Positions

Overview

  • Dr. Mountz is a Professor of Medicine and Director of the UAB Recombinant Inbred Strain Facility. Dr. Mountz is the Co-Director of the UAB Bone Center, the UAB Center for Aging, Basic Biology Component, and is a Physician at the Birmingham Veterans Administration Medical Center. Dr. Mountz is the recipient of the J. W. & Virginia Goodwin-Warren D. Blackburn, Jr. Research Chair in Rheumatology (2002) and recipient of the Max Cooper Award for Excellence in Research (2003). Dr. Mountz was designated one of 50 Arthritis Foundation ¡§Heroes¡¨for outstanding contributions for research in Rheumatology (2002). Dr. Mountz was Co-Chair of the National Institutes on Aging Task Force on Immunology and Aging and Co-Chair of the ¡§Leukocyte Trafficking in Inflammatory Disease¡¨ symposium at the 2004 annual meeting of the American Association of Immunologists. Dr. Mountz received a Ph.D. in High Energy Physics and graduated Summa Cum Laude before carrying out a post-doctoral fellowship in the area of biophysics studying bilayer lipid membranes. Dr. Mountz then received an MD from Ohio State University and carried out an internship of residency and a one-year fellowship in Internal Medicine in Rheumatology. Dr. Mountz was a research staff fellow at the National Institutes of Health for five years and also an Assistant Professor of Medicine at the Naval Bethesda Medical Center. During this time, Dr. Mountz was the first investigator to identify that Onco genes were elevated in autoimmune mice and humans. Dr. Mountz became an Assistant Professor of Medicine at The University of Alabama at Birmingham in 1987, where he produced the first transgenic mouse expressing Fas in T cells and ameliorated the lymphoproliferative autoimmune disease in /lpr (Fas mutant mice). Dr. Mountz then identified the Fas mutation in MRL-lpr/lpr mice as being an insertion of the Etn retrotransposon. Dr. Mountz also was the first investigator to study clono-deletion and energy induction in PCR transgenic mice on the lpr/lpr background. Dr. Mountz continues an active research program in lupus, arthritis, molecular nuclear imaging, immune response to virus and poxvirus and gene therapy, as well as T-cell senescence in aging in both mice and humans.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Cutting Edge: Intracellular IFN-β and Distinct Type I IFN Expression Patterns in Circulating Systemic Lupus Erythematosus B Cells.Journal of Immunology.  201:2203-2208. 2018
    2018 Editorial: STATus of STAT3 in Psoriatic Arthritis.Arthritis and Rheumatology.  70:801-804. 2018
    2018 Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and Diseases.Cell Chemical Biology.  25:499-512. 2018
    2018 Role of production of type I interferons by B cells in the mechanisms and pathogenesis of systemic lupus erythematosus.Discovery medicine.  25:21-29. 2018
    2017 Cutting Edge: Endogenous IFN-β Regulates Survival and Development of Transitional B Cells.Journal of Immunology.  199:2618-2623. 2017
    2015 Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases.Journal of Periodontology.  86:972-983. 2015
    2015 Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus.Journal of Clinical Investigation.  125:2877-2890. 2015
    2015 General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice.Journal of Immunology.  194:5022-5034. 2015
    2015 Identification of follicular T helper cells in tissue sections.Methods in Molecular Biology.  1291:13-25. 2015
    2014 Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritis.Arthritis and Rheumatology.  66:2368-2379. 2014
    2014 Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice.Arthritis and Rheumatology.  66:2601-2612. 2014
    2014 IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.Nature Communications.  5:4259. 2014
    2014 Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupus.PLoS ONE.  9:e102151. 2014
    2013 The Dynamic Duo-Inflammatory M1 macrophages and Th17 cells in Rheumatic Diseases.Journal of Orthopedics & Rheumatology.  1:4. 2013
    2013 Death receptor 5-targeted depletion of interleukin-23-producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritis.Arthritis and Rheumatism.  65:2594-2605. 2013
    2013 Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice.Arthritis and Rheumatism.  65:2703-2712. 2013
    2013 The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis.Journal of Immunology.  191:2967-2977. 2013
    2013 Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction.Bone Research.  1:267-281. 2013
    2013 IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells.Journal of Immunology.  191:1614-1624. 2013
    2013 Cutting Edge: defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice.Journal of Immunology.  190:4465-4469. 2013
    2013 Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging.Advances in Aging Research.  2:72-80. 2013
    2012 Emerging optical and nuclear medicine imaging methods in rheumatoid arthritis.Nature Reviews Rheumatology.  8:719-728. 2012
    2012 Managing macrophages in rheumatoid arthritis by reform or removal.Current Rheumatology Reports.  14:445-454. 2012
    2012 Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model.Arthritis and Rheumatism.  64:1098-1109. 2012
    2012 Systemic autoimmunity caused by fas deficiency in macrophages: a new perspective on the first identified autoimmunity gene.Arthritis and Rheumatism.  64:609-612. 2012
    2011 Longitudinal assessment of cognitive and psychosocial functioning after Hurricanes Katrina and Rita: Exploring disaster impact on middle-aged, older, and oldest-old adultsJournal of Applied Biobehavioral Research.  16:187-211. 2011
    2011 mRNA editing, FAS, and systemic lupus erythematosus.Human Mutation.  32:v-vi. 2011
    2011 ReplyArthritis and Rheumatism.  63:3175-3177. 2011
    2011 Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice.Arthritis and Rheumatism.  63:2038-2048. 2011
    2011 Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages.Blood.  117:4796-4804. 2011
    2011 Alloantigen specific deletion of primary human T cells by Fas ligand (CD95L)-transduced monocyte-derived killer-dendritic cells.Immunology.  133:115-122. 2011
    2011 Type I interferon-dependent CD86(high) marginal zone precursor B cells are potent T cell costimulators in mice.Arthritis and Rheumatism.  63:1054-1064. 2011
    2011 Emerging MRI methods in rheumatoid arthritis.Nature Reviews Rheumatology.  7:85-95. 2011
    2011 Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease.Discovery medicine.  11:76-85. 2011
    2010 Metabolic syndrome, hormones, and maintenance of T cells during aging.Current Opinion in Immunology.  22:541-548. 2010
    2010 IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.Journal of Immunology.  184:2289-2296. 2010
    2010 IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells.Journal of Immunology.  184:2281-2288. 2010
    2010 Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model.British Journal of Dermatology.  162:487-496. 2010
    2010 Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3.Mechanisms of Ageing and Development.  131:29-37. 2010
    2010 Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity.Journal of Immunology.  184:442-451. 2010
    2009 Assessment of genetic shielding for adenovirus vectorsOpen Gene Therapy Journal.  2:1-11. 2009
    2009 Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis.Scandinavian Journal of Immunology.  70:309-316. 2009
    2008 Cancer gene therapy using mesenchymal stem cells expressing interferon-beta in a mouse prostate cancer lung metastasis model.Gene Therapy.  15:1446-1453. 2008
    2008 Therapeutic potential of mesenchymal stem cells producing interferon-alpha in a mouse melanoma lung metastasis model.STEM CELLS.  26:2332-2338. 2008
    2008 Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach.Virology Journal.  5:98. 2008
    2008 Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession.Molecular Therapy.  16:1500-1506. 2008
    2008 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.Nature Immunology.  9:166-175. 2008
    2007 Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice.Mechanisms of Ageing and Development.  128:672-680. 2007
    2007 Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies.Journal of Immunology.  178:5357-5365. 2007
    2007 Quantitative trait locus (QTL) mapping in aging systemsMethods in Molecular Biology.  371:321-348. 2007
    2007 Quantitative trait locus (QTL) mapping in aging systems.Methods in Molecular Biology.  371:321-348. 2007
    2006 Principal component analysis of quantitative trait loci for immune response to adenovirus in mice.Hereditas.  143:189-197. 2006
    2006 Targeted and shielded adenovectors for cancer therapy.Cancer Immunology, Immunotherapy.  55:1412-1419. 2006
    2006 Phenotype of genetically regulated thymic involution in young BXD RI strains of mice.Scandinavian Journal of Immunology.  64:287-294. 2006
    2006 Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha.Arthritis and Rheumatism.  54:2872-2885. 2006
    2006 In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, fas ligand, and perforin.Human Gene Therapy.  17:669-682. 2006
    2006 CD8 T-cell immune phenotype of successful aging.Mechanisms of Ageing and Development.  127:231-239. 2006
    2006 Determination of specific CD4 and CD8 T cell epitopes after AAV2- and AAV8-hF.IX gene therapy.Molecular Therapy.  13:260-269. 2006
    2006 Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis.Arthritis and Rheumatism.  54:343-355. 2006
    2006 Tumor necrosis factor ligand-receptor superfamily and arthritis.Current Directions in Autoimmunity.  9:37-54. 2006
    2005 Rheumatoid arthritis: safe and sound.Gene Therapy.  12:1542-1543. 2005
    2005 Safe and soundGene Therapy.  12:1542-1543. 2005
    2005 Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis.Arthritis and Rheumatism.  52:3257-3268. 2005
    2005 Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts.American Journal of Pathology.  167:705-719. 2005
    2005 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation.Gene Therapy.  12:1079-1088. 2005
    2005 Genetic analysis of the antibody response to AAV2 and factor IX.Molecular Therapy.  11:866-874. 2005
    2005 Impaired apoptosis and immune senescence - cause or effect?Immunological Reviews.  205:130-146. 2005
    2005 Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function.Nature Genetics.  37:233-242. 2005
    2005 Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice.Scandinavian Journal of Immunology.  61:128-138. 2005
    2005 Genetic regulation of thymic involution.Mechanisms of Ageing and Development.  126:87-97. 2005
    2004 Nur77 family of nuclear hormone receptors.Current Drug Targets -Inflammation and Allergy-.  3:413-423. 2004
    2004 Defective clearance of adenovirus in IRF-1 mice associated with defects in NK and T cells but not macrophages.Scandinavian Journal of Immunology.  60:89-99. 2004
    2004 Regulation of apoptosis proteins in cancer cells by ubiquitin.Oncogene.  23:2009-2015. 2004
    2004 IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation.Journal of Immunology.  172:2909-2916. 2004
    2004 Novel tumor necrosis factor alpha-regulated genes in rheumatoid arthritis.Arthritis and Rheumatism.  50:420-431. 2004
    2004 Chebyshev's inequality for nonparametric testing with small N and α in microarray researchJournal of the Royal Statistical Society: Series C.  53:95-108. 2004
    2004 Elimination of activated but not resting primary human CD4+ and CD8+ T cells by Fas ligand (FasL/CD95L)-expressing Killer-dendritic cells.Immunobiology.  208:463-475. 2004
    2004 Identification of multiple genetic loci that regulate adenovirus gene therapy.Gene Therapy.  11:4-14. 2004
    2004 Power and sample size estimation in high dimensional biologyStatistical Methods in Medical Research.  13:325-338. 2004
    2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritisJournal of Clinical Investigation.  112:1332-1341. 2003
    2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis.Journal of Clinical Investigation.  112:1332-1341. 2003
    2003 The nature and identification of quantitative trait loci: a community's view.Nature Reviews Genetics.  4:911-916. 2003
    2003 Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10.Genes and Immunity.  4:402-410. 2003
    2003 Randomization tests for small samples: An application for genetic expression dataJournal of the Royal Statistical Society: Series C.  52:365-376. 2003
    2003 TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis.Journal of Immunology.  171:1061-1069. 2003
    2003 Erratum: Cellular mechanism of thymic involution (Scandinavian Journal of Immunology (2003) 57 (410-422))Scandinavian Journal of Immunology.  58:118. 2003
    2003 Mature but not immature Fas ligand (CD95L)-transduced human monocyte-derived dendritic cells are protected from Fas-mediated apoptosis and can be used as killer APC.Journal of Immunology.  170:5406-5413. 2003
    2003 Cellular mechanism of thymic involution.Scandinavian Journal of Immunology.  57:410-422. 2003
    2003 Impact of immune senescence on human agingImmunology and Allergy Clinics of North America.  23. 2003
    2003 Monkey see, monkey doGene Therapy.  10:194-196. 2003
    2003 Origin of late-onset autoimmune disease.Immunology and Allergy Clinics of North America.  23:65-vi. 2003
    2002 Addition of six-His-tagged peptide to the C terminus of adeno-associated virus VP3 does not affect viral tropism or production.Journal of Virology.  76:12023-12031. 2002
    2002 Molecular imaging: New applications for biochemistryJournal of Cellular Biochemistry.  162-171. 2002
    2002 Significance of increased circulating proteasome in autoimmune disease.Journal of Rheumatology.  29:2027-2030. 2002
    2002 BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model.International Journal of Cancer.  101:270-279. 2002
    2002 Different role of Apaf-1 in positive selection, negative selection and death by neglect in foetal thymic organ culture.Scandinavian Journal of Immunology.  56:174-184. 2002
    2002 Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver.Journal of Virology.  76:5692-5700. 2002
    2002 Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-alpha production by Kupffer cells.Cell Death and Differentiation.  9:626-635. 2002
    2002 Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11.Mechanisms of Ageing and Development.  123:1145-1158. 2002
    2002 Beneficial influences of systemic cooperation and sociological behavior on longevity.Mechanisms of Ageing and Development.  123:963-973. 2002
    2002 Depletion of collagen II-reactive T cells and blocking of B cell activation prevents collagen II-induced arthritis in DBA/1j mice.Journal of Immunology.  168:4164-4172. 2002
    2002 Local production of complement proteins in rheumatoid arthritis synovium.Arthritis and Rheumatism.  46:934-945. 2002
    2002 A universal distribution for component failure timesMeasurement Techniques.  45:710-713. 2002
    2002 Immunobiology of tumor necrosis factor receptor superfamily.Immunologic Research.  26:323-336. 2002
    2002 Molecular imaging: new applications for biochemistry.Journal of Cellular Biochemistry -Supplement-.  39:162-171. 2002
    2002 Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cells.Immunologic Research.  26:235-246. 2002
    2001 "Inverse wrap": An improved implantation technique for virus-transduced synovial fibroblasts in the SCID mouse model for rheumatoid arthritisModern Rheumatology.  11:145-150. 2001
    2001 Activated CD8(+) T cells from aged mice exhibit decreased activation-induced cell death.Mechanisms of Ageing and Development.  122:1663-1684. 2001
    2001 Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles.Journal of Immunological Methods.  256:89-105. 2001
    2001 Defective Fas Ligand-Mediated Apoptosis Predisposes to Development of a Chronic Erosive Arthritis Subsequent to Mycoplasma pulmonis InfectionArthritis and Rheumatism.  44:2146-2159. 2001
    2001 Defective Fas ligand-mediated apoptosis predisposes to development of a chronic erosive arthritis subsequent to Mycoplasma pulmonis infection.Arthritis and Rheumatism.  44:2146-2159. 2001
    2001 Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.Nature Medicine.  7:954-960. 2001
    2001 Regulation of tumor necrosis factor α-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase AktArthritis and Rheumatism.  44:1555-1567. 2001
    2001 Decreased T cell stimulatory capacity of monocyte-derived human macrophages following herpes simplex virus type 1 infection.Scandinavian Journal of Immunology.  54:93-99. 2001
    2001 Genetic dissection of age-related changes of immune function in mice.Scandinavian Journal of Immunology.  54:10-20. 2001
    2001 Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.Arthritis and Rheumatism.  44:1555-1567. 2001
    2001 "Inverse wrap": an improved implantation technique for virus-transduced synovial fibroblasts in the SCID mouse model for rheumatoid arthritis.Modern Rheumatology.  11:145-150. 2001
    2001 Re: "collagen-induced arthritis in TNF receptor-1-deficient mice: TNF receptor-2 can modulate arthritis in the absence of TNF receptor 1".Clinical Immunology.  99:305-307. 2001
    2001 Recombinant adenovirus expressing adeno-associated virus cap and rep proteins supports production of high-titer recombinant adeno-associated virus.Gene Therapy.  8:704-712. 2001
    2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transferArthritis and Rheumatism.  44:964-973. 2001
    2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transfer.Arthritis and Rheumatism.  44:964-973. 2001
    2001 Aged mice exhibit in vivo defective peripheral clonal deletion of D(b)/H-Y reactive CD8(+) T cells.Mechanisms of Ageing and Development.  122:305-326. 2001
    2001 Apoptosis and rheumatoid arthritis: past, present, and future directions.Current Rheumatology Reports.  3:70-78. 2001
    2001 Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice.Journal of Immunology.  166:772-780. 2001
    2001 Regulation of apoptosis of synovial fibroblasts.Current Directions in Autoimmunity.  3:216-239. 2001
    2001 The Fas signaling connection between autoimmunity and embryonic lethality.Journal of Clinical Immunology.  21:1-14. 2001
    2000 Adeno-associated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor alpha and reduces arthritis.Human Gene Therapy.  11:2431-2442. 2000
    2000 The prodomain of caspase-1 enhances Fas-mediated apoptosis through facilitation of caspase-8 activation.Journal of Biological Chemistry.  275:14248-14254. 2000
    2000 Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts.Arthritis and Rheumatism.  43:1094-1105. 2000
    2000 Gene therapy that inhibits nuclear translocation of nuclear factor κB results in tumor necrosis factor α-induced apoptosis of human synovial fibroblastsArthritis and Rheumatism.  43:1094-1105. 2000
    2000 Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient mice.Journal of Clinical Investigation.  105:813-821. 2000
    2000 Serum levels of soluble Fas correlate with indices of organ damage in systemic lupus erythematosus.Lupus.  9:132-139. 2000
    1999 Specific targeting of activated endothelium in rat adjuvant arthritis with a 99mTc-radiolabeled E-selectin-binding peptide.Arthritis and Rheumatism.  42:641-649. 1999
    1999 Specific targeting of activated endothelium in rat adjuvant arthritis with a 99mTc-radiolabeled e-selectin-binding peptideArthritis and Rheumatism.  42:641-649. 1999
    1999 Construction of a recombinant adenovirus vector encoding Fas ligand with a CRE/Loxp inducible system.Transplantation Proceedings.  31:792-793. 1999
    1999 Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells.Journal of Immunology.  162:1423-1430. 1999
    1999 Apoptosis and cell death in the endocrine system.Recent Progress in Hormone Research.  54:235-268. 1999
    1999 Herpes simplex virus type 2 infection induced apoptosis in peritoneal macrophages independent of Fas and tumor necrosis factor-receptor signaling.Viral Immunology.  12:263-275. 1999
    1999 Regulation of Fas-mediated apoptosis in CD2-fas transgenic mice.International Reviews of Immunology.  18:309-327. 1999
    1998 Murine cytomegalovirus induces a Sjogren's syndrome-like disease in C57B1/6-lpr/lpr miceArthritis and Rheumatism.  41:2175-2184. 1998
    1998 Murine cytomegalovirus induces a Sjögren's syndrome-like disease in C57Bl/6-lpr/lpr mice.Arthritis and Rheumatism.  41:2175-2184. 1998
    1998 Familial painful restless legs syndrome correlates with pain dependent variation of blood flow to the caudate, thalamus, and anterior cingulate gyrus.Journal of Rheumatology.  25:2270-2275. 1998
    1998 Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand-producing antigen presenting cells.Nature Biotechnology.  16:1045-1049. 1998
    1998 Apoptosis mediated by Fas but not tumor necrosis factor receptor 1 prevents chronic disease in mice infected with murine cytomegalovirus.Journal of Clinical Investigation.  102:1431-1443. 1998
    1998 Inhibition of tumor necrosis factor alpha decreases inflammation and prolongs adenovirus gene expression in lung and liver.Human Gene Therapy.  9:1875-1884. 1998
    1998 Calmodulin antagonists inhibit apoptosis of CD4+ T-cells from patients with AIDS.Immunopharmacology -New York-.  40:91-103. 1998
    1998 Autocrine and paracrine apoptosis are mediated by differential regulation of Fas ligand activity in two distinct Jurkat T cell populations.Journal of Immunology.  160:5288-5293. 1998
    1998 Effect of age and apoptosis on the mouse homologue of the huWRN gene.Mechanisms of Ageing and Development.  103:27-44. 1998
    1998 Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5).Gene Therapy.  5:798-808. 1998
    1998 Cell death mediated by Fas-FasL interaction between glial cells and MBP-reactive T cells.Journal of Neuroscience Research.  52:458-467. 1998
    1998 Increased susceptibility to apoptosis induced by anti-Fas antibody in a Rothmund-Thomson syndrome lymphoblastoid cell line.Proceedings of the Association of American Physicians.  110:218-225. 1998
    1998 Fas/Fas ligand signaling during gestational T cell development.Journal of Immunology.  160:3766-3775. 1998
    1998 Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression.Journal of Virology.  72:2483-2490. 1998
    1998 Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptorArthritis and Rheumatism.  41:139-149. 1998
    1998 Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor.Arthritis and Rheumatism.  41:139-149. 1998
    1997 Cell death and longevity: implications of Fas-mediated apoptosis in T-cell senescence.Immunological Reviews.  160:19-30. 1997
    1997 Clinical features associated with correction of T-cell senescence: increased acute-phase response, amyloidosis and arthritis.Developmental and Comparative Immunology.  21:509-523. 1997
    1997 Lymphoid cell accumulation in salivary glands of autoimmune MRL mice can be due to impaired apoptosis.Scandinavian Journal of Immunology.  46:373-378. 1997
    1997 Increased lymphocyte apoptosis in Fas ligand transgenic mice.Journal of Immunology.  159:674-684. 1997
    1997 Increased acute-phase response and renal amyloidosis in aged CD2-fas-transgenic mice.Journal of Immunology.  158:5988-5996. 1997
    1997 Increased apoptosis of CD45RO- T cells with aging.Mechanisms of Ageing and Development.  94:123-134. 1997
    1997 Kinetics of Fas-induced apoptosis in thymic organ culture.Journal of Clinical Immunology.  17:74-84. 1997
    1997 Persistent expression of a soluble form of Fas/APO1 in continuously activated T cells from a patient with SLE.Clinical and Experimental Rheumatology.  15:19-23. 1997
    1996 CD2-FAS transgene increases t cell immune response and elevates amyloidosis in the kidney of aged CD-I miceFederation proceedings.  10. 1996
    1996 Fas and tumor necrosis factor-receptor i-mediated activation-induced cell death of macrophagesFederation proceedings.  10. 1996
    1996 HCP-deficient motheaten mice exhibit T cell apoptosis defectFederation proceedings.  10. 1996
    1996 Improved survival and decreased inflammatory lung and skin diseases in motheaten mice by treatment of tnf binding proteinFederation proceedings.  10. 1996
    1996 Intracellular il-ib is an inhibitor of the ICE pathway of FAS-mediated apoptosisFederation proceedings.  10. 1996
    1996 Oncogene c-myb is a direct transcriptional activator of the human fas geneFederation proceedings.  10. 1996
    1996 The cloning and identification of two novel isoforms of human ICEFederation proceedings.  10. 1996
    1996 The possible role of fas/fas-l mediated apoptosis in early thymocyte developmentFederation proceedings.  10. 1996
    1996 Intracellular IL-1beta is an inhibitor of Fas-mediated apoptosis.Journal of Immunology.  157:3949-3957. 1996
    1996 Autoimmune disease results from multiple interactive defects in apoptosis induction molecules and signaling pathways.Behring Institute Mitteilungen.  200-219. 1996
    1996 Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.Journal of Clinical Investigation.  98:1107-1113. 1996
    1996 Role of calmodulin in HIV-potentiated Fas-mediated apoptosis.American Journal of Pathology.  149:903-910. 1996
    1996 The role of programmed cell death as an emerging new concept for the pathogenesis of autoimmune diseases.Clinical immunology and immunopathology.  80:S2-14. 1996
    1996 Use of sensitive assays to detect soluble Fas in patients with systemic lupus erythematosus: comment on the article by Knipping et al and the article by Goel et al.Arthritis and Rheumatism.  39:1611-1612. 1996
    1996 Inhibition of superantigen-induced proinflammatory cytokine production and inflammatory arthritis in MRL-lpr/lpr mice by a transcriptional inhibitor of TNF-alpha.Journal of Immunology.  157:1758-1772. 1996
    1996 Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect.Journal of Immunology.  156:4198-4208. 1996
    1996 Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I.Journal of Immunology.  156:2661-2665. 1996
    1996 Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.Journal of Experimental Medicine.  183:1879-1892. 1996
    1996 Autoimmunity due to defective Nur77, Fas, and TNF-RI apoptosis.Advances in Experimental Medicine and Biology.  406:241-262. 1996
    1996 Increased t cell apoptosis in thymus and lymph node of fas ligand transgenic miceJournal of Investigative Medicine.  44. 1996
    1996 Oncogene c-myb is a direct transcriptional activator of the human fas geneJournal of Investigative Medicine.  44. 1996
    1995 Increased susceptibility of fas mutant MRL-lpr/lpr mice to staphylococcal enterotoxin B-induced septic shock.Journal of Immunology.  155:4829-4837. 1995
    1995 Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation.Biochemical Journal.  310 ( Pt 3):957-963. 1995
    1995 Fibromyalgia in women. Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels.Arthritis and Rheumatism.  38:926-938. 1995
    1995 Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.Journal of Experimental Medicine.  182:129-137. 1995
    1995 Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis.Immunity.  2:353-362. 1995
    1995 Characterization of human Fas gene. Exon/intron organization and promoter region.Journal of Immunology.  154:1239-1245. 1995
    1995 A fas antigen receptor mutation allows development of toxic shock syndrome toxin-1-induced lethal shock in V beta 8.2 T-cell receptor transgenic mice.Pathobiology.  63:293-304. 1995
    1995 Autoimmunity, apoptosis defects and retroviruses.Advances in Experimental Medicine and Biology.  374:183-201. 1995
    1995 Regulation of apoptosis in immune cells.Journal of Clinical Immunology.  15:1-16. 1995
    1994 Autoimmune disease. A problem of defective apoptosis.Arthritis and Rheumatism.  37:1415-1420. 1994
    1994 T cells of staphylococcal enterotoxin B-tolerized autoimmune MRL-lpr/lpr mice require co-stimulation through the B7-CD28/CTLA-4 pathway for activation and can be reanergized in vivo by stimulation of the T cell receptor in the absence of this co-stimulatory signal.European Journal of Immunology.  24:1019-1025. 1994
    1994 Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule.Science.  263:1759-1762. 1994
    1994 Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.Proceedings of the National Academy of Sciences.  91:2344-2348. 1994
    1994 Defective clonal deletion and anergy induction in TCR transgenic lpr/lpr mice.Seminars in Immunology.  6:27-37. 1994
    1994 Apoptosis defects analyzed in TcR transgenic and fas transgenic lpr mice.International Reviews of Immunology.  11:321-342. 1994
    1994 T cell influence on superantigen-induced arthritis in MRL-lpr/lpr mice.Arthritis and Rheumatism.  37:113-124. 1994
    1993 Retroviruses, apoptosis and autogenes.Immunology Today.  14:532-536. 1993
    1993 Murine models of autoimmune disease and Sjögren's syndrome.Current Opinion in Rheumatology.  5:557-569. 1993
    1993 Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.Journal of Experimental Medicine.  178:461-468. 1993
    1993 Regulation of c-myb oncogene expression in immature and mature murine T cells.Molecular Immunology.  30:787-795. 1993
    1993 Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.Journal of Immunology.  150:3651-3667. 1993
    1993 Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice: Clues from a T cell receptor β transgenic mouseJournal of Immunology.  150:3651-3667. 1993
    1993 Retroviruses, apoptosis and autogenesImmunology Today.  14:532-536. 1993
    1992 Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice.Journal of Experimental Medicine.  176:1063-1072. 1992
    1992 Murine models of autoimmune disease.Current Opinion in Rheumatology.  4:621-629. 1992
    1992 Murine models of autoimmunity: T-cell and B-cell defects.Current Opinion in Rheumatology.  4:612-620. 1992
    1992 Molecular studies of mouse medium and long-chain acyl-CoA dehydrogenase genes for site-directed mutagenesis of embryonic stem cells.Progress in clinical and biological research.  375:151-160. 1992
    1991 Nonhomologous recombination at sites within the mouse JH-C delta locus accompanies C mu deletion and switch to immunoglobulin D secretion.Molecular and Cellular Biology.  11:5660-5670. 1991
    1991 Murine models for systemic lupus erythematosus and Sjögren's syndrome.Current Opinion in Rheumatology.  3:738-756. 1991
    1991 Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice.Journal of Immunology.  147:466-474. 1991
    1990 Transgenic rearranged T cell receptor gene inhibits lymphadenopathy and accumulation of CD4-CD8-B220+ T cells in lpr/lpr mice.Journal of Experimental Medicine.  172:1805-1817. 1990
    1990 Production of transgenic mice and application to immunology and autoimmunity.American Journal of the Medical Sciences.  300:322-329. 1990
    1990 Animal models of systemic lupus erythematosus and Sjögren's syndrome.Current Opinion in Rheumatology.  2:740-748. 1990
    1990 Elucidating the pathogenesis of autoimmune disease: recent advances at the molecular level and relevance to oral mucosal disease.Journal of Oral Pathology and Medicine.  19:341-350. 1990
    1990 The in vivo generation of murine IgD-secreting cells is accompanied by deletion of the C mu gene and occasional deletion of the gene for the C delta 1 domain.Journal of Immunology.  145:1583-1591. 1990
    1990 Altered expression of self-reactive T cell receptor V beta regions in autoimmune mice.Journal of Immunology.  144:2159-2166. 1990
    1989 Studies of c-myb gene regulation in MRL-lpr/lpr mice. Identification of a 5' c-myb nuclear protein binding site and high levels of binding factors in nuclear extracts of lpr/lpr lymph node cells.Journal of Immunology.  142:328-335. 1989
    1988 Activation of CD 4-, CD 8- thymocytes with IL 4 vs IL 1 + IL 2.Journal of Immunology.  141:2240-2245. 1988
    1988 Prevention of lymphadenopathy in MRL-lpr/lpr mice by blocking peripheral lymph node homing with Mel-14 in vivo.Journal of Immunology.  140:2943-2949. 1988
    1988 The expression and modulation of IL-1 alpha in murine keratinocytes.Journal of Immunology.  140:2274-2278. 1988
    1988 Characteristics and functions of CD4-, CD8- T cells in normal and autoimmune mice.Concepts in immunopathology.  6:89-118. 1988
    1988 Characterization and differentiation of CD4-, CD8- thymocytes sorted with the Ly-24 marker.Journal of Immunology.  140:1-7. 1988
    1988 Expression of the murine proto-oncogene bcl-2 is stage specific and cell-type specific.Current Topics in Microbiology and Immunology.  141:332-336. 1988
    1987 Polyclonal activation of the murine immune system by an antibody to IgD. VIII. Stimulation of IgD secretion.Journal of Immunology.  139:2172-2178. 1987
    1987 Subpopulations of CD4-, CD8- thymocytes.European Journal of Immunology.  17:1387-1390. 1987
    1987 Genetic and molecular genetic studies of murine and human lupus.Journal of Rheumatology -Supplement-.  14 Suppl 13:166-176. 1987
    1987 Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response.Journal of Immunology.  138:2826-2830. 1987
    1987 IL-2 modulation of murine T-cell oncogene expression.Proceedings of the Society for Experimental Biology and Medicine.  184:186-190. 1987
    1987 CS-A therapy in MRL-lpr/lpr mice: amelioration of immunopathology despite autoantibody production.Journal of Immunology.  138:157-163. 1987
    1986 Pks, a raf-related sequence in humans.Proceedings of the National Academy of Sciences.  83:6312-6316. 1986
    1986 T cell receptor gene expression in autoimmune mice.Journal of Immunology.  137:1029-1036. 1986
    1986 Oncogene expression in autoimmune and normal peripheral blood mononuclear cells.Journal of Experimental Medicine.  163:1292-1307. 1986
    1986 Studies of the effects of Y chromosome factors on the expression of autoimmune disease.Annals of the New York Academy of Sciences.  475:200-218. 1986
    1985 Modulation of c-myb transcription in autoimmune disease by cyclophosphamide.Journal of Immunology.  135:2417-2422. 1985
    1985 Unusual expression of IL 2 receptors and both the c-myb and c-raf oncogenes in T cell lines and clones derived from autoimmune MRL-lpr/lpr mice.Journal of Immunology.  134:3120-3123. 1985
    1985 Altered myb expression is associated with abnormal T cell development in the thymus of MRL-lpr/lpr miceFederation proceedings.  44. 1985
    1985 Antinucleic acid antibodies, gene expression, and autoimmune mice.Scandinavian Journal of Rheumatology -Supplement-.  56:101-109. 1985
    1985 Differential gene expression in autoimmune mice.Survey of immunologic research.  4:48-64. 1985
    1985 Effects of UV radiation on autoimmune strains of mice: Increased mortality and accelerated autoimmunity in BXSB male miceJournal of Investigative Dermatology.  85:181-186. 1985
    1985 Oncogene expression in autoimmune mice.The Journal of molecular and cellular immunology : JMCI.  2:121-131. 1985
    1984 Autoimmunity and increased c-myb transcription.Science.  226:1087-1089. 1984
    1984 Rheumatoid arthritis and small airways function. Effects of disease activity, smoking, and alpha 1-antitrypsin deficiency.Arthritis and Rheumatism.  27:728-736. 1984
    1984 Studies of immune defective RIII/AnN mice.Clinical immunology and immunopathology.  30:346-361. 1984
    1984 Abnormal T cell proliferation in MRL-lpr/lpr mice is associated with high c-myb expressionFederation proceedings.  43. 1984
    1984 Recent advances in SLEClinical Immunology Newsletter.  5:33-37. 1984
    1983 An autopsy study of the prevalence of monosodium urate and calcium pyrophosphate dihydrate crystal deposition in first metatarsophalangeal joints.Arthritis and Rheumatism.  26:1522-1524. 1983
    1983 Bleomycin-induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (scleroderma).British Journal of Dermatology.  108:679-686. 1983
    1983 Neutrophil migration in response to chemotactic factors: effects of generation conditions and chemotherapeutic agents.Inflammation.  7:57-65. 1983
    1981 Ethambutol-induced toxic epidermal necrolysis.Archives of Internal Medicine -New Series-.  141:1677-1678. 1981
    1981 Rheumatoid arthritis therapeutic agent effects on chemotaxisFederation proceedings.  40. 1981
    1978 Bilayer lipid membranes (BLM) study of antigen-antibody interactions.Journal of Bioenergetics and Biomembranes.  10:139-151. 1978
    1975 Some features of the reaction p p→Δ+ +(1236) n at 6 GeV/cPhysical Review D, Particles and fields.  12:1211-1218. 1975

    Chapter

    Year Title Altmetric
    2017 Regulation of negative selection in the thymus by cytokines: Novel Role of IL-23 to Regulate RORγt.  41-52. 2017
    2009 Gene therapy and immune senescence.  1629-1646. 2009

    Principal Investigator On

  • B Cell Intrinsic Interferon-beta Regulates Autoreactive B Cell Development  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2023
  • Follicular Exclusion of Self Antigens Prevents Development of Autoantibodies  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2020
  • Next Generation Cell Sorting to Streamline Core Operation in CFCC  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2017 - 2019
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core B: Comprehensive Flow Cytometry Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • B-Cell Control Point Dysregulation in African Americans with SLE  awarded by LUPUS RESEARCH ALLIANCE 2018 - 2019
  • Next Generation Flow Cytometer to Streamline Core Operation in CFCC  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2015 - 2017
  • Laser and Filter Upgrade for the Flow Cytometers in CFCC at Shelby  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2014 - 2016
  • Induction of Apoptotic Cell Reactive B Cells by Type I IFN in BXD2 Mice  awarded by Lupus Foundation of America, Inc. 2015
  • Optimal Approach to Block M1 Macrophages/Th17 Inflammation in Arthritis  awarded by American College of Rheumatology 2012 - 2014
  • Suppression of Pathogenic Autoantibodies in Lupus by Inhibition of AID  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2008 - 2014
  • DR5 Glycosylation Mediates Apoptosis Resistance in RA Synovial Fibroblasts  awarded by Arthritis Foundation 2010 - 2013
  • Rheumatic Diseases Core Center: Pilot Project - P & F 6  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Rheumatic Diseases Core Center: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Rheumatic Diseases Core Center: Core C - Analytic and Preparative Cytometry Facility  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Disruption of Autoreactive Germinal Centers as a Novel Therapy for Lupus  awarded by LUPUS RESEARCH ALLIANCE 2008 - 2011
  • Investigator On

  • Characterizing the Mechanism by which Endogenous Negative Regulators of Osteoclasts Control Bone Homeostasis under Physiological and Pathological Conditions in Mouse Models  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • Improving Resolution and Throughput on the HRIF Institutional Core  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2018 - 2020
  • REduCing Immunogenicity to PegloticasE (RECIPE)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2020
  • CbfB Mediates Articular Cartilage Regeneration and Repair in Aging  awarded by National Institute on Aging/NIH/DHHS 2017 - 2019
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • Repopulation of Tolerogenic B Cells Post B Cell Depletion Therapy in Lupus  awarded by LUPUS RESEARCH ALLIANCE 2016 - 2019
  • Inhibiting Periodontitis by Targeting Cathepsin K and Attenuating TLR Signaling  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2014 - 2018
  • Flow Cytometry Core Enhancement: ISS PC1 Photon Counting Spectrofluorimeter  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2011 - 2014
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Education And Training

  • Doctor of Medicine, Ohio State University System : Columbus
  • Doctor of Philosophy, Michigan State University
  • Full Name

  • John Mountz
  • Blazerid

  • jdmountz