Positions

Overview

  • I am a trained molecular geneticist, having earned my PhD from Northwestern University and completed postdoctoral training at a small biotech start-up company in Birmingham. In 2004, I joined UAB as a program manager, a position in which I gained administrative responsibility of a large set of multidisciplinary and interdisciplinary research and training grants. I continue to have direct responsibility for ensuring the regulatory excellence (e.g., IRB, IACUC, OH&S, COI) of programs like these, and based on this experience, I am now an active member of several institutional committees guiding the human subjects, sponsored programs, innovation, scientific review and clinical trial activities of the enterprise. As the Senior Administrative Director of the Center for Clinical and Translational Science (CCTS; UAB Hub), I am a member of the Office of the Director, joining the leadership team in overseeing the strategic vector of the Center in addition to managing day-to- day operations. With the Director, I am responsible for all Center reporting and serve as the liaison to other CTSA institutions and CTSA national committees. I also have the privilege to remain connected to my research roots. As an Assistant Professor of Medicine, I have participated in several national and international consortia to advance the understanding of genetic predisposition to disease and disease outcome, with an emphasis on systemic lupus. In parallel to this work, I am interested in investigating the methodologic approaches and opportunities for process optimization for enhanced scientific peer review, self-directed learning, translational thinking and tactics for collaborative innovation.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Scientific Review Committees as part of institutional review of human participant research: Initial implementation at institutions with Clinical and Translational Science Awards.Journal of Clinical and Translational Science.  4:115-124. 2020
    2020 Creating and testing a GCP game in an asynchronous course environment: The game and future plans.Journal of Clinical and Translational Science.  4:36-42. 2020
    2019 The CTSA External Reviewer Exchange Consortium (CEREC): Engagement and efficacy.Journal of Clinical and Translational Science.  3:325-331. 2019
    2018 Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1–second gene interactionsKidney International.  94:599-607. 2018
    2018 Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African AmericansHuman Molecular Genetics.  27:3813-3824. 2018
    2017 Transancestral mapping and genetic load in systemic lupus erythematosusNature Communications.  8. 2017
    2014 End-stage renal disease in African Americans with lupus nephritis is associated with APOL1Arthritis and Rheumatology.  66:390-396. 2014
    2006 Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domainsDevelopmental Biology.  291:368-381. 2006
    2005 SLE: Challenges and candidates in human disease 2005
    2005 Genetics of susceptibility and severity in systemic lupus erythematosusCurrent Opinion in Rheumatology.  17:529-537. 2005

    Chapter

    Year Title Altmetric
    2008 Fc and Related Receptors.  120-136. 2008

    Research Overview

  • My initial studies used genetic approaches in model systems to dissect signal transduction mechanisms involved in organ development and cellular communications, aberrations of which are implicated in several cancers and congenital syndromes. On this foundation, I am interested in the use of large-scale genetic association studies and genomic characterization to enhance our appreciation of gene variants and modifications that contribute to disease risk and severity, including systemic lupus erythematosus, lupus nephritis and end state renal disease. In the process, I have been part of a transdisciplinary team that has assembled an unprecedented cohort of clinically phenotyped subjects and genetic data, which allows continued opportunity to identify risk factors for LN/ESRD and to understand racial disparities in health outcomes. With this team, I am currently pursuing projects that use current, cutting-edge genomic sequencing methods to create an algorithm to predict genetic risk in autoimmune disease that may inform opportunities for earlier diagnostics and better therapeutic intervention. In parallel to this work, I have become interested in investigating the methodologic approaches, opportunities for process optimization and effective strategies in team dynamics that contribute to successful clinical investigation and translation in genomic medicine and beyond. This work is examining mechanisms for enhanced scientific peer review, self-directed learning, multi-site outcomes research, quality improvement analysis, return of genetic results and tactics for collaborative innovation.
  • Investigator On

  • Private Grant  awarded by REGENERON GENETICS CENTER 2017 - 2023
  • Institute for Clinical and Translational Science  awarded by University of California, Irvine 2018 - 2019
  • Innovation and Economic Development in Clinical and Translational Science  awarded by ALABAMA DEPARTMENT OF COMMERCE 2012 - 2015
  • UAB Center for Clinical and Translational Science (CCTS) (3 linked awards: UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2014 - 2015
  • Private Grant  awarded by ALEXION PHARMACEUTICALS, INC. 2013 - 2014
  • Genomics of Lupus  awarded by Oklahoma Medical Research Foundation (OMRF) 2009 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center - Methods Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center - Project 1  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center - Project 3  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center - Project 4  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Program Project in the Genetics of SLE  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Program Project in the Genetics of SLE - Administrative Unit ( Administrative Core & Specimen Repository)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Flow Cytometry Core Enhancement: ISS PC1 Photon Counting Spectrofluorimeter  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2011 - 2014
  • SLEGEN ImmunoChip Proposal  awarded by LUPUS RESEARCH ALLIANCE 2011 - 2013
  • NIAMS Multidiscipllinary Clinical Research Center - Project 2  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2013
  • Program Project in the Genetics of SLE - Diversity Supplement  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2011 - 2013
  • Program Project in the Genetics of SLE - Core 1 (Genetic Epidemiology & Biostatisics Core)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2013
  • Program Project in the Genetics of SLE - Project 4 (A Genetic Risk Profile on Longitudinal SLE Cohorts)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2013
  • Program Project in the Genetics of SLE - Project 2 (Genomics of Lupus Associations in the Hispanic 12q24 Linkage)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2013
  • Program Project in the Genetics of SLE - Project 3 (Genetic Susceptibilty to SLE in African Americans Using Admixture)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2013
  • Rheumatic Diseases Core Center: Pilot Project - P & F 4  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Rheumatic Diseases Core Center: Pilot Project - P & F 5  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Rheumatic Diseases Core Center: Pilot Project - P & F 6  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Genes and Phenotypes (GAP) Studies of Immunologic and Inflammatory Pathways  awarded by FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 2010 - 2012
  • A National Consortium to Explore the Genotypic Basis for ESRD in Lupus  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2012
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Mononuclear Phagocyte Function in Immunologic Diseases  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2006 - 2012
  • Private Grant  awarded by PIKAMAB, INC. 2011 - 2012
  • Private Grant  awarded by PIKAMAB, INC. 2011 - 2012
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Training Program in Rheumatic Diseases Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2007 - 2011
  • Program Project in the Genetics of SLE - Core 1 (Genetic Epidemiology & Biostatisics Core)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2009
  • Program Project in the Genetics of SLE - Project 4 (A Genetic Risk Profile on Longitudinal SLE Cohorts)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2009
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2008
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2008
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2008
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2007
  • Education And Training

  • Doctor of Science in Molecular Genetics, Northwestern University 2004
  • Bachelor of Science or Mathematics, North Central College 1997
  • Full Name

  • Jennifer Croker