Positions

Overview

  • John Chatham received his D.Phil. in 1987 from John Chatham received his D.Phil. in 1987 from the Department of Biochemistry at the University of Oxford in the UK. He completed his post-doctoral training at Johns Hopkins School of Medicine in 1989. He is currently Professor of Pathology in the Division of Molecular and Cellular Pathology at the University of Alabama at Birmingham.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Acute increases in O-glcNAc indirectly impair mitochondrial bioenergetics through dysregulation of lonp1-mediated mitochondrial protein complex turnover 2019
    2019 Novel role of the ER/SR Ca2+ sensor STIM1 in the regulation of cardiac metabolism 2019
    2019 O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity 2019
    2018 Temporal partitioning of adaptive responses of the murine heart to fasting 2018
    2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart 2017
    2017 Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus 2017
    2017 O-GlcNAc regulation of autophagy and α-synuclein homeostasis; Implications for Parkinson's disease 2017
    2017 O-GlcNAcylation and neurodegeneration 2017
    2017 O-GlcNAcylation and cardiovascular disease 2017
    2017 Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications 2017
    2016 Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism 2016
    2016 Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice 2016
    2016 TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling 2016
    2016 Biotinylation: A novel posttranslational modification linking cell autonomous circadian clocks with metabolism 2016
    2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 2016
    2015 Non-voltage-gated Ca<sup>2+</sup> entry pathways in the heart: The untold STOrai? 2015
    2015 Regulation of autophagy by protein post-translational modification 2015
    2014 Protein O-GlcNAcylation and cardiovascular (patho)physiology 2014
    2014 High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats 2014
    2014 Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function 2014
    2014 Activation of AKT by O-linked N-Acetylglucosamine induces vascular calcification in diabetes mellitus 2014
    2014 O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses 2014
    2014 Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart 2014
    2013 STIM1/Orai1-mediated SOCE: Current perspectives and potential roles in cardiac function and pathology 2013
    2013 APS election results 2013
    2013 Metabolic effects of glutamine on the heart: Anaplerosis versus the hexosamine biosynthetic pathway 2013
    2013 Regulation of myocardial metabolism by the cardiomyocyte circadian clock 2013
    2013 Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heart 2013
    2013 Post-translational protein modification by O-linked N-acetyl-glucosamine: Its role in mediating the adverse effects of diabetes on the heart 2013
    2012 Modification of STIM1 by O-linked N-Acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes 2012
    2012 Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependent 2012
    2012 Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction 2012
    2012 Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes 2012
    2012 Metabolic remodeling in the hypertrophic heart: Fuel for thought 2012
    2012 Chronic ingestion of a Western diet increases O-linked-β-N- acetylglucosamine (O-GlcNAc) protein modification in the rat heart 2012
    2012 Protein O-linked β-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function 2012
    2011 O-glcnacylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clock 2011
    2011 Assessing bioenergetic function in response to oxidative stress by metabolic profiling 2011
    2011 O-GlcNAc modification of nfκb p65 inhibits tnf-α-induced inflammatory mediator expression in rat aortic smooth muscle cells 2011
    2011 Physiological concentration of glutamine increases exogenous fatty acid utilization in the ex vivo working heart: role of the hexosamine biosynthetic pathway 2011
    2011 Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury 2011
    2011 Cardiac anaplerosis in health and disease: Food for thought 2011
    2011 Glutamine modulates fatty acid metabolism in ex vivo working rat hearts via the hexosamine biosynthetic pathway 2011
    2011 In cardiomyocytes glucose deprivation induced increase in O-GlcNAc is calcium dependent 2011
    2011 Increased O-GlcNAcylation Induces Synaptic Depression and Prevents LTP at Hippocampal CA3-CA1 Synapses 2011
    2011 Nicotinamide adenine dinucleotide hydrate (NAD) contributes to the regulation of O-linked-N-acetylglucosamine (O-GlcNAc) levels on cardiomyocyte proteins 2011
    2011 Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice 2011
    2011 The paradoxical world of protein O-GlcNAcylation: A novel effector of cardiovascular (dys)function 2011
    2011 Acute regulation of cardiac metabolism by the hexosamine biosynthesis pathway and protein O-GlcNAcylation 2011
    2010 Increased Protein O-GlcNAcylation Inhibits TNF-alpha-Induced NFkB Signaling in Rat Aortic Smooth Muscle Cells 2010
    2010 Inhibition of STIM1 Oligomerization by Protein O-Linked N-Acetylglucosamine: A Novel Metabolically Mediated Regulation of Cardiomyocyte Calcium Overload 2010
    2010 Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner 2010
    2010 Insights into the role of oxidative protein modifications in regulating cellular bioenergetics 2010
    2010 Acute effects of increased hexosamine biosynthesis and protein O-GlcNAcylation on cardiac gene expression 2010
    2010 Carboxybutyrylated glucosamine inhibits LPS-induced iNOS expression in RAW 264.7 macrophages via increased protein O-GlcNAc levels 2010
    2010 Generation of O-GlcNAc specific monoclonal antibodies using a novel synthetic immunogen 2010
    2010 Glucose deprivation induced Cyclooxygenase-2 and Heme oxygenase-1 expression via P38 pathway in neonatal rat ventricular cardiomyocytes 2010
    2010 O-GlcNAc agonist treatment attenuates early inflammatory response in the lung after cecal puncture and ligation induced sepsis in rats 2010
    2010 Protein O-GlcNAcylation Influences the Mammalian Circadian Clock 2010
    2010 Peroxisome proliferator-activated receptor δ is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart 2010
    2010 The role of protein O-linked β-N-acetylglucosamine in mediating cardiac stress responses 2010
    2010 Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc 2010
    2010 Increased O-linked β-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats 2010
    2010 Protein O-GlcNAcylation: A critical regulator of the cellular response to stress 2010
    2009 Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal 2009
    2009 Direct Relationship Between Protein O-GlcNAcylation and the Cardiomyocyte Circadian Clock 2009
    2009 Increased Cardiomyocyte 0-linked-beta-N-acetylglucosamine (0-GlcNAc) Levels Induced by Glucose Deprivation Mediated by Decreased 0-GlcNAcase Expression and Reduced Hexosamine Biosynthesis Flux 2009
    2009 O-linked-beta-N-acetylglucosamine (O-GlcNAc) Mediated Ischemic Cardioprotection Associated with Increased O-GlcNAcylation of Cytoskeletal Z-Line Proteins 2009
    2009 Glucosamine increases hexosamine biosynthesis and O-linked N-acetylglucosamine in the heart, and leads to metabolic alterations similar to those seen in diabetic cardiomyopathy 2009
    2009 Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats 2009
    2009 Pugnac and Glucosamine Exaggerate Inflammatory and Vascular Injury Response in Balloon-Injured Rat Carotid Artery 2009
    2009 Abnormal autophagic response contributes to cardiac dysfunction in diabetic rat hearts following pressure overload 2009
    2009 Consumption of a western diet and the pancreatic O-GlcNAc response 2009
    2009 Glucose deprivation induced increase in O-GlcNAc levels in cardiomyocytes is not mediated via increased OGT expression 2009
    2009 Impaired cardiomyocyte autophagy in diabetes is associated with increased hexosamine biosynthesis and protein O-GlcNAc levels 2009
    2009 Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc dependent manner 2009
    2009 Pro-inflammatory effect of hyperglycemia in cultured macrophages and neonatal rat ventricular cardiomyocytes is blunted by inhibition of hexosamine biosynthesis 2009
    2009 Evidence of O-linked N-acetylglucosamine in diabetic nephropathy 2009
    2009 O-glycosylation is increased in diabetic nephropathy, both in the tubuli and in the glomeruli 2009
    2009 Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-κB signaling 2009
    2009 Interaction of diet and diabetes on cardiovascular function in rats 2009
    2009 MECHANISM OF CARDIOPROTECTION BY ESTROGEN (E2) FOLLOWING TRAUMA-HEMORRHAGE (T-H): UPREGULATION OF CARDIAC O-GLYCOSALATION 2009
    2009 Protein O-GlcNAcylation: A new signaling paradigm for the cardiovascular system 2009
    2008 Changes in O-linked N-acetylglucosamine is associated with diabetic nephropathy in the human kidney 2008
    2008 Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury 2008
    2008 Glucosamine inhibits TNF-alpha-induced inflammatory response in arterial SMCs 2008
    2008 Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2 2008
    2008 Imaging of cardiotoxicity 2008
    2008 Effect of ischemia-reperfusion on O-GlcNAcylation of specific proteins in isolated rat hearts 2008
    2008 Glucosamine Inhibits TNF-alpha -Induced Expression of Inflammatory Mediators In Rat Aortic Smooth Muscle Cells through Inhibition of NF kappa B Activation 2008
    2008 Hexosamine biosynthesis and protein O-glycosylation: The first line of defense against stress, ischemia, and trauma 2008
    2008 In isolated cardiomyocytes NF-kappa B activation is modulated by alterations in protein O-GlcNAc levels 2008
    2008 In the isolated perfused heart phenylephrine-induced activation of ERK is attenuated by glucosamine 2008
    2008 O-GLYCOSYLATION IS INCREASED IN THE TUBULI AND GLOMERULI OF PATIENTS WITH DIABETIC NEPHROPATHY 2008
    2008 O-GlcNAc agonist treatment improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats 2008
    2008 Pressure overload exacerbates insulin resistance in obesity and type 2 diabetes 2008
    2008 Regulation of cardiac substrate utilization by protein O-glycosylation 2008
    2008 Short term consumption of diets high in fat and/or sugar in young animals increase cardiovascular risk factors prior to the onset of obesity 2008
    2008 Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes 2008
    2008 Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats 2008
    2008 Direct Measurement of Bioenergetic Stress in Cardiomyocytes Exposed to Hydrogen Peroxide and Protection by O-Glcnac 2008
    2008 Mechanism of estradiol-mediated cardio-protection following trauma-hemorrhage: Upregulation of cardiac O-glycosylation/phosphorylation 2008
    2007 Glucosamine administration improves survival rate after severe hemorrhagic shock combined with trauma in rats 2007
    2007 Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis 2007
    2007 Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: Role of hydronephrosis 2007
    2007 Estrogen improves hepatic function following trauma-hemorrhage: Increased estrogen receptor-alpha expression and antioxidant activity 2007
    2007 Mechanism of the salutary effects of 17 beta-estradiol on cardiac function following trauma-hemorrhage: Inhibition of cardiomyocyte L-type calcium current (ICa-L) 2007
    2007 Regulation of cardiac substrate utilization by protein O-glycosylation 2007
    2007 Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation 2007
    2007 A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion 2007
    2007 Dietary consumption of saturated fats and simple sugars exacerbates systolic and diastolic dysfunction and abnormal LV remodeling in diabetic rats 2007
    2007 Glucosamine inhibits acute inflammatory mediator expression and neointima formation in balloon-injured rat carotid artery 2007
    2007 Glucosamine protects neonatal cardiomyocytes from IschemiaReperfusion injury through translocation of BCL2 family proteins 2007
    2007 Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart 2007
    2007 Overexpression of TRPC3 increases apoptosis in response to ischemia/reperfusion but not TNF-alpha in adult mouse cardiomyocytes 2007
    2007 The effect of aging on the hexosamine biosynthesis pathway and on O-linked N-acetylglucosamine levels in rats 2007
    2007 The protective effect of estrogen receptor (ER)-beta agonist on cardiac function following trauma-hemorrhage: Downregulation of cardiomyocyte L-type calcium current (ICa-L) 2007
    2007 The protective effect of glucosamine on cardiac function following trauma hemorrhage: Downregulation of cardiac NF-kappa B signaling 2007
    2007 The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels 2007
    2007 Z Increasing levels of O-linked N-acetylglucosamine (O-GlcNAc) on cardiac proteins during reperfusion improves recovery following ischemia/reperfusion and attenuates calpain-mediated proteolysis 2007
    2007 Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system 2007
    2007 Aging-related accumulation of O-glcnacylated proteins in the cardiovascular system. 2007
    2007 Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc 2007
    2007 Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels 2007
    2006 Glcosamine inhibits inflammatory response to tumor necrosis factor-alpha in vascular smooth muscle cells via augmentation of protein O-GlcNAcylation 2006
    2006 The role of O-GlcNAcylation in aging-related loss of estrogenic vasoprotection 2006
    2006 Protein O-glycosylation improves survival and effects cytokine release following trauma-hemorrhage in rats 2006
    2006 Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats 2006
    2006 Glucosamine administration during resuscitation improves organ function after trauma hemorrhage 2006
    2006 Glucosamine administration improves survival following trauma-hemorrhage in rats 2006
    2006 Increasing protein O-GlcNAc levels by inhibition of O-GlcNAcase improves cardiac function following trauma hemorrhage and resuscitation in rat 2006
    2006 Cardiovascular dysfunction is caused by pre-existing hydronephrosis in young lean, obese and diabetic Zucker rats 2006
    2006 Glutamine protects isolated rat heart from ischemia/reperfusion injury through the hexosamine biosynthesis pathway 2006
    2006 Impact of type-2 diabetes on the hexosamine biosynthesis pathway and protein O-glycosylation 2006
    2006 Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemia 2006
    2006 Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine 2006
    2005 Myocardial phenotyping using isotopomer analysis of metabolic fluxes 2005
    2005 Glucosamine-induced cardioprotection mediated by the hexosamine biosynthesis pathway and increased levels of O-linked N-acetylglucosamine on nucleocytoplasmic proteins 2005
    2005 Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats 2005
    2005 Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart 2005
    2005 Glucosamine improves recovery following trauma hemorrhage in rat 2005
    2005 Effects of glucosamine on the isolated rat heart 2005
    2005 O-linked N-acetylglucosamine modification of proteins protect isolated perfused rat heart from ischemia/reperfusion injury 2005
    2005 The effect of insulin resistance on the regulation of cardiac carbohydrate and fatty acid metabolism 2005
    2004 Protection from ischemic and hypovolemic injury by hyperglycemia transduced by hexosamine biosynthesis and O-linked N-acetylglucosamine on cytoplasmic proteins 2004
    2004 Diabetes and cardiac carbohydrate metabolism 2004
    2004 Diabetes, the hexosamine biosynthesis pathway and protein O-glycsoylation in the heart 2004
    2004 Impact of low-flow ischemia on substrate oxidation and glycolysis in the isolated perfused rat heart 2004
    2004 Increased carbohydrate oxidation and decreased fatty acid oxidation do not improve cardiac function after ischemia 2004
    2004 Oxidative and non-oxidative metabolic substrate fluxes in normal and ischemic rat heart 2004
    2004 Lactate isotopomer analysis by 1H NMR spectroscopy: Consideration of long-range nuclear spin-spin interactions 2004
    2004 Onset of diabetes in Zucker diabetic fatty (ZDF) rats leads to improved recovery of function after ischemia in the isolated perfused heart 2004
    2004 Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced Inotropy 2004
    2004 Ischemic cardiac protection of high glucose/high insulin is not due to increased glucose oxidation 2004
    2004 A critical perspective of the use of 13C-isotopomer analysis by GCMS and NMR as applied to cardiac metabolism 2004
    2004 Glucosamine provides protection from ischemia/reperfusion injury and calcium overload in isolated hearts and leads to an increase in O-linked glycosylation 2004
    2003 Increased oxidation of free fatty acids does not lead to increased susceptibility to ischemia in hearts from type-2 diabetic rats 2003
    2003 A comparison between NMR and GCMS 13 C-isotopomer analysis in cardiac metabolism 2003
    2003 Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart 2003
    2003 Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart. 2003
    2003 Metabolic substrate utilization in isolated rat heart during low flow ischemia determined by C-13 NMR spectroscopy 2003
    2002 Differential modulation of lactate, pyruvate and glucose oxidation by insulin and dichloroacetate 2002
    2002 IGF-I promotes a shift in metabolic flux in vascular smooth muscle cells 2002
    2002 IGF-I promotes a shift in metabolic flux in vascular smooth muscle cells. 2002
    2002 Lactate - The forgotten fuel! 2002
    2002 Lactate -- the forgotten fuel! 2002
    2002 08 Altered substrate provision and cardiac function during ischemia and reperfusion 2002
    2002 11 Type-2 diabetes leads to improved recovery of myocardial ischemia/reperfusion injury 2002
    2002 Cardiac carbohydrate metabolism in Zucker diabetic fatty rats 2002
    2002 Type 2 diabetes leads to progressive impairment of cardiac contractility 2002
    2002 An increase in the myocardial PCr/ATP ratio in GLUT4 null mice 2002
    2002 Regulation of carbohydrate metabolism in perfused rat heart 2002
    2002 Type 2 diabetes impairs cardiac function but does not increase susceptibility to low flow ischemia 2002
    2002 An increase in the myocardial PCr/ATP ratio in GLUT4 null mice. 2002
    2001 Evidence of separate pathways for lactate uptake and release by the perfused rat heart 2001
    2001 Evidence of separate pathways for lactate uptake and release by the perfused rat heart. 2001
    2001 Changes in cardiac metabolism precede development of contractile dysfunction in Type 2 diabetes 2001
    2001 Glutamate and glutamine exchange in the isolated perfused rat heart. 2001
    2001 Upregulation of GLUT1 and IGF-1 in vascular smooth muscle cells (VSMC) stimulates glucose metabolism: Potential role of metabolic regulation in neointimal lesion formation. 2001
    2001 Nuclear magnetic resonance spectroscopy and imaging in animal research 2001
    2001 Upregulation of glucose metabolism during intimal lesion formation is coupled to the inhibition of vascular smooth muscle cell apoptosis: Role of GSK3β 2001
    2000 Preservation of glucose metabolism in hypertrophic GLUT4-null hearts 2000
    2000 Preservation of glucose metabolism in hypertrophic GLUT4-null hearts. 2000
    1999 Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: A pilot study 1999
    1999 Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidation 1999
    1999 Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidation 1999
    1999 Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidation. 1999
    1999 Preferential inhibition of lactate oxidation relative to glucose oxidation in the rat heart following diabetes 1999
    1999 Altered liver ATP metabolism in human nonalcoholic steatohepatitis (NASH). 1999
    1999 Influence of palmitate on lactate uptake and efflux in hearts from control and diabetic rats. 1999
    1999 Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion 1999
    1999 Lactic acid and protein interactions: Implications for the NMR visibility of lactate in biological systems 1999
    1998 In vivo cardiac energetics in GLUT4-null mice 1998
    1997 Effect of ischemia and reperfusion on substrate selection in the blood-perfused working rabbit heart 1997
    1997 Fatty acid and lactate oxidation in control and diabetic rat hearts 1997
    1997 Relationship between cardiac function and substrate oxidation in hearts of diabetic rats 1997
    1997 Relationship between cardiac function and substrate oxidation in hearts of diabetic rats 1997
    1997 Relationship between cardiac function and substrate oxidation in hearts of diabetic rats 1997
    1997 Relationship between cardiac function and substrate oxidation in hearts of diabetic rats. 1997
    1997 The effects of hypertrophy and diabetes on cardiac pyruvate dehydrogenase activity 1997
    1996 Acute L-triiodothyronine administration potentiates inotropic responses to β-adrenergic stimulation in the isolated perfused rat heart 1996
    1996 The effects of diabetes on glucose and lactate oxidation in isolated rat hearts by C-13-NMR spectroscopy. 1996
    1996 Metabolic compartmentation of lactate in the glucose-perfused rat heart 1996
    1996 Metabolic compartmentation of lactate in the glucose-perfused rat heart 1996
    1996 Metabolic compartmentation of lactate in the glucose-perfused rat heart. 1996
    1995 EFFECT OF D-BETA-HYDROXYBUTYRATE UPON FATTY-ACID AND GLUCOSE-OXIDATION IN THE ISOLATED RAT-HEART - ASSESSMENT USING C-13-NMR SPECTROSCOPY 1995
    1995 Calculation of absolute metabolic flux and the elucidation of the pathways of glutamate labeling in perfused rat heart by 13C NMR spectroscopy and nonlinear least squares analysis 1995
    1995 Cerebral metabolites in patients with acute and subacute strokes: Concentrations determined by quantitative proton MR spectroscopy 1995
    1994 CALCULATION OF ABSOLUTE METABOLIC FLUXES IN THE PERFUSED RAT-HEART BY C-13 NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY 1994
    1994 Glucose metabolism in RIF‐1 tumors after reduction in blood flow: An in Vivo 13C and 31P NMR study 1994
    1994 Quantitative proton spectroscopy of canine brain: in Vivo and in Vitro correlations 1994
    1993 A 13C-NMR study of glucose oxidation in the intact functioning rat heart following diabetes-induced cardiomyopathy 1993
    1993 Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference 1993
    1993 Quantitative proton spectroscopy and histology of a canine brain tumor model 1993
    1992 ALTERATIONS IN MYOCARDIAL GLUCOSE-METABOLISM IN DIABETES-INDUCED HEART-FAILURE 1992
    1992 Altered glucose metabolism in adriamycin-induced heart failure 1992
    1992 Energy metabolism, pH changes, and lactate production in RIF-1 tumors following intratumoral injection of glucose 1992
    1991 In Vivo13C NMR spectroscopy of glucose metabolism of RIF-1 tumors 1991
    1991 High‐resolution 1H NMR imaging of regional ischemia in the isolated perfused rabbit heart at 4.7 T 1991
    1991 In Vivo 13C NMR spectroscopy of glucose metabolism of RIF‐1 tumors 1991
    1990 Sleep-related focal motor seizures in bilateral central macrogyria. 1990
    1990 31P NMR of mammalian cells encapsulated in alginate gels utilizing a new phosphate‐free perfusion medium 1990
    1990 31P chemical shift imaging of the regionally ischemic perfused heart 1990
    1990 Echo planar imaging of isolated perfused rat hearts at 4.7 T: A comparison of Langendorff and working heart preparations 1990
    1990 Effects of repeated low calcium perfusion on the rat heart: A grandual induction of calcium related damage 1990
    1990 Phosphorus magnetic resonance spectroscopy of patients with mitochondrial cytopathies demonstrates decreased levels of brain phosphocreatine 1990
    1990 Reply 1990
    1990 The relationship between cardiac function and metabolism in acute adriamycin-treated perfused rat hearts studied by 31P and 13C NMR spectroscopy 1990
    1989 Functional and metabolic analysis of vasopressin-induced coronary artery spasm in the isolated perfused working rabbit heart 1989
    1989 The metabolic consequences of hydroperoxide perfusion on the isolated rat heart 1989
    1988 Inhibition of glucose phosphorylation by fatty acids in the perfused rat heart 1988
    1988 Depletion of myocardial glutathione: Its effects on heart function and metabolism during ischaemia and reperfusion 1988
    1985 Studies of the protective effect of ribose in myocardial ischaemia by using 31P-nuclear-magnetic-resonance spectroscopy 1985

    Research Overview

  • His recent research has focused on the role of the glucose-dependent, post-translational modifications of proteins by O-linked beta-N-acetylglucosamine moiety (O-GlcNAc) in mediating cardiomyocyte stress responses. Work from his laboratory has demonstrated that acute increases of O-GlcNAc levels are cardioprotective; conversely, in the setting of diabetes where O-GlcNAc levels are chronically elevated cardiomyocytes cell survival pathways such as autophagy are impaired in an O-GlcNAc dependent manner. Additional interests include the role of store-operated calcium entry (SOCE) in cardiomyocytes and how this is regulated by O-GlcNAc.
  • Investigator On

  • Circadian Regulation of Vascular Aging  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2022
  • Aberrant Circadian Regulation Of Autophagy In The Heart During Diabetes  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2022
  • Rapid modulation of hippocampal GABAergic Inhibition by O-GlcNAcylation  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2019 - 2021
  • O-GlcNAc Regulation of Protein Clearance in the Context of AD and DLB  awarded by National Institute on Aging/NIH/DHHS 2019 - 2020
  • O-GlcNAcylation Regulates Vascular Smooth Muscle Cells in Diabetic Vasculopathy  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • O-GlcNAcylation and Hippocampal Synaptic Plasticity  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2011 - 2017
  • The Role of PPARdelta Signaling in Diabetic Cardiomyopathy  awarded by American Diabetes Association, Inc. 2012 - 2016
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2015
  • Influence of the Cardiomyocyte Circadian Clock on Cardiac Hypertrophy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2012 - 2015
  • Exploring Barriers to PHER Grant Fund Expenditures  awarded by CDC - Centers for Disease Control and Prevention/DHHS 2011 - 2012
  • SCCOR in Cardiac Dysfunction and Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2005 - 2010
  • Full Name

  • John Chatham