Positions

Overview

  • John Chatham received his D.Phil. in 1987 from John Chatham received his D.Phil. in 1987 from the Department of Biochemistry at the University of Oxford in the UK. He completed his post-doctoral training at Johns Hopkins School of Medicine in 1989. He is currently Professor of Pathology in the Division of Molecular and Cellular Pathology at the University of Alabama at Birmingham.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity.Laboratory Investigation.  99:260-270. 2019
    2018 Temporal partitioning of adaptive responses of the murine heart to fasting.Life Sciences.  197:30-39. 2018
    2017 Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus.Journal of Neuroscience.  37:8207-8215. 2017
    2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart.Journal of Molecular and Cellular Cardiology.  110:80-95. 2017
    2017 O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease.Molecular Brain.  10:32. 2017
    2017 O-GlcNAcylation and neurodegeneration.Brain Research Bulletin.  133:80-87. 2017
    2017 O-GlcNAcylation and cardiovascular disease.Biochemical Society Transactions.  45:545-553. 2017
    2016 Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications.Pharmacological Research.  116:45-56. 2016
    2016 Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism.Free Radical Biology and Medicine.  100:94-107. 2016
    2016 TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.AJP - Heart and Circulatory Physiology.  311:H64-H75. 2016
    2016 Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism.AJP - Heart and Circulatory Physiology.  310:H1520-H1532. 2016
    2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy.  12:1-222. 2016
    2015 Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice.BBA - Biochimica et Biophysica Acta.  1861:1579-1595. 2015
    2015 Non-voltage-gated Ca²⁺ entry pathways in the heart: the untold STOrai?Cardiovascular Research.  105:233-234. 2015
    2015 Regulation of autophagy by protein post-translational modification.Laboratory Investigation.  95:14-25. 2015
    2014 Protein O-GlcNAcylation and cardiovascular (patho)physiology.Journal of Biological Chemistry.  289:34449-34456. 2014
    2014 High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats.AJP - Heart and Circulatory Physiology.  307:H598-H608. 2014
    2014 Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart.Journal of Biological Rhythms.  29:257-276. 2014
    2014 Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function.AJP - Heart and Circulatory Physiology.  306:H1231-H1239. 2014
    2014 Activation of AKT by O-linked N-acetylglucosamine induces vascular calcification in diabetes mellitus.Circulation Research.  114:1094-1102. 2014
    2014 O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses.Journal of Neuroscience.  34:10-21. 2014
    2013 STIM1/Orai1-mediated SOCE: current perspectives and potential roles in cardiac function and pathology.AJP - Heart and Circulatory Physiology.  305:H446-H458. 2013
    2013 Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heart.Life Sciences.  92:648-656. 2013
    2013 Post-translational protein modification by O-linked N-acetyl-glucosamine: its role in mediating the adverse effects of diabetes on the heart.Life Sciences.  92:621-627. 2013
    2013 APS election resultsPhysiologist.  56:44. 2013
    2013 Metabolic effects of glutamine on the heart: anaplerosis versus the hexosamine biosynthetic pathway.Journal of Molecular and Cellular Cardiology.  55:92-100. 2013
    2013 Regulation of myocardial metabolism by the cardiomyocyte circadian clock.Journal of Molecular and Cellular Cardiology.  55:139-146. 2013
    2012 Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes.Journal of Biological Chemistry.  287:39094-39106. 2012
    2012 Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependent.Journal of Biological Chemistry.  287:34419-34431. 2012
    2012 Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction.AJP - Heart and Circulatory Physiology.  303:H513-H522. 2012
    2012 Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes.Molecular Pharmacology.  82:541-549. 2012
    2012 Metabolic remodeling in the hypertrophic heart: fuel for thought.Circulation Research.  111:666-668. 2012
    2012 Chronic ingestion of a Western diet increases O-linked-β-N-acetylglucosamine (O-GlcNAc) protein modification in the rat heart.Life Sciences.  90:883-888. 2012
    2012 Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function.Journal of Molecular and Cellular Cardiology.  52:538-549. 2012
    2011 O-GlcNAcylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clock.Journal of Biological Chemistry.  286:44606-44619. 2011
    2011 Assessing bioenergetic function in response to oxidative stress by metabolic profiling.Free Radical Biology and Medicine.  51:1621-1635. 2011
    2011 Physiological concentration of glutamine increases exogenous fatty acid utilization in the ex vivo working heart: role of the hexosamine biosynthetic pathwayEuropean Heart Journal.  32:1003-1003. 2011
    2011 Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury.Molecular Medicine.  17:542-549. 2011
    2011 Cardiac anaplerosis in health and disease: food for thought.Cardiovascular Research.  90:210-219. 2011
    2011 Acute regulation of cardiac metabolism by the hexosamine biosynthesis pathway and protein O-GlcNAcylation.PLoS ONE.  6:e18417. 2011
    2011 Glutamine modulates fatty acid metabolism in ex vivo working rat hearts via the hexosamine biosynthetic pathwayFederation proceedings.  25. 2011
    2011 In cardiomyocytes glucose deprivation induced increase in O-GlcNAc is calcium dependentFederation proceedings.  25. 2011
    2011 Increased O-GlcNAcylation Induces Synaptic Depression and Prevents LTP at Hippocampal CA3-CA1 SynapsesFederation proceedings.  25. 2011
    2011 Nicotinamide adenine dinucleotide hydrate (NAD) contributes to the regulation of O-linked-N-acetylglucosamine (O-GlcNAc) levels on cardiomyocyte proteinsFederation proceedings.  25. 2011
    2011 Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice.Amino Acids.  40:819-828. 2011
    2011 The paradoxical world of protein O-GlcNAcylation: a novel effector of cardiovascular (dys)function.Cardiovascular Research.  89:487-488. 2011
    2011 O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells.PLoS ONE.  6:e24021. 2011
    2010 Increased Protein O-GlcNAcylation Inhibits TNF-alpha-Induced NFkB Signaling in Rat Aortic Smooth Muscle CellsCirculation.  122. 2010
    2010 Inhibition of STIM1 Oligomerization by Protein O-Linked N-Acetylglucosamine: A Novel Metabolically Mediated Regulation of Cardiomyocyte Calcium OverloadCirculation.  122. 2010
    2010 Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner.AJP - Heart and Circulatory Physiology.  299:H1715-H1727. 2010
    2010 Insights into the role of oxidative protein modifications in regulating cellular bioenergeticsNitric Oxide: Biology and Chemistry.  22:S23-S23. 2010
    2010 Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc.Nature Chemical Biology.  6:338-343. 2010
    2010 Acute effects of increased hexosamine biosynthesis and protein O-GlcNAcylation on cardiac gene expressionFederation proceedings.  24. 2010
    2010 Carboxybutyrylated glucosamine inhibits LPS-induced iNOS expression in RAW 264.7 macrophages via increased protein O-GlcNAc levelsFederation proceedings.  24. 2010
    2010 Generation of O-GlcNAc specific monoclonal antibodies using a novel synthetic immunogenFederation proceedings.  24. 2010
    2010 Glucose deprivation induced Cyclooxygenase-2 and Heme oxygenase-1 expression via P38 pathway in neonatal rat ventricular cardiomyocytesFederation proceedings.  24. 2010
    2010 O-GlcNAc agonist treatment attenuates early inflammatory response in the lung after cecal puncture and ligation induced sepsis in ratsFederation proceedings.  24. 2010
    2010 Protein O-GlcNAcylation Influences the Mammalian Circadian ClockFederation proceedings.  24. 2010
    2010 Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart.Circulation Research.  106:911-919. 2010
    2010 Increased O-linked beta-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats.Critical Care Medicine.  38:562-571. 2010
    2010 The role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses.BBA - Biochimica et Biophysica Acta.  1800:57-66. 2010
    2010 Protein O-GlcNAcylation: A critical regulator of the cellular response to stress.Current Signal Transduction Therapy.  5:49-59. 2010
    2009 Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal.Biochemical Journal.  424:99-107. 2009
    2009 Direct Relationship Between Protein O-GlcNAcylation and the Cardiomyocyte Circadian ClockCirculation Research.  105:E50-E50. 2009
    2009 Increased Cardiomyocyte 0-linked-beta-N-acetylglucosamine (0-GlcNAc) Levels Induced by Glucose Deprivation Mediated by Decreased 0-GlcNAcase Expression and Reduced Hexosamine Biosynthesis FluxCirculation Research.  105:E34-E35. 2009
    2009 O-linked-beta-N-acetylglucosamine (O-GlcNAc) Mediated Ischemic Cardioprotection Associated with Increased O-GlcNAcylation of Cytoskeletal Z-Line ProteinsCirculation Research.  105:E13-E13. 2009
    2009 Glucosamine increases hexosamine biosynthesis and O-linked N-acetylglucosamine in the heart, and leads to metabolic alterations similar to those seen in diabetic cardiomyopathyDiabetologia.  52:S15-S15. 2009
    2009 Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats.AJP - Heart and Circulatory Physiology.  297:H866-H873. 2009
    2009 Pugnac and Glucosamine Exaggerate Inflammatory and Vascular Injury Response in Balloon-Injured Rat Carotid ArteryArteriosclerosis, Thrombosis, and Vascular Biology.  29:E28-E28. 2009
    2009 Abnormal autophagic response contributes to cardiac dysfunction in diabetic rat hearts following pressure overloadFederation proceedings.  23. 2009
    2009 Consumption of a western diet and the pancreatic O-GlcNAc responseFederation proceedings.  23. 2009
    2009 Glucose deprivation induced increase in O-GlcNAc levels in cardiomyocytes is not mediated via increased OGT expressionFederation proceedings.  23. 2009
    2009 Impaired cardiomyocyte autophagy in diabetes is associated with increased hexosamine biosynthesis and protein O-GlcNAc levelsFederation proceedings.  23. 2009
    2009 Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc dependent mannerFederation proceedings.  23. 2009
    2009 Pro-inflammatory effect of hyperglycemia in cultured macrophages and neonatal rat ventricular cardiomyocytes is blunted by inhibition of hexosamine biosynthesisFederation proceedings.  23. 2009
    2009 Evidence of O-linked N-acetylglucosamine in diabetic nephropathy.Life Sciences.  84:389-393. 2009
    2009 O-glycosylation is increased in diabetic nephropathy, both in the tubuli and in the glomeruliActa Physiologica Hungarica.  96:76-76. 2009
    2009 Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-{kappa}B signaling.AJP - Heart and Circulatory Physiology.  296:H515-H523. 2009
    2009 Interaction of diet and diabetes on cardiovascular function in rats.AJP - Heart and Circulatory Physiology.  296:H282-H292. 2009
    2009 MECHANISM OF CARDIOPROTECTION BY ESTROGEN (E2) FOLLOWING TRAUMA-HEMORRHAGE (T-H): UPREGULATION OF CARDIAC O-GLYCOSALATIONShock.  31:89-89. 2009
    2009 Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system.AJP - Heart and Circulatory Physiology.  296:H13-H28. 2009
    2008 Changes in O-linked N-acetylglucosamine is associated with diabetic nephropathy in the human kidneyDiabetologia.  51:S488-S488. 2008
    2008 Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury.AJP - Heart and Circulatory Physiology.  295:H335-H342. 2008
    2008 Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats.Biogerontology.  9:139. 2008
    2008 Glucosamine inhibits TNF-alpha-induced inflammatory response in arterial SMCsArteriosclerosis, Thrombosis, and Vascular Biology.  28:E125-E126. 2008
    2008 Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2.American Journal of Physiology - Cell Physiology.  294:C1509-C1520. 2008
    2008 Imaging of cardiotoxicity.Molecular Imaging.  7:115-117. 2008
    2008 Effect of ischemia-reperfusion on O-GlcNAcylation of specific proteins in isolated rat heartsFederation proceedings.  22. 2008
    2008 Glucosamine Inhibits TNF-alpha -Induced Expression of Inflammatory Mediators In Rat Aortic Smooth Muscle Cells through Inhibition of NF kappa B ActivationFederation proceedings.  22. 2008
    2008 Hexosamine biosynthesis and protein O-glycosylation: the first line of defense against stress, ischemia, and trauma.Shock.  29:431-440. 2008
    2008 In isolated cardiomyocytes NF-kappa B activation is modulated by alterations in protein O-GlcNAc levelsFederation proceedings.  22. 2008
    2008 In the isolated perfused heart phenylephrine-induced activation of ERK is attenuated by glucosamineFederation proceedings.  22. 2008
    2008 O-GLYCOSYLATION IS INCREASED IN THE TUBULI AND GLOMERULI OF PATIENTS WITH DIABETIC NEPHROPATHYFederation proceedings.  22. 2008
    2008 O-GlcNAc agonist treatment improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in ratsFederation proceedings.  22. 2008
    2008 Pressure overload exacerbates insulin resistance in obesity and type 2 diabetesFederation proceedings.  22. 2008
    2008 Regulation of cardiac substrate utilization by protein O-glycosylationCardiovascular Drugs and Therapy.  22:140-140. 2008
    2008 Short term consumption of diets high in fat and/or sugar in young animals increase cardiovascular risk factors prior to the onset of obesityFederation proceedings.  22. 2008
    2008 Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes.American Journal of Physiology - Cell Physiology.  294:C833-C841. 2008
    2008 Direct Measurement of Bioenergetic Stress in Cardiomyocytes Exposed to Hydrogen Peroxide and Protection by O-GlcnacFree Radical Biology and Medicine.  45:S143-S143. 2008
    2008 Mechanism of estradiol-mediated cardio-protection following trauma-hemorrhage: Upregulation of cardiac O-glycosylation/phosphorylationShock.  29:21-22. 2008
    2007 Glucosamine administration improves survival rate after severe hemorrhagic shock combined with trauma in rats.Shock.  28:345-352. 2007
    2007 Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis.AJP - Heart and Circulatory Physiology.  293:H1391-H1399. 2007
    2007 Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: role of hydronephrosis.AJP - Heart and Circulatory Physiology.  293:H292-H298. 2007
    2007 Estrogen improves hepatic function following trauma-hemorrhage: Increased estrogen receptor-alpha expression and antioxidant activityShock.  27:59-59. 2007
    2007 Mechanism of the salutary effects of 17 beta-estradiol on cardiac function following trauma-hemorrhage: Inhibition of cardiomyocyte L-type calcium current (ICa-L)Shock.  27:60-60. 2007
    2007 Regulation of cardiac substrate utilization by protein O-glycosylationJournal of Molecular and Cellular Cardiology.  42:S64-S64. 2007
    2007 Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation.AJP - Heart and Circulatory Physiology.  292:H2227-H2236. 2007
    2007 A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion.Journal of Pharmacology and Experimental Therapeutics.  321:213-220. 2007
    2007 Dietary consumption of saturated fats and simple sugars exacerbates systolic and diastolic dysfunction and abnormal LV remodeling in diabetic ratsFederation proceedings.  21:A1197-A1197. 2007
    2007 Glucosamine inhibits acute inflammatory mediator expression and neointima formation in balloon-injured rat carotid arteryFederation proceedings.  21:A851-A851. 2007
    2007 Glucosamine protects neonatal cardiomyocytes from IschemiaReperfusion injury through translocation of BCL2 family proteinsFederation proceedings.  21:A866-A866. 2007
    2007 Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart.American Journal of Physiology - Cell Physiology.  292:C1370-C1378. 2007
    2007 Overexpression of TRPC3 increases apoptosis in response to ischemia/reperfusion but not TNF-alpha in adult mouse cardiomyocytesFederation proceedings.  21:A865-A865. 2007
    2007 The effect of aging on the hexosamine biosynthesis pathway and on O-linked N-acetylglucosamine levels in ratsFederation proceedings.  21:A1255-A1255. 2007
    2007 The protective effect of estrogen receptor (ER)-beta agonist on cardiac function following trauma-hemorrhage: Downregulation of cardiomyocyte L-type calcium current (ICa-L)Federation proceedings.  21:A1261-A1261. 2007
    2007 The protective effect of glucosamine on cardiac function following trauma hemorrhage: Downregulation of cardiac NF-kappa B signalingFederation proceedings.  21:A1278-A1279. 2007
    2007 The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels.Shock.  27:402-408. 2007
    2007 Z Increasing levels of O-linked N-acetylglucosamine (O-GlcNAc) on cardiac proteins during reperfusion improves recovery following ischemia/reperfusion and attenuates calpain-mediated proteolysisFederation proceedings.  21:A865-A865. 2007
    2007 Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system.Cardiovascular Research.  73:288-297. 2007
    2007 Aging-related accumulation of O-glcnacylated proteins in the cardiovascular system.Journal of Investigative Medicine.  55:S279-S279. 2007
    2007 Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc.American Journal of Physiology - Cell Physiology.  292:C178-C187. 2007
    2007 Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels.Journal of Molecular and Cellular Cardiology.  42:177-185. 2007
    2006 Glcosamine inhibits inflammatory response to tumor necrosis factor-alpha in vascular smooth muscle cells via augmentation of protein O-GlcNAcylationJournal of Hypertension.  24:179-180. 2006
    2006 The role of O-GlcNAcylation in aging-related loss of estrogenic vasoprotectionCirculation Research.  99:1282-1282. 2006
    2006 Protein O-glycosylation improves survival and effects cytokine release following trauma-hemorrhage in ratsCirculation.  114:426-426. 2006
    2006 Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats.AJP - Endocrinology and Metabolism.  291:E675-E682. 2006
    2006 Glucosamine administration during resuscitation improves organ function after trauma hemorrhage.Shock.  25:600-607. 2006
    2006 Glucosamine administration improves survival following trauma-hemorrhage in ratsFederation proceedings.  20:A1471-A1471. 2006
    2006 Increasing protein O-GlcNAc levels by inhibition of O-GlcNAcase improves cardiac function following trauma hemorrhage and resuscitation in ratFederation proceedings.  20:A1471-A1471. 2006
    2006 Cardiovascular dysfunction is caused by pre-existing hydronephrosis in young lean, obese and diabetic Zucker ratsFederation proceedings.  20:A298-A298. 2006
    2006 Glutamine protects isolated rat heart from ischemia/reperfusion injury through the hexosamine biosynthesis pathwayFederation proceedings.  20:A317-A317. 2006
    2006 Impact of type-2 diabetes on the hexosamine biosynthesis pathway and protein O-glycosylationFederation proceedings.  20:A297-A297. 2006
    2006 Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemia.Journal of Molecular and Cellular Cardiology.  40:303-312. 2006
    2006 Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine.American Journal of Physiology - Cell Physiology.  290:C57-C65. 2006
    2005 Myocardial phenotyping using isotopomer analysis of metabolic fluxes.Biochemical Society Transactions.  33:1413-1417. 2005
    2005 Glucosamine-induced cardioprotection mediated by the hexosamine biosynthesis pathway and increased levels of O-linked N-acetylglucosamine on nucleocytoplasmic proteinsCirculation Research.  97:E28-E28. 2005
    2005 Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats.AJP - Heart and Circulatory Physiology.  288:H2102-H2110. 2005
    2005 Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart.Circulation.  111:2066-2072. 2005
    2005 Glucosamine improves recovery following trauma hemorrhage in ratFederation proceedings.  19:A1224-A1224. 2005
    2005 Effects of glucosamine on the isolated rat heartFederation proceedings.  19:A689-A690. 2005
    2005 O-linked N-acetylglucosamine modification of proteins protect isolated perfused rat heart from ischemia/reperfusion injuryFederation proceedings.  19:A691-A691. 2005
    2005 The effect of insulin resistance on the regulation of cardiac carbohydrate and fatty acid metabolismFederation proceedings.  19:A692-A692. 2005
    2004 Protection from ischemic and hypovolemic injury by hyperglycemia transduced by hexosamine biosynthesis and O-linked N-acetylglucosamine on cytoplasmic proteinsCirculation.  110:1099-1099. 2004
    2004 Diabetes and cardiac carbohydrate metabolismJournal of Molecular and Cellular Cardiology.  37:328-328. 2004
    2004 Diabetes, the hexosamine biosynthesis pathway and protein O-glycsoylation in the heartJournal of Molecular and Cellular Cardiology.  37:286-287. 2004
    2004 Impact of low-flow ischemia on substrate oxidation and glycolysis in the isolated perfused rat heart.AJP - Heart and Circulatory Physiology.  287:H351-H362. 2004
    2004 Increased carbohydrate oxidation and decreased fatty acid oxidation do not improve cardiac function after ischemiaJournal of Molecular and Cellular Cardiology.  37:287-287. 2004
    2004 Oxidative and non-oxidative metabolic substrate fluxes in normal and ischemic rat heartJournal of Molecular and Cellular Cardiology.  37:287-287. 2004
    2004 Lactate isotopomer analysis by 1H NMR spectroscopy: consideration of long-range nuclear spin-spin interactions.Magnetic Resonance in Medicine.  51:1279-1282. 2004
    2004 Onset of diabetes in Zucker diabetic fatty (ZDF) rats leads to improved recovery of function after ischemia in the isolated perfused heart.AJP - Endocrinology and Metabolism.  286:E725-E736. 2004
    2004 Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy.Diabetes.  53:1074-1081. 2004
    2004 Ischemic cardiac protection of high glucose/high insulin is not due to increased glucose oxidationJournal of Molecular and Cellular Cardiology.  36:633-633. 2004
    2004 A critical perspective of the use of (13)C-isotopomer analysis by GCMS and NMR as applied to cardiac metabolism.Metabolic Engineering.  6:44-58. 2004
    2004 Glucosamine provides protection from ischemia/reperfusion injury and calcium overload in isolated hearts and leads to an increase in O-linked glycosylationShock.  21:58-58. 2004
    2003 Increased oxidation of free fatty acids does not lead to increased susceptibility to ischemia in hearts from type-2 diabetic ratsCirculation.  108:17-17. 2003
    2003 A comparison between NMR and GCMS 13C-isotopomer analysis in cardiac metabolism.Enzymologia.  249:105-112. 2003
    2003 Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heartAJP - Heart and Circulatory Physiology.  285. 2003
    2003 Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart.AJP - Heart and Circulatory Physiology.  285:H163-H172. 2003
    2003 Metabolic substrate utilization in isolated rat heart during low flow ischemia determined by C-13 NMR spectroscopyFederation proceedings.  17:A516-A516. 2003
    2002 Differential modulation of lactate, pyruvate and glucose oxidation by insulin and dichloroacetateCirculation.  106:195-196. 2002
    2002 IGF-I promotes a shift in metabolic flux in vascular smooth muscle cellsAJP - Endocrinology and Metabolism.  283. 2002
    2002 IGF-I promotes a shift in metabolic flux in vascular smooth muscle cells.AJP - Endocrinology and Metabolism.  283:E465-E471. 2002
    2002 Lactate - The forgotten fuel!Journal of Physiology.  542:333. 2002
    2002 Lactate -- the forgotten fuel!Journal of Physiology.  542:333. 2002
    2002 08 Altered substrate provision and cardiac function during ischemia and reperfusionJournal of Molecular and Cellular Cardiology.  34:A24-A24. 2002
    2002 11 Type-2 diabetes leads to improved recovery of myocardial ischemia/reperfusion injuryJournal of Molecular and Cellular Cardiology.  34:A25-A25. 2002
    2002 Cardiac carbohydrate metabolism in Zucker diabetic fatty rats.Cardiovascular Research.  55:104-112. 2002
    2002 Type 2 diabetes leads to progressive impairment of cardiac contractilityDiabetes.  51:A553-A553. 2002
    2002 An increase in the myocardial PCr/ATP ratio in GLUT4 null miceFederation proceedings.  16:613-615. 2002
    2002 An increase in the myocardial PCr/ATP ratio in GLUT4 null mice.Federation proceedings.  16:613-615. 2002
    2002 Regulation of carbohydrate metabolism in perfused rat heartFederation proceedings.  16:A856-A857. 2002
    2002 Type 2 diabetes impairs cardiac function but does not increase susceptibility to low flow ischemiaFederation proceedings.  16:A488-A488. 2002
    2001 Evidence of separate pathways for lactate uptake and release by the perfused rat heartAJP - Endocrinology and Metabolism.  281. 2001
    2001 Evidence of separate pathways for lactate uptake and release by the perfused rat heart.AJP - Endocrinology and Metabolism.  281:E794-E802. 2001
    2001 Upregulation of glucose metabolism during intimal lesion formation is coupled to the inhibition of vascular smooth muscle cell apoptosis. Role of GSK3beta.Diabetes.  50:1171-1179. 2001
    2001 Changes in cardiac metabolism precede development of contractile dysfunction in Type 2 diabetesFederation proceedings.  15:A1141-A1141. 2001
    2001 Glutamate and glutamine exchange in the isolated perfused rat heart.Federation proceedings.  15:A1142-A1142. 2001
    2001 Upregulation of GLUT1 and IGF-1 in vascular smooth muscle cells (VSMC) stimulates glucose metabolism: Potential role of metabolic regulation in neointimal lesion formation.Federation proceedings.  15:A868-A868. 2001
    2001 Nuclear magnetic resonance spectroscopy and imaging in animal research.ILAR news.  42:189-208. 2001
    2000 Preservation of glucose metabolism in hypertrophic GLUT4-null heartsAJP - Heart and Circulatory Physiology.  279. 2000
    2000 Preservation of glucose metabolism in hypertrophic GLUT4-null hearts.AJP - Heart and Circulatory Physiology.  279:H313-H318. 2000
    1999 Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study.Journal of the American Medical Association.  282:1659-1664. 1999
    1999 Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidationAJP - Endocrinology and Metabolism.  277:E342-E351. 1999
    1999 Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidationAJP - Endocrinology and Metabolism.  277. 1999
    1999 Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidation.American Journal of Physiology.  277:E342-E351. 1999
    1999 Preferential inhibition of lactate oxidation relative to glucose oxidation in the rat heart following diabetes.Cardiovascular Research.  43:96-106. 1999
    1999 Altered liver ATP metabolism in human nonalcoholic steatohepatitis (NASH).Federation proceedings.  13:A737-A737. 1999
    1999 Influence of palmitate on lactate uptake and efflux in hearts from control and diabetic rats.Federation proceedings.  13:A765-A765. 1999
    1999 Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion.Journal of Biological Chemistry.  274:5692-5700. 1999
    1999 Lactic acid and protein interactions: implications for the NMR visibility of lactate in biological systems.BBA - Biochimica et Biophysica Acta.  1426:177-184. 1999
    1998 In vivo cardiac energetics in GLUT4-null miceCirculation.  98:627-628. 1998
    1997 Effect of ischemia and reperfusion on substrate selection in the blood-perfused working rabbit heartFederation proceedings.  11. 1997
    1997 Fatty acid and lactate oxidation in control and diabetic rat heartsFederation proceedings.  11. 1997
    1997 Relationship between cardiac function and substrate oxidation in hearts of diabetic ratsAJP - Heart and Circulatory Physiology.  42. 1997
    1997 The effects of hypertrophy and diabetes on cardiac pyruvate dehydrogenase activity.Journal of Molecular and Cellular Cardiology.  29:2771-2778. 1997
    1997 Relationship between cardiac function and substrate oxidation in hearts of diabetic ratsAJP - Heart and Circulatory Physiology.  273:H52-H58. 1997
    1997 Relationship between cardiac function and substrate oxidation in hearts of diabetic ratsAJP - Heart and Circulatory Physiology.  273. 1997
    1997 Relationship between cardiac function and substrate oxidation in hearts of diabetic rats.American Journal of Physiology.  273:H52-H58. 1997
    1996 Acute L-triiodothyronine administration potentiates inotropic responses to beta-adrenergic stimulation in the isolated perfused rat heart.Cardiovascular Research.  32:306-310. 1996
    1996 The effects of diabetes on glucose and lactate oxidation in isolated rat hearts by C-13-NMR spectroscopy.Federation proceedings.  10:1878-1878. 1996
    1996 Metabolic compartmentation of lactate in the glucose-perfused rat heartAJP - Heart and Circulatory Physiology.  270. 1996
    1996 Metabolic compartmentation of lactate in the glucose-perfused rat heartAJP - Heart and Circulatory Physiology.  270:H224-H229. 1996
    1996 Metabolic compartmentation of lactate in the glucose-perfused rat heart.American Journal of Physiology.  270:H224-H229. 1996
    1995 Cerebral metabolites in patients with acute and subacute strokes: concentrations determined by quantitative proton MR spectroscopy.American Journal of Roentgenology.  165:633-638. 1995
    1995 Calculation of absolute metabolic flux and the elucidation of the pathways of glutamate labeling in perfused rat heart by 13C NMR spectroscopy and nonlinear least squares analysis.Journal of Biological Chemistry.  270:7999-8008. 1995
    1995 EFFECT OF D-BETA-HYDROXYBUTYRATE UPON FATTY-ACID AND GLUCOSE-OXIDATION IN THE ISOLATED RAT-HEART - ASSESSMENT USING C-13-NMR SPECTROSCOPYFederation proceedings.  9:A879-A879. 1995
    1994 CALCULATION OF ABSOLUTE METABOLIC FLUXES IN THE PERFUSED RAT-HEART BY C-13 NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPYCirculation.  90:629-629. 1994
    1994 Glucose metabolism in RIF-1 tumors after reduction in blood flow: an in vivo 13C and 31P NMR study.Magnetic Resonance in Medicine.  32:303-309. 1994
    1994 Quantitative proton spectroscopy of canine brain: in vivo and in vitro correlations.Magnetic Resonance in Medicine.  32:157-163. 1994
    1993 A 13C-NMR study of glucose oxidation in the intact functioning rat heart following diabetes-induced cardiomyopathy.Journal of Molecular and Cellular Cardiology.  25:1203-1213. 1993
    1993 Quantitative proton spectroscopy and histology of a canine brain tumor model.Magnetic Resonance in Medicine.  30:458-464. 1993
    1993 Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference.NMR in Biomedicine.  6:89-94. 1993
    1992 ALTERATIONS IN MYOCARDIAL GLUCOSE-METABOLISM IN DIABETES-INDUCED HEART-FAILURECirculation.  86:281-281. 1992
    1992 Altered glucose metabolism in adriamycin-induced heart failure.BBA - Biochimica et Biophysica Acta.  1138:1-5. 1992
    1992 Energy metabolism, pH changes, and lactate production in RIF-1 tumors following intratumoral injection of glucose.International Journal of Radiation Oncology - Biology - Physics.  22:95-101. 1992
    1991 High-resolution 1H NMR imaging of regional ischemia in the isolated perfused rabbit heart at 4.7 T.Magnetic Resonance in Medicine.  21:144-150. 1991
    1991 In Vivo13C NMR spectroscopy of glucose metabolism of RIF-1 tumorsMagnetic Resonance in Medicine.  20:17-26. 1991
    1991 In vivo 13CNMR spectroscopy of glucose metabolism of RIF-1 tumors.Magnetic Resonance in Medicine.  20:17-26. 1991
    1990 Sleep-related focal motor seizures in bilateral central macrogyria.Annals of Neurology.  28:840-842. 1990
    1990 The relationship between cardiac function and metabolism in acute adriamycin-treated perfused rat hearts studied by 31P and 13C NMR spectroscopy.Journal of Molecular and Cellular Cardiology.  22:1187-1197. 1990
    1990 31P chemical shift imaging of the regionally ischemic perfused heart.NMR in Biomedicine.  3:190-193. 1990
    1990 Echo planar imaging of isolated perfused rat hearts at 4.7 T: a comparison of Langendorff and working heart preparations.Magnetic Resonance in Medicine.  15:240-245. 1990
    1990 Phosphorus magnetic resonance spectroscopy of patients with mitochondrial cytopathies demonstrates decreased levels of brain phosphocreatine.Annals of Neurology.  27:626-630. 1990
    1990 31P NMR of mammalian cells encapsulated in alginate gels utilizing a new phosphate-free perfusion medium.NMR in Biomedicine.  3:23-26. 1990
    1990 Effects of repeated low calcium perfusion on the rat heart: a gradual induction of calcium related damage.Journal of Molecular and Cellular Cardiology.  22:131-141. 1990
    1990 ReplyAnnals of Neurology.  28:840-840. 1990
    1989 The metabolic consequences of hydroperoxide perfusion on the isolated rat heart.European Journal of Biochemistry.  184:657-662. 1989
    1989 Functional and metabolic analysis of vasopressin-induced coronary artery spasm in the isolated perfused working rabbit heartJournal of applied cardiology.  4:117-126. 1989
    1988 Depletion of myocardial glutathione: its effects on heart function and metabolism during ischaemia and reperfusion.Cardiovascular Research.  22:833-839. 1988
    1988 Inhibition of glucose phosphorylation by fatty acids in the perfused rat heart.FEBS Letters.  238:445-449. 1988
    1985 Studies of the protective effect of ribose in myocardial ischaemia by using 31P-nuclear-magnetic-resonance spectroscopyBiochemical Society Transactions.  13:885-886. 1985

    Research Overview

  • His recent research has focused on the role of the glucose-dependent, post-translational modifications of proteins by O-linked beta-N-acetylglucosamine moiety (O-GlcNAc) in mediating cardiomyocyte stress responses. Work from his laboratory has demonstrated that acute increases of O-GlcNAc levels are cardioprotective; conversely, in the setting of diabetes where O-GlcNAc levels are chronically elevated cardiomyocytes cell survival pathways such as autophagy are impaired in an O-GlcNAc dependent manner. Additional interests include the role of store-operated calcium entry (SOCE) in cardiomyocytes and how this is regulated by O-GlcNAc.
  • Education And Training

  • Doctorate Level Degree in Biochemistry, University of Oxford
  • Full Name

  • John Chatham