Positions

Overview

  • I graduated from Yonsei University, Seoul, Korea with B.S and M.S degrees in Nutrition and Biochemistry, respectively. I have broad training and extensive experience in area spanning regulation of gene transcription, signal transduction, cell biology, metabolic and vascular animal physiology, and translational studies with an eye towards therapeutic discovery for human diseases. While in graduate school at Iowa State University and during post-doctoral training at Penn State University, I focused on elucidating mechanisms for transcriptional activation. of cAMP responsive element binding protein (CREB) to regulate glucose metabolism in the liver. I received the second post-doctoral training with Dr. Michael Quon in the Diabetes Unit, NIH. Here, I developed deep expertise in signal transduction, particularly related to insulin action and endothelial function. I also gained a more thorough understanding of animal and human physiology and pathophsyiology related to diabetes, obesity, and their cardiovascular complications. After post-doctoral training, I obtained an independent position at the University of Missouri, Columbia. While at Missouri, I expanded my research from basic science to animal physiology and translational research. Since 2010, I have been appointed as a tenure-track Assistant Professor at the University of Alabama, Birmingham (UAB).
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents.Diabetes.  67:2157-2166. 2018
    2018 Nanomatrix Coated Stent Enhances Endothelialization but Reduces Platelet, Smooth Muscle Cell, and Monocyte Adhesion under Physiologic ConditionsACS Biomaterials Science and Engineering.  4:107-115. 2018
    2017 Encapsulation of Human Islets Using a Biomimetic Self-Assembled Nanomatrix Gel for Protection against Cellular Inflammatory ResponsesACS Biomaterials Science and Engineering.  3:2110-2119. 2017
    2017 Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity.Immunity, Inflammation and Disease.  5:526-540. 2017
    2016 Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid.European Journal of Pharmacology.  785:24-35. 2016
    2016 Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo.ACS Applied Materials and Interfaces.  8:5178-5187. 2016
    2015 Toll-like receptor 4-induced endoplasmic reticulum stress contributes to impairment of vasodilator action of insulin.AJP - Endocrinology and Metabolism.  309:E767-E776. 2015
    2015 Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate.Current Medicinal Chemistry.  22:59-69. 2015
    2014 Enhanced MIN-6 beta cell survival and function on a nitric oxide-releasing peptide amphiphile nanomatrix.International Journal of Nanomedicine.  9 Suppl 1:13-21. 2014
    2014 New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate.Redox Biology.  2:187-195. 2014
    2013 Effects of the green tea polyphenol epigallocatechin-3-gallate on high-fat diet-induced insulin resistance and endothelial dysfunction.AJP - Endocrinology and Metabolism.  305:E1444-E1451. 2013
    2013 Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.Journal of Biological Chemistry.  288:22693-22705. 2013
    2013 Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin.AJP - Endocrinology and Metabolism.  304:E1077-E1088. 2013
    2012 Extracellular conversion of adiponectin hexamers into trimers.Bioscience Reports.  32:641-652. 2012
    2012 Role of lipotoxicity in endothelial dysfunction.Heart Failure Clinics.  8:589-607. 2012
    2012 Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation.AJP - Endocrinology and Metabolism.  302:E201-E208. 2012
    2011 Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.Journal of Clinical Endocrinology and Metabolism.  96:E782-E792. 2011
    2010 Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat.Hypertension.  55:880-888. 2010
    2010 Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1.Endocrinology.  151:103-114. 2010
    2008 Mechanisms underlying beneficial health effects of tea catechins to improve insulin resistance and endothelial dysfunction.Endocrine, Metabolic and Immune Disorders - Drug Targets.  8:82-88. 2008
    2008 Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.Endocrinology.  149:2451-2458. 2008
    2008 Role of mitochondrial dysfunction in insulin resistance.Circulation Research.  102:401-414. 2008
    2007 Additive beneficial cardiovascular and metabolic effects of combination therapy with ramipril and candesartan in hypertensive patients.European Heart Journal.  28:1440-1447. 2007
    2007 Efonidipine simultaneously improves blood pressure, endothelial function, and metabolic parameters in nondiabetic patients with hypertension.Diabetes Care.  30:1605-1607. 2007
    2007 Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn.Journal of Biological Chemistry.  282:13736-13745. 2007
    2007 EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR.AJP - Endocrinology and Metabolism.  292:E1378-E1387. 2007
    2007 Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells.AJP - Endocrinology and Metabolism.  292:E756-E764. 2007
    2007 Adiponectin and cardiovascular disease: response to therapeutic interventions.Journal of the American College of Cardiology.  49:531-538. 2007
    2006 PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function.Biochemical and Biophysical Research Communications.  349:976-986. 2006
    2006 Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium.Molecular Endocrinology -Baltimore-.  20:1153-1163. 2006
    2006 Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.Circulation.  113:1888-1904. 2006
    2006 Vascular and metabolic effects of candesartan: insights from therapeutic interventions.Journal of Hypertension -Supplement-.  24:S31-S38. 2006
    2006 Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic hypertensive patients.Diabetes Care.  29:195-201. 2006
    2005 Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance.Journal of Biological Chemistry.  280:23173-23183. 2005
    2005 The union of vascular and metabolic actions of insulin in sickness and in health.Arteriosclerosis, Thrombosis, and Vascular Biology.  25:889-891. 2005
    2005 Monocrotaline-induced pulmonary hypertension correlates with upregulation of connective tissue growth factor expression in the lung.Experimental and Molecular Medicine EMM.  37:27-35. 2005
    2004 Aldosterone upregulates connective tissue growth factor gene expression via p38 MAPK pathway and mineralocorticoid receptor in ventricular myocytes.Journal of Korean Medical Science.  19:805-811. 2004
    2004 A novel ex vivo angiogenesis assay based on electroporation-mediated delivery of naked plasmid DNA to skeletal muscle.Molecular Therapy.  9:464-474. 2004
    2003 Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve.Investigative Ophthalmology & Visual Science.  44:1747-1752. 2003
    2002 Optimal salt concentration of vehicle for plasmid DNA enhances gene transfer mediated by electroporation.Experimental and Molecular Medicine EMM.  34:265-272. 2002
    2002 Intraperitoneal gene delivery mediated by a novel cationic liposome in a peritoneal disseminated ovarian cancer model.Gene Therapy.  9:859-866. 2002
    2002 Activation of caspase-3 during degeneration of the outer nuclear layer in the rd mouse retina.Ophthalmic Research.  34:150-157. 2002
    2001 Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells.Biochemical Journal.  358:41-48. 2001
    2001 Hydrogen peroxide is a novel inducer of connective tissue growth factor.Biochemical and Biophysical Research Communications.  284:966-971. 2001
    2001 Downregulated expression of integrin alpha6 by transforming growth factor-beta(1) on lens epithelial cells in vitro.Biochemical and Biophysical Research Communications.  284:33-41. 2001
    2001 Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB, independently of CREB phosphorylation.Molecular and Cellular Biology.  21:1001-1010. 2001
    2000 Failure to activate NF-kappaB promotes apoptosis of retinal ganglion cells following optic nerve transection.Brain Research.  883:60-68. 2000
    2000 Identification of Brucella abortus OxyR and its role in control of catalase expression.Journal of Bacteriology.  182:5631-5633. 2000
    2000 Regulation of Brucella abortus catalase.Infection and Immunity.  68:3861-3866. 2000
    1997 Brucella abortus arginase and ornithine cyclodeaminase genes are similar to Ti plasmid arginase and ornithine cyclodeaminase.BBA - Biochimica et Biophysica Acta.  1354:55-57. 1997
    1996 Ultrastructure of subcapsular lens epithelial cells in various kinds of cataractous lensInvestigative Ophthalmology & Visual Science.  37. 1996

    Research Overview

  • My research area focuses on understanding the mechanisms of insulin resistance and endothelial dysfunction. This includes identification and characterization of molecules that are responsible for the saturated fatty acid-mediated inflammatory response in the vasculature that contribute to impairment of insulin signaling and cardiometabolic functions. The research project involves molecular, cellular, and pharmacological tools to investigate physiological roles of eNOS/NO in vasodilation and metabolism. Second research project is to understand the role of vascular autophagy in nutrient metabolism. Since autophagy is one of the essential cellular process in normal and stress conditions, uncovering the roles of vascular autophagy in metabolic disorders will provide additional information to elucidate the relationship between vascular function and metabolism. These projects will help better understanding of physiology and pathophysiology of cross-talk between multiple tissues via vascular endothelium. That being said, we are working on developing pharmacological and molecular strategies to improve public health regarding metabolic disorders.
  • Education And Training

  • Doctor of Philosophy in Genetics, Iowa State University
  • Full Name

  • Jeonga Kim
  • Blazerid

  • jakim