Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 miRNA networks modulate human endothelial cell adaptation to cyclic hypoxia.Cellular Signalling.  54:150-160. 2019
2018 PIWI proteins contribute to apoptosis during the UPR in human airway epithelial cells.Scientific Reports.  8:16431. 2018
2018 eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells.Angiogenesis.  21:711-724. 2018
2018 miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target.Angiogenesis.  21:183-202. 2018
2018 Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling.Circulation Research.  122:319-336. 2018
2018 microRNA single polynucleotide polymorphism influences on microRNA biogenesis and mRNA target specificity.Gene.  640:66-72. 2018
2018 Therapeutic attenuation of the epithelial sodium channel with a SPLUNC1-derived peptide in airway diseases.AJP - Lung Cellular and Molecular Physiology.  314:L239-L242. 2018
2017 miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells.Cytobiologie.  96:758-766. 2017
2017 The therapeutic potential of CFTR modulators for COPD and other airway diseases.Current Opinion in Pharmacology.  34:132-139. 2017
2017 Influenza virus infection alters ion channel function of airway and alveolar cells: mechanisms and physiological sequelae.AJP - Lung Cellular and Molecular Physiology.  313:L845-L858. 2017
2017 Ion channels of the lung and their role in disease pathogenesis.AJP - Lung Cellular and Molecular Physiology.  313:L859-L872. 2017
2017 Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.AJP - Heart and Circulatory Physiology.  313:H32-H45. 2017
2017 SNPs in microRNA target sites and their potential role in human disease.Open Biology.  7. 2017
2017 miR-200b downregulates CFTR during hypoxia in human lung epithelial cells.Cellular and Molecular Biology Letters.  22:23. 2017
2016 Analysis of cystic fibrosis-associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases.JCI insight.  1. 2016
2016 Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme.Biochemical and Biophysical Research Communications.  478:559-564. 2016
2016 Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function.Journal of Thoracic and Cardiovascular Surgery.  152:1059-1070.e2. 2016
2016 Intracrine angiotensin II functions originate from noncanonical pathways in the human heart.AJP - Heart and Circulatory Physiology.  311:H404-H414. 2016
2016 miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells.Scientific Reports.  6:22775. 2016
2016 Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload.Journal of Molecular and Cellular Cardiology.  92:1-9. 2016
2016 Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator.Cellular and Molecular Biology Letters.  21:23. 2016
2016 Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role of microRNAs.Cellular and Molecular Biology Letters.  21:16. 2016
2015 Role of epithelial sodium channels in the regulation of lung fluid homeostasis.AJP - Lung Cellular and Molecular Physiology.  309:L1229-L1238. 2015
2015 Volume overload induces autophagic degradation of procollagen in cardiac fibroblasts.Journal of Molecular and Cellular Cardiology.  89:241-250. 2015
2015 The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop.Federation proceedings.  29:1467-1479. 2015
2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overloadAJP - Heart and Circulatory Physiology.  308:H651-H663. 2015
2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload.AJP - Heart and Circulatory Physiology.  308:H651-H663. 2015
2015 ΔF508 CFTR surface stability is regulated by DAB2 and CHIP-mediated ubiquitination in post-endocytic compartments.PLoS ONE.  10:e0123131. 2015
2014 CFTR and lung homeostasis.AJP - Lung Cellular and Molecular Physiology.  307:L917-L923. 2014
2014 Rescuing ΔF508 CFTR with trimethylangelicin, a dual-acting corrector and potentiator.AJP - Lung Cellular and Molecular Physiology.  307:L431-L434. 2014
2014 Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein.Journal of Biological Chemistry.  289:18270-18278. 2014
2014 Whole-genome profiling highlights the molecular complexity underlying eccentric cardiac hypertrophy.Therapeutic Advances in Cardiovascular Disease.  8:97-118. 2014
2014 Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog.PLoS ONE.  9:e94732. 2014
2014 RNAdigest: a web-based tool for the analysis and prediction of structure-specific RNAse digestion results.PLoS ONE.  9:e96759. 2014
2013 Regulation of the unfolded protein response by microRNAs.Cellular and Molecular Biology Letters.  18:555-578. 2013
2013 The silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunction.Federation proceedings.  27:4630-4645. 2013
2013 Cigarette smoke and CFTR: implications in the pathogenesis of COPD.AJP - Lung Cellular and Molecular Physiology.  305:L530-L541. 2013
2013 Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity.AJP - Lung Cellular and Molecular Physiology.  304:L582-L592. 2013
2013 Regulation of angiogenesis by hypoxia: the role of microRNA.Cellular and Molecular Biology Letters.  18:47-57. 2013
2012 The role of CFTR in transepithelial liquid transport in pig alveolar epithelia.AJP - Lung Cellular and Molecular Physiology.  303:L489-L491. 2012
2012 The CFTR and ENaC debate: how important is ENaC in CF lung disease?AJP - Lung Cellular and Molecular Physiology.  302:L1141-L1146. 2012
2012 Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator.Biochemical Journal.  441:633-643. 2012
2011 The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.Journal of Biological Chemistry.  286:41862-41870. 2011
2011 Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung.AJP - Lung Cellular and Molecular Physiology.  301:L557-L567. 2011
2011 ARFGAP1 promotes AP-2-dependent endocytosis.Nature Cell Biology.  13:559-567. 2011
2011 CFTR expression regulation by the unfolded protein response.Methods in Enzymology.  491:3-24. 2011
2010 A synonymous single nucleotide polymorphism in DeltaF508 CFTR alters the secondary structure of the mRNA and the expression of the mutant protein.Journal of Biological Chemistry.  285:28741-28748. 2010
2010 DeltaF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers.Pulmonary Pharmacology and Therapeutics.  23:268-278. 2010
2010 Targets for cystic fibrosis therapy: proteomic analysis and correction of mutant cystic fibrosis transmembrane conductance regulator.Expert Review of Proteomics.  7:495-506. 2010
2010 Functional stability of rescued delta F508 cystic fibrosis transmembrane conductance regulator in airway epithelial cells.American Journal of Respiratory Cell and Molecular Biology.  42:363-372. 2010
2009 Search and rescue: finding ways to correct deltaF508 CFTR.American Journal of Respiratory Cell and Molecular Biology.  40:385-387. 2009
2008 Activation of the unfolded protein response by deltaF508 CFTR.American Journal of Respiratory Cell and Molecular Biology.  39:448-457. 2008
2008 DETANO and nitrated lipids increase chloride secretion across lung airway cells.American Journal of Respiratory Cell and Molecular Biology.  39:150-162. 2008
2008 Enhanced cell-surface stability of rescued DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones.Biochemical Journal.  410:555-564. 2008
2007 VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator.American Journal of Respiratory Cell and Molecular Biology.  36:706-714. 2007
2007 Endoplasmic reticulum stress and the unfolded protein response regulate genomic cystic fibrosis transmembrane conductance regulator expression.American Journal of Physiology - Cell Physiology.  292:C756-C766. 2007
2006 Unlocking the mysteries of Na+-K+-ATPase endocytosis: phosphorylation is the key.American Journal of Respiratory Cell and Molecular Biology.  35:1-2. 2006
2006 Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening.Gene Therapy.  13:781-788. 2006
2006 Mutations in the amino terminus of the cystic fibrosis transmembrane conductance regulator enhance endocytosis.Journal of Biological Chemistry.  281:3329-3334. 2006
2005 Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers.Journal of Physiology.  569:601-615. 2005
2005 Improved gene delivery into neuroglial cells using a fiber-modified adenovirus vector.Biochemical and Biophysical Research Communications.  328:1182-1187. 2005
2004 Efficient intracellular processing of the endogenous cystic fibrosis transmembrane conductance regulator in epithelial cell lines.Journal of Biological Chemistry.  279:22578-22584. 2004
2003 Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipidsAmerican Journal of Physiology - Cell Physiology.  284. 2003
2003 Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipids.American Journal of Physiology - Cell Physiology.  284:C791-C804. 2003
2003 Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif.Molecular and Cellular Biology.  23:594-606. 2003
2002 Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression.Journal of Biological Chemistry.  277:49952-49957. 2002
2002 Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl- secretion in airway epithelia.Journal of Biological Chemistry.  277:43041-43049. 2002
2002 PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator.Journal of Biological Chemistry.  277:40099-40105. 2002
2002 Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts.Journal of Biological Chemistry.  277:33632-33640. 2002
2002 Enhancement of MHC class II-restricted responses by receptor-mediated uptake of peptide antigens.Journal of Immunology.  169:2337-2345. 2002
2002 AP2 adaptor complex-dependent internalization of CD5: differential regulation in T and B cells.Journal of Immunology.  168:5612-5620. 2002
2002 Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells.Cell regulation.  13:739-754. 2002
2002 Inhibition of T cell responses by transferrin-coupled competitor peptides.Immunologic Research.  26:77-85. 2002
2001 Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy.Journal of Experimental Medicine.  194:417-425. 2001
2001 Receptor mediated uptake of peptides that bind the human transferrin receptor.European Journal of Biochemistry.  268:2004-2012. 2001
2000 Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain.Cell regulation.  11:2643-2655. 2000
1999 Casein kinase II activity is required for transferrin receptor endocytosis.Journal of Biological Chemistry.  274:30550-30556. 1999
1999 Regulation of MHC class II expression in the central nervous system.Microbes and Infection.  1:893-902. 1999
1999 Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal.Journal of Biological Chemistry.  274:3602-3609. 1999
1998 Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions.Proceedings of the National Academy of Sciences.  95:10972-10977. 1998
1998 Structural requirements for major histocompatibility complex class II invariant chain endocytosis and lysosomal targeting.Journal of Biological Chemistry.  273:20644-20652. 1998
1998 Analysis of the structural requirements for lysosomal membrane targeting using transferrin receptor chimeras.Journal of Biological Chemistry.  273:14355-14362. 1998
1998 Construction and characterization of encapsidated poliovirus replicons that express biologically active murine interleukin-2.Journal of Interferon and Cytokine Research.  18:305-313. 1998
1996 Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding.European Journal of Biochemistry.  235:9-17. 1996
1994 Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.Journal of Cell Biology.  126:317-330. 1994
1993 YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis.Journal of Biological Chemistry.  268:21686-21692. 1993
1993 Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.Journal of Biological Chemistry.  268:19312-19320. 1993
1993 Signal-dependent membrane protein trafficking in the endocytic pathway.Annual review of cell biology.  9:129-161. 1993
1992 Structural requirements for high efficiency endocytosis of the human transferrin receptor.Journal of Inorganic Biochemistry.  47:209-217. 1992
1991 Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor.EMBO Journal.  10:3247-3253. 1991
1990 Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis.Cell.  63:1061-1072. 1990
1990 Stabilization of helical structure in two 17-residue amphipathic analogues of the C-terminal peptide of cytochrome C.Biopolymers.  29:1289-1296. 1990
1989 An analysis of the physical properties of peptides that influence the pigeon cytochrome c specific T lymphocyte response.Molecular Immunology.  26:1069-1079. 1989
1989 Substitutions engineered by chemical synthesis at three conserved sites in mitochondrial cytochrome c. Thermodynamic and functional consequences.Journal of Biological Chemistry.  264:15199-15209. 1989
1988 Monoclonal antibodies as probes of conformational changes in protein-engineered cytochrome c.Journal of Biological Chemistry.  263:8625-8634. 1988
1987 Isolation and partial amino acid sequence of three subunit species of porcine spleen ferritin: evidence of multiple H subunits.Archives of Biochemistry and Biophysics.  259:105-113. 1987
1986 Separation of multiple ferritin subunit types by reversed-phase HPLCJournal of liquid chromatography.  9:1679-1688. 1986
1980 Behavior of glycopolypeptides with empirical molecular weight estimation methods. 1. In sodium dodecyl sulfate.Biochemistry.  19:5734-5741. 1980
1980 Behavior of glycopolypeptides with empirical molecular weight estimation methods. 2. In random coil producing solvents.Biochemistry.  19:5741-5747. 1980

Book

Year Title Altmetric
2008 Chapter 1 Structure and Functions of Biomembranes.  Ed. 61.  2008

Chapter

Year Title Altmetric
2015 Regulation of Airway Lining Fluid in Health and Disease.  467-477. 2015

Education And Training

  • Doctor of Philosophy in Biochemistry, University of South Carolina System : Aiken
  • Full Name

  • James Collawn
  • Blazerid

  • jcollawn