Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Chymase uptake by cardiomyocytes results in myosin degradation in cardiac volume overload 2019
2019 Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension 2019
2019 miRNA networks modulate human endothelial cell adaptation to cyclic hypoxia 2019
2018 PIWI proteins contribute to apoptosis during the UPR in human airway epithelial cells 2018
2018 eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells 2018
2018 miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target 2018
2018 Therapeutic attenuation of the epithelial sodium channel with a SPLUNC1-derived peptide in airway diseases 2018
2018 microRNA single polynucleotide polymorphism influences on microRNA biogenesis and mRNA target specificity 2018
2018 Multifunctional role of chymase in acute and chronic tissue injury and remodeling 2018
2017 miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells 2017
2017 miR-200b downregulates CFTR during hypoxia in human lung epithelial cells 2017
2017 Influenza virus infection alters ion channel function of airway and alveolar cells: Mechanisms and physiological sequelae 2017
2017 Ion channels of the lung and their role in disease pathogenesis 2017
2017 The therapeutic potential of CFTR modulators for COPD and other airway diseases 2017
2017 Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure 2017
2017 SNPs in microRNA target sites and their potential role in human disease 2017
2016 Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator 2016
2016 Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function 2016
2016 Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme 2016
2016 Analysis of cystic fibrosis-associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases. 2016
2016 Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: The role of microRNAs 2016
2016 Intracrine angiotensin ii functions originate from noncanonical pathways in the human heart 2016
2016 MiR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells 2016
2016 Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload 2016
2015 Volume overload induces autophagic degradation of procollagen in cardiac fibroblasts 2015
2015 ▵F508 CFTR surface stability is regulated by DAB2 and CHIP-mediated ubiquitination in post-endocytic compartments 2015
2015 The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop 2015
2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload 2015
2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload 2015
2015 Role of epithelial sodium channels in the regulation of lung fluid homeostasis 2015
2014 Rescuing ΔF508 CFTR with trimethylangelicin, A dual-acting corrector and potentiator 2014
2014 Negative regulation of NADPH oxidase 4 by Hydrogen peroxide-inducible clone 5 (Hic-5) protein 2014
2014 RNAdigest: A web-based tool for the analysis and prediction of structure - Specific RNAse digestion results 2014
2014 Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog 2014
2014 CFTR and lung homeostasis 2014
2014 Whole-genome profiling highlights the molecular complexity underlying eccentric cardiac hypertrophy 2014
2013 The silent codon change I507-ATC→ATT contributes to the severity of the AF508 CFTR channel dysfunction 2013
2013 Cigarette smoke and CFTR: Implications in the pathogenesis of COPD 2013
2013 Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity 2013
2013 Regulation of angiogenesis by hypoxia: The role of microRNA 2013
2013 Regulation of the unfolded protein response by microRNAs 2013
2012 The role of CFTR in transepithelial liquid transport in pig alveolar epithelia 2012
2012 The CFTR and ENaC debate: How important is ENaC in CF lung disease? 2012
2012 Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator 2012
2011 The Unfolded Protein Response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes 2011
2011 Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung 2011
2011 ARFGAP1 promotes AP-2-dependent endocytosis 2011
2011 CFTR expression regulation by the unfolded protein response 2011
2010 A synonymous single nucleotide polymorphism in ΔF508 CFTR alters the secondary structure of the mRNA and the expression of the mutant protein 2010
2010 Targets for cystic fibrosis therapy: Proteomic analysis and correction of mutant cystic fibrosis transmembrane conductance regulator 2010
2010 ΔF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers 2010
2010 Functional stability of rescued ΔF508 cystic fibrosis transmembrane conductance regulator in airway epithelial cells 2010
2009 Search and rescue finding ways to correct ΔF508 CFTR 2009
2008 Activation of the unfolded protein response by ΔF508 CFTR 2008
2008 DETANO and nitrated lipids increase chloride secretion across lung airway cells 2008
2008 Enhanced cell-surface stability of rescued ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones 2008
2007 VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator 2007
2007 Endoplasmic reticulum stress and the unfolded protein response regulate genomic cystic fibrosis transmembrane conductance regulator expression 2007
2006 Unlocking the mysteries of Na+-K+-ATPase endocytosis: Phosphorylation is the key 2006
2006 Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening 2006
2006 Mutations in the amino terminus of the cystic fibrosis transmembrane conductance regulator enhance endocytosis 2006
2005 Failure of cAMP agonists to activate rescued ΔF508 CFTR in CFBE41o- airway epithelial monolayers 2005
2005 Improved gene delivery into neuroglial cells using a fiber-modified adenovirus vector 2005
2004 Efficient intracellular processing of the endogenous cystic fibrosis transmembrane conductance regulator in epithelial cell lines 2004
2003 Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipids 2003
2003 Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipids. 2003
2003 Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif 2003
2002 Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression 2002
2002 Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl- secretion in airway epithelia 2002
2002 PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator 2002
2002 Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts 2002
2002 Enhancement of MHC class II-restricted responses by receptor-mediated uptake of peptide antigens 2002
2002 AP2 adaptor complex-dependent internalization of CD5: Differential regulation in T and B cells 2002
2002 Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells 2002
2002 Inhibition of T cell responses by transferrin-coupled competitor peptides 2002
2001 Receptor mediated uptake of peptides that bind the human transferrin receptor 2001
2001 Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in Iga nephropathy 2001
2000 Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain 2000
1999 Casein kinase II activity is required for transferrin receptor endocytosis 1999
1999 Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal 1999
1999 Regulation of MHC class II expression in the central nervous system 1999
1998 Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions 1998
1998 Structural requirements for major histocompatibility complex class II invariant chain endocytosis and lysosomal targeting 1998
1998 Analysis of the structural requirements for lysosomal membrane targeting using transferrin receptor chimeras 1998
1998 Construction and characterization of encapsidated poliovirus replicons that express biologically active murine interleukin-2 1998
1996 Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding 1996
1994 Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment 1994
1993 Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors 1993
1993 Signal-dependent membrane protein trafficking in the endocytic pathway 1993
1993 YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis 1993
1992 Structural requirements for high efficiency endocytosis of the human transferrin receptor 1992
1991 Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor 1991
1990 Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis 1990
1990 Stabilization of helical structure in two 17‐residue amphipathic analogues of the C‐terminal peptide of cytochrome c 1990
1989 An analysis of the physical properties of peptides that influence the pigeon cytochrome c specific T lymphocyte response 1989
1989 Substitutions engineered by chemical synthesis at three conserved sites in mitochondrial cytochrome c. Thermodynamic and functional consequences 1989
1988 Monoclonal antibodies as probes of conformational changes in protein-engineered cytochrome c 1988
1987 Isolation and partial amino acid sequence of three subunit species of porcine spleen ferritin: evidence of multiple H subunits. 1987
1986 Separation of multiple ferritin subunit types by reversed-phase HPLC 1986
1980 Behavior of Glycopolypeptides with Empirical Molecular Weight Estimation Methods. 1. In Sodium Dodecyl Sulfate 1980
1980 Behavior of Glycopolypeptides with Empirical Molecular Weight Estimation Methods. 2. In Random Coil Producing Solvents 1980

Book

Year Title Altmetric
2008 Chapter 1 Structure and Functions of Biomembranes.  Ed. 61.  2008

Chapter

Year Title Altmetric
2015 Regulation of Airway Lining Fluid in Health and Disease.  467-477. 2015

Teaching Activities

  • GBS716 - Grantsmanship & Sci Writing (Spring Term 2019) 2019
  • CB799 - Dissertation Research (Spring Term 2018) 2018
  • GBS716 - Grantsmanship & Sci Writing (Spring Term 2018) 2018
  • CB799 - Dissertation Research (Summer Term 2017) 2017
  • CB799 - Dissertation Research (Spring Term 2017) 2017
  • GBS716 - Grantsmanship & Sci Writing (Spring Term 2017) 2017
  • GBS716 - Grantsmanship & Sci Writing (Spring Term 2016) 2016
  • CB798 - Non-Dissertation Research (Fall Term 2015) 2015
  • CB798 - Non-Dissertation Research (Summer Term 2015) 2015
  • GBS794 - Lab Rotation 4 (Summer Term 2015) 2015
  • GBS795 - Lab Rotation 1 (Summer Term 2015) 2015
  • GBS797 - Lab Rotation 3 (Summer Term 2015) 2015
  • GBS798 - Non dissertation Research (Summer Term 2015) 2015
  • GBS799 - Dissertation Research (Summer Term 2015) 2015
  • CB799 - Dissertation Research (Spring Term 2015) 2015
  • GBS716 - Grantsmanship & Sci Writing (Spring Term 2015) 2015
  • GBS796 - Lab Rotation 2 (Spring Term 2015) 2015
  • GBS797 - Lab Rotation 3 (Spring Term 2015) 2015
  • GBS798 - Non dissertation Research (Spring Term 2015) 2015
  • GBS799 - Dissertation Research (Spring Term 2015) 2015
  • PHY699 - Thesis Research (Spring Term 2015) 2015
  • PHY799 - Dissertation Research (Spring Term 2015) 2015
  • CB799 - Dissertation Research (Fall Term 2014) 2014
  • GBS795 - Lab Rotation 1 (Fall Term 2014) 2014
  • GBS796 - Lab Rotation 2 (Fall Term 2014) 2014
  • GBS798 - Non dissertation Research (Fall Term 2014) 2014
  • GBS799 - Dissertation Research (Fall Term 2014) 2014
  • PHY699 - Thesis Research (Fall Term 2014) 2014
  • PHY799 - Dissertation Research (Fall Term 2014) 2014
  • CB799 - Dissertation Research (Summer Term 2014) 2014
  • GBS794 - Lab Rotation 4 (Summer Term 2014) 2014
  • GBS795 - Lab Rotation 1 (Summer Term 2014) 2014
  • GBS797 - Lab Rotation 3 (Summer Term 2014) 2014
  • GBS798 - Non dissertation Research (Summer Term 2014) 2014
  • GBS799 - Dissertation Research (Summer Term 2014) 2014
  • GBS799 - Dissertation Research (Summer Term 2014) 2014
  • PHY799 - Dissertation Research (Summer Term 2014) 2014
  • CB799 - Dissertation Research (Spring Term 2014) 2014
  • GBS716 - Grantsmanship & Sci Writing (Spring Term 2014) 2014
  • GBS796 - Lab Rotation 2 (Spring Term 2014) 2014
  • GBS797 - Lab Rotation 3 (Spring Term 2014) 2014
  • GBS798 - Non dissertation Research (Spring Term 2014) 2014
  • GBS799 - Dissertation Research (Spring Term 2014) 2014
  • CB799 - Dissertation Research (Fall Term 2013) 2013
  • GBS795 - Lab Rotation 1 (Fall Term 2013) 2013
  • GBS796 - Lab Rotation 2 (Fall Term 2013) 2013
  • GBS798 - Non dissertation Research (Fall Term 2013) 2013
  • GBS799 - Dissertation Research (Fall Term 2013) 2013
  • PHY798 - Non-Dissertation Research (Fall Term 2013) 2013
  • PHY799 - Dissertation Research (Fall Term 2013) 2013
  • GBS795 - Lab Rotation 1 (Summer Term 2013) 2013
  • CB799 - Dissertation Research (Summer Term 2013) 2013
  • GBS794 - Lab Rotation 4 (Summer Term 2013) 2013
  • GBS797 - Lab Rotation 3 (Summer Term 2013) 2013
  • GBS798 - Non dissertation Research (Summer Term 2013) 2013
  • GBS799 - Dissertation Research (Summer Term 2013) 2013
  • CB799 - Dissertation Research (Spring Term 2013) 2013
  • GBS716 - Grantsmanship & Sci Writing (Spring Term 2013) 2013
  • GBS796 - Lab Rotation 2 (Spring Term 2013) 2013
  • GBS797 - Lab Rotation 3 (Spring Term 2013) 2013
  • GBS798 - Non dissertation Research (Spring Term 2013) 2013
  • GBS799 - Dissertation Research (Spring Term 2013) 2013
  • CB798 - Non-Dissertation Research (Fall Term 2012) 2012
  • CB799 - Dissertation Research (Fall Term 2012) 2012
  • GBS795 - Lab Rotation I (Fall Term 2012) 2012
  • GBS796 - Lab Rotation II (Fall Term 2012) 2012
  • GBS798 - Non dissertation Research (Fall Term 2012) 2012
  • GBS799 - Dissertation Research (Fall Term 2012) 2012
  • PHY698 - Non-Thesis Research (Fall Term 2012) 2012
  • PHY798 - Non-Dissertation Research (Fall Term 2012) 2012
  • PHY799 - Dissertation Research (Fall Term 2012) 2012
  • CB798 - Non-Dissertation Research (Summer Term 2012) 2012
  • CB799 - Dissertation Research (Summer Term 2012) 2012
  • CB798 - Non-Dissertation Research (Spring Term 2012) 2012
  • CB799 - Dissertation Research (Spring Term 2012) 2012
  • GBS716 - Grantsmanship & Sci Writing (Spring Term 2012) 2012
  • CB798 - Non-Dissertation Research (Fall Term 2011) 2011
  • CB799 - Dissertation Research (Fall Term 2011) 2011
  • GBS709 - Basic Bio Organization (Fall Term 2011) 2011
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011) 2011
  • CB798 - Non-Dissertation Research (Summer Term 2011) 2011
  • CB799 - Dissertation Research (Summer Term 2011) 2011
  • CB798 - Non-Dissertation Research (Spring Term 2011) 2011
  • CB799 - Dissertation Research (Spring Term 2011) 2011
  • GBS716 - Grantsmanship & Sci Writing (Spring Term 2011) 2011
  • CB798 - Non-Dissertation Research (Fall Term 2010) 2010
  • CB798B - Non-Dissertation Research (Fall Term 2010) 2010
  • CB799 - Dissertation Research (Fall Term 2010) 2010
  • CB799B - Dissertation Research (Fall Term 2010) 2010
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010) 2010
  • CB798 - Non-Dissertation Research (Summer Term 2010) 2010
  • CB798 - Non-Dissertation Research (Summer Term 2010) 2010
  • CB798 - Non-Dissertation Research (Summer Term 2010) 2010
  • CB799 - Dissertation Research (Summer Term 2010) 2010
  • CB799 - Dissertation Research (Summer Term 2010) 2010
  • CB798 - Non-Dissertation Research (Spring Term 2010) 2010
  • CB799 - Dissertation Research (Spring Term 2010) 2010
  • CB799B - Dissertation Research (Spring Term 2010) 2010
  • CB798 - Non-Dissertation Research (Fall Term 2009) 2009
  • CB799 - Dissertation Research (Fall Term 2009) 2009
  • CB799B - Dissertation Research (Fall Term 2009) 2009
  • CB798 - Non-Dissertation Research (Summer Term 2009) 2009
  • CB798 - Non-Dissertation Research (Summer Term 2009) 2009
  • CB799 - Dissertation Research (Summer Term 2009) 2009
  • CB799 - Dissertation Research (Summer Term 2009) 2009
  • CB798 - Non-Dissertation Research (Spring Term 2009) 2009
  • CB798B - Non-Dissertation Research (Spring Term 2009) 2009
  • CB799 - Dissertation Research (Spring Term 2009) 2009
  • CB799B - Dissertation Research (Spring Term 2009) 2009
  • CB798 - Non-Dissertation Research (Fall Term 2008) 2008
  • CB798B - Non-Dissertation Research (Fall Term 2008) 2008
  • CB799 - Dissertation Research (Fall Term 2008) 2008
  • CB799B - Dissertation Research (Fall Term 2008) 2008
  • CB798 - Non-Dissertation Research (Summer Term 2008) 2008
  • CB798 - Non-Dissertation Research (Summer Term 2008) 2008
  • CB799 - Dissertation Research (Summer Term 2008) 2008
  • CB799 - Dissertation Research (Summer Term 2008) 2008
  • CB798 - Non-Dissertation Research (Spring Term 2008) 2008
  • CB799 - Dissertation Research (Spring Term 2008) 2008
  • CB752 - Graduate Histology (Fall Term 2007) 2007
  • CB798 - Non-Dissertation Research (Fall Term 2007) 2007
  • CB799 - Dissertation Research (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Biochemistry, University of South Carolina System : Aiken 1986
  • Full Name

  • James Collawn