co-Chair of the National Institutes on Aging Task Force on Immunology and Aging and Co-Chair of the ¡§Leukocyte Trafficking in Inflammatory Disease¡¨ symposium at the 2004 annual meeting of the American Association of Immunologists. Dr. Mountz received a Ph.D. in High Energy Physics and graduated Summa Cum Laude before carrying out a post-doctoral fellowship in the area of biophysics studying bilayer lipid membranes. Dr. Mountz then received an MD from Ohio State University and carried out an internship of residency and a one-year fellowship in Internal Medicine in Rheumatology. Dr. Mountz was a research staff fellow at the National Institutes of Health for five years and also an Assistant Professor of Medicine at the Naval Bethesda Medical Center. During this time, Dr. Mountz was the first investigator to identify that Onco genes were elevated in autoimmune mice and humans. Dr. Mountz became an Assistant Professor of Medicine at The University of Alabama at Birmingham in 1987, where he produced the first transgenic mouse expressing Fas in T cells and ameliorated the lymphoproliferative autoimmune disease in /lpr (Fas mutant mice). Dr. Mountz then identified the Fas mutation in MRL-lpr/lpr mice as being an insertion of the Etn retrotransposon. Dr. Mountz also was the first investigator to study clono-deletion and energy induction in PCR transgenic mice on the lpr/lpr background. Dr. Mountz continues an active research program in lupus, arthritis, molecular nuclear imaging, immune response to virus and poxvirus and gene therapy, as well as T-cell senescence in aging in both mice and humans.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Dysregulation of T follicular helper cells in lupusJournal of Immunology.  202:1649-1658. 2019
    2018 Cutting edge: Intracellular IFN-β and distinct type i IFN expression patterns in circulating systemic lupus erythematosus B cellsJournal of Immunology.  201:2203-2208. 2018
    2018 Editorial: STATus of STAT3 in Psoriatic ArthritisArthritis and Rheumatology.  70:801-804. 2018
    2018 Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and DiseasesCell Chemical Biology.  25:499-512. 2018
    2018 Role of production of type I interferons by B cells in the mechanisms and pathogenesis of systemic lupus erythematosusDiscovery medicine.  25:21-29. 2018
    2017 Cutting Edge: Endogenous IFN-β regulates survival and development of transitional B cellsJournal of Immunology.  199:2618-2623. 2017
    2015 General approach for tetramer-based identification of autoantigen-reactive B cells: Characterization of La- and snRNP-reactive B cells in autoimmune BXD2 miceJournal of Immunology.  194:5022-5034. 2015
    2015 Identification of follicular T helper cells in tissue sectionsMethods in Molecular Biology.  1291:13-25. 2015
    2015 Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupusJournal of Clinical Investigation.  125:2877-2890. 2015
    2015 Odanacatib, a cathepsin K-specific inhibitor, inhibits inflammation and bone loss caused by periodontal diseasesJournal of Periodontology.  86:972-983. 2015
    2014 Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupusPLoS ONE.  9. 2014
    2014 IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγtNature Communications.  5. 2014
    2014 Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritisArthritis and Rheumatology.  66:2368-2379. 2014
    2014 Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 miceArthritis and Rheumatology.  66:2601-2612. 2014
    2013 The Dynamic Duo-Inflammatory M1 macrophages and Th17 cells in Rheumatic Diseases.Journal of Orthopedics & Rheumatology.  1:4. 2013
    2013 Death receptor 5-targeted depletion of interleukin-23-producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritisArthritis and Rheumatism.  65:2594-2605. 2013
    2013 Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 miceArthritis and Rheumatism.  65:2703-2712. 2013
    2013 Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone DestructionBone Research.  1:267-281. 2013
    2013 The interdependent, overlapping, and differential roles of type i and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitisJournal of Immunology.  191:2967-2977. 2013
    2013 IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cellsJournal of Immunology.  191:1614-1624. 2013
    2013 Cutting edge: Defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 miceJournal of Immunology.  190:4465-4469. 2013
    2013 Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging.Advances in Aging Research.  2:72-80. 2013
    2012 Emerging optical and nuclear medicine imaging methods in rheumatoid arthritisNature Reviews Rheumatology.  8:719-728. 2012
    2012 Managing macrophages in rheumatoid arthritis by reform or removalCurrent Rheumatology Reports.  14:445-454. 2012
    2012 Systemic autoimmunity caused by fas deficiency in macrophages: A new perspective on the first identified autoimmunity geneArthritis and Rheumatism.  64:609-612. 2012
    2012 Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model.Arthritis and Rheumatism.  64:1098-1109. 2012
    2011 Longitudinal assessment of cognitive and psychosocial functioning after Hurricanes Katrina and Rita: Exploring disaster impact on middle-aged, older, and oldest-old adultsJournal of Applied Biobehavioral Research.  16:187-211. 2011
    2011 mRNA editing, FAS, and systemic lupus erythematosus.Human Mutation.  32. 2011
    2011 ReplyArthritis and Rheumatism.  63:3175-3177. 2011
    2011 Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 miceArthritis and Rheumatism.  63:2038-2048. 2011
    2011 Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophagesBlood.  117:4796-4804. 2011
    2011 Alloantigen specific deletion of primary human T cells by Fas ligand (CD95L)-transduced monocyte-derived killer-dendritic cellsImmunology.  133:115-122. 2011
    2011 Type i interferon-dependent CD86high marginal zone precursor b cells are potent T cell costimulators in miceArthritis and Rheumatism.  63:1054-1064. 2011
    2011 Emerging MRI methods in rheumatoid arthritisNature Reviews Rheumatology.  7:85-95. 2011
    2011 Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease.Discovery medicine.  11:76-85. 2011
    2010 Metabolic syndrome, hormones, and maintenance of T cells during agingCurrent Opinion in Immunology.  22:541-548. 2010
    2010 IL-17 activates the canonical NF-κB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16Journal of Immunology.  184:2289-2296. 2010
    2010 IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cellsJournal of Immunology.  184:2281-2288. 2010
    2010 Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3Mechanisms of Ageing and Development.  131:29-37. 2010
    2010 Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunityJournal of Immunology.  184:442-451. 2010
    2010 Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging modelBritish Journal of Dermatology.  162:487-496. 2010
    2009 Assessment of genetic shielding for adenovirus vectorsOpen Gene Therapy Journal.  2:1-11. 2009
    2009 Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritisScandinavian Journal of Immunology.  70:309-316. 2009
    2008 Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approachVirology Journal.  5. 2008
    2008 Therapeutic potential of mesenchymal stem cells producing interferon-α in a mouse melanoma lung metastasis modelSTEM CELLS.  26:2332-2338. 2008
    2008 Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid successionMolecular Therapy.  16:1500-1506. 2008
    2008 Cancer gene therapy using mesenchymal stem cells expressing interferon-β in a mouse prostate cancer lung metastasis modelGene Therapy.  15:1446-1453. 2008
    2008 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 miceNature Immunology.  9:166-175. 2008
    2007 Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 miceMechanisms of Ageing and Development.  128:672-680. 2007
    2007 Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodiesJournal of Immunology.  178:5357-5365. 2007
    2007 Quantitative trait locus (QTL) mapping in aging systemsMethods in Molecular Biology.  371:321-348. 2007
    2007 Quantitative trait locus (QTL) mapping in aging systems.Methods in Molecular Biology.  371:321-348. 2007
    2006 Principal component analysis of quantitative trait loci for immune response to adenovirus in miceHereditas.  143:189-197. 2006
    2006 Targeted and shielded adenovectors for cancer therapyCancer Immunology, Immunotherapy.  55:1412-1419. 2006
    2006 Phenotype of genetically regulated thymic involution in young BXD RI strains of miceScandinavian Journal of Immunology.  64:287-294. 2006
    2006 Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor αArthritis and Rheumatism.  54:2872-2885. 2006
    2006 In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, Fas ligand, and perforinHuman Gene Therapy.  17:669-682. 2006
    2006 CD8 T-cell immune phenotype of successful agingMechanisms of Ageing and Development.  127:231-239. 2006
    2006 Determination of specific CD4 and CD8 T cell epitopes after AAV2- and AAV8-hF.IX gene therapyMolecular Therapy.  13:260-269. 2006
    2006 Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritisArthritis and Rheumatism.  54:343-355. 2006
    2006 Tumor necrosis factor ligand-receptor superfamily and arthritis.Current Directions in Autoimmunity.  9:37-54. 2006
    2005 Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system functionNature Genetics.  37:233-242. 2005
    2005 Rheumatoid arthritis: safe and sound.Gene Therapy.  12:1542-1543. 2005
    2005 Safe and soundGene Therapy.  12:1542-1543. 2005
    2005 Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritisArthritis and Rheumatism.  52:3257-3268. 2005
    2005 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevationGene Therapy.  12:1079-1088. 2005
    2005 Genetic analysis of the antibody response to AAV2 and factor IXMolecular Therapy.  11:866-874. 2005
    2005 Impaired apoptosis and immune senescence - Cause or effect?Immunological Reviews.  205:130-146. 2005
    2005 Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of miceScandinavian Journal of Immunology.  61:128-138. 2005
    2005 Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblastsAmerican Journal of Pathology.  167:705-719. 2005
    2005 Genetic regulation of thymic involutionMechanisms of Ageing and Development.  126:87-97. 2005
    2004 Nur77 family of nuclear hormone receptorsCurrent Drug Targets -Inflammation and Allergy-.  3:413-423. 2004
    2004 Defective clearance of adenovirus in IRF-1 -/- mice associated with defects in NK and T cells but not macrophagesScandinavian Journal of Immunology.  60:89-99. 2004
    2004 Regulation of apoptosis proteins in cancer cells by ubiquitinOncogene.  23:2009-2015. 2004
    2004 IL-12 Inhibits Thymic Involution by Enhancing IL-7- and IL-2-Induced Thymocyte ProliferationJournal of Immunology.  172:2909-2916. 2004
    2004 Novel Tumor Necrosis Factor α-Regulated Genes in Rheumatoid ArthritisArthritis and Rheumatism.  50:420-431. 2004
    2004 Chebyshev's inequality for nonparametric testing with small N and α in microarray researchJournal of the Royal Statistical Society: Series C.  53:95-108. 2004
    2004 Elimanation of activated but not resting primary human CD4+ and CD8+ T cells by Fas ligand (FasL/Cd95L)-expressing Killer-dendritic cellsImmunobiology.  208:463-475. 2004
    2004 Identification of multiple genetic loci that regulate adenovirus gene therapyGene Therapy.  11:4-14. 2004
    2004 Power and sample size estimation in high dimensional biologyStatistical Methods in Medical Research.  13:325-338. 2004
    2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritisJournal of Clinical Investigation.  112:1332-1341. 2003
    2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis.Journal of Clinical Investigation.  112:1332-1341. 2003
    2003 The nature and identification of quantitative trait loci: A community's viewNature Reviews Genetics.  4:911-916. 2003
    2003 Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10Genes and Immunity.  4:402-410. 2003
    2003 Randomization tests for small samples: An application for genetic expression dataJournal of the Royal Statistical Society: Series C.  52:365-376. 2003
    2003 TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritisJournal of Immunology.  171:1061-1069. 2003
    2003 Erratum: Cellular mechanism of thymic involution (Scandinavian Journal of Immunology (2003) 57 (410-422))Scandinavian Journal of Immunology.  58:118. 2003
    2003 Mature but not immature Fas Ligand (CD95L)-transduced human monocyte-derived dendritic cells are protected from Fas-mediated apoptosis and can be used as killer APCJournal of Immunology.  170:5406-5413. 2003
    2003 Cellular mechanism of thymic involutionScandinavian Journal of Immunology.  57:410-422. 2003
    2003 Impact of immune senescence on human agingImmunology and Allergy Clinics of North America.  23. 2003
    2003 Monkey see, monkey doGene Therapy.  10:194-196. 2003
    2003 Origin of late-onset autoimmune diseaseImmunology and Allergy Clinics of North America.  23:65-82. 2003
    2002 Addition of six-His-tagged peptide to the C terminus of adeno-associated virus VP3 does not affect viral tropism or productionJournal of Virology.  76:12023-12031. 2002
    2002 Molecular imaging: New applications for biochemistryJournal of Cellular Biochemistry.  162-171. 2002
    2002 Immunobiology of tumor necrosis factor receptor superfamilyImmunologic Research.  26:323-336. 2002
    2002 Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cellsImmunologic Research.  26:235-246. 2002
    2002 Significance of increased circulating proteasome in autoimmune diseaseJournal of Rheumatology.  29:2027-2030. 2002
    2002 BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor modelInternational Journal of Cancer.  101:270-279. 2002
    2002 Different role of Apaf-1 in positive selection, negative selection and death by neglect in foetal thymic organ cultureScandinavian Journal of Immunology.  56:174-184. 2002
    2002 Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liverJournal of Virology.  76:5692-5700. 2002
    2002 Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11Mechanisms of Ageing and Development.  123:1145-1158. 2002
    2002 Beneficial influences of systemic cooperation and sociological behavior on longevityMechanisms of Ageing and Development.  123:963-973. 2002
    2002 Local production of complement proteins in rheumatoid arthritis synoviumArthritis and Rheumatism.  46:934-945. 2002
    2002 Depletion of collagen II-reactive T cells and blocking of B cell activation prevents collagen II-induced arthritis in DBA/1j miceJournal of Immunology.  168:4164-4172. 2002
    2002 A universal distribution for component failure timesMeasurement Techniques.  45:710-713. 2002
    2002 Molecular imaging: new applications for biochemistry.Journal of Cellular Biochemistry -Supplement-.  39:162-171. 2002
    2002 Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cellsCell Death and Differentiation.  9:626-635. 2002
    2001 "Inverse wrap": An improved implantation technique for virus-transduced synovial fibroblasts in the SCID mouse model for rheumatoid arthritisModern Rheumatology.  11:145-150. 2001
    2001 Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticlesJournal of Immunological Methods.  256:89-105. 2001
    2001 Activated CD8+ T cells from aged mice exhibit decreased activation-induced cell deathMechanisms of Ageing and Development.  122:1663-1684. 2001
    2001 Defective Fas Ligand-Mediated Apoptosis Predisposes to Development of a Chronic Erosive Arthritis Subsequent to Mycoplasma pulmonis InfectionArthritis and Rheumatism.  44:2146-2159. 2001
    2001 Defective Fas ligand-mediated apoptosis predisposes to development of a chronic erosive arthritis subsequent to Mycoplasma pulmonis infection.Arthritis and Rheumatism.  44:2146-2159. 2001
    2001 Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicityNature Medicine.  7:954-960. 2001
    2001 Regulation of tumor necrosis factor α-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase AktArthritis and Rheumatism.  44:1555-1567. 2001
    2001 Decreased T cell stimulatory capacity of monocyte-derived human macrophages following herpes simplex virus type 1 infectionScandinavian Journal of Immunology.  54:93-99. 2001
    2001 Genetic dissection of age-related changes of immune function in miceScandinavian Journal of Immunology.  54:10-20. 2001
    2001 Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.Arthritis and Rheumatism.  44:1555-1567. 2001
    2001 Recombinant adenovirus expressing adeno-associated virus cap and rep proteins supports production of high-titer recombinant adeno-associated virusGene Therapy.  8:704-712. 2001
    2001 "Inverse wrap": an improved implantation technique for virus-transduced synovial fibroblasts in the SCID mouse model for rheumatoid arthritis.Modern Rheumatology.  11:145-150. 2001
    2001 Aged mice exhibit in vivo defective peripheral clonal deletion of Db/H-Y reactive CD8+ T cellsMechanisms of Ageing and Development.  122:305-326. 2001
    2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transferArthritis and Rheumatism.  44:964-973. 2001
    2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transfer.Arthritis and Rheumatism.  44:964-973. 2001
    2001 Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to γ-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant miceJournal of Immunology.  166:772-780. 2001
    2001 Apoptosis and rheumatoid arthritis: past, present, and future directions.Current Rheumatology Reports.  3:70-78. 2001
    2001 Re: "collagen-induced arthritis in TNF receptor-1-deficient mice: TNF receptor-2 can modulate arthritis in the absence of TNF receptor 1"Clinical Immunology.  99:305-307. 2001
    2001 Regulation of apoptosis of synovial fibroblasts.Current Directions in Autoimmunity.  3:216-239. 2001
    2001 The Fas signaling connection between autoimmunity and embryonic lethalityJournal of Clinical Immunology.  21:1-14. 2001
    2000 Adeno-associated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor α and reduces arthritisHuman Gene Therapy.  11:2431-2442. 2000
    2000 The prodomain of caspase-1 enhances Fas-mediated apoptosis through facilitation of caspase-8 activationJournal of Biological Chemistry.  275:14248-14254. 2000
    2000 Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts.Arthritis and Rheumatism.  43:1094-1105. 2000
    2000 Gene therapy that inhibits nuclear translocation of nuclear factor κB results in tumor necrosis factor α-induced apoptosis of human synovial fibroblastsArthritis and Rheumatism.  43:1094-1105. 2000
    2000 Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient miceJournal of Clinical Investigation.  105:813-821. 2000
    2000 Serum levels of soluble Fas correlate with indices of organ damage in systemic lupus erythematosusLupus.  9:132-139. 2000
    1999 Apoptosis and cell death in the endocrine systemRecent Progress in Hormone Research.  54:235-269. 1999
    1999 Specific targeting of activated endothelium in rat adjuvant arthritis with a 99mTc-radiolabeled E-selectin-binding peptide.Arthritis and Rheumatism.  42:641-649. 1999
    1999 Specific targeting of activated endothelium in rat adjuvant arthritis with a 99mTc-radiolabeled e-selectin-binding peptideArthritis and Rheumatism.  42:641-649. 1999
    1999 Construction of a recombinant adenovirus vector encoding Fas ligand with a CRE/Loxp inducible systemTransplantation Proceedings.  31:792-793. 1999
    1999 Induction of specific T cell tolerance by Fas ligand-expressing antigen- presenting cellsJournal of Immunology.  162:1423-1430. 1999
    1999 Herpes simplex virus type 2 infection induced apoptosis in peritoneal macrophages independent of Fas and tumor necrosis factor-receptor signalingViral Immunology.  12:263-275. 1999
    1999 Regulation of Fas-mediated apoptosis in CD2-fas transgenic miceInternational Reviews of Immunology.  18:309-327. 1999
    1998 Murine cytomegalovirus induces a Sjogren's syndrome-like disease in C57B1/6-lpr/lpr miceArthritis and Rheumatism.  41:2175-2184. 1998
    1998 Murine cytomegalovirus induces a Sjögren's syndrome-like disease in C57Bl/6-lpr/lpr mice.Arthritis and Rheumatism.  41:2175-2184. 1998
    1998 Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand - Producing antigen presenting cellsNature Biotechnology.  16:1045-1049. 1998
    1998 Familial painful restless legs syndrome correlates with pain dependent variation of blood flow to the caudate, thalamus, and anterior cingulate gyrusJournal of Rheumatology.  25:2270-2275. 1998
    1998 Apoptosis mediated by Fas but not tumor necrosis factor receptor 1 prevents chronic disease in mice infected with murine cytomegalovirusJournal of Clinical Investigation.  102:1431-1443. 1998
    1998 Inhibition of tumor necrosis factor α decreases inflammation and prolongs adenovirus gene expression in lung and liverHuman Gene Therapy.  9:1875-1884. 1998
    1998 Calmodulin antagonists inhibit apoptosis of CD4+ T-cells from patients with AIDSImmunopharmacology -New York-.  40:91-103. 1998
    1998 Increased susceptibility to apoptosis induced by anti-Fas antibody in a Rothmund-Thomson syndrome lymphoblastoid cell lineProceedings of the Association of American Physicians.  110:218-225. 1998
    1998 Autocrine and paracrine apoptosis are mediated by differential regulation of Fas ligand activity in two distinct Jurkat T cell populationsJournal of Immunology.  160:5288-5293. 1998
    1998 Effect of age and apoptosis on the mouse homologue of the huWRN geneMechanisms of Ageing and Development.  103:27-44. 1998
    1998 Cell death mediated by Fas-FasL interaction between glial cells and MBP- reactive T cellsJournal of Neuroscience Research.  52:458-467. 1998
    1998 Fas/Fas ligand signaling during gestational T cell developmentJournal of Immunology.  160:3766-3775. 1998
    1998 Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expressionJournal of Virology.  72:2483-2490. 1998
    1998 Imaging and tissue biodistribution of 99m Tc-labeled adenovirus knob (serotype 5)Gene Therapy.  5:798-808. 1998
    1998 Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptorArthritis and Rheumatism.  41:139-149. 1998
    1998 Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor.Arthritis and Rheumatism.  41:139-149. 1998
    1997 Cell death and longevity: Implications of Fas-mediated apoptosis in T-cell senescenceImmunological Reviews.  160:19-30. 1997
    1997 Increased Lymphocyte Apoptosis in Fas Ligand Transgenic MiceJournal of Immunology.  159:674-684. 1997
    1997 Increased Acute-Phase Response and Renal Amyloidosis in Aged CD2-fas-Transgenic MiceJournal of Immunology.  158:5988-5996. 1997
    1997 Increased apoptosis of CD45RO- T cells with agingMechanisms of Ageing and Development.  94:123-134. 1997
    1997 Kinetics of Fas-induced apoptosis in thymic organ cultureJournal of Clinical Immunology.  17:74-84. 1997
    1997 Clinical features associated with correction of T-cell senescence: Increased acute-phase response, amyloidosis and arthritisDevelopmental and Comparative Immunology.  21:509-523. 1997
    1997 Lymphoid cell accumulation in salivary glands of autoimmune MRL mice can be due to impaired apoptosisScandinavian Journal of Immunology.  46:373-378. 1997
    1997 Persistent expression of a soluble form of Fas/APO1 in continuously activated T cells from a patient with SLEClinical and Experimental Rheumatology.  15:19-23. 1997
    1996 CD2-FAS transgene increases t cell immune response and elevates amyloidosis in the kidney of aged CD-I miceFederation proceedings.  10. 1996
    1996 Fas and tumor necrosis factor-receptor i-mediated activation-induced cell death of macrophagesFederation proceedings.  10. 1996
    1996 HCP-deficient motheaten mice exhibit T cell apoptosis defectFederation proceedings.  10. 1996
    1996 Improved survival and decreased inflammatory lung and skin diseases in motheaten mice by treatment of tnf binding proteinFederation proceedings.  10. 1996
    1996 Intracellular il-ib is an inhibitor of the ICE pathway of FAS-mediated apoptosisFederation proceedings.  10. 1996
    1996 Oncogene c-myb is a direct transcriptional activator of the human fas geneFederation proceedings.  10. 1996
    1996 The cloning and identification of two novel isoforms of human ICEFederation proceedings.  10. 1996
    1996 The possible role of fas/fas-l mediated apoptosis in early thymocyte developmentFederation proceedings.  10. 1996
    1996 Autoimmunity due to defective Nur77, Fas, and TNF-RI apoptosisAdvances in Experimental Medicine and Biology.  406:241-262. 1996
    1996 Intracellular IL-1β Is an Inhibitor of Fas-Mediated ApoptosisJournal of Immunology.  157:3949-3957. 1996
    1996 Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative diseaseJournal of Clinical Investigation.  98:1107-1113. 1996
    1996 Role of calmodulin in HIV-potentiated fas-mediated apoptosisAmerican Journal of Pathology.  149:903-910. 1996
    1996 The role of programmed cell death as an emerging new concept for the pathogenesis of autoimmune diseases.Clinical immunology and immunopathology.  80:S2-14. 1996
    1996 Inhibition of Superantigen-Induced Proinflammatory Cytokine Production and Inflammatory Arthritis in MRL-Ipr/Ipr Mice by a Transcriptional Inhibitor of TNF-αJournal of Immunology.  157:1758-1772. 1996
    1996 Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defectJournal of Immunology.  156:4198-4208. 1996
    1996 Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor IJournal of Immunology.  156:2661-2665. 1996
    1996 Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cellsJournal of Experimental Medicine.  183:1879-1892. 1996
    1996 Autoimmune disease results from multiple interactive defects in apoptosis induction molecules and signaling pathways.Behring Institute Mitteilungen.  200-219. 1996
    1996 Increased t cell apoptosis in thymus and lymph node of fas ligand transgenic miceJournal of Investigative Medicine.  44. 1996
    1996 Oncogene c-myb is a direct transcriptional activator of the human fas geneJournal of Investigative Medicine.  44. 1996
    1996 Use of sensitive assays to detect soluble Fas in patients with systemic lupus erythematosus: comment on the article by Knipping et al and the article by Goel et al.Arthritis and Rheumatism.  39:1611-1612. 1996
    1995 Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic miceJournal of Experimental Medicine.  182:129-137. 1995
    1995 A fas antigen receptor mutation allows development of toxic shock syndrome toxin-1 -induced lethal shock in Vβ8.2T-cell receptor transgenic micePathobiology.  63:293-304. 1995
    1995 Autoimmunity, apoptosis defects and retrovirusesAdvances in Experimental Medicine and Biology.  374:183-201. 1995
    1995 Characterization of human Fas gene: Exon/intron organization and promoter regionJournal of Immunology.  154:1239-1245. 1995
    1995 Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosisImmunity.  2:353-362. 1995
    1995 Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activationBiochemical Journal.  310:957-963. 1995
    1995 Fibromyalgia in womenArthritis and Rheumatism.  38:926-938. 1995
    1995 Increased susceptability of fas mutant MRL-lpr/lpr mice to staphylococcal enterotoxin B-induced septic shockJournal of Immunology.  155:4829-4837. 1995
    1995 Regulation of apoptosis in immune cellsJournal of Clinical Immunology.  15:1-16. 1995
    1994 Protection from Fas-mediated apoptosis by a soluble form of the Fas moleculeScience.  263:1759-1762. 1994
    1994 Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr miceProceedings of the National Academy of Sciences.  91:2344-2348. 1994
    1994 Apoptosis defects analyzed in tcr transgenic and fas transgenic ipr miceInternational Reviews of Immunology.  11:321-342. 1994
    1994 Autoimmune disease. a problem of defective apoptosisArthritis and Rheumatism.  37:1415-1420. 1994
    1994 Defective clonal deletion and anergy induction in tcr transgenic lpr/lpr miceSeminars in Immunology.  6:27-37. 1994
    1994 T Cell Influence on Superantigen‐Induced Arthritis in MRL‐lpr/lpr MiceArthritis and Rheumatism.  37:113-124. 1994
    1994 T cells of staphylococcal enterotoxin B‐tolerized autoimmune MRL‐lpr/lpr mice require co‐stimulation through the B7‐CD28/CTLA‐4 pathway for activation and can be reanergized in vivo by stimulation of the T cell receptor in the absence of this co‐stimulatory signalEuropean Journal of Immunology.  24:1019-1025. 1994
    1993 Autoinnnune disease in mice due to integration of an endogenous retrovirus in an apoptosis geneJournal of Experimental Medicine.  178:461-468. 1993
    1993 Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.Journal of Immunology.  150:3651-3667. 1993
    1993 Murine models of autoimmune disease and Sjogren's syndromeCurrent Opinion in Rheumatology.  5:557-569. 1993
    1993 Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice: Clues from a T cell receptor β transgenic mouseJournal of Immunology.  150:3651-3667. 1993
    1993 Regulation of c-myb oncogene expression in immature and mature murine T cellsMolecular Immunology.  30:787-795. 1993
    1993 Retroviruses, apoptosis and autogenesImmunology Today.  14:532-536. 1993
    1993 Retroviruses, apoptosis and autogenesImmunology Today.  14:532-536. 1993
    1992 Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr miceJournal of Experimental Medicine.  176:1063-1072. 1992
    1992 Molecular studies of mouse medium and long-chain acyl-CoA dehydrogenase genes for site-directed mutagenesis of embryonic stem cells.Progress in clinical and biological research.  375:151-160. 1992
    1992 Murine models of autoimmune diseaseCurrent Opinion in Rheumatology.  4:621-629. 1992
    1992 Murine models of autoimmunity: T-cell and B-cell defectsCurrent Opinion in Rheumatology.  4:612-620. 1992
    1991 Nonhomologous recombination at sites within the mouse J(H)-C(δ) locus accompanies Cμ deletion and switch to immunoglobulin D secretionMolecular and Cellular Biology.  11:5660-5670. 1991
    1991 Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune miceJournal of Immunology.  147:466-474. 1991
    1991 Murine models for systemic lupus erythematosus and Sjogren's syndromeCurrent Opinion in Rheumatology.  3:738-756. 1991
    1990 Transgenic Rearranged T Cell Receptor Gene Inhibits Lymphadenopathy and Accumulation of CD4-CD8- B220 + T Cells in lpr/lpr MiceJournal of Experimental Medicine.  172:1805-1817. 1990
    1990 The in vivo generation of murine IgD-secreting cells is accompanied by deletion of the Cμ gene and occasional deletion of the gene for the Cδ1 domainJournal of Immunology.  145:1583-1591. 1990
    1990 Altered expression of self-reactive T cell receptor Vβ regions in autoimmune miceJournal of Immunology.  144:2159-2166. 1990
    1990 Animal models of systemic lupus erythematosus and Sjogren's syndromeCurrent Opinion in Rheumatology.  2:740-748. 1990
    1990 Elucidating the pathogenesis of autoimmune disease: recent advances at the molecular level and relevance to oral mucosal diseaseJournal of Oral Pathology and Medicine.  19:341-350. 1990
    1990 Production of trangenic mice and application to immunology and autoimmunityAmerican Journal of the Medical Sciences.  300:322-329. 1990
    1989 Studies of c-myb gene regulation in MRL-1pr/1pr mice. Identification of a 5' c-myb nuclear protein binding site and high levels of binding factors in nuclear extracts of 1pr/1pr lymph node cellsJournal of Immunology.  142:328-335. 1989
    1988 Expression of the murine proto-oncogene bcl-2 is stage specific and cell-type specific.Current Topics in Microbiology and Immunology.  141:332-336. 1988
    1988 Activation of CD 4-, CD 8-thymocytes with IL 4 vs IL 1 + IL 2Journal of Immunology.  141:2240-2245. 1988
    1988 Characteristics and functions of CD4-, CD8- T cells in normal and autoimmune mice.Concepts in immunopathology.  6:89-118. 1988
    1988 Characterization and differentiation of CD4-, CD8- thymocytes sorted with the Ly-24 markerJournal of Immunology.  140:1-7. 1988
    1988 Prevention of lymphadenopathy in MRL-lpr/lpr mice by blocking peripheral lymph node homing with Mel-14 in vivoJournal of Immunology.  140:2943-2949. 1988
    1988 The expression and modulation of IL-1α in murine keratinocytesJournal of Immunology.  140:2274-2278. 1988
    1987 Genetic and molecular genetic studies of murine and human lupus.Journal of Rheumatology.  14 Suppl 13:166-176. 1987
    1987 CS-A therapy in MRL-lpr/lpr mice: Amelioration of immunopathology despite autoantibody productionJournal of Immunology.  138:157-163. 1987
    1987 IL-2 Modulation of Murine T-Cell Oncogene ExpressionProceedings of the Society for Experimental Biology and Medicine.  184:186-190. 1987
    1987 Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE responseJournal of Immunology.  138:2826-2830. 1987
    1987 Polyclonal activation of the murine immune system by an antibody to IgD. VIII. Stimulation of IgD secretionJournal of Immunology.  139:2172-2178. 1987
    1987 Subpopulations of CD4, CD8 thymocytesEuropean Journal of Immunology.  17:1387-1390. 1987
    1986 T cell receptor gene expression in autoimmune miceJournal of Immunology.  137:1029-1036. 1986
    1986 Oncogene expression in autoimmune and normal peripheral blood mononuclear cellsJournal of Experimental Medicine.  163:1292-1307. 1986
    1986 Studies of the Effects of Y Chromosome Factors on the Expression of Autoimmune DiseaseAnnals of the New York Academy of Sciences.  475:200-218. 1986
    1986 pks, a raf-related sequence in humansProceedings of the National Academy of Sciences.  83:6312-6316. 1986
    1985 Modulation of c-myb transcription in autoimmune disease by cyclophosphamideJournal of Immunology.  135:2417-2422. 1985
    1985 Oncogene expression in autoimmune miceThe Journal of molecular and cellular immunology : JMCI.  2:121-131. 1985
    1985 Unusual expression of IL 2 receptors and both the c-myb and c-raf oncogenes in T cell lines and clones derived from autoimmune MRL-lpr/lpr miceJournal of Immunology.  134:3120-3123. 1985
    1985 Altered myb expression is associated with abnormal T cell development in the thymus of MRL-lpr/lpr miceFederation proceedings.  44. 1985
    1985 Antinucleic acid antibodies, gene expression, and autoimmune miceScandinavian Journal of Rheumatology.  14:101-109. 1985
    1985 Differential gene expression in autoimmune mice.Survey of immunologic research.  4:48-64. 1985
    1985 Effects of UV radiation on autoimmune strains of mice: Increased mortality and accelerated autoimmunity in BXSB male miceJournal of Investigative Dermatology.  85:181-186. 1985
    1984 Abnormal T cell proliferation in MRL-lpr/lpr mice is associated with high c-myb expressionFederation proceedings.  43. 1984
    1984 Autoimmunity and increased c-myb transcriptionScience.  226:1087-1089. 1984
    1984 Recent advances in SLEClinical Immunology Newsletter.  5:33-37. 1984
    1984 Rheumatoid arthritis and small airways functionArthritis and Rheumatism.  27:728-736. 1984
    1984 Studies of immune defective RII AnN miceClinical immunology and immunopathology.  30:346-361. 1984
    1983 Neutrophil migration in response to chemotactic factors - Effects of generation conditions and chemotherapeutic agentsInflammation.  7:57-65. 1983
    1983 An autopsy study of the prevalence of monosodium urate and calcium pyrophosphate dihydrate crystal deposition in first metatarsophalangeal jointsArthritis and Rheumatism.  26:1522-1524. 1983
    1983 Bleomycin‐induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (sclerodermaBritish Journal of Dermatology.  108:679-686. 1983
    1981 Analysis of double-scattering mechanisms in pd annihilation processes between 1.09 and 1.43 GeV/cPhysical Review D, Particles and fields.  23:1473-1483. 1981
    1981 Ethambutol-Induced Toxic Epidermal NecrolysisArchives of Internal Medicine -New Series-.  141:1677-1678. 1981
    1981 Rheumatoid arthritis therapeutic agent effects on chemotaxisFederation proceedings.  40. 1981
    1979 PHOTOELECTRIC EFFECTS IN DYE‐SENSITIZED ARTIFICIAL LIPID MEMBRANESPhotochemistry and Photobiology.  29:93-97. 1979
    1979 PHOTOGALVANOVOLTAIC CELLS AND PHOTOVOLTAIC CELLS USING GLASSY CARBON ELECTRODES.Transactions and Journal of the British Ceramic Society.  203-235. 1979
    1978 Bilayer lipid membranes (BLM): Study of antigen-antibody interactionsJournal of Bioenergetics and Biomembranes.  10:139-151. 1978
    1978 PHOTOEFFECTS OF PIGMENTED LIPID MEMBRANES IN A MICROPOROUS FILTERPhotochemistry and Photobiology.  28:395-400. 1978
    1978 Photo‐galvano‐voltaic cell: A new approach to the use of solar energyInternational Journal of Energy Research.  2:197-200. 1978
    1978 Study of the reaction pn+ - Between 1.09 and 1.43 GeV/cPhysical Review D, Particles and fields.  18:2227-2234. 1978
    1978 The Photogalvanic Effect in a Modified Iron Thionine SystemJournal of The Electrochemical Society.  125:885-886. 1978
    1978 The photogalvanovoltaic cellSolar Energy.  21:291-295. 1978
    1977 Study of double-scattering effects in p̄d annihilation processesPhysical Review Letters.  38:1443-1446. 1977
    1976 ρ{variant}0ρ{variant}0π- formation in the reaction pn → 3π-+ near 2190 MeV c.m. energyNuclear Physics B.  103:537-546. 1976
    1975 Some features of the reaction p p→Δ+ +(1236) n at 6 GeV/cPhysical Review D, Particles and fields.  12:1211-1218. 1975
    1974 An isospin analysis of the reaction pN→NNπ from threshold to 2.90 GeV/cNuclear Physics B.  68:214-220. 1974


    Year Title Altmetric
    2017 Regulation of negative selection in the thymus by cytokines: Novel Role of IL-23 to Regulate RORγt.  41-52. 2017
    2009 Gene therapy and immune senescence.  1629-1646. 2009

    Education And Training

  • Doctor of Medicine, Ohio State University System : Columbus 1978
  • Doctor of Philosophy, Michigan State University 1974
  • Full Name

  • John Mountz