• James Bibb received bachelor’s and master’s degrees with honors from Murray State University and the University of Kentucky, respectively. He worked in the Cell Biology and Physiology Department at Washington University in St. Louis before completing his doctorate in cellular and developmental biology at the State University of New York at Stony Brook. His doctoral thesis characterized the poliovirus receptor protein in Eckard Wimmer’s laboratory. Dr. Bibb’s postdoctoral training was conducted in the Laboratory on Molecular and Cellular Neuroscience at the Rockefeller University under the direction of Paul Greengard. His work on the regulation of dopamine neurotransmission was cited in the Nobel Prize in Physiology for Medicine in 2000. From 2001 to 2015 Dr. Bibb was a principal investigator and tenured faculty in the Psychiatry and Neurology and Neurotherapeutics Departments The University of Texas Southwestern Medical Center in Dallas. His lab focuses on signal transduction as it pertains to cognition, neurological and neuropsychiatric disorders, and cancer.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Anti-SSTR2 antibody-drug conjugate for neuroendocrine tumor therapyCancer Gene Therapy2020
    2020 Non-toxic fragment of botulinum neurotoxin type A and monomethyl auristatin E conjugate for targeted therapy for neuroendocrine tumorsCancer Gene Therapy2020
    2019 Management of Gastrointestinal Neuroendocrine TumorsClinical Medicine Insights : Endocrinology and Diabetes.  12. 2019
    2013 The Role of Cdk5 in Neuroendocrine Thyroid CancerCancer Cell.  24:499-511. 2013
    2013 Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formationDevelopmental Biology.  378:94-106. 2013
    2011 Striatal signal transduction and drug addictionFrontiers in Neuroanatomy2011
    2011 The role of Cdk5 in cognition and neuropsychiatric and neurological pathologyBrain Research Bulletin.  85:9-13. 2011
    2011 Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heartCirculation Research.  108:437-445. 2011
    2010 Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35Biological Psychiatry.  68:1163-1171. 2010
    2008 Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C 2008
    2007 Alternative roles for Cdk5 in learning and synaptic plasticityBiotechnology Journal.  2:941-948. 2007
    2007 Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signalingBrain Research.  1129:1-14. 2007
    2005 Decoding Dopamine SignalingCell.  122:153-155. 2005
    2004 Role of Cdk5 in drug abuse and plasticityAnnals of the New York Academy of Sciences.  1025:335-344. 2004
    1995 The Human Poliovirus Receptor: Receptor‐Virus Interaction and Parameters of Disease SpecificityAnnals of the New York Academy of Sciences.  753:19-36. 1995
    1990 Functional analysis of the modes of anion transport in neutrophils and HL-60 cellsAnnual Review of Physiology.  52:381-397. 1990


    Year Title Altmetric
    2012 Serine and Threonine Phosphorylation.  467-492. 2012

    Research Overview

  • Dr. Bibb's research is aimed broadly at understanding the mechanistic basis of cellular functions and disease with emphasis on features of intracellular signal transduction and protein phosphorylation/dephosphorylation. Multidisciplinary approaches and advanced technologies are combined to identify signaling mechanisms and characterize their physiological functions, from basic molecular interactions to behavior or disease. This research has revealed, for example, common features between brain circuitry function, neuronal injury and oncogenesis. His goals are to import clinical information and perspectives into the lab, model and explore disease causes and then return new treatment approaches and solutions to help patients.
  • Education And Training

  • Doctor of Philosophy in Cell / Cellular Biology and Anatomical Sciences, State University of New York System : Stony Brook 1994
  • Full Name

  • James Bibb